Conventional Line Research Articles

Assessment of Structural Dynamic Response and Vehicle-Track Interaction of Precast Slab Track Systems

Recently, precast slab tracks have been used widely in railway applications, especially in conventional urban railway lines. These types of tracks are rapidly constructed and limit interruptions to train operation. However, the problems of dynamic stability when the trains run on the discontinuous type of tracks must be seriously considered. This paper focuses on analyzing the train-track interaction in two types of tracks under the dynamic load by using the numerical analysis program (APATSI) to evaluate the structural response as well as the running safety to precisely understand the load transfer efficiency of precast slab track systems.

Persistent impact of conventional seismic lines on boreal vegetation structure following wildfire

Linear disturbances from geological exploration (i.e., seismic lines) have an extensive footprint across much of Canada’s western boreal forest; however, how seismic lines interact with subsequent wildfire remains poorly understood. We assessed whether wildfires effectively mitigate the footprint of seismic lines by promoting forest recovery. We evaluated the forest structure of legacy seismic lines burned in 2001 and 2002 by comparing them against adjacent unburned control plots, using metrics derived from airborne laser scanning (ALS) data collected between 2007 and 2009. ALS metrics identified persistent differences in vegetation height and structure between seismic lines and adjacent forest controls, 7–9 years post-fire. Median canopy height was 2.90 m lower on upland seismic lines and 1.94 m lower on lowland seismic lines than on adjacent controls, corresponding to a 21% and 25% height reduction, respectively. Field surveys revealed greater graminoid and nonvascular plant cover, and lower tall-tree cover and dead vegetative matter, on seismic lines, in comparison with controls. Our results show that tree recovery remains significantly delayed on most upland and lowland burned seismic lines in our study area, and that additional management efforts or longer timescales may be required to restore these fragmented landscapes.

Development of mechanical urea briquette applicator for SRI

India is the second largest consumer of fertilizers in the world. In wetland paddy cultivation, only 30-40% of nitrogen applied is fruitfully utilized as about two-third is lost through gaseous losses, runoff, and leaching or is immobilized in the soil. Deep placement of urea briquette (UB) by hand after conventional line transplanting at the rate of one UB near the centre of each four rice hills and at soil depth of 7-10 cm reduces nitrogen losses and increases fertilizer use efficiency, but is a time consuming and labour intensive process. A two-row prototype urea briquette applicator was designed, developed and evaluated under simulated condition of system of rice intensification technique (25 cm × 25 cm) in the field of ICAR-IARI in 2013-14. Row-to-row spacing was 50 cm as the distance between two furrow openers. The mechanical urea briquette applicator recorded average distance of placement of 51.44 cm in the row, depth of placement of 7.66 cm, draft of 92.41 N, field capacity of 0.05 ha/h, field efficiency of 69% and field machine index of 69.6% during the operation in the field at forward speed of 0.87 km/h.

UMG silicon for solar PV: From defects detection to PV module degradation

Upgraded metallurgical grade silicon (UMG-Si) for photovoltaic (PV) solar applications has been manufactured through the metallurgical route by means of the process developed by Ferrosolar. In an ambitious mass production test, performed in commercial solar cells and modules production lines, the silicon was proven to be appropriate for photovoltaics applications (Forniés et al., 2019 Mass production test of solar cells and modules made of 100% umg silicon. 20.76% record efficiency. Energies 12), reaching, in a conventional production line, up to 20.76% of solar cell efficiency with multicrystalline cells made of 100% UMG silicon. In this paper we present more results from the mentioned massive test. Defect engineering is being applied to improve the bulk lifetime of the UMG wafers and to guide in the identification of the limiting defects in the material. Moreover, the modules produced with 100% UMG silicon solar cells were installed together with the modules produced in the same production line with polysilicon material to assess the degradation of the UMG silicon when compared to polysilicon. After 24 months of outdoor PV generation, the degradation, in terms of Performance Ratio at 25 °C (25PR) diminution, has been the same for both types of modules. Additionally, a Life Cycle Assessment (LCA) has been performed for this UMG silicon and state-of-the-art Siemens polysilicon to compare the environmental impact of both silicon feedstocks. The results presented in this paper; chemical analysis of wafers, defect engineering, low degradation, average efficiency and environmental assessment, lead to a complete study of UMG silicon, confirming its potential to be used as raw material for PV applications.

Magnetic Fluid Hyperthermia as Treatment Option for Pancreatic Cancer Cells and Pancreatic Cancer Organoids.

IntroductionPancreatic ductal adenocarcinoma (PDAC) is a cancer with a meager prognosis due to its chemotherapy resistance. A new treatment method may be magnetic fluid hyperthermia (MFH). Magnetoliposomes (ML), consisting of superparamagnetic iron oxide nanoparticles (SPION) stabilized with a phospholipid-bilayer, are exposed to an alternating magnetic field (AMF) to generate heat. To optimize this therapy, we investigated the effects of MFH on human PDAC cell lines and 3D organoid cultures.Material and MethodsML cytotoxicity was tested on Mia PaCa-2 and PANC-1 cells and on PDAC 3D organoid cultures, generated from resected tissue of patients. The MFH was achieved by AMF application with an amplitude of 40–47 kA/m and a frequency of 270 kHz. The MFH effect on the cell viability of the cell lines and the organoid cultures was investigated at two different time points. Clonogenic assays evaluated the impairment of colony formation. Altering ML set-ups addressed differences arising from intra- vs extracellular ML locations.ResultsMia PaCa-2 and PANC-1 cells showed no cytotoxic effects at ML concentrations up to 300 µg(Fe)/mL and 225 µg(Fe)/mL, respectively. ML at a concentration of 225 µg(Fe)/mL were also non-toxic for PDAC organoid cultures. MFH treatment using exclusively extracellular ML presented the highest impact on cell viability. Clonogenic assays demonstrated remarkable impairment as long-term outcome in MFH-treated PDAC cell lines. Additionally, we successfully treated PDAC organoids with extracellular ML-derived MFH, resulting in notably reduced cell viabilities 2h and 24 h post treatment. Still, PDAC organoids seem to partly recover from MFH after 24 h as opposed to conventional 2D-cultures.ConclusionTreatment with MFH strongly diminished pancreatic cancer cell viability in vitro, making it a promising treatment strategy. As organoids resemble the more advanced in vivo conditions better than conventional 2D cell lines, our organoid model holds great potential for further investigations.

Giant cell hepatitis associated with autoimmune hemolytic anemia: an update

Giant cell hepatitis associated with autoimmune hemolytic anemia (GCH-AHA) is a rare and severe disease characterized by autoimmune hemolysis associated with acute liver injury, histologically defined by widespread giant cell transformation. It occurs after the neonatal period, most commonly in the first year of life and uniquely affects pediatric patients. It is still poorly understood and likely underdiagnosed, although in recent years there have been advances in the understanding of its pathogenesis and the liver injury is now hypothesized to be secondary to a humoral immune mechanism. Although no laboratory test specific for the diagnosis currently exists, given its severity, it is fundamental to rule out GCH-AHA when evaluating a patient in the first year of life presenting with AHA and/or with acute liver disease of unknown etiology. While GCH-AHA is progressive in nature as other autoimmune liver disorders, it differs significantly from juvenile autoimmune hepatitis (JAIH) in that a cure can be achieved after several years of intensive treatment in a portion of patients. Conventional first line therapy consist of prednisone/prednisolone combined with azathioprine, however, several immunosuppressive drugs, commonly used in the treatment of JAIH have been tried as second line therapy, including cyclosporine, cyclophosphamide, mycophenolate mofetil, 6-mercaptopurine, calcineurin inhibitors, and sirolimus. Intravenous immunoglobulins have also been used in cases of severe liver dysfunction and/or severe anemia allowing for transitory remission. More recently treatment with B-cell depletion has been attempted in some patients and encouraging results have been reported in refractory cases. Although what constitutes optimal treatment has yet to be determined, the recent progress in the understanding of the pathogenetic mechanisms of GCH-AHA have made positive strides, cautiously pointing toward a hopeful prognosis for some of these patients.

Tensile properties of hybrid kenaf/glass fiber reinforced epoxy composites with different stacking sequence using experimental and FEA simulation method

The conventional overhead transmission line insulators are usually made of glass and ceramics, but the materials are heavy and bulky. Therefore, kenaf fibre was chosen as partial replacement material to be reinforced with Glass/epoxy composite to reduce the weight and bulkiness of the composite structures. This study used Epoxy as matrix and kenaf/glass fibres to reinforce fillers to fabricate the composites in various stacking sequences. Finite Element Analysis (FEA) was carried out using LS-DYNA software to investigate the tensile properties of the hybrid composite. The results showed a significant improvement in tensile values of the modelled composite exhibited by the kenaf/glass fibre. The tensile strength of the hybrid composites was comparable with the Glass/Kenaf/Epoxy hybrid composites’ experimental results. About 200% tensile strength improvement can be observed for both experimental and numerical for G/K/G/E sample than pure epoxy samples, thus making the new composite a potential substitute for insulator applications.

Millimeter-Long Silicon Photonic Antenna for Optical Phased Arrays at 2-μm Wavelength Band

Silicon photonic optical phased arrays are promising solutions for solid-state LIDAR. But the nonlinear absorption significantly saturates the optical power in the waveguides at 1.5-μm wavelengths. Besides, the high refractive index contrast of silicon grating exhibits a strong diffraction strength of the antenna, which results in a limited aperture of the device. These ultimately place a limit on the detection accuracy and reach. Here, a shallow etched two-dimensional subwavelength grating structure is proposed to improve the efficiency and aperture of the waveguide antenna. A reduction of diffraction strength is achieved via nanohole structure instead of conventional grating lines. Thus, a millimeter-long optical antenna is demonstrated with a peak efficiency of 71%. The far-field diffracted beam width of 0.035° and vertical field-of-view of 17.5° are achieved within 100 nm wavelengths range from 1.95 μm to 2.05 μm. The operation at 2-μm waveband also guarantees better eye-safety and significantly reduces the nonlinear absorption in silicon waveguide compared with conventional 1.5-μm band.

The Role of 3D Printing in the Fight Against Covid-19 Outbreak

Along with the COVID-19 pandemic, urgent needs for medical and specialized products, especially personal protective equipment, has been overwhelming. The conventional production line of medical devices has been challenged by excessive global demand, and the need for an easy, low-cost and rapid fabrication method is felt more than ever. In a scramble to address this shortfall, manufacturers referred to additive manufacturing or 3D printing to fill the gap and increase the production line of medical devices. Various previously/conventionally fabricated designs have been modified and redesigned to suit the 3D printing requirement to fight against COVID-19. In this perspective, various designs accommodated for the current worldwide outbreak of COVID-19 are discussed and how 3D printing could help the global community against the current and future conditions has been explored.

Assessment of Risk Factors and Outcome of Early Versus Late Cytomegalovirus Infection Infection in Living-related D+/R + Renal Allograft Recipients.

Introduction:Cytomegalovirus infection (CMV) in a kidney transplant recipient (KTR) is a serious complication resulting in increased morbidity, mortality and reduced graft survival. There is limited data on early (within 3 months posttransplant) CMV infection (ECMVI) vs. late CMV infection (LCMVI) in patients not receiving CMV prophylaxis. In India, majority of kidney transplants are D + R + combination. This study aimed to compare the risk factors and outcome of ECMVI vs. LCMVI in living related post-KTR.Methods:This was a single-center ambispective study of adult KTR from living donor between January 2001 and December 2015 who had CMV infection. This study had two cohorts: retrospective and prospective. Retrospective cohort included all KTR from January 2001 to September 2014. Prospective cohort included KTR who received transplants from October 2014 to December 2015. Of both cohorts, patients with early and late CMV infection were included. All patients received triple-drug immunosuppression. CMV infection was diagnosed when KTR had detectable CMV copies > 500/mL. In the prospective cohort, CMV PCR was done at 45 days, 3, 6, 9 and 12 months in all patients. Patients with CMV were treated on conventional lines. All patients were followed up till June 2016.Results:Of 2175 retrospective cohort, 97 and of the 155 prospective cohorts 75 had CMV infection, total being 172 CMV infections. Of these, 90 patients had ECNVI and 82 LCMVI. Induction was used in 48.8% in ECMVI group vs. 35.3% in LCMVI group (p = 0.02). CNI toxicity was present prior to CMV infection in 15 (17.4%) in ECMVI as compared to 14 (17.9%) in LCMVI (P = 0.93). In the ECMVI, 6 (6.6%) had acute rejection as compared to 13 (15.8%) in the LCMVI (P = 0.05). While asymptomatic CMV infection was more common in early (63.3% vs 37.8%, P = 0.001), symptomatic CMV without tissue diagnosis was more common in late (54.8% vs. 31.1%, P = 0.002). Total duration of post-transplant follow-up was 22.8 ± 22.1 months in ECMVI as compared to 49.7 + 40.9 months in the LCMVI (P < 0.001). The serum creatinine at last follow-up was 1.9 ± 1.6 mg/dL in ECMVI group and 2.4 ± 2.0 mg/dL in LCMVI (P = 0.02).Conclusion:In D+/R + living renal transplant recipients, without routine CMV prophylaxis, late CMV infection had more tissue invasive disease and is associated with inferior graft function on long-term follow-up.

Political Legitimacy and Democracy in Central Africa

This paper offers evidence of the intrinsic relationship between political legitimacy and democracy and scrutinizes the factors that provoke a crisis of political legitimacy and democracy in Central Africa. It contends that there is a need for the reconceptualization of political legitimacy and democracy in Africa as the conventional lines between democracy and totalitarianism seem to be clouding. It then concludes that despite the fact that democratic foundations in the region suffer from daunting challenges, demands for democratization continues to grow, resulting in the need to pay close attention to state legitimacy to ensure a democratic consolidation.

ETMM-02. PRECLINICAL MODELS REVEAL BRAIN-MICROENVIRONMENT SPECIFIC METABOLIC DEPENDENCIES IN GLIOBLASTOMA

Metabolic reprogramming is a hallmark of cancer, and malignant cells must acquire metabolic adaptations in response to a multitude of intrinsic and extrinsic factors to fuel neoplastic progression. Mutations or changes in metabolic gene expression can impose nutrient dependencies in tumors, and even in the absence of metabolic defects, cancer cells can become auxotrophic for particular nutrients or metabolic byproducts generated by other cells in the tumor microenvironment (TME). Conventional cell lines do not recapitulate the metabolic heterogeneity of glioblastoma (GBM), while primary cultured cells do not account for the influences of the microenvironment and the blood brain barrier on tumor biology. Additionally, these systems are under strong selective pressure divergent from that in vivo, leading to reduced heterogeneity between cultured tumor cells. Here, we describe a biobank of direct-from-patient derived orthotopic xenografts (GliomaPDOX) and gliomaspheres that reveal a subset of gliomas that, while able to form in vivo, cannot survive in vitro. RNA sequencing of tumors that can form both in vivo and in vitro (termed “TME-Indifferent”) compared to that of tumors that can only form in vivo (termed “TME-Dependent”) revealed transcriptional changes associated with altered nutrient availability, emphasizing the unique metabolic programs impacted by the tumor microenvironment. Furthermore, TME-dependent tumors lack metabolic signatures associated with nutrient biosynthesis, thus indicating a potential dependency of these tumors on scavenging specific nutrients from the extracellular milieu. Collectively, these data emphasize the metabolic heterogeneity within GBM and reveal a subset of gliomas that lack metabolic plasticity, indicating a potential brain-microenvironment specific metabolic dependency that can be targeted for therapy.

Realising a system of coupled microgrid networks using single‐phase interconnection lines

Overloading and renewable-based excessive generation are a frequently observed phenomena in an autonomously operating islanded microgrid (MG) which will lead to unacceptable voltage or frequency deviation in the MG. Such problems can be alleviated by mechanisms such as load shedding or curtailment of renewable sources. Alternatively, coupling the neighbouring MGs and enabling a provisional power exchange amongst them can improve the situation more effectively. The power exchange link between the MGs can be in the form of a conventional three-phase ac line but a single-phase ac link is more cost-effective, especially considering the amount of the power that needs to be transferred through this link. This approach requires power electronics-based converters to convert a three-phase ac MG into a single-phase power exchange link and control the power sharing amongst them. The same is needed when the MGs have to be coupled while maintaining their autonomy, but the corresponding costs of the single-phase system are less. This article has proposed a decentralised approach to control and couple the neighbouring MGs to realise provisional power exchange through such a structure. The performance of the proposed control mechanism is evaluated through simulation studies in PSIM®, and its sensitivity and stability are analysed against its key design and operational factors.

Full-Dimension Relative Positioning for RFID-Enabled Self-Checkout Services

Self-checkout services in today's retail stores are well received as they set free the labor force of cashiers and shorten conventional checkout lines. However, existing self-checkout options either require customers to scan items one by one, which is troublesome and inefficient, or rely on deployments of massive sensors and cameras together with complex tracking algorithms. On the other hand, RFID-based item-level tagging in retail offers an extraordinary opportunity to enhance current checkout experiences. In this work, we propose Taggo, a lightweight and efficient self-checkout schema utilizing well-deployed RFIDs. Taggo attaches a few anchor tags on the four upper edges of each shopping cart, so as to figure out which cart each item belongs to, through relative positioning among the tagged items and anchor tags without knowing their absolute positions. Specifically, a full-dimension ordering technique is devised to accurately determine the order of tags in each dimension, as well as to address the negative impacts from imperfect measurements in indoor surroundings. Besides, we design a holistic classifying solution based on probabilistic modeling to map each item to the correct cart that carries it. We have implemented Taggo with commercial RFID devices and evaluated it extensively in our lab environment. On average, Taggo achieves 90% ordering accuracy in real-time, eventually producing 95% classifying accuracy.

Establishment of a Reverse Genetic System from a Bovine Derived Influenza D Virus Isolate.

The ruminant-associated influenza D virus (IDV) has a broad host tropism and was shown to have zoonotic potential. To identify and characterize molecular viral determinants influencing the host spectrum of IDV, a reverse genetic system is required. For this, we first performed 5′ and 3′ rapid amplification of cDNA ends (RACE) of all seven genomic segments, followed by assessment of the 5′ and 3′ NCR activity prior to constructing the viral genomic segments of a contemporary Swiss bovine IDV isolate (D/CN286) into the bidirectional pHW2000 vector. The bidirectional plasmids were transfected in HRT-18G cells followed by viral rescue on the same cell type. Analysis of the segment specific 5′ and 3′ non-coding regions (NCR) highlighted that the terminal 3′ end of all segments harbours an uracil instead of a cytosine nucleotide, similar to other influenza viruses. Subsequent analysis on the functionality of the 5′ and 3′ NCR in a minireplicon assay revealed that these sequences were functional and that the variable sequence length of the 5′ and 3′ NCR influences reporter gene expression. Thereafter, we evaluated the replication efficiency of the reverse genetic clone on conventional cell lines of human, swine and bovine origin, as well as by using an in vitro model recapitulating the natural replication site of IDV in bovine and swine. This revealed that the reverse genetic clone D/CN286 replicates efficiently in all cell culture models. Combined, these results demonstrate the successful establishment of a reverse genetic system from a contemporary bovine IDV isolate that can be used for future identification and characterization of viral determinants influencing the broad host tropism of IDV.

A human stem cell-derived test system for agents modifying neuronal N-methyl-D-aspartate-type glutamate receptor Ca2+-signalling.

Methods to assess neuronal receptor functions are needed in toxicology and for drug development. Human-based test systems that allow studies on glutamate signalling are still scarce. To address this issue, we developed and characterized pluripotent stem cell (PSC)-based neural cultures capable of forming a functional network. Starting from a stably proliferating neuroepithelial stem cell (NESC) population, we generate “mixed cortical cultures” (MCC) within 24 days. Characterization by immunocytochemistry, gene expression profiling and functional tests (multi-electrode arrays) showed that MCC contain various functional neurotransmitter receptors, and in particular, the N-methyl-d-aspartate subtype of ionotropic glutamate receptors (NMDA-R). As this important receptor is found neither on conventional neural cell lines nor on most stem cell-derived neurons, we focused here on the characterization of rapid glutamate-triggered Ca2+ signalling. Changes of the intracellular free calcium ion concentration ([Ca2+]i) were measured by fluorescent imaging as the main endpoint, and a method to evaluate and quantify signals in hundreds of cells at the same time was developed. We observed responses to glutamate in the low µM range. MCC responded to kainate and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), and a subpopulation of 50% had functional NMDA-R. The receptor was modulated by Mg2+, Zn2+ and Pb2+ in the expected ways, and various toxicologically relevant agonists (quinolinic acid, ibotenic acid, domoic acid) triggered [Ca2+]i responses in MCC. Antagonists, such as phencyclidine, ketamine and dextromethorphan, were also readily identified. Thus, the MCC developed here may fill an important gap in the panel of test systems available to characterize the effects of chemicals on neurotransmitter receptors.

Tunable optical second-order Volterra nonlinear filter using wave mixing and delays to equalize a 10-20 Gbaud 4-APSK channel.

We experimentally demonstrate a tunable optical second-order Volterra filter using wave mixing and delays. Wave mixing is performed in a periodically poled lithium niobate waveguide with the cascaded sum-frequency generation and difference-frequency generation processes. Compared to conventional optical tapped delay line structures, second-order taps are added through the wave mixing of two signal copies. We measure the frequency response of the filter by sending a frequency-swept sinusoidal wave as the input. The tap weights are tuned with a liquid-crystal-on-silicon waveshaper for different filter configurations. With the additional second-order taps, the filter is able to perform a nonlinear function. As an example, we demonstrate the compensation of a nonlinearly distorted 10-20 Gbaud 4-amplitude and phase shift keying signal.

Islamic banking sustainability: theory and evidence using a novel quadruple bottom line framework

PurposeThe study aims to extend the conventional triple bottom line (TBL) framework (prosperity, people and planet) to the quadruple bottom line (QBL) by newly adding a “prophet” dimension for Islamic banks seeking compliance with Islamic law in their pursuit of sustainability.Design/methodology/approachEmploy Chapra's corollaries of maqasid al-shari'ah (the goals of Islamic law) to develop constructs for a survey of 504 Islamic bank stakeholders from five Indonesian provinces to gather primary data to quantitatively verify the dimensions and items in the proposed QBL framework. Categorical principal component analysis (CATPCA) then identifies the sustainability of ten Islamic banks from ten countries as a trial application of the resulting QBL index.FindingsUsing the dimensions and items identified using CATPCA, the authors develop a QBL index to assess the sustainability of the ten Islamic banks. The findings suggest that half of the banks are sufficiently sustainable, with three being proactive (doing more than is required) and two being accommodative (doing all that is required). The remaining five banks are unsustainable, with two banks being defensive (doing the least that is required) and three being reactive (doing less than is required). Most of the banks perform relatively poorly according to the “planet” (38%) and “people” (41%) dimensions and perform better on the “prosperity” (53%) and “prophet” (63%) dimensions. Nonetheless, there is ample room for improvement across all dimensions of sustainability.Research limitations/implicationsThe generalizability of the findings is limited by the small-scale single-country survey used in the CATPCA part of the analysis. Only ten Islamic banks were included in the QBL scoring and ranking exercisesPractical implicationsIslamic banks can improve their sustainability by increasing green financing and reaching out to rural areas and disadvantaged populations. In countries with Islamic banking systems, regulators can support this through training, guidance and incentives.Originality/valuePioneering exploration of TBL from maqasid al-shari'ah perspective. First, we develop a QBL index to assess the sustainability of Islamic banks in line with actual stakeholder expectations.

Crosstalk Reduction on Delay Line with Rectangular-Patches (RPs) Design

In this paper, a novel helix delay line with RPs structures is proposed to investigate the performance of crosstalk reduction. In the past, conventional delay lines consist of equal-length parallel unit lines which are closely packed to minimize the fabricated cost and routing area. All spacing between the adjacent parallel unit lines of delay lines should be smaller. When the operating signal frequency ups to the GHz level, the electromagnetic noise has become a dominant issue coupling from adjacent lines. It is called as a crosstalk source. The crosstalk may affect system-level timing. Besides, it causes error switching of logic gates that will reduce the signal quality. The feature of proposed helix delay line is that the far-end crosstalk (FEXT) is a dominated noise that accumulates at the receiving end. RPs structures are added and aligned at the center of the two parallel adjacent unit lines of the proposed helix delay line, which are used to reduce the difference between inductive and capacitive coupling coefficient ratios, and to reduce FEXT that maintains the signal integrity (SI) quality on receiving end.

Chinese perspectives on the ad bellum/in bello relationship and a cultural critique of the ad bellum/in bello separation in international humanitarian law

AbstractThe intriguing relationship between jus ad bellum and jus in bello has provoked perennial academic debates. This article examines this issue from Chinese perspectives and offers a cultural critique of the well-entrenched norm of the ad bellum/in bello separation in international humanitarian law. Based on its distinctive traditional perception of the world order and the meaning of war, China embraces a holistic understanding of the ad bellum/in bello relationship. This relationship is construed as essentially harmonized. The cardinal moral principle underpinning it is that a just war should be conducted in a just way. The ad bellum/in bello separation in international humanitarian law has a Western origin, and the rationale behind it intimates Western sensitivity to the European just war tradition in which jus in bello was parasitic on jus ad bellum. It is assumed that jus ad bellum and jus in bello are irreconcilably in conflict once they come into contact with one another. This assumption is followed by a widely-held belief that any attempt to reconnect the two concepts would bring nothing but the subordination of jus in bello to jus ad bellum as experienced in European just war and, consequently, the collapse of the former. Chinese perspectives nevertheless evidence that this conventional line of thinking, hampering scholars from thinking beyond the sealed ad bellum/in bello separation, is not sound. A proposal for a more constructive solution should be taken into consideration.