Conventional Suspension Research Articles

Optimization of Dynamic Characteristics of Rubber-Based SMA Composite Dampers Using Multi-Body Dynamics and Response Surface Methodology

The suspension system of a commercial vehicle cab plays a crucial role in enhancing ride comfort by mitigating vibrations. However, conventional rubber suspension systems have relatively fixed stiffness and damping properties, rendering them inflexible to load variations and resulting in suboptimal ride comfort under extreme road conditions. Shape memory alloys (SMAs) represent an innovative class of intelligent materials characterized by superelasticity, shape memory effects, and high damping properties. Recent advancements in materials science and engineering technology have focused on rubber-based SMA composite dampers due to their adjustable stiffness and damping through temperature or strain rate. This paper investigates how various structural parameters affect the stiffness and damping characteristics of sleeve-type rubber-based SMA composite vibration dampers. We developed a six-degree-of-freedom vibration differential equation and an Adams multi-body dynamics model for the rubber-based SMA suspension system in commercial vehicle cabins. We validated the model’s reliability through theoretical analysis and simulation comparisons. To achieve a 45% increase in stiffness and a 64.5% increase in damping, we optimized the suspension system’s z-axis stiffness and damping parameters under different operating conditions. This optimization aimed to minimize the z-axis vibration acceleration at the driver’s seat. We employed response surface methodology to design the composite shock absorber structure and then conducted a comparative analysis of the vibration reduction performance of the optimized front and rear suspension systems. This study provides significant theoretical foundations and practical guidelines for enhancing the performance of commercial vehicle cab suspension systems.

Conventional suspension delivery versus tattooing pen-assistedsuspension delivery in non-cultured epidermal cell suspension procedure for vitiligo: A randomized controlled trial.

Non-cultured epidermal suspension (NCES) is one of the most widely used surgical therapy for stable vitiligo patients in which recipient size preparation plays an important role in the outcome of NCES. The primary objective is to evaluate and compare the efficacy and safety of conventional suspension delivery after manual dermabrasion (CSMD) versus tattooing pen-assisted suspension delivery (TPSD) in NCES. Paired vitiligo units (VU) in 36 patients, matched with respect to size and location were divided into two groups. The VU in Group 1 underwent suspension delivery by CSMD while the VU in Group 2 underwent same by TPSD. All the VU were followed up at regular intervals until 24 weeks. At the end of 24 weeks, 31 VU (86.1%) in Group 1 achieved >75% repigmentation which was significantly higher (p = .02, chi-square test) as compared to 22 VU (61.1%) in Group 2. The color matching in both the groups VU was also comparable (p = .84, chi-square test). The patient global assessment (PGA) was significantly higher in Group 1 VU as compared to Group 2. Treatment response in terms of repigmentation and PGA was significantly better in VU treated with CSMD as compared to TPSD. Recipient site complications were seen more commonly in Group 1 VU as compared to Group 2. Perilesional halo at the recipient site was seen in none of the VU in Group 2 which was significantly lower than 6 VU in Group 1 than (p = .02, chi-square test). Better results may be possible with technical improvisations in tattooing pen needle diameter and depth of penetration.

Review Paper on Development of Mini Refrigerator

Abstract: This project focuses on the innovative development of a regenerative magnetic suspension system that uses permanent magnets to capture energy from the vibrations and movements of vehicles, aiming to improve energy efficiency and sustainability within the automotive sector. Unlike conventional suspension systems that dissipate energy as heat, this design utilizes highperformance neodymium magnets and wound copper coils to convert mechanical energy into electrical energy via electromagnetic induction as the vehicle moves across varying terrains. The energy recovered through this process can potentially power auxiliary vehicle systems such as sensors, lights, and infotainment units, thereby contributing to overall vehicle efficiency. Preliminary simulations and calculations indicate a substantial potential for energy recovery, positioning the system as a cost-effective and practical solution that can be integrated into existing vehicle architectures with minimal modifications. By leveraging readily available materials, this project addresses the challenges of energy waste in conventional suspensions while promoting sustainable practices. The research not only advances regenerative technologies within the automotive industry but also paves the way for future innovations in vehicle design and broader engineering applications

Adaptive robust constraint-following control method for improving carbody hunting stability of high-speed trains

The low-frequency carbody hunting motion of high-speed trains (HSTs) frequently occurs due to the complex operating environment and deterioration of wheel–rail contact conditions. It not only affects ride comfort but also poses a risk of derailment safety accidents for HSTs. In such scenarios, traditional passive suspension systems struggle to ensure satisfactory dynamic performance of HSTs. However, active suspension systems can offer an effective solution. To enhance the low-frequency carbody hunting stability and environmental adaptability of HSTs, this study proposes a novel adaptive robust displacement inequality constraint following control (AICFC) method for active suspension utilising the beneficial nonlinearity inspired by bio-inspired structures (BIS). The effectiveness of the proposed AICFC-BIS method is validated through numerical simulations comparing it with other control strategies. Simulation results show that the AICFC-BIS method can effectively suppress low-frequency carbody hunting motion and improve the dynamic performance of HSTs. Compared with conventional passive suspensions and other active suspensions, HSTs equipped with AICFC-BIS active suspension exhibit significantly reduced operational safety risk and improved ride comfort indices while being energy efficient.

Enhancing exemestane delivery: Solid lipid nanoparticles formulation and pharmacokinetic evaluation

This research investigates the development of exemestane (EXM) solid lipid nanoparticles (SLNs) for the purpose of improving drug delivery. To prepare EXM SLNs, glycerol monostearate was used as the lipid and Tween 80 as the surfactant and solvent injection followed by high-pressure homogenization as a method of preparation. The formulation parameters were optimized, leading to the development of a promising formula. The formula has a particle size of 188.72 ± 5.62 nm, a polydispersity index (PDI) of 0.215 ± 0.023, and an %EE of 65.39 ± 2.54 %. The formulation's robustness was indicated by minimal changes in particle size and %EE over 30 days, as revealed by stability studies. The bioavailability of EXM SLNs was found to be significantly improved in Wistar rats compared to conventional EXM suspension, as shown by pharmacokinetic studies. The formula that was optimized showed a higher maximum plasma concentration (Cmax) of 168.92 ± 2.40 ng/mL, a delayed time to reach Cmax (Tmax) of 4 hours, and significantly higher area under the curve (AUC) values. These results highlight the effectiveness of the optimized formula in improving drug absorption and bioavailability. The findings indicate that EXM SLNs show potential for enhancing the delivery and effectiveness of EXM, specifically in the treatment of breast cancer.

Integrating machine vision in the development of automatic mounting system for massive electroplating components

Abstract The traditional industrial electroplating parts manufacturing process typically relies on manual labour to suspend them in the electroplating tank, requiring a significant amount of manual work. However, due to a shortage of manpower and frequent staff turnover, this has posed challenges to production efficiency. Therefore, this research proposes an automated mounting system by integrating machine vision technology and the development of robotic arms to replace the conventional manual suspension method. The automated mounting system initially separates individual ring-shaped electroplating components using a disk vibratory feeder. Subsequently, it utilizes a unidirectional reciprocating mechanism and infrared detection to position these electroplating components onto a backlit panel. Then, the IDS uEye XS2 autofocus camera captures images, and in conjunction with machine vision technology, rapidly determines the position, characteristics, and orientation of these ring components. Finally, through TCP communication protocol, commands for gripping points are transmitted to the robotic arm, which uses electromagnetic valves on the arm to pick up the components and suspend them onto the hanger using an optimized path. The final test results demonstrate that the automated installation system can complete 14 installation operations per minute, effectively reducing the time and cost associated with manual labour, significantly enhancing the production output of the assembly line. Therefore, this study combines machine vision technology to propose a solution for the automated installation system of large-scale electroplating components.

Design, pharmacokinetic, and pharmacodynamic evaluation of a lecithin-chitosan hybrid nanoparticle-loaded dual-responsive in situ gel of nebivolol for effective treatment of glaucoma

In this research work, optimized nebivolol-loaded lecithin-chitosan hybrid nanoparticles (NEB-LCNPs) were prepared using sequential screening and optimization designs. The design of experiments software (DoE) was used to obtain a robust formulation that can improve ocular delivery of the NEB in the treatment of glaucoma. The optimized NEB-LCNPs had a mean particle size of 170.5 ± 5.3 nm and drug loading of 10.5 ± 1.2%. These were further loaded in a dual-responsive in situ gel, designed and reported previously by our group. The NEB-LCNPs loaded in situ gel (NEB-LCNPs-ISG) was characterized for physicochemical properties, rheological behavior, stability, in vitro dissolution, and ocular in vivo studies. The ocular pharmacokinetics showed that NEB-LCNPs-ISG had two-fold higher aqueous humor exposure with AUC0–tlast of 375.4 ng × h/mL and sustained drug concentrations for longer durations (1.7-folds higher duration with a mean residence time of 10.6 h) in comparison to a conventional aqueous suspension of NEB (NEB-Susp). Similarly, the pharmacodynamic study showed that NEB-LCNPs-ISG resulted in a higher percentage reduction in intraocular pressure (% ΔIOP) of 28.1 ± 1.8% × h, which was 2.2-times higher reduction compared to NEB-Susp (74.2 ± 3.2% × h). In addition, the pharmacodynamic effect was more sustained with a mean response time of 11.3 ± 0.2 h, a 2.8-times higher response time compared to NEB-Susp (4.06 ± 0.3 h). These results suggest that NEB-LCNPs-ISG was more effective than the conventional aqueous suspension of NEB in the treatment of glaucoma.

Integrating of LMIs with Buckingham Π theorem for control of uncertain oscillating systems

This paper introduces a novel framework for robust controller synthesis in oscillating systems by synergistically combining generalized linear matrix inequalities (GLMIs) with the Buckingham Π theorem. The primary goal is to enhance the design of robust controllers for systems with uncertain parameters through the exploitation of dimensionless groups derived from the Buckingham Π theorem. By establishing a dimensionless state-space representation, the proposed approach demonstrates adaptability to a broad spectrum of similar systems. The LMI-based formulation facilitates the systematic design of controllers capable of effectively mitigating the impact of parametric uncertainties. Simulation results for an uncertain inverted pendulum and a vehicle active suspension system validate the superior performance of the proposed method compared to conventional control techniques, such as MPC, LQG, SMC, PID, and LQR. For the uncertain inverted pendulum system, the proposed robust control scheme achieves a cart position stabilization in 5.35 s and pendulum stabilization in 6.3 s, which is faster than standard control algorithms. In the context of the vehicle active suspension system, the performance indices for sprung mass acceleration, suspension deflection, and tire deflection are 0.19, 0.47, and 0.07, respectively. These values indicate significant reductions when compared to conventional passive suspension systems and standard robust control methodologies.

Design and evaluation of self-tuning optimal control for vibration suppression of magnetorheological semi-active suspension

The objective of this paper is to enhance the vibration damping capabilities of magnetorheological (MR) semi-active suspension by utilizing a self-tuning LQG control method. Firstly, to determine the mechanical model of MR damper using the hyperbolic tangent model, mechanical experiments were performed with a damping force test machine under various input excitations. Experimental and simulation data were compared to confirm the accuracy of the mechanical model for MR damper. The MR damper is then incorporated into the vehicle’s semi-active suspension system to create a quarter-car suspension model. In order to tackle the problems associated with low control accuracy and poor dynamic adjustment in traditional LQG controllers where the weighting matrix coefficients are difficult to determine, a self-tuning LQG controller based on gravity search algorithm (GSA-LQG) was designed. Finally, the designed controller performance was evaluated by the simulation and experimental results obtained from the random and sinusoidal excitation roads. Experimental data reveal that when subjected to GSA-LQG control, the suspension control performance is considerably enhanced compared to the passive control, PID control and conventional LQG control suspension. Based on these outcome, it can be concluded that the proposed algorithm is effective and the experimental platform is feasible.

Tradeoff analysis of the energy-harvesting vehicle suspension system employing inerter element

This paper explores the vibration isolation performance and vibration energy recovery performance of an energy-harvesting vehicle suspension system employing inerter element. The study takes into account the structural changes in the suspension caused by introducing the inerter as a new type of vibration isolation element. According to the parallel-series combination of an inerter and a damper, two different structures of energy-harvesting suspension dynamic models are constructed. The mechanism of the suspension parameter uptake on vehicle ride comfort and energy-harvesting characteristics is analyzed. A multi-objective optimal design method for the energy-harvesting vehicle suspension system employing inerter element is proposed, which considers both vehicle ride comfort and energy-harvesting characteristics. A trade-off was found between suspension isolation performance and energy-harvesting efficiency. The results indicate that various structures of energy-harvesting vehicle suspension systems employing inerter element exhibit different vibration isolation performances. Compared with the conventional energy-harvesting suspension, the series structure reduces body acceleration by 15.9 %, and the root mean square (RMS) of energy-harvesting power of the suspension is 22.2 W. The parallel structure reduces the RMS of body acceleration by 14.3 % and the RMS of energy-harvesting efficiency is 56.3 %, with the RMS energy-harvesting power of 84.9 W. The parallel structure demonstrates superior overall performance.

Proof of Concept of an All-in-One System for Measuring Hepatic Influx, Egress, and Metabolic Clearance Based on the Extended Clearance Concept.

Hepatic clearance (CLH ) prediction is a critical parameter to estimate human dose. However, CLH underpredictions are common, especially for slowly metabolized drugs, and may be attributable to drug properties that pose challenges for conventional in vitro absorption, distribution, metabolism, and elimination (ADME) assays, resulting in nonvalid data, which prevents in vitro to in vivo extrapolation and CLH predictions. Other processes, including hepatocyte and biliary distribution via transporters, can also play significant roles in CLH Recent advances in understanding the interplay of metabolism and drug transport for clearance processes have aided in developing the extended clearance model. In this study, we demonstrate proof of concept of a novel two-step assay enabling the measurement of multiple kinetic parameters from a single experiment in plated human primary hepatocytes with and without transporter and cytochrome P450 inhibitors-the hepatocyte uptake and loss assay (HUpLA). HUpLA accurately predicted the CLH of eight of the nine drugs (within twofold of the observed CLH ). Distribution clearances were within threefold of observed literature values in standard uptake and efflux assays. In comparison, the conventional suspension hepatocyte stability assay poorly predicted the CLH The CLH of only two drugs was predicted within twofold of the observed CLH Therefore, HUpLA is advantageous by enabling the measurement of enzymatic and transport processes concurrently within the same system, alleviating the need for applying scaling factors independently. The use of primary human hepatocytes enables physiologically relevant exploration of transporter-enzyme interplay. Most importantly, HUpLA shows promise as a sensitive measure for low-turnover drugs. Further evaluation across different drug characteristics is needed to demonstrate method robustness. SIGNIFICANCE STATEMENT: The hepatocyte uptake and loss assay involves measuring four commonly derived in vitro hepatic clearance endpoints. Since endpoints are generated within a single test system, it blunts experimental error originating from assays otherwise conducted independently. A key advantage is the concept of removing drug-containing media following intracellular drug loading, enabling the measurement of drug reappearance rate in media as well as the measurement of loss of total drug in the test system unencumbered by background quantities of drug in media otherwise present in a conventional assay.

Vibration damping by enhancing of magneto-rheological damper performance using novel smart fluid

The objective of the present work is to improve the speed and vibration characteristics of tracked vehicles via a semi-active suspension system that uses a Magneto-Rheological (MR) damper. MR damper is designed, manufactured, and tested with different harmonic excitations. The MR damper reliability under high-frequency stresses is considered in the mechanical design phase as well as the configurations and dimensions of the damper. Two fluid samples DELTA and GAMA are prepared, which differ in carrier fluid dynamic viscosities to have different rheological properties and tested to determine the dynamic characteristics of the damper. The damper’s ability to isolate vibration is measured by MTS. The investigation performed not only clarifies MR fluid characteristics but also proves the fact that the fluid is non-Newtonian with good rheological properties. One of the two fluid samples called DELTA is found to have the required properties. The MR damper filled with this DELTA shows a significant increase in damping force according to the excitation current and is much higher than the conventional passive suspension damping force. The proposed damper can cope with the increase in both magnitude and frequency of the input, which represents the speed of the truck and roughness of the road. Upgrading the suspension system of the vehicle from a passive damper to a manufactured semi-active MR damper with MR fluid DELTA can increase the damping force that the passive damper produces by 207% in compression stroke and 136.2% in rebound stroke at the same testing conditions.

Design a new algorithm (iL-GA) to optimize controller parameters for an automotive suspension system

Purpose This paper aims to design a PD controller for an active suspension system to improve the car’s moving smoothness. Design/methodology/approach The controller parameters are optimized by an in-loop genetic algorithm (iL-GA). Unlike previous studies that only used conventional GAs to tune coefficients for the controller, the iL-GA designed in this paper provides outstanding efficiency when determining the optimal value range for the system. The optimal value range of parameters is determined by the in-loop algorithm based on criteria related to systematic errors. The optimal values are then calculated by the GA based on this range instead of an uncertain one. Findings Simulation results show that vehicle body acceleration and displacement values are significantly reduced when using the active suspension system compared to the conventional passive suspension system. The phase difference phenomenon does not occur in the iL-GA situation. In addition, the frequency domain investigation also shows the system’s stability when using iL-GA instead of conventional GA. Originality/value To the best of the authors’ knowledge, this is a new application that provides positive effects to the suspension controller. This algorithm can be applied to tune coefficients for direct controllers in the future.

Constructing Thermal Convection Film for Low Heat Loss and High Salt Resistance in Wood-Based Solar Evaporators.

Unique suspension solar evaporator is one of the effective measures to address the major bottleneck of the emerging interfacial evaporators, i.e., the accumulation of salts on the surface. Yet, it remains a considerable challenge to avoid substantial heat loss underwater. Herein, a suspension wood-based evaporator is proposed with a thermal convection structure that effectively balances the contradiction between salt-resistance ability and heat loss. Benefitting from the heat centralization due to thermal convection, such suspension evaporator exhibits an excellent steam generation rate, which increases from 1.23 to 1.63kg m-2h-1 compared to the conventional suspension evaporator. Simultaneously, the steam generation rate retention improves from 64.9% over 20 test cycles to nearly 100% compared to the interfacial evaporator. This work provides an effective pathway for exploring efficient and stable suspension evaporators, offering essential directions for the future development and application of solar-driven evaporation technologies.

Chassis concept of the individually steerable five-link suspension: a novel approach to maximize the road wheel angle to improve vehicle agility

The Institute of Vehicle Systems Engineering at Ulm University of Applied Sciences is currently developing the autonomous concept vehicle Nimbulus-e in the strategic field “Intelligent Commercial Vehicles” with the aim of maneuvering as agilely as possible in confined spaces. To achieve high agility under the conditions mentioned, large road wheel steering angles are necessary. As part of the basic vehicle concept, the first step is to select a suitable chassis for this purpose. Conventional suspensions cannot be applied due to the mechanical connection of the tie rod to the steering knuckle limiting the road wheel angles. Therefore, the approaches published so far for individual chassis concepts with large steering angles are analyzed and evaluated for use. In this paper, the concept of a novel individually steerable five-link suspension is described. The concept includes a vehicle body mounted steering actuator connected to the chassis via a self-locking worm gear. Due to the body mounted connection of the steering actuator, it does not contribute to the unsprung mass. An analysis of the kinematic and elastokinematic properties and the achievable road wheel steering angle is presented. In the Nimbulus e concept vehicle, the individually steerable corner module is used on both the front and the rear axle. The system is driven by four wheel hub motors. This means that eight control variables are available for the vehicle.

Cryopreservation and Rapid Recovery of Differentiated Intestinal Epithelial Barrier Cells at Complex Transwell Interfaces Is Enabled by Chemically Induced Ice Nucleation.

Cell-based models, such as organ-on-chips, can replace and inform in vivo (animal) studies for drug discovery, toxicology, and biomedical science, but most cannot be banked "ready to use" as they do not survive conventional cryopreservation with DMSO alone. Here, we demonstrate how macromolecular ice nucleators enable the successful cryopreservation of epithelial intestinal models supported upon the interface of transwells, allowing recovery of function in just 7 days post-thaw directly from the freezer, compared to 21 days from conventional suspension cryopreservation. Caco-2 cells and Caco-2/HT29-MTX cocultures are cryopreserved on transwell inserts, with chemically induced ice nucleation at warmer temperatures resulting in increased cell viability but crucially retaining the complex cellular adhesion on the transwell insert interfaces, which other cryoprotectants do not. Trans-epithelial electrical resistance measurements, confocal microscopy, histology, and whole-cell proteomics demonstrated the rapid recovery of differentiated cell function, including the formation of tight junctions. Lucifer yellow permeability assays confirmed that the barrier functions of the cells were intact. This work will help solve the long-standing problem of transwell tissue barrier model storage, facilitating access to advanced predictive cellular models. This is underpinned by precise control of the nucleation temperature, addressing a crucial biophysical mode of damage.

Dynamic behavior of three-wheel vehicle with inerter-based dynamic absorber suspension system

Three-wheeled vehicles may be a better choice as compared with four-wheeler cars provided they are properly designed to improve the rollover stabilities and ride comfort. The design modifications need improvement in geometry and suspension. This article presents the dynamic behavior of three-wheeled vehicle equipped with an inerter-based dynamic absorber and compares the same with the conventional suspension system. The performance parameters analyzed are vertical-lateral acceleration, front & rear suspension deflection, and front & rear dynamic tyre loads. The analytical rigid body model is formulated by assigning 9 degrees of freedom to the system for the evaluation of performance parameters to compare the inerter-based absorber suspension with the conventional passive suspension system.

Design and development of a novel Four-Links rotational hybrid Energy-Harvesting suspension system compatible with conventional suspension technologies

This study introduces a novel rotational Energy Harvesting Shock Absorber (EHSA), specifically designed for use alongside existing vehicle suspension systems. Addressing issues faced by standalone EHSAs, this design incorporates a four-bar mechanism coupled to a rotary energy recovery system. The proposed EHSA system, dubbed the FL-EHSA (Four Links Energy Harvesting Shock Absorber), is based on link connections and is highly versatile. It has the potential to significantly improve vehicle efficiency by harnessing energy usually wasted by traditional shock absorbers. Using a geometric definition process influenced by various factors such as vehicle suspension type and commercial availability of components, the FL-EHSA system was modeled, and bench-tested to validate the system’s energy recovery potential and performance. The movement of the mechanism was analyzed to achieve the target damping value matching the value of a conventional suspension and to maximize efficiency through DOE analysis and to avoid mechanical locking (singular positions). It explains the effect of backlash in mechanical components through simulation and highlights the importance of using dedicated gearboxes for energy recovery. In addition, this work highlights the untapped potential of four-bar mechanisms in automotive energy recovery applications. Moreover, the proposed design is easily integrated into any vehicle, making it a promising solution for EHSA systems.

Numerical Study of Reinforced Aluminum Composites for Steering Knuckles in Last-Mile Electric Vehicles

The steering knuckle is a critical component of the suspension and steering drive systems of electric vehicles. The electrification of last-mile vehicles presents a challenge in terms of cost, driving range and compensation of battery weight. This work presents a numerical methodology to evaluate 60XX series aluminum metal matrix composites (AMMCs) with reinforcement ceramic particles for steering knuckle components in medium heavy-duty last-mile cargo vehicles. The use of AMMCs provides lightweight knuckles with sufficient strength, stiffness and safety conditions for electrical vehicle cargo configurations. The numerical study includes three aluminum alloys, two AMMC alloys and an Al 6061-T6 alloy as reference materials. The medium-duty heavy vehicle class < 12 t, such as electrical vehicle cargo configurations, is considered for the numerical study (class 1–4). The maximum von Mises stress for class 4 AMMC alloys exceeds 350 MPa, limited by fracture toughness. The weight reduction is about 65% when compared with commercial cast iron. Moreover, Al 6061-T6 alloys exhibit stress values surpassing 300 MPa, constraining their suitability for heavier vehicles. The study proposes assessing the feasibility of implementing AMMC alloys in critical components like steering knuckles and suggests solutions to enhance conventional vehicle suspension systems and overcome associated challenges. It aims to serve as a lightweight design guide, offering insights into stress variations with differing load conditions across various cargo vehicles.

Anti-rheumatoid arthritis potential of Halodule pinifolia: development, characterization and in vivo evaluation of H. pinifolia-based oral suspension and lipid nano-emulsion.

For treating chronic diseases like rheumatoid arthritis, herbal medicines are preferred due to their evident therapeutic effects and lesser side effects as compared to the long-term used conventional drugs. In this study, the anti-rheumatoid arthritis effect of an unexplored marine grass Halodule pinifolia (HP), and a combination of it with Glycyrrhiza glabra (liquorice; LQ), prepared as a conventional suspension (C1) and a lipid nano-emulsion (C1-N) was evaluated in Freund's complete adjuvant (FCA)- and collagen-induced arthritis (CIA) models. Formulations C1 and C1-N contained standardized extract HP (100mg/kg) as major active ingredient and liquorice LQ (50mg/kg) as both active ingredient (anti-inflammatory and anti-ulcer) and sweetening agent. Oral administration of HP and C1 to FCA-induced Sprague-Dawley rats significantly reduced the paw oedema, spleen index, controlled the haematological parameters, cytokine levels (IL-1β, IL-6, TNF-α estimated by ELISA), mRNA expression of cytokines and osteoclast markers (RANK, TRAP and cathepsin K measured by RTPCR). Histopathology and radiological scanning demonstrated lesser joint deterioration in sample-treated rats, as evident phenotypically. The downregulation of CD51 and MMP-3 (western blot) corroborated the anti-arthritic effect of HP and C1. HP showed better results among all. Further, under the CIA model, both C1 and C1-N were found to be potentially active as evidenced by their effect on rat paw oedema, spleen index, haematological parameters, rheumatoid factor, cytokines, osteoclast markers, histology and X-rays. The results proved the anti-arthritic effect of HP and the formulations, particularly the lipid nano-emulsion that showed improved stability as well as activity.