AbstractIn order to address two‐dimensional (2D) control issue for a class of batch chemical processes, we propose a novel high‐order iterative learning model predictive control (HILMPC) method in this paper. A set of local state‐space models are first constructed to represent the batch chemical processes by adopting the just‐in‐time learning (JITL) technique. Meanwhile, a pre‐clustered strategy is used to lessen the computational burden of the modelling process and improve the modelling efficiency. Then, a two‐stage 2D controller is designed to achieve integrated control by combining high‐order iterative learning control (HILC) on the batch domain with model predictive control (MPC) on the time domain. The resulting HILMPC controller can not only guarantee the convergence of the system on the batch domain, but also guarantee the closed‐loop stability of the system on the time domain. The convergence of the HILMPC method is ensured by rigorous analysis. Two examples are presented in the end to demonstrate that the developed method provides better control performance than its previous counterpart.