Before the retrofit, the equipments of the turbine high pressure cylinder of the Daya Bay Nuclear Power Plant is of the old technology. The design of the leaf shape and the steam runner is not advanced, and the equipments are aged after more than 20 years’ operation. From the point of increasing the power and improving the reliability of the equipments, it’s decided to retrofit the turbine high pressure cylinder of Daya Bay Nuclear Power Plant unit 1 and unit 2. The retrofit relates to the design and modification of many secondary loop thermodynamic systems’ instrument & control parameters, in order to match with the first loop reactor control systems, and also the mechanism and electric systems, it’s necessary to verify and optimize these designed parameters of the units after the retrofit. This design and analysis method and experience of the secondary loop thermodynamic systems’ instrument & control parameters can be referred by the similar retrofit of other nuclear power plants.