This paper proposes a novel proportional-integral observer (PIO) based high-order data-driven iterative learning control (HODDILC) for nonlinear batch processes with non-repetitive disturbances subject to input constraints. First, an equivalent dynamic linearization data model (DLDM) with an uncertainty term arising from the nonrepetitive disturbances is constructed in the batch direction. Based on the established DLDM along with a gradient estimation algorithm, a data-driven PIO is then designed to estimate the uncertainty term along the batch direction, followed by designing a HODDILC law in terms of the tracking errors over more than one previous batches and control inputs in the previous time instants of the current batch. Using the contraction mapping principle and matrix theory, rigorous convergence analysis is conducted in the iteration domain. A notable advantage of the proposed design is that only input and output measurement data are used rather than a process model. Finally, an illustrative example from the literature is given to demonstrate the effectiveness and merit of the proposed method.