Control Tests Research Articles

An innovation in the method of assessing the fire resistance of a reinforced concrete girderless ceiling of a building

The article presents a new method for assessing the fire resistance of monolithic girderless non-accumulating floors of buildings and structures. The essence of the method lies in the fact that thermal (fire) tests of the floor are carried out without destruction, according to a set of single indicators of the quality of working fittings and structural concrete of continuous slabs. The use of the method makes it possible to determine the fire resistance of an uncut reinforced concrete slab of a girderless ceiling of a building without full-scale fire exposure, increases the reliability of statistical quality control and non-destructive testing, reduces economic costs.

Assessment of non-destructive nuclear and non-nuclear asphalt density testing devices for Australian road construction

ABSTRACT Non-nuclear density gauges, also known as Pavement Quality Indicators (PQIs), offer several advantages over widely used destructive test methods and nuclear density gauges (NDGs) for asphalt density measurement. Replacing NDGs with PQIs would simplify regulatory requirements and reduce the cost and complexity of in-situ asphalt density measurement. This is due to the absence of nuclear materials and the ability of PQIs to provide measurements rapidly. However, PQIs have not gained widespread use in Australia due to concerns regarding accuracy. This work assesses the suitability of PQIs for both acceptance and quality control testing by analysing a dataset collected over an extended period and across a wide range of construction sites in Australia. Accuracy was evaluated based on the strength of the relationship between gauge measurements and core density results. Although some evidence supporting the use of PQIs for quality control purposes has been found, their use for acceptance testing remains unwarranted. Recommendations for establishing standard testing methods are provided to encourage wider adoption of PQIs.

Gender-modulated influence of BDNF concentration and Val66Met polymorphism on cognitive outcomes in chronic limb ischemia patients

IntroductionWhile numerous studies have established associations between brain-derived neurotrophic factor (BDNF) and cognitive functioning, limited research has delved into the role of BDNF concerning cognitive outcomes in atherosclerosis-related conditions. This study aimed to investigate the correlations between cognitive performance, serum BDNF levels, and the BDNF Val66Met polymorphism in individuals diagnosed with chronic limb ischemia (CLI).Participants and procedureThe study encompassed 159 CLI patients (52 females, 107 males) aged 59-73 years. Genetic analysis involved assessing the BDNF Val66Met single-nucleotide polymorphism using a TaqMan SNP Genotyping Assay and the ViiA™ 7 Real-Time PCR System. Serum BDNF levels were quantified. Cognitive functioning was evaluated through a computerized battery of tests, including the simple reaction test (SRT) for speed and accuracy assessment, verbal memory test (VMT) for short and long-term memory evaluation, and the GoNoGo test for cognitive control and inhibition.ResultsGender differences in cognitive performance were observed, with women excelling in VMT, while men demonstrated superior performance in SRT and the GoNoGo test. No statistically significant differences were noted between the Met/Met or Met/Val and Val/Val subgroups. However, notable differences emerged in female Met carriers, exhibiting superior VMT scores but more incorrect Go responses in the GoNoGo test. Conversely, female Val homozygotes showed significantly more incorrect NoGo responses compared to male Val homozygotes. In men carrying the Met allele, higher BDNF concentrations correlated with improved GoNoGo test results (r = 0.248, p = 0.01). Conversely, in women with the Val/Val variant, lower BDNF concentrations were associated with better VMT scores.ConclusionsThis study underscores the sex-specific impact of BDNF serum levels and the BDNF polymorphism on cognitive processes among CLI patients. The findings highlight the nuanced influence of BDNF in shaping cognitive functioning, emphasizing the need for further research into these sex-dependent associations.

Reliability of Sensorimotor Control Tests in Individuals with Adolescent Idiopathic Scoliosis

Background: The presence of sensorimotor control deficits in adolescent idiopathic scoliosis compared to typically developed adolescents is supported by the literature but lacks reliability studies for assessment in this population. This study aimed to assess the reliability of eight sensorimotor control tests, in terms of static and dynamic balance, joint position sense (JPS) tests of the extremities and the spine, and a functional upper extremity proprioceptive test in adolescent idiopathic scoliosis subjects. Methods: Sixty adolescent idiopathic scoliosis subjects were divided into four groups. Each group underwent two tests by the same examiner, repeated at 15 min intervals. Reliability was measured using the intraclass correlation coefficient (ICC), standard error of measurement (SEM), and smallest detectable difference (SDD). Results: The results showed high reliability for the upper extremity functional proprioception test, for the dynamic and static balance test, and for the spinal lateral flexion joint position sense test in both directions. On the other hand, the shoulder external rotation, knee extension, elbow flexion, and spinal flexion joint position sense tests demonstrated poor reliability in adolescent idiopathic scoliosis subjects. Conclusions: Therapists are recommended to use the functional upper extremity proprioception test, the Fukuda test, the static balance test using a force footplate, and the spinal lateral flexion joint position sense test for assessing treatment progress in this population.

Validation of the technological process for the production of riamilovir-based solution for aerodispersible administration

BACKGROUND: An important step in the production of riamilovir-based solution for inhalation administration is the validation of critical stages of the technological process. First, a detailed study of all production steps, from the preparation of the initial ingredients to the final packaging, is carried out. Control tests are then conducted, including measuring key process parameters and analyzing the physical and chemical properties of the solution. One of the important aspects of process validation is also the training of production personnel. Proper understanding and adherence to all process instructions and requirements ensures that the process is followed correctly. AIM: Carry out validation activities throughout the stages of the technological process for the production of a solution for inhalation administration based on the active substance “riamilovir”. MATERIALS AND METHODS: The study was carried out using the developed Pilot Industrial Regulations for the production of the medicina. The quality assessment of pharmaceutical substances, excipients and pilot samples was carried out in accordance with the requirements of the State Pharmacopoeia of the Russian Federation and GMP rules. RESULTS: It has been established that the technological scheme for the production of a solution based on the active substance “riamilovir” contains 6 main stages. The greatest risk is observed at the following stages: Auxiliary work 3. Obtaining water — risk of bacterial contamination. Тechnological process 4. Preparation and sterilizing filtration of the solution — risks of insufficient concentration and unsterility of the solution. Тechnological process 5. Dosing the solution into vials is a risk due to underfilling, as well as violation of sterility. CONCLUSION: Validation of the technological process of production of solution for inhalation administration based on the active substance “riamilovir” has been carried out. Critical stages in the technological production process have been identified. The optimal parameters of the technological process have been determined and documented, leading to a predictable result — the release of a high-quality and safe drug.

Electrical Resistivity Testing of Concrete Cylinders: Bias, Precision, and Use in Process Control

Electrical resistivity is increasingly used as a test method to assess the transport properties of concrete. This paper describes an interlaboratory study that was conducted to determine precision and bias for resistivity measurements made in surface and bulk configurations of concrete cylinders. Tests were performed following AASHTO T 358-22 and AASHTO T 402-23. A verification device is introduced with a known resistivity (and impedance) to aid in determining the bias associated with resistivity measurements. However, this device can also be used as a training tool and as a tool to evaluate the qualifications of those new to performing the test. Concrete cylinders were prepared, cured, and conditioned using three methods: immersed in simulated pore solution, sealed, and immersed in lime solution. The samples were tested to determine the precision in the resistivity measurements of the samples for the different curing conditions. The paper discusses how resistivity testing can be used for quality control testing as well as quality acceptance. The results were used to develop precision and bias statements for resistivity measurements, which have been adopted in the latest American Association of State Highway and Transportation Officials (AASTHO) standards.

WOB fuzzy control and experimental study on horizontal well experimental setup

This paper developed a horizontal drillstring-wellbore-bit experimental setup based on the similarity of physical behaviors. A data acquisition and control system was established to achieve real-time control over the Rotations Per Minute (RPM) and Rate of Penetration (ROP). Combining experts’ experience and practical drilling experiments, a constant Weight on Bit (WOB) fuzzy controller was designed for rock-breaking experiment. To validate the reliability of the control system, control tests were conducted with different WOB settings at varying RPM. The results indicated that the WOB control error was within 60 N, with an error rate below 3%. Rock drilling experiments were conducted on different rocks. In sandstone drilling experiments, as WOB increased from 600N to 900 N, the ROP, Torque on Bit (TOB), and Stick-slip Vibration Intensity (SSVI) increased significantly, reaching 114.12, 3.6, and 2.97 times of the original values, respectively. When the RPM increased from 21 to 30 RPM, TOB, SSVI, and ROP changed to 1.43, 0.89, and 3.84 times of the original values. The increase in ROP during sandstone drilling was evident, suggesting a moderate increase in drilling parameters, with caution against stick-slip vibrations, which can be mitigated by increasing RPM. In limestone drilling experiments, as WOB increased from 900 to 3300 N, TOB, SSVI, and ROP increased by 2.45, 3.17, and 56.34 times, respectively. When RPM was increased from 45 to 63 RPM, TOB, SSVI, and ROP changed by 0.88, 0.74, and 1.68 times, respectively. Under conditions of high WOB and RPM, the limestone drilling speed increased more significantly.

Policy Forum: Sailing Beyond the Sunset? Are De Jure Control and Other Bright-Line Tests Relevant After Deans Knight and the New GAAR?

Policy Forum: Sailing Beyond the Sunset? Are De Jure Control and Other Bright-Line Tests Relevant After Deans Knight and the New GAAR?

Population Health Management and Guideline-Concordant Care in CKD: A Secondary Analysis of K-CHAMP.

Gaps in guideline-concordant care for chronic kidney disease (CKD) lead to poor outcomes. The Kidney Coordinated HeAlth Management Partnership (K-CHAMP) cluster randomized trial tested the effect of a population health management intervention versus usual care on CKD progression and evidence-based care delivery in the primary care setting. K-CHAMP included adults aged 18-85 years with eGFR <60 mL/min/1.73m2 and moderate-high risk of CKD progression who were not seeing a nephrologist. The multi-faceted intervention included nephrology e-consult, pharmacist-led medication management, and patient education. In this post-hoc analysis, we evaluate the effectiveness of K-CHAMP on guideline-concordant care processes (blood pressure and glycemic control, annual albuminuria testing), and medication exposure days (ACEi/ARB, moderate-high intensity statin, SGLT-2i, GLP-1RA). Given multiplicity of outcomes, Benjamini-Hochberg method was used to control false discovery rate (FDR). All 1,596 (754 intervention, 842 usual care) enrolled patients (mean age 74±9 years, eGFR 37±8 mL/min/1.73m2, 928 (58%) female, 127 (8%) Black) were analyzed. After a median 17-month follow-up, intervention arm patients had significantly higher exposure days per year to SGLT-2i (56 vs 32 days, relative benefit 1.72, 95% CI 1.14-2.30) and GLP-1RA (78 vs 29 days, relative benefit 2.65, 95% CI 1.59-3.71) compared to usual care in adjusted analysis. At study initiation in 2019, similar proportion of patients were prescribed SGLT-2i and/or GLP-1RA in intervention and control arm (8% vs 6% respectively, rate ratio 1.23, 95% CI 0-2.99), but by 2022, prescription of these medications was significantly higher in intervention arm (44% vs 27% respectively, rate ratio 1.63, 95% CI 1.32-1.94). There was no significant difference in any process measures or exposure days to ACEi/ARB in patients with albuminuria or moderate-high intensity statin. K-CHAMP was effective in accelerating implementation of SGLT-2i and GLP-1RA but did not increase ACEi/ARB in patients with albuminuria or moderate-high intensity statin use, or improve blood pressure control, glycemic control, or albuminuria testing in individuals with CKD in the primary care setting.

Factors influencing the initiation of biologic therapy in children with severe asthma: Results of the pediatric asthma noninvasive diagnostic approaches (PANDA) study.

Despite the availability of biologics for severe pediatric asthma, real-life studies reporting on drivers behind initiating biologics and their alignment with the Global Initiative for Asthma (GINA) recommendations are lacking. We performed analysis within the pediatric asthma noninvasive diagnostic approaches study, a prospective cohort of 6- to 17-year-old children with severe asthma. Information was collected on demographic factors, symptom control, treatment, comorbidities, and diagnostic tests from medical records and questionnaires. We divided patients into "starters" or "nonstarters" based on the clinical decision to initiate biologics and performed multivariate logistic regression analysis to identify drivers behind initiating therapy. Additionally, we assessed patient suitability for biologics according to key factors in the GINA recommendations: Type 2 inflammation, frequency of exacerbations, and optimization of treatment adherence. In total, 72 children (mean age 11.5 ± 3.0 years, 65.3% male) were included (13 starters). Initiation of biologics was associated with a higher GINA treatment step (adjusted odds ratio's [aOR] = 5.0, 95%CI 1.33-18.76), steroid toxicity (aOR = 21.1, 95%CI 3.73-119.91), frequency of exacerbations (aOR = 1.6, 95%CI 1.10-2.39), improved therapy adherence (aOR = 1.7, 95%CI 1.10-2.46), Caucasian ethnicity (aOR = 0.20, 95%CI 0.05-0.80), ≥1 allergic sensitization (aOR = 0.06, 95%CI 0.004-0.97), and allergic rhinitis (aOR = 0.13, 95%CI 0.03-0.65). Furthermore, steroid toxicity was identified as an important factor for deviation from the current recommendations on biologic prescription. We identified multiple drivers and inhibitors for initiating biologics, and showed the clinical need for biologics in severe pediatric asthmatics suffering from steroid toxicity. These findings may help refine asthma management guidelines.

Severe Uncontrolled Asthma: A Longitudinal Retrospective Study Illustrating the Experience of the Pulmonology Clinic of Târgu-Mureș, Romania.

Introduction: Severe uncontrolled asthma (SUA) affects approximately 5% of asthma patients, leading to frequent exacerbations, reduced lung function, and lower quality of life. Recent biologic therapies target specific inflammatory pathways, offering new options for SUA. Objective: This study aimed to evaluate clinical characteristics, treatment outcomes, and biomarkers in patients with SUA treated with biologics (Omalizumab, Benralizumab, and Dupilumab) at our clinic. Material and Methods: A six-month retrospective longitudinal study was conducted on 28 patients aged 36-83 years with SUA. Patients were divided into three groups: Omalizumab (n = 4), Benralizumab (n = 18), and Dupilumab (n = 6). Lung function tests and biomarkers such as eosinophil and IgE levels were measured over 3-month periods (T0, T1, and T2). Asthma control was assessed using asthma control tests (ACT), and non-parametric statistical methods were applied. Results: The median patient age was 64 years, with 75% showing elevated eosinophil counts (>300 cells/µL). Benralizumab significantly improved lung function (p < 0.05) and ACT scores (p < 0.001), reducing eosinophil counts to zero (p < 0.001). Patients on Dupilumab and Omalizumab showed improved asthma control (p < 0.05) and reduced exacerbations, albeit to a lesser extent (p > 0.05). Conclusions: Biologics, particularly Benralizumab and Dupilumab, improved asthma control, lung function, and quality of life in SUA patients, with improved ACT scores and spirometry values. Some patients remained poorly controlled, emphasizing the need for personalized treatment and regular biomarker monitoring. Multidisciplinary management and lifestyle changes are critical for better outcomes in SUA.

The effects of hybrid physical activity program on various motor skills in primary school children

Background and Study Aim. Physical activity in children is fundamental to the development of motor skills. Despite its importance, physical activity programs do not fully address the needs of this age group. This study examined the effects of a hybrid physical activity program on specific motor skills in primary school children. Material and Methods. A quantitative single-group pretest-posttest model was used in this study. The research group included 34 voluntary students, with 19 boys and 15 girls, all in the 3rd and 4th grades of primary school. Participants followed a hybrid physical activity program developed by the researcher. The program lasted for 8 weeks, with sessions conducted 3 days a week face-to-face and 4 days a week at home. Home sessions involved parental support through the Moodle system, using educational videos or visual games. Each session lasted one hour and was supervised by an expert trainer. Motor competence data were collected using the second version of the "Test of Gross Motor Development-2" (TGMD-2), known for its reliability and validity. The data were analyzed using the SPSS 26.0 statistical package, with a significance level set at p&lt;0.05. Results. The study's findings showed significant differences in some sub-skills and total raw scores of the locomotor and object control tests between boys and girls (p &lt; 0.05). Significant differences were also found between the 8- and 9-year-old groups in sub-skills and total raw scores (p &lt; 0.05). Additionally, a significant difference was observed in certain sub-skills and total raw score assessments between the 3rd and 4th grades (p &lt; 0.05). Conclusions. The hybrid physical activity program proved to be an effective approach for enhancing motor skills in primary school children. The findings highlight the importance of tailored physical activity programs that consider individual characteristics such as age, gender, and grade level. Implementing such programs in both school and home settings can promote more comprehensive motor development in children.

Multi-functional additively constructed honeycomb walls for housing and sheltering

Honeycomb designs have become increasingly popular in additive manufacturing due to their great mechanical properties. The honeycomb infill pattern has allowed the creation of lightweight objects without sacrificing the strength of solid objects. Honeycombs have been utilized in different applications, including architecture, aerospace, and automotive. However, there is a lack of honeycomb designs within the construction industry. With the growth of concrete additive construction, there is an opportunity to introduce honeycomb designs into construction practices. This paper proposes a methodology for manufacturing multi-functional walls through additive construction. The methodology includes several key steps, from material development and quality control testing to wall assembly and experimental investigation. Two multi-functional wall segments were additively constructed, reaching a height of 1180 mm, a width of 610 mm, and a thickness of 90 mm. These measurements led to the manufacturing of seven distinct cellular sections per wall, comprising three main, two intermediate, and two end cellular units. In addition, a columnar unit was additively constructed for corner connection, featuring two vertical octagonal cells with end brackets. A preliminary wall system made up of honeycomb wall segments was assembled using various additional materials such as sealant, clamping systems, and insulative materials. Furthermore, an additional wall segment with end connections was designed and manufactured to test its load-carrying capacity. The wall segment performed well compared to wooden stud walls and showed sufficient load-carrying capacity. Unlike traditional un-reinforced concrete structures, which are brittle and experience small plastic deformations before failing, the honeycomb wall structure experienced large plastic deformation before failure due to the use of insulation foam and silicon rubber. The preliminary testing showed that the honeycomb wall system could be an alternative to traditional housing construction, especially for shelters.

Development of an Improved Thiosulfate-Utilizing Denitrifying Bacteria-Based Ecotoxicity Test with High Detection Sensitivity and Reproducibility

Microorganism-based ecotoxicity assessment has been widely used as a reliable tool showing direct biochemical impacts of contaminants on ecosystems and the environment. The present study aimed at developing a thiosulfate-utilizing denitrifying bacteria (TUDB)-based ecotoxicity test with high detection sensitivity and favorable reproducibility. To achieve this goal, existing TUDB toxicity tests were improved by employing a pure culture of Thiobacillus thioparus ATCC 8158 and optimizing test conditions, particularly in terms of inoculated microbial biomass, incubating temperature, and operational pH. From control tests, it was found that 4 h is a sufficient processing time for TUDB test kits. As a result of optimization, 20 mg VSS/L of initial bacterial biomass, 25 °C of incubating temperature, and 6 of operational pH were determined as the most favorable test conditions, providing enhanced detection sensitivity and reproducibility. Under these optimal test conditions, I conducted toxicity tests for diverse toxic metals and obtained 0.65 ± 0.03, 1.09 ± 0.04, 1.21 ± 0.07, 0.13 ± 0.01, 0.56 ± 0.04, 1.42 ± 0.03, 0.98 ± 0.02, and 2.12 ± 0.05 mg/L of 4 h EC50 values for Ag+, As3+, Cd2+, Cr6+, Cu2+, Hg2+, Ni2+, and Pb2+, respectively. These EC50 values are substantially lower than those from earlier TUDB tests, demonstrating the high detection sensitivity of the current TUDB tests. Moreover, the present TUDB tests attained very low coefficient of variation (CV) values (1.6–6.3%) for the EC50, showing favorable reproducibility of the test methodology. In addition, the current TUDB toxicity tests offer numerous advantages for ecotoxicity assessment, including versatility for diverse test samples, no requirement for advanced equipment, and no distortion of end-point measurement. These refinements render the TUDB tests a favorable ecotoxicity assessment with enhanced sensitivity and reproducibility.

Experimental Investigations on the On-Site Crack Control of Pier Concrete in High-Altitude Environments

Concrete structures in high-altitude environments face many challenges. Establishing concrete crack control methods in high-altitude environments is crucial for enhancing the service capacity of concrete structures. In this study, a multi-field (hydration-temperature–humidity-constraint) coupling model was used to quantitatively assess the cracking risk of pier bodies at high altitude. On-site crack control tests were conducted on pier bodies using a micro-expansion anti-cracking agent to demonstrate the effectiveness of deformation shrinkage compensation in crack control at high altitudes. The results indicated that there was a risk of cracking in the pier body at high-altitude conditions, especially within 0.3 m from the pile cap and ±2.5 m from the center of the pier side surface. Compared with conventional piers, the micro-expansion anti-cracking agent approximately doubled the unit expansion deflection of piers at high temperatures while reducing the unit shrinkage deflection of piers by 11% to 12% at low temperatures. The concrete in conventional pier bodies was in a tension state after long-term hardening, while the concrete treated with the micro-expansive anti-cracking agent was in compression. Therefore, the deformation compensation effect of the micro-expansive anti-cracking agent was significant and reduced the risk of concrete cracking. In addition, early freezing had a significant impact on concrete strength, underscoring the importance of effective temperature control during the early stages of concrete placement in high-altitude environments.

Characterization of X-ray Beams: Determination of K\(_{a,e}\) for Comparison with DRLs

Aims: The aim of this experimental study was to quantify the entrance surface air kerma (Ka,e) of X-ray beams in radiographic examinations, and the obtained values were compared with national and international Diagnostic Reference Levels (DRLs). Place and Duration of Study: Sample: Department of Medical Physics and Radiology, Franciscan University (UFN), between June 2023 and August 2024. Methodology: Initially, the main quality control (QC) tests were applied to characterize the radiographic equipment. During the evaluation of the X-ray beam, a dosimetric set was used, and for the same QC geometry, Air Kerma Rate (KAIR) measurements were obtained to determine the output of the X-ray tube. Under the same conditions, a phantom without water and the same filled with water were used to determine the backscatter factor (BSF), which was then used to estimate the Ka,e for the main radiographic examinations. Results: The results of this study are consistent with other studies and identified the region/anatomy with the highest radiation exposure, highlighting the importance of its optimization and verifying that continued professional training should be integrated into best practices to ensure greater safety in procedures. The results obtained evidence the necessity for adjustments in image acquisition protocols, as the Ka,e values found in this study, although within the limits established by the national DRLs, exceed the reference values of countries such as the United Kingdom and Japan in the areas of the skull, abdomen, and lumbar spine. This discrepancy highlights the importance of the periodic review and update of DRLs, in accordance with international recommendations and the technological evolution of equipment. Dose optimization is an ongoing process that involves the evaluation of image quality, the appropriate selection of technical parameters, and the implementation of specific dose protocols. The continuous training of radiology professionals is essential to ensure the correct application of imaging techniques and the minimization of patient exposure to ionizing radiation. Conclusion: This study shows the importance of evaluating radiation dose in diagnostic imaging and the need for a multidisciplinary approach to dose optimization. Implementing quality assurance programs, updating DRLs, and providing ongoing training for professionals are essential to ensure patient safety and high-quality diagnostic imaging. The methodology adopted in this study can contribute to the ongoing education of radiology professionals, promoting the correct application of imaging techniques and reducing patient exposure to ionizing radiation.

Diffusion Tensor Imaging of the Auditory Pathway in Prelingual Deaf Children in Comparison to Normal Hearing Children in the 1 to 7 Years of Age Group

Abstract Objective This article aims to determine the microstructural alterations in the auditory pathway in prelingual deaf children using diffusion tensor imaging (DTI)-derived parameters—fractional anisotropy (FA) and apparent diffusion coefficient (ADC), and secondarily to evaluate these changes in rubella and cytomegalovirus (CMV) positive cases. Method A consecutive series of consenting deaf and normal children between 1 and 7 years of age, forming the case and control groups, respectively, underwent DTI, audiological tests, and testing for rubella, CMV, and toxoplasma infections. FA and ADC were measured at four locations bilaterally: lateral lemniscus (LL), inferior colliculus, medial geniculate body, and auditory cortex (AC). Result The mean ADC values were higher and the mean FA values were lower in cases (19 males, 21 females, mean age 2.65 years) than the controls (21 males, 19 females, mean age 4.63 years) at all eight sites. Sixteen (40%), 17 (42.5%), and 7 (17.5%) cases had severe, severe to profound, and profound hearing loss, respectively, the FA and ADC values being significantly different for LL. For rubella and CMV immunoglobulin G, 20/40and 17/40 cases were positive, respectively, 11 for both, and none for toxoplasma. Significant decrease in FA was seen at LL and AC in rubella/CMV positive cases. Conclusion Microstructural changes are seen throughout the auditory pathway in prelingual deaf children, especially with rubella and/or CMV positive status. Further studies may pave the path to segregate out patient groups potentially more responsive to cochlear implant.

The Design of Novel 3D-Printed, Moulded, and Oral Viscous Budesonide Formulations for Paediatrics: A Comparative Evaluation of Their Mucoadhesive Properties.

Paediatric eosinophilic oesophagitis (EoE) treatment is challenging due to the limited number of age-appropriate formulations. This study aims to develop and evaluate oral viscous suspensions and solid formulations of budesonide (BUD), focusing on their in vitro mucoadhesive properties, to enhance drug delivery and therapeutic outcomes in paediatric EoE. This study encompasses the development of oral viscous suspensions and orodispersible solid formulations (moulded tablets and 3D-printed dosage forms) containing BUD. The formulations underwent quality control tests as per the European Pharmacopoeia, chemical stability assessments, and an in vitro evaluation of their mucoadhesiveness properties. A validated analytical method enabled accurate BUD quantification and efficient extraction, and all developed formulations demonstrated chemical stability for 30 days, meeting Ph. Eur. quality standards. Three-dimensional printing using SSE successfully produced 1 mg and 0.5 mg BUD printlets, complying with quality tests for conventional tablets. Formulations containing xanthan gum (L2-XG and P1-0.5-XG) exhibited superior mucoadhesive properties. L2-XG showed significantly higher mucoadhesion than L1-MC. Among the solid formulations, P1-0.5-XG demonstrated the highest mucoadhesive properties. This is the first study to develop solid oral dosage forms of BUD at a very low dose, specifically for paediatric use. The results highlight the potential of 3D printing for developing individualised orodispersible BUD formulations with improved bioadhesion for paediatric EoE treatment. The L2-XG formulation and the XG-containing printlets are the most promising formulations in terms of increasing contact time with the oesophageal mucosa, which could translate into improved therapeutic efficacy in this patient population.

Unconventional mechanical responses and mechanisms of Ti-6Al-4V sheet subjected to electrically-assisted cyclic loading-unloading: Thermal and athermal effects

For the sake of unveiling the macro-micro behaviors and underlying control mechanisms of electroplastic effect (EPE) of sheet metals during recent thriving electrically-assisted incremental forming (EAIF) processes, electrically-assisted cyclic loading-unloading tension (EACT) experiments were carried out at a current density of 14～20A/mm2 followed by forced and unforced cooling. The electro-thermo-mechanical responses and the evolution rules of dislocation configurations, fracture modes, phase composition and local orientation distribution were characterized by IR imaging, SEM, quantitative EBSD and TEM tests. Moreover, the thermal and athermal components of the electrically-induced stress drop throughout the EACT processes were decoupled and systematically analyzed via temperature control tests and isothermal correction. The results show that thermal effect of electric current possesses a great proportion of 75 % in the overall stress drop and plays a key role in elastic modulus degradation and ductility enhancement by activating pyramidal {101‾1}⟨12‾10⟩ slip systems, weakening (0001) texture and promoting dynamic recrystallization (DRX) and α→β→α′ phase transformation. While the athermal effect only operates after reaching both threshold current density and plastic strain, it increases monotonically with current density, brings about “hot spots” effect, local charge imbalance and weakened atomic bonding, and further causes intensified local strain gradient, substructure formation and DRX nucleation. The ratio of athermal stress drop first decreases and then increases significantly with loading cycle at the later stage of EACT under the combined effect of local Joule heating effect and flow localization. Additionally, the athermal effect only activates short-range solute diffusion and localized diffusional α→β phase transformation, while the combined thermal and athermal effects promote long-range solute diffusion and an increasing rate in β content of 261.8 %. The present work provides theoretical basis for optimizing the EAIF forming process and realizing extreme manufacture of light-weight thin-walled complex components.

Design and Use of a Custom Phantom for Regular Tests of Radiography Apparatus: A Feasibility Study.

This study investigates the feasibility of employing an in-house-developed physical phantom dedicated to the weekly quality control testing of radiographic systems, performed by radiographers. For this purpose, a 3D phantom was fabricated, featuring test objects, including a model representing a lesion. Alongside this phantom, a commercial phantom, specifically, IBA's Primus L, was utilized. Weekly imaging of both phantoms was conducted over a span of four weeks, involving different imaging protocols and anode voltages. Subsequently, the obtained data underwent visual evaluation, as well as measurement of the intensity of selected regions of interest. The average values for three incident kilovoltages remained consistently stable over the four weeks, with the exception of the "low energy" case, which exhibited variability during the first week of measurements. Following experiments in "Week 1", the X-Ray unit was identified as malfunctioning and underwent necessary repairs. The in-house-developed phantom demonstrated its utility in assessing the performance of the X-Ray system.