This paper considers a generalization of the permutation flow shop problem that combines the scheduling function with the planning stage. In this problem, each work center consists of parallel identical machines. Each job has a different release date and consists of ordered operations that have to be processed on machines from different machine centers in the same order. In addition, the processing times of the operations on some machines may vary between a minimum and a maximum value depending on the use of a continuously divisible resource. We consider a nonregular optimization criterion based on due dates which are not a priori given but can be fixed by a decision-maker. A due date assignment cost is included into the objective function. For this type of problems, we generalize well-known approaches for the heuristic solution of classical problems and propose constructive algorithms based on job insertion techniques and iterative algorithms based on local search. For the latter, we deal with the design of appropriate neighborhoods to find better quality solution. Computational results for problems with up to 20 jobs and 10 machine centers are given. Scope and purpose Traditional research to solve multi-stage scheduling problems has focused on regular measures of performance based on a single criterion and assumes that several decisions related to due dates and processing times have already been made. However, in many industrial scheduling practices, managers develop schedules based on multicriteria and have to decide the due dates and processing times as part of the scheduling activities. Further, in practical scheduling situations, there are multiple machines at each stage and the objective function often reflects the total cost of processing, earliness and tardiness. Such scheduling problems require significantly more effort in finding acceptable solutions and hence have not received much attention in the literature. For this reason, this paper considers one such hybrid flow shop scheduling problem involving nonregular measures of performance, controllable processing times, and assignable due dates. We combine and generalize the existing approaches for the classical flow shop problem to the problem under consideration. Computational experiments are used to evaluate the utility of the proposed algorithms for the generalized scheduling problems. Brah and Hunsucker (European Journal of Operational Research 1991;51:88–99) and Nowicki and Smutnicki (European Journal of Operational Research 1998;106:226–253) describe branch and bound and tabu search algorithms for the approach used in the development of heuristic algorithms can also be adapted to several other complex practical scheduling problems.