The accurate assessment of parameters such as burn degree, volume, and depth is a prerequisite for the effective treatment of patients. However, as an unsteady heat transfer process, the temperature of the burn damage volume changes over time, and it is difficult to accurately calculate the integral value of the damage, which is used to assess the burn degree. Therefore, it is impossible to accurately determine the location and volume of damage at all burn degrees. In this study, the C language is used to program a user-defined function of the burn damage integral formula, and the coupled numerical simulation method is used to calculate the heat transfer and damage in a high-temperature water burn process. Then, the temperature and burn damage integral value of each point can be determined to accurately assess and distinguish the burn degree in real time, and estimate the position distribution, volume size, and transient change trend of each burn degree. Under the working conditions selected in this paper, the heat source mainly affects the epidermis and dermis directly below, and has less influence on the area above, which is in convective heat transfer. The damage integral value is very sensitive to temperature, and the highest damage integral value caused by 373 K is two and four orders of magnitude higher than that of 363 K and 353 K, respectively. The increase in the heat source temperature caused the volume of a third-degree burn to increase rapidly in the early stage of injury, but the volume of second-degree and first-degree burns did not change much. After heating at 373 K for 15 s and delaying the action for 45 s, the volume of first-, second-, and third-degree burns accounted for 0.4, 2.9, and 1.9%, respectively, and the total volume of damage accounted for only 5.2% of the total volume.
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