Conventional Formula Research Articles

The effect of blended tube feeding compared to conventional formula on clinical outcomes in adults: A systematic review.

To explore the effect of blended tube feeding compared to conventional formulas on nutritional status, quality of life, anthropometry, diarrhoea and tube blockages in adults receiving tube feeding. The protocol was registered (PROSPERO CRD42022372443). Five databases (MEDLINE, EMBASE, CINAHL, Scopus, CENTRAL) were searched from commencement of database to 14th June 2023 to identify studies comparing blended tube feeding to conventional formulas in adults receiving tube feeding. Certainty assessment was conducted using the Cochrane Risk of Bias Tools and the Grading of Recommendations, Assessment, Development and Evaluations framework, and a narrative synthesis of results is provided. From 4227 studies screened, eight were included (total n = 763 patients, 9-215 patients). Three studies were hospital-based and five were home-based with duration from 8 days-8 months. Blended tube feeding and conventional formulas were nutritionally equivalent in only three studies; energy and protein concentration of formulas ranged from 1.7-7.1 kJ/mL and 21-68.5 g/L for the blended tube feeding groups, and 4.2-6.7 kJ/mL and 39-100 g/L for the conventional groups. No studies assessed nutrition status or quality of life using validated measures. Blended tube feeding was associated with a clinically relevant reduction in diarrhoea with a low level of certainty. For remaining outcomes, there were inconclusive findings and an overall very low certainty of evidence for each. The effect of blended tube feeding compared to conventional formulas on all outcomes remains uncertain. Blended tube feeding may reduce the incidence of diarrhoea. Future research using nutritionally equivalent comparisons and validated outcome measures is required.

A clinical study on the optimal placement depth for peripherally inserted central catheter through the great saphenous vein in preterm infants

To investigate the correlation between optimal placement depth (OPD) and physical measurement parameters in preterm infants receiving placement of peripherally inserted central catheter (PICC) through the great saphenous vein (GSV), and to establish a predictive formula for OPD during the placement of PICC through the GSV. A retrospective analysis was performed for the preterm infants who received the placement of PICC through the GSV in the Neonatal Intensive Care Unit of the Third Xiangya Hospital of Central South University from December 2022 to February 2024. According to the site of puncture [GSV of the knee joint (KJ) or the ankle joint (AJ)], they were divided into a GSV-KJ placement group (n=38) and a GSV-AJ placement group (n=33). The infants were measured in terms of body weight (BW), body length, the length of the upper and lower parts of the body, head circumference, and abdominal circumference at the time of placement. The Pearson correlation analysis was used to investigate the correlation between the above variables and OPD. A predictive formula was established for OPD in the placement of PICC via the GSV in preterm infants, and the predicted residual between the predicted depth and the ideal OPD was compared between the conventional predictive formula and the new predictive formula. The Pearson correlation analysis showed that PICC OPD was significantly positively correlated with BW, body length, the length of the upper and lower parts of the body, head circumference, and abdominal circumference in both the GSV-KJ placement group and GSV-AJ placement group (P<0.05), with the highest degree of correlation between OPD and BW. The univariate linear regression analysis showed a linear relationship between PICC OPD and BW in both groups. The predictive formulas for OPD were as follows: GSV-KJ PICC OPD (cm) = 13.1 + 2.7 × BW (kg) and GSV-AJ PICC OPD (cm) = 13.4 + 6.0 × BW (kg), and the new predictive formulas had a significantly lower predicted residual than the conventional predictive formula (P<0.05). OPD for PICC through the GSV is positively correlated with BW, and the prediction results of the new predictive formula based on BW are closer to the ideal OPD.

Determination of Inoue Balloon Size by Analysis of Mitral Valve Geometry Using Three-Dimensional Transesophageal Echocardiography in Patients with Mitral Stenosis

In percutaneous mitral balloon commissurotomy (PMBC) for patients with mitral stenosis (MS), the size of the balloon has traditionally been determined using a crude method based on the patient's height or body surface area. We aimed to evaluate the clinical value of balloon size selection by quantitatively analyzing mitral valve (MV) geometry using 3D transesophageal echocardiography (TEE). In 184 consecutive patients who underwent PMBC, the geometry of the MV annulus was analyzed during mid-diastole, including the measurement of lateral-medial diameters obtained from dedicated 3D software (LMD-3d) or from analysis using multiplanar reconstruction images (LMD-mpr). Patients were categorized into three groups: those with successful results after PMBC (SU group), those with residual mitral stenosis (MS, group), and those with significant MR (MR group). The SU, MS, and MR groups included 110, 50, and 17 patients, respectively. We compared three conventional formulas (Formula 1, 2, 3) based on the patient's height or body surface area with two new formulas derived from data in the SU group: balloon size = 0.0684 × LMD-3d + 24.309 (Formula 4) and 0.061 × LMD-mpr + 24.573 (Formula 5). Compared with the calculated balloon sizes using Formula 4, the inflated balloon sizes were significantly smaller (-0.78±1.02; p<0.001) in the MS group, while they were significantly larger (0.56±1.05; p=0.04) in the MR group. This pattern was also consistent in Formula 5. In conclusion, selecting the Inoue balloon inflation size based on the mitral annulus diameter determined by 3D TEE might be a reasonable approach.

Impact of Regular and Irregular Pore Distributions on the Elasticity of Porous Materials: A Microstructure-Free Finite Element Study.

Conventional analytical formulas for predicting the effective Young's modulus of porous materials often rely on simplifying assumptions and do not explicitly incorporate microstructural information. This study investigates the impact of regular versus irregular pore distributions on the stiffness of porous materials using microstructure-free finite element modeling (MF-FEM). After conducting a convergence study, MF-FEM predictions were validated against experimental data and used to assess the accuracy of commonly employed analytical models. The results demonstrate that materials with irregular microstructures exhibit a rapid decrease in Young's modulus, approaching zero at porosities slightly greater than 50%. In contrast, regular microstructures show a more gradual decline, maintaining significant stiffness until the porosity exceeds 90%. Additionally, the study reveals that some analytical formulas align better with irregular microstructures while others are more suited to regular ones, attributable to the underlying assumptions of these models. These findings underscore the necessity of considering pore distribution patterns in modeling to accurately predict the mechanical behavior of porous materials.

P166 EXPLORING AGE-ASSOCIATED CHANGES IN HEMODYNAMICS: INSIGHTS FROM 24-HOUR BLOOD PRESSURE MONITORING

Background and Objective: Aging is associated with progressive alterations in the structure and function of the heart and arteries, which can occur independently. This study aims to investigate the hemodynamic changes occurring in aging normotensive subjects concerning heart and arterial function. We employed a novel method based on blood pressure values obtained during 24-hour ambulatory blood pressure monitoring (24-h ABPM). Methods: A cross-sectional study was conducted involving 3,220 non-obese patients referred for 24-h ABPM, who did not have hypertension and were not taking any medications. 24-hour mean hemodynamics was obtained using a non-invasive method based on Ct. Ct was estimated as: Ct/BSA= 38/PPth+ 4/5 × Td/T - 3/7, where BSA: body surface area, Td: diastolic time, T: cardiac period, and PPth: theoretical pulse pressure. The stroke volume (SV) was estimation as: SV= Ct (PP+MSP ×Ts/τ), where PP: pulse pressure, MSP: mean systolic pressure, Ts: systolic time, τ: diastolic pressure decay time constant. Cardiac output (CO) and SVR were obtained using conventional formulas. Results: Among the participants, 64.6% were female, with an average age of 51.0±15.3 years, Ct of 0.96±0.21 mL/mmHg, CO of 5.2±0.68 L/min, and SRV of 1394±178 dyn.s/cm5. An age-related reduction in stroke index and cardiac index are noteworthy, stabilizing from the sixth decade of life onward (41.1±2.0 mL/m2 and 3.0±0.23 L/min/m2, respectively). Conversely, Ct exhibits an early increase from the third to fifth decades of life (1.04±0.18 mL/mmHg), followed by a continuous and gradual decline until the ninth decade (0.71±0.16 mL/mmHg). Meanwhile, SVR demonstrates an upward trend until reaching and maintaining high values from the sixth decade of life (1426±167 dyn.s/cm5) onward with a clear shift in arterial hemodynamics (Analysis of variance [ANOVA]; P value &lt;0.001) (Figure). Conclusions: The current method based on 24-hour ABPM effectively portrays the cardiac and arterial hemodynamics that mirror age-related circulatory alterations. This method offers a valuable pathophysiological basis for understanding the aging blood pressure profile.

Dynamic Analysis of Rockfall Impact on Bridges: Implications for Train Safety

The threat of rockfall impacting bridges in mountainous areas poses a great risk to the safety of passing trains. This study delves into the dynamics of rockfall impact and its implications on the interaction between train vehicles and bridges. Leveraging LS-DYNA, this study first captured the force–time history of rockfall impact on bridge structures. Subsequently, there was a comparison with the impact forces generated at various speeds with those predicted by established formulas, validating the accuracy of simulations. Employing BANSYS software, the dynamic responses of both bridge structures and the vehicle–bridge coupling system to falling rocks were analyzed. The investigation encompassed parameters such as impact speed, position, and train location. The findings reveal that escalating impact speeds correlate with increased average and maximum impact forces from falling rocks. Notably, the average impact force does not linearly correspond with rock speed and often exceeds values calculated by conventional formulas. Impact position minimally affects maximum impact force, yet alterations in position prolong impact duration, consequently reducing average impact force. Rockfall-induced impacts precipitate notable spikes in train lateral acceleration, lateral wheelset force, wheel unloading rate, and derailment coefficient, albeit with a comparatively lesser impact on vertical acceleration. Increasing impact speed and altering position intensifies the vehicle’s response, particularly when the train is in close proximity to the impact site.

Change in Surface Roughness on the Inner and Outer Surfaces of the Microtube during Hollow Sinking.

Hollow sinking experiments and tensile tests were conducted to clarify the evolution of surface roughness during hollow sinking. Stainless steel tubes (outer diameter: 1.5 mm; wall thickness: 0.045 mm) featuring a single grain spanning the wall thickness achieved via annealing as the starting material. The tube was drawn without an internal tool using a draw bench by controlling the tube drawing speed ratio of the die entrance and exit sides. The surface roughnesses of the inner and outer surfaces at the die entrance and exit sides of the drawn tube were compared with the surface roughnesses of the inner and outer surfaces under the uniaxial tensile deformation of the starting material. As a result, two major findings were revealed; the surface roughness formation behavior during the hollow sinking; the uniaxial tensile deformation exhibits a tube on both sides of the entrance and the exit of a die. Former uniaxial tensile deformation forms surface roughness of the tube at the die-entrance-side. However, hollow sinking reduces the roughness. The tube keeps its small roughness even though it is applied the later uniaxial tensile deformation behind the die exit. Furthermore, the conventional formula to predict the surface roughness of a metal sheet caused by the uniaxial tensile deformation can predict the surface roughness of a tube in the hollow sinking. At both die entrance and exit sides, the roughness of the inner surface was larger than that of the outer surface at the die entrance and exit side. The outer surface of the tube contacts the inside of a die when the tube passes through the die. The height of the convex parts decreased at that moment. Hollow sinking suppressed the increase in surface roughness of the inner surface as the outer surface was smoothed in the die. However, due to the formation of surface roughness after leaving the die, there is an overall increasing trend in inner surface roughness.

Mengembangkan Inspirasi Kewirausahaan dan Kualitas Perdagangan Skala Kecil Melalui Manajemen Aset Manusia

Within the confront of fast worldwide nourishment patterns and modernization, concerns are rising almost the potential misfortune of nearby culinary conventions that exemplify a nation's imaginativeness, culture, history, and character. To address this, STIEPARI Semarang propelled a community benefit extend in Nongkosawit, Gunungpati, pointed at protecting and advancing its one of a kind culinary legacy. The venture included recording conventional formulas and their social centrality, guaranteeing that this information is passed down and shared. The group collaborated with neighborhood cooks to coordinated present day culinary methods whereas keeping up genuineness. Workshops were held to educate the community how to showcase their conventional dishes, emphasizing storytelling as a way to associate with visitors. To maintain these endeavors, the venture presented computerized stages for nearby culinary businesses to reach broader gatherings of people through social media and e-commerce. This activity not as it were jam Nongkosawit s culinary bequest but moreover engages the neighborhood community by making modern financial openings tied to their wealthy social conventions. Throughthese endeavors, Nongkosawit Town represents the significance of defending and celebrating culinary conventions that characterize our social personality.

Penggabungan Kearifan Lokal dan Teknopreneurship dalam Wisata Kuliner Desa Nongkosawit Gunungpati Semarang

Within the confront of fast worldwide nourishment patterns and modernization, concerns are rising almost the potential misfortune of nearby culinary conventions that exemplify a nation's imaginativeness, culture, history, and character. To address this, STIEPARI Semarang propelled a community benefit extend in Nongkosawit, Gunungpati, pointed at protecting and advancing its one of a kind culinary legacy. The venture included recording conventional formulas and their social centrality, guaranteeing that this information is passed down and shared. The group collaborated with neighborhood cooks to coordinated present day culinary methods whereas keeping up genuineness. Workshops were held to educate the community how to showcase their conventional dishes, emphasizing storytelling as a way to associate with visitors. To maintain these endeavors, the venture presented computerized stages for nearby culinary businesses to reach broader gatherings of people through social media and e-commerce. This activity not as it were jam Nongkosawit s culinary bequest but moreover engages the neighborhood community by making modern financial openings tied to their wealthy social conventions. Through these endeavors, Nongkosawit Town represents the significance of defending and celebrating culinary conventions that characterize our social personality.

Comparative Dissolution Study Between Resveratrol Nanocream Formula and Conventional Resveratrol Cream with Dimethylsulfoxide Addition

Resveratrol has potential activity as an antioxidant. Several studies have formulated resveratrol into topical preparations, but the low solubility of resveratrol causes low release of the active substance. Dimethylsulfoxide is a widely used ingredient in topical preparations, which can be used to increase the solubility of poorly soluble substances Nanocream is a nanoparticle-based topical drug delivery. The globule size is nanoscale, which can help improve drug solubility. The aim of the research was to conduct a comparative dissolution study between resveratrol nanocream formula and resveratrol conventional cream preparation with the addition of dimethylsulfoxide at various concentrations of 3%, 5% and 7%. The research method began with formulating resveratrol nanocream preparation. The preparation consisted of lipid components dispersed into a cream base. The lipids consisted of VCO, tween 80 and propylenglycol. Loading drug of resveratrol lipid was 300 mg, then tested for transimtance value and globule size. Conventional resveratrol cream formula was made into FI, FII and FIII, where each formula used different concentration of DMSO. Physical characteristics testing was conducted on nanocream and conventional resveratrol cream.Analysis of dissolution test results was observed among FI, FII and FIII in conventional cream formulas. The dissolution test results of these three formulas were also compared with the resveratrol nanocream preparation. Observation of dissolution results was assessed from the percentage of active substance released at minutes 5, 10, 15, 30, 45, 60.The dissolution test results showed that there was no significant difference in the percentage of active substance released between the conventional resveratrol cream preparation formulas, but there was a significant difference between the three conventional resveratrol cream preparation formulas and the resveratrol nanocream preparation.

Thermo-osmosis of a near-critical binary fluid mixture: A general formulation and universal flow direction.

We consider a binary fluid mixture, which lies in the one-phase region near the demixing critical point, and study its transport through a capillary tube linking two large reservoirs. We assume that short-range interactions cause preferential adsorption of one component onto the tube's wall. The adsorption layer can become much thicker than the molecular size, which enables us to apply hydrodynamics based on a coarse-grained free-energy functional. For transport processes induced by gradients of the pressure, composition, and temperature along a cylindrical tube, we obtain the formulas of the Onsager coefficients to extend our previous results on isothermal transport, assuming the critical composition in the middle of each reservoir in the reference equilibrium state. Among the processes, we focus on thermo-osmosis-mass flow due to a temperature gradient. We explicitly derive a formula for the thermal force density, which is nonvanishing in the adsorption layer and causes thermo-osmosis. This formula for a near-critical binary fluid mixture is an extension of the conventional formula for a one-component fluid, expressed in terms of local excess enthalpy. We predict that the direction of thermo-osmotic flow of a mixture near the upper (lower) consolute point is the same as (opposite to) that of the temperature gradient, irrespective of which component is adsorbed on the wall. Our procedure would also be applied to dynamics of a soft material, whose mesoscopic inhomogeneity can be described by a coarse-grained free-energy functional.

Experiments on flow velocity profiles in mountain river channels

ABSTRACT Research on the vertical profiles of flow velocity in mountainous river channels is limited, particularly in scenarios where complex bed geometries are absent. Due to the coarse roughness and seepage flow on streambeds composed of gravel, the conventional formulae for flow velocity profiles derived from fluvial river channels do not apply to mountainous river channels. Based on flume experiments with a bed packed with natural gravel and a slope ranging from 0.006 to 0.16, we derived a theoretical formula for flow velocity profiles. This new formula integrates the influence of the subsurface flow and velocity reduction near the water surface, demonstrating a strong alignment with measurements. Our findings indicate that for shallow water flow over rough bed surfaces, the turbulence intensity diminishes along the vertical direction in the near-bed region while remaining relatively constant in the upper water body. Contrary to conventional theories which attribute the increase in flow resistance and the decrease in sediment transport rates in mountainous river channels to form drag, our study emphasizes that the subsurface flow plays a significant role in the overall flow resistance of mountainous river channels and should not be overlooked.

Blenderized tube feeding in pediatrics - current evidence, guidelines, and considerations.

Recently, blenderized tube feeding (BTF) consisting of blended whole food components is emerging as a preferred approach to enteral nutrition in pediatric patients. Differences in the nutritional profile, viscosity, and other characteristics between BTF and conventional tube feeding formulas may impact clinical outcomes and practice considerations. Increasing guidance and evidence are emerging for BTF in pediatric populations requiring tube feeding. The characteristics of each BTF formulation vary, which may affect patient tolerance and clinical outcome. BTF is safe and generally well tolerated in children. It is shown to improve symptoms, clinical outcomes, and quality of life for many patients. A thorough risk assessment and nuanced approach may be required to optimize BTF administration.

Form pressure exerted by concrete for a large-scale structure: Its quantification and physicochemical interpretation

Securing safety in formwork is one of the most important tasks to be carried out in the initial stage of construction. The form pressure exerted by fresh concrete needs to be identified, and it should be retained by a formwork system. A design pressure is given in literature and standards, but for large structures its precise prediction is required through a detailed analysis or a mock-up test. This study reports the lateral form pressure distribution generated by fresh concrete through a series of mock-up tests. The tests are designed considering the placement for nuclear containment structures; 3.4 m tall and 1.2 m thick concrete wall. The experimental program includes the measurements of setting and temperature of concrete samples in addition to the lateral pressure measurement. The maximum form pressure during layer-by-layer placements depends on the concrete temperature and setting time. These are compared with conventional prediction formulas specified in ACI 347 and DIN 18218. Finally, this paper proposes the simplified prediction formula for maximum form pressure based on concrete temperature.

Effect of a Simultaneous Increase in Crude Protein and Total Digestible Nutrients Contents on Late Fattening Hanwoo Steers

Background: Shortening the fattening period can reduce production costs and inedible fat, but may simultaneously negatively affect productivity and profitability. We hypothesized that increasing the crude protein and total digestible nutrients (TDN) in the formula feed could address the issues associated with shortened fattening periods without adversely affecting rumen fermentation. This study investigated the effect of a simultaneous increase of crude protein and TDN contents compared to conventional formula feed on growth performance, blood metabolites, carcass characteristics and meat composition of late fattening Hanwoo steers. Methods: Thirty Hanwoo steers were randomly assigned to one of two dietary groups: control group (16.4% crude protein and 83.6% TDN based on dry matter) and treatment group (17.4% crude protein and 84.6% TDN based on dry matter). Result: The rumen parameters were similar between the control and treatment groups. Likewise, the effect of additional crude protein and TDN contents in the formula feed showed no significant impact on the growth performance or blood metabolites. The carcass weight and yield index were slightly higher in the treatment group compared to the control, yet these differences were not statistically significant. Furthermore, the dietary treatment did not affect marbling score, meat color, fat color, texture, maturity, pH, surface colors, drip loss, cooking loss, sensory characteristics, or fatty acid composition in the longissimus muscle.

Transmittance spectra expression for dye-doped cholesteric liquid crystal with large optical activity

ABSTRACT Dye-doped cholesteric liquid crystals (DDCLCs) with a homeotropic initial state are more practical due to their lower power consumption and higher security. However, achieving the homeotropic initial state necessitates the use of long-pitch DDCLCs. The conventional formula for determining the planar (P) state transmittance of DDCLCs is inadequate for calculating the P state transmittance of long-pitch DDCLCs with pronounced optical activity. Therefore, in the experimental calculations and fitting, optical activity was introduced to amend the conventional formula and expand the calculation range to include visible wavelengths (400 nm-800 nm). Following numerous validations, a modified formula for calculating the P-state transmittance of DDCLCs was derived, which yields results closer to the actual values when optical activity is significant. This modification is of great significance in the design of long-pitch DDCLCs.

Revised inflow performance relationship for productivity prediction from marine sandy hydrate reservoirs in Nankai Trough

Productivity prediction is crucial for the safe and efficient exploitation of marine methane hydrate. As a feasible method, inflow performance relationship (IPR) can characterize productivity results and provide a theoretical basis for optimization of depressurization schemes. In this study, we propose two modified IPR models based on field data from limited trial production and numerical fitting in the Nankai Trough. Prediction results are obtained by depressurization, together with IPR curves under different recovery ratios. According to the conventional formulas, the reservoir pressure of the deliverability equation is revised, considering the dual contributions of hydrate dissociation and pressure drop. The comparison results show that the modified Vogel formula and Fetkovich formula can suitably describe the IPR for the single vertical well and horizontal well, respectively. Sensitivity analyses of various reservoir physical parameters indicate that changes in porosity and hydrate saturation cause diverse values for the undetermined coefficient A, primarily due to the alterations in the key coefficient pr′ in the revised Vogel formula for the vertical well scenario. However, absolute permeability has only a slight influence on the shape of the IPR curve. In contrast, absolute permeability plays a crucial role in affecting the Fetkovich-modified IPR curves for horizontal wells. Productions under varying porosities exhibit a consistent linear trend on the Fetkovich-modified IPR curve because of the comparable impact of gas production rate and pressure square variance. Besides, changing hydrate saturation can also have some effect on the IPR. Our research provides a feasible productivity prediction methodology for the safe and efficient extraction of similar hydrate reservoirs.

Retrospective assessment of accuracy of nine intraocular lens power calculation formulae in eyes with axial myopia.

To compare the accuracy of nine conventional and newer-generation formulae in calculating intraocular lens power in eyes with axial myopia. Tertiary eye care center, Bengaluru, India. Retrospective cross-sectional, comparative study conducted in India. Patients undergoing uneventful phacoemulsification in eyes with axial length >26 mm were included. Preoperative biometry was done using Lenstar LS 900 (Haag-Streit AG, Switzerland). Single eye of patients undergoing bilateral implantation was randomly selected. Optimized lens constants were used to calculate the predicted postoperative refraction of each formula, which was then compared with the actual refractive outcomes to give the prediction errors, following which subgroup analysis was performed. The Kane formula, Barrett universal II, Emmetropia Verifying Optical (EVO) 2.0, Hill Radial Basis Function (Hill RBF) 3.0, Olsen formula, along with Wang Koch-adjusted four formulae, that is, Sanders Retzlaff Kraff/Theoretical (SRK/T), Holladay 1, Haigis, and Hoffer Q formula, were compared for intraocular lens power calculations. One hundred and sixty-five eyes that fulfilled all the inclusion criteria were studied. Hill RBF 3.0 had the lowest mean and median absolute prediction errors (0.355 and 0.275, respectively) compared to all formulas. In subgroup analysis (26-28, >28-30, and >30 mm), significant difference was seen only in extremely long eyes (>30 mm). The Hill RBF 3.0 formula generated the maximum percentage of eyes with refractive errors within ±0.25, ±0.5, ±0.75, and ±1 D (46%, 76.2%, 89.9%, and 95.8%, respectively). This is the first study evaluating all the formulas exclusively in the myopic eyes. Hill RBF 3 was found to be superior in accuracy to all other formulas.

A Comparison of Currently Approved Small Interfering RNA (siRNA) Medications to Alternative Treatments by Costs, Indications, and Medicaid Coverage.

Small interfering RNA (siRNA)-based medications offer the ability to target previously undruggable targets and have now received FDA approval in five instances for orphan or uncommon diseases. The current siRNA "-sirans" are directed towards hepatic molecular targets. Because they are not conventional drug formulae, their ultimate clinical success will require overcoming multiple barriers beyond their pharmacology. The minimal patient numbers leave fewer patients to bear the costs of R&D and manufacture; therefore, the cost of these drugs, questionable third-party reimbursement, and competition from other drug classes for the same low number of patients are impediments to patient access. The parenteral route of administration, as well as emerging safety restrictions, are also drawbacks to siRNA. With this review, we document currently approved siRNA drugs by condition, approval date, administration route and frequencies. We have estimated the available patient populations for siran therapies using the U.S. Medicaid and Medicare populations and sought to identify the frequency with which large Medicaid formularies list siRNA drugs. Current comparative costs between the siRNA drugs and alternatives have been presented, and the review summarizes current adverse events as reported to the FDA's Adverse Event Reporting System. Our review and data indicate that sirans are extremely expensive and seldom recognized in posted Medicaid formularies. However, alternative treatments for these conditions are no less costly, usually do not have significantly different adverse events, and are often less convenient for the patient.

Calculation of mutual inductance between arbitrarily positioned planar spiral coils for wireless power applications

Mutual inductance is one of the main parameters required to determine the power link’s performance (output voltage, efficiency) in wireless power transfer. The coils are often misaligned angularly in these applications, which affects the mutual inductance and thus the performance. Hence, an accurate calculation of mutual inductance is necessary to decide the working region of the coil. This paper presents an analytical calculation of mutual inductance between two planar spiral coils under angular misalignment conditions. By solving the Neumann integral formula, mutual inductance is derived for constant current-carrying coils, and the final mutual inductance value is calculated numerically. The influence of angular misalignment of the coil, which can be due to nutation and spin angles, on mutual inductance is studied in detail. The mutual inductance of the spiral coil is calculated for different misalignment cases. The accuracy of the calculation results is verified by comparing it with conventional formulas (mainly the Liu, the Babic formula, and the Poletkin formula) and by simulation using the finite element method. The proposed method is a more generalized and simpler one that can be used to calculate the mutual inductance of any size of coils, either spiral or circular, with any lateral and angular misalignments. Finally, a couple of spiral coils are fabricated to validate it experimentally. The comparison of the simulation and experiment results with the calculation result shows its accuracy. Thus, the proposed method can be applied to compute mutual inductance in any angularly misaligned coupling coils for the optimization of the wireless power transfer and their design.