Aim: Factors such as the low pH of acidic foods and beverages can affect long-term clinical success of restorative materials in the oral cavity. The aim of this study was to compare the solubility of Bulk-fill and Conventional Nano-Hybrid Resin Based Composites (RBCs) in different solutions. Material and Methods: A total of 60 cylindrical specimens were prepared from two RBCs (Tetric N-Ceram, Tetric N-Ceram Bulk-fill) and their constant weight was measured. The specimens were divided into six groups ( N = 10) in accordance with RBC type and pH solution (solution 1, 2, 3 with pH = 2.5, 5, 7, respectively), and were immersed in desired solutions for 30 days. Then they were weighed again and solubility levels of the specimens were calculated according to ISO 4049. Data were analysed by two-way ANOVA. The test power was considered at 80%. Results: The type of RBC had no significant effect on solubility; while the effect of PH was significant. Solution 1 caused significantly the highest solubility. No statistically significant differences were found among other groups. Conclusions: Considering the limitations of the laboratory investigations, it was concluded that solubility rate of Bulk-fill and Conventional RBCs was higher in solutions with lower pH. There was no difference among the RBCs. However, the solubility rates of all groups are within the clinically normal range.