The accurate simulation of typhoon hydrometeors remains a challenge. This study attempts to evaluate the performances of five microphysics schemes (MPSs) in the Weather Research and Forecasting (WRF) model in simulating the supertyphoon Neoguri in July 2014. The observed microwave brightness temperature, as well as retrieved data from the microwave radiometer imager (MWRI) onboard Chinese FY-3B satellite, are used to test hydrometeor simulations. In particular, two MWRI radiance indices, including the emission index (EI) and scattering index (SI), are used to assess the performance of five MPSs in simulating liquid and frozen hydrometeors, respectively. Overall, the WRF model can well reproduce the overall pattern of typhoon-produced precipitation, albeit with slightly overestimated precipitation in the inner rainband and underestimated precipitation in the stratiform rainband. Moreover, ice water paths (IWPs) from all five MPS simulations are higher than those estimated from MWRI retrieval in most areas, and the spatial pattern and values of IWP for the National Severe Storms Laboratory double-moment MPS (NSSL) are much closer to those for MWRI. The NSSL scheme reproduces a more realistic joint histogram distribution of SI and EI than other MPSs do, relative to the observation. Besides, the nonlinear Lucas–Kanade optical flow approach has been used to reflect the horizontal distribution of hydrometeors in the typhoon. The results show that the simulated EI and SI from the five MPSs show a systematic southwest bias of approximately about 10∼20 km and significant intensity bias in the convection area. Further model sensitivity tests confirm that the NSSL scheme generates more realistic graupel and supercooled water close to the observations among all MPSs. The findings suggest that satellite measurements would be helpful to assess MPSs in numeric weather models, especially for hydrometeor distributions in the whole typhoon system.