Abstract A small plot field study was conducted on the Plant Science Research Farm of the Mississippi Agriculture and Forestry Experiment Station, Mississippi State, MS, to determine if insecticide carriers (vegetable oil and water) and droplet characteristics (droplet size and droplet concentration) influence control of Heliothis spp. in cotton. Four-row plots (3.87 m × 15.24 m) with 10-row buffers were planted to ‘Stoneville 825’ on 15 May and 1 Jun (2 replications required replanting) in a randomized complete block design. Vegetable oil treatments were varied by manipulating droplet size with Micro Max rotary atomizers set at 1600, 3500 and 5000 RPM and by using 3 different application rates (0.25, 0.5 and 1.0 gpa) attained by varying the ground speed. Water treatments were similarly varied by using 3 different droplet sizes, attained with TX-6, TX-4 and TX-1 hollow cone nozzles, and 3 volumetric application rates (3.0, 6.0 and 12.0 gpa) attained by varying the number of nozzles per row and the ground speed. Permethrin (Pounce 3.2 EC) was used at 0.1 lb (AI)/acre for all droplet size-carrier-volumetric application rate combinations. The controls consisted of a water-only treatment, an oil only treatment and an untreated. Treatments were applied on 15, 20 and 27 Aug. Plots were evaluated 17 Aug by randomly pulling 25 squares from plants in each plot and observing the number of squares damaged by Heliothis spp. larvae. On 25 Aug whole-plant observations were made on 5 row feet to observe Heliothis spp. damage and numbers of fruiting structures present. On 5 Oct open bolls, unopened bolls and total bolls were counted on 5 row feet in each plot. Yield data were obtained by mechanically harvesting the 2 center rows of each plot on 21 Nov.