Conventional Spin-echo Pulse Sequences Research Articles

Magnetic Resonance Imaging Parameters Selected for Optimal Visualization of the Occipitoatlantal Interspace.

Disorders of the rectus capitis posterior minor (RCPm) muscles have been associated with chronic headache. Magnetic resonance (MR) imaging protocols currently used in clinical settings do not result in image sets that can be used to adequately visualize the integrity of occipitoatlantal structures or to definitively quantify time-dependent functional morphologic changes. To develop an MR imaging protocol that provides the superior image quality needed to visualize occipitoatlantal soft tissue structures and quantify time-dependent pathologic changes. Asymptomatic participants were recruited from the Michigan State University College of Osteopathic Medicine student body. Magnetic resonance imaging data were collected from each participant at enrollment and 2 weeks after enrollment using a 3T magnet. A conventional spin-echo pulse sequence was used to construct 24 axial, T1-weighted images with the following measurement parameters: repetition time, 467 milliseconds; echo time, 13.5 milliseconds; number of excitations, 4; slice thickness, 3.0 mm; and in-plane resolution, 0.625×0.625 mm. Image planes were aligned approximately perpendicular to the long axes of the RCPm muscles to facilitate the authors' ability to accurately draw regions of interest around the specific muscle boundaries. Cross-sectional area (CSA) of the right and left RCPm muscles was quantified for each participant at the 2 points in time. The null hypothesis was that there would be no significant difference between mean values of muscle CSA collected at enrollment and 2 weeks after enrollment for a given participant and a given side of his or her body. Thirteen participants were enrolled. No significant difference was found between mean values of either right or left RCPm muscle CSA for any of the participants measured at enrollment and 2 weeks after enrollment (all P>.05). The protocol achieves the superior image quality necessary to compare the functional form of occipitoatlantal structures at progressive points in time.

254. Fast T1,T2, M0 mapping in clinical MRI: Look-locker based inversion recovery balanced turbo field echo

Purpose T1, T2 maps in MRI allows to evaluate quantitatively the state of organs and to recognize anomalies. Look-Locker based Inversion Recovery Balanced Turbo Field Echo (LL-IR-BTFE) is a distortion free sequence that hold high SNR allowing fast mapping in every region of the body, in particular myocardial tissue, liver and brain. This study investigated a method to achieve fast T1, T2, M0 maps of phantoms and their accuracy. Methods The Philips MRI phantom has been used centred in the head coil of the Philips scanner Ingenia 3T. After local shimming, the scans have been performed using conventional spin echo pulse sequences to find the real T1 and T2. Next the phantoms have been scanned using the LL-IR- BTFE. We recovered an estimation of T1, T2 and M0 (in arbitrary units) using 3 parameter fit and correction expressions [1] , next we compared the maps obtained increasing flip angles and profile corrections [2] . Results The images were free of distortion but the susceptibility artifact was found, the percentage difference between the T1 in a central ROI using IR-BTFE and spin echo is less than 8% for the scans at different flip angles in the full T1 range after profile correction. The standard deviation was around 1.2% of T1 and T2; the values are reproducible in identical scans with percent differences of 1.3%. Conclusions The process needs an accurate choice of parameters to maximize the accuracy in maps and the range of T1,T2 involved must be known in advance in order to find the best flip angle.

J-based Magnetic Resonance Conductivity Tensor Imaging (MRCTI) at 3 T.

In this study, current density (J) - based Magnetic Resonance Conductivity Tensor Imaging (MRCTI) reconstruction algorithms namely, the Anisotropic Equipotential Projection (AEPP), the Anisotropic J-Substitution (AJS) and the Anisotropic Hybrid J-Substitution (AHJS) algorithms are implemented to reconstruct conductivity tensor images of a physical phantom using a 3T magnetic resonance imaging system. 10mA current pulses are injected in synchrony with a conventional spin-echo pulse sequence. Furthermore, a new J-based hybrid algorithm namely, the Anisotropic Hybrid Equipotential Projection (AHEPP) is proposed. In addition, reconstruction performances of the four algorithms are evaluated.

Contrast-enhanced T1-weighted Fluid-attenuated Inversion-recovery BLADE Magnetic Resonance Imaging of the Brain: An Alternative to Spin-echo Technique for Detection of Brain Lesions in the Unsedated Pediatric Patient?

We compared contrast-enhanced T1-weighted magnetic resonance (MR) imaging of the brain using different types of data acquisition techniques: periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER, BLADE) imaging versus standard k-space sampling (conventional spin-echo pulse sequence) in the unsedated pediatric patient with focus on artifact reduction, overall image quality, and lesion detectability. Forty-eight pediatric patients (aged 3 months to 18 years) were scanned with a clinical 1.5-T whole body MR scanner. Cross-sectional contrast-enhanced T1-weighted spin-echo sequence was compared to a T1-weighted dark-fluid fluid-attenuated inversion-recovery (FLAIR) BLADE sequence for qualitative and quantitative criteria (image artifacts, image quality, lesion detectability) by two experienced radiologists. Imaging protocols were matched for imaging parameters. Reader agreement was assessed using the exact Bowker test. BLADE images showed significantly less pulsation and motion artifacts than the standard T1-weighted spin-echo sequence scan. BLADE images showed statistically significant lower signal-to-noise ratio but higher contrast-to-noise ratios with superior gray-white matter contrast. All lesions were demonstrated on FLAIR BLADE imaging, and one false-positive lesion was visible in spin-echo sequence images. BLADE MR imaging at 1.5 T is applicable for central nervous system imaging of the unsedated pediatric patient, reduces motion and pulsation artifacts, and minimizes the need for sedation or general anesthesia without loss of relevant diagnostic information.

Quantitative evaluation of metal artifact reduction techniques.

To develop a technique to quantify artifact, and to use it to compare the effectiveness of several approaches to metal artifact reduction, including view angle tilting and increasing the slice select and image bandwidths (BWs), in terms of metal artifact reduction, noise, and blur. Nonmetallic replicas of two metal implants (stainless steel and titanium/chromium-cobalt femoral prostheses) were fabricated from wax, and MR images were obtained of each component immersed in water. The differences between the images of each metal prosthesis and its wax counterpart were measured. The contributions from noise and blur were isolated, resulting in a measure of the metal artifact. Several off-resonance artifact reduction techniques were assessed in terms of metal artifact reduction capability, as well as signal to noise ratio and blur. Increasing the image BW from +/-16 kHz to +/-64 kHz was found to reduce the artifact by an average of 60%, while employing view angle tilting (VAT) alone was found to reduce the artifact by an average of 63%. The metal artifact reduction sequence (MARS), which combines several susceptibility artifact reduction techniques, resulted in the least amount of image distortion, reducing the artifact by an average of 79%. The results indicate that while VAT alone (with an image BW of +/-16 kHz) resulted in the smallest amount of total energy and no reduction in the signal-to-noise ratio compared to a conventional spin-echo pulse sequence, MARS resulted in significantly less artifact and dramatically less blur.

Die Modulations-Übertragungs-Funktion in der Magnetresonanztomographie – Praktische Anwendung und Grenzen

The modulation transfer function (MTF) of an imaging system can be derived by Fourier transformation of its line spread function. A perspex/water phantom providing an interface with a variable contrast step was used to obtain MTF's in a magnetic resonance imaging system. A conventional spin echo pulse sequence, gradient echo plus sequences and fast imaging techniques were applied. The impact of particular pixel sizes was investigated by varying the field of view and the size of the acquisition matrix in a conventional spin echo sequence (TRITE 500/15 ms). The calculated MTF's for pixel sizes from 0.3 to 2.0 mm had cutoff frequencies slightly less than the theoretically achievable Nyquist frequency. No influence was seen when different contrast steps were applied. However, different pulse sequences such as spin echo, gradient echo or rapid gradient echo and fast spin echo sequences provided different MTF's. The impact on the practical application and the limitations of the procedure are discussed.

Appearance of low signal intensity lines in MRI of silicone breast implants

Magnetic resonance (MR) images of five explanted mammary prostheses were obtained with a 1.5 T GE Signa ® system using a conventional spin-echo pulse sequence, in order to investigate the low-intensity curvilinear lines which may be observed in MR images of silicone gel-filled breast implants under pressure from fibrous capsules. MR images showed ellipsoid prostheses, often containing multiple low-intensity curvilinear lines which in some cases presented an appearance very similar to that of the linguine sign. Upon opening the fibrous capsules, however, all of the prostheses were found to be completely intact demonstrating that the appearance of multiple low signal intensity curvilinear lines in MR images of silicone gel-filled prostheses is not necessarily a sign of prosthesis rupture. The MR image features which are specific to the linguine sign must be more precisely defined.

A Modified Imaging Sequence for Accurate T2 Measurements Using NMR Microscopy

A modified spin-echo pulse sequence is described that enables accurate T 2 measurements to be made in NMR microimaging experiments. The modified sequence eliminates cumulative diffusion losses that lead to an underestimation of the T 2 relaxation time using conventional spin-echo pulse sequences. The approach is theoretically justified and confirmed in comparative experiments on phantoms.

MR imaging of focal liver lesions: comparison between turbo spin-echo and conventional spin-echo pulse sequences

The aim of this study was to compare conventional spin-echo (CSE) T2-weighted (T2W) images with turbo spin-echo (TSE) T2W pulse sequences in their ability to detect focal liver lesions. Seventy-eight consecutive patients with focal liver lesions were entered into this study. All patients were imaged using the gradient-echo (GE) sequence with the breath-hold technique for T1-weighted (T1W) images, and CSE and TSE sequences for T2W images. Qualitative evaluation included lesion detection (number of lesions detected) and conspicuity (extent of visualization of lesional borders); quantitative evaluation included the signal-to-noise (S/N) ratio and the contrast-to-noise (C/N) ratio. TSE showed the best performance in terms of lesion detection; however, the difference between TSE and CSE was significant only in the case of benign cysts (p < 0.01). Conspicuity was higher with TSE and CSE, and lower with GE. The S/N and C/N ratios of the two T2W sequences were also comparable, and better than those of GE. However, the combined use of GE and TSE resulted in improved lesion detection. The results show that, because the acquisition time is greatly reduced with TSE sequences, these should be considered as first-line approach to magnetic resonance imaging of the liver for the study of focal lesions.

NMR microscopy of single neurons using spin echo and line narrowed 2DFT imaging.

NMR microimages of single neural cells were acquired at 500 MHz using a conventional spin echo pulse sequence and a line-narrowing sequence that eliminates susceptibility effects. The data show that any contribution to the measured T2 relaxation rate arising from diffusion in local field inhomogeneities using spin echo sequences at high fields and high spatial resolution is relatively small. We conclude that the measured T2 difference between the nucleus and cytoplasm in these cells represents primarily a true T2 relaxation effect arising from the interactions of water with macromolecules in the two compartments and does not result from microsusceptibility differences. These observations have implications regarding water compartmentation in single cells and the interpretation of the MR characteristics of tissues in vivo.

MR detection of white matter disease of the brain in patients with HIV infection: fast spin-echo vs conventional spin-echo pulse sequences.

Although fast spin-echo images and slower spin-echo images have similar contrast characteristics, the two techniques have not yet been shown to be equivalent in all aspects of brain imaging. To determine if the two sequences are equivalent, we compared detection of white matter lesions, image quality, and artifact degradation on fast spin-echo and spin-echo proton density-weighted and T2-weighted MR images of the brain in prospectively selected patients who were seropositive for HIV. Fast spin-echo and spin-echo MR images of the brain were obtained in 153 consecutive subjects. The images were reviewed independently by three experienced neuroradiologists. The size, number, and location of white matter lesions were compared for the two techniques. Image quality, motion artifact, CSF flow artifact, and gray-white matter differentiation were graded on a five-point scale. No statistical difference was found in gray-white matter differentiation. Overall image quality, CSF flow artifacts, and motion artifacts were slightly worse on the fast spin-echo images (p < .05). Although some variability existed in the detection of lesions less than 5 mm in diameter, the differences was small, and all larger lesions were detected by both techniques. Agreement between fast spin-echo and conventional spin-echo techniques was nearly exact with respect to characterizing findings in brain as either normal or abnormal. Fast spin-echo and spin-echo MR of the brain produce images of similar quality and show white matter lesions equally well. These results support the replacement of slower, conventional spin-echo pulse sequences with faster fast spin-echo sequences.

Prospective comparison of T2-weighted fast spin-echo, with and without fat suppression, and conventional spin-echo pulse sequences in the upper abdomen.

To evaluate use of fast spin-echo (FSE) magnetic resonance imaging with and without fat suppression in the liver and upper abdomen. Conventional spin-echo (SE) T2-weighted, FSE T2-weighted, and fat-suppressed FSE T2-weighted images from 37 patients strongly suspected to have focal hepatic lesions were evaluated. Quantitative analysis demonstrated that fat-suppressed FSE imaging had the highest lesion-liver contrast-to-noise ratio; conventional SE imaging, the lowest. In a qualitative analysis, FSE imaging was preferred. In a rank order analysis, FSE imaging was preferred 83% of the time and fat-suppressed FSE imaging 17% of the time as regards overall image quality; fat-suppressed FSE imaging was preferred 64% of the time, FSE imaging 23% of the time, and conventional SE imaging 13% of the time as regards signal abnormality detection. FSE imaging with and without fat suppression is a potentially useful pulse sequence for evaluating the upper abdomen.

MR fat suppression technique in the evaluation of normal structures of the knee.

The chopper fat suppression (CFS) pulse sequence, which is a phase sensitive implementation of the Dixon fat suppression method and the spin echo (SE) pulse sequence, was used in the evaluation of anatomic structures of the normal knee using 48 sets of imaging sequences in six volunteers using a repetition time/echo time combination of 1,500/30, 60 ms. A demonstration of the CFS technique in 10 patients with suspected knee pathology is also presented. A semiquantitative grading scale was established to rate anatomic visualization and used to compare CFS and SE pulse sequence techniques. The results in normal subjects demonstrate that hyaline cartilage is significantly better visualized by fat suppression pulse sequence than by conventional SE pulse sequence in the coronal and sagittal planes of imaging (p less than 0.001). The preliminary results from patients studies suggest that CFS imaging may be useful in the evaluation of meniscal tears, in the differentiation of hyaline cartilage from joint fluid, and in the detection of both soft tissue and bone injuries.

Instant images of the human heart using a new, whole-body MR imaging system.

An extremely rapid MR imaging technique is described, and its use on a new 2.0-T high-speed MR system is demonstrated. This implementation permits complete filling of the two-dimensional spatial-frequency domain (k-space) within an acquisition window of 26 msec. With this acquisition window placed under the spin-echo signal envelope generated by a 90-180 degree pulse pair, the image contrast is the same as that of a conventional spin-echo pulse sequence. Resultant proton images have a motion-independent voxel resolution of 0.08 cm3 and a signal-to-noise ratio for cardiac muscle of approximately 30:1 (for TE = 30 msec) with no signal averaging. The pulse sequence yields images that are chemical shift-resolved. The total proton density distribution is optionally presented with lipid and water signals displayed in two different colors. Cardiac function is observed by displaying multiple images, acquired at different times in successive cardiac periods, in a cyclic movie format. Such motion pictures are obtained within a single period of suspended respiration, thereby assuring freedom from respiratory related motion artifacts. As preliminary examples, we present MR images of the normal adult human heart that have total acquisition times of only 40 msec/image and that show the major cardiac anatomy. Frames from movie loops show contraction of cardiac chambers and left ventricular wall thickening. The extremely rapid acquisition time of this technique suggests that it may hold promise for the routine and cost-effective evaluation of cardiac anatomy and function.

Optimizing conventional MR imaging of the spine.

With the use of conventional spin-echo pulse sequences with a long repetition time (TR), the echo time (TE) and the number of echoes were varied to minimize cerebrospinal fluid (CSF) flow artifacts in a spine phantom and in cervical spines of three volunteers. The following echo trains were compared in both axial and sagittal planes with a TR of 2,000 msec: TE of 25, 80 msec ("asymmetric"); TE of 40, 80 msec ("symmetric long TE"); and TE of 20, 40, 60, and 80 msec ("symmetric short TE"). Variable degrees of even-echo rephasing of CSF flow artifacts were observed during sagittal but not axial imaging, depending on the echo train used. Even-echo rephasing was most complete with the symmetric short-TE echo train, less complete with the symmetric long-TE echo train, and absent with the asymmetric echo train. Switching the orientation of the phase and frequency encoding gradients and slightly modifying TR on the basis of the heart rate further improved image quality. The results suggest that a symmetric short-TE echo train may be used to provide velocity compensation (similar to that observed with rephasing gradients) on even echoes of conventional spin-echo pulse sequences during spine imaging.