Bronchial asthma is one of the most common chronic diseases in childhood. Pooled vitD levels were positively correlated with pooled ACT scores, Treg counts, FEV1% values and VDBP levels. Vitamin D supplementation reduced the rate of asthma exacerbation, especially in patients with vitamin D insufficiency. The 25-OH vitamin D levels were lower in pediatric asthma patients with worse spirometry results. Lower vitamin D levels in children with STRA were associated with increased ASM mass and worse asthma control and lung function. Materials and methods: The study was performed in children aged 6 -15 years old, including patients with asthma (n=50), who referred to Sachkhere medical center for a visit. The status of asthma control in the basic group was classified as controlled (n=31) and uncontrolled (n=19). The children underwent serum vitamin D and IgE level, spirometry and skin prick tests for the study. Results: Using the multivariate logistic regression analysis, the presence of asthma was associated with the reduced level of vitamin D (OR=1.35, 95% CI (1,14-1.58) P=0.011; X²=6.78; F-0.022) in children with uncontrolled bronchial asthma. 48% of the patients in the group- controlled asthma (n=15) had vitamin D deficit, and in 52% of the cases (n=16) was confirmed with vitamin D insufficient. In the group –uncontrolled asthma - 5% of the patients (n=1) had Vitamin D insufficiency in blood serum. In 95% (n=18) of the patients vitamin D level was significantly low < 20 ng/ml. According the results, decreased pulmonary function (p-0.039; x2-3.12) is strongly associated with low level of vitamin D; but neither serum IgE level (p-0.54; x2-10.9), nor skin prick test result on dust mite (p-0.50, x2-5.12) was correlations with serum vitamin D low level. Conclusion: The presence of vitamin D deficiency effectively predict increased risk of uncontrolled bronchial asthma in children. Serum vitamin D level is related to lung function too. Therefore, by normalize vitamin D level in blood serum maybe improve lung function and control status in children with bronchial asthma.
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