In order to achieve on time delivery and win in competition, the Protection Mechanism of On Time Delivery with Smart Production Control System in Industry 4.0 is proposed in this paper from the perspective of process control. The Smart Production Control System is set up for Protection Mechanism with the shortest transmission path and the endogenous security strategy by minimum device cost in Internet of things. The statistical techniques of the Measurement System Analysis, Statistical Process Control and Hypothesis Testing are utilized to analyze the real-time data and monitor business order workflow in the Smart Production Control System. The performance evaluation shows the Protection Mechanism has sufficient capability of Cp>1.33 and Cpk>1 with output increased 51% and days saved 33% for on time delivery, which demonstrates that the Protection Mechanism with Smart Production Control System can ensure on time delivery and achieve business goal in supply chain management in Industry 4.0.