Control Items Research Articles

Standardization of radiation therapy quality control system through mutual quality control based on failure mode and effects analysis.

The advancement of irradiation technology has increased the demand for quality control of radiation therapy equipment. Consequently, the number of quality control items and required personnel have also increased. However, differences in the proportion of qualified personnel to irradiation techniques have caused bias in quality control systems among institutions. To standardize the quality across institutions, researchers should conduct mutual quality control by analyzing the quality control data of one institution at another institution and comparing the results with those of their own institutions. This study uses failure mode and effects analysis (FMEA) to identify potential risks in 12 radiation therapy institutions, compares the results before and after implementation of mutual quality control, and examines the utility of mutual quality control in risk reduction. Furthermore, a cost-effectiveness factor is introduced into FMEA to evaluate the utility of mutual quality control.

Identifying non-cooperative participation in web-based elicitation of acceptability judgments

In this paper, we discuss different sources of noise or other detrimental effects in the elicitation of experimental data. These effects may emerge due to the loss of control in unsupervised web-based elicitation, be task-related, or emerge due to questionnaire designs that lack sufficient means to identify inapt participants. We describe a stepwise process to reach elicited data at the highest attainable level in web-based Acceptability Judgment Tasks (AJTs). In the first step, the questionnaire design, we focus especially on a careful construction of appropriate filler and control items and introduce an alternative to instructional manipulation checks appropriate for AJTs, namely attention items. The second step is to choose the right platform to elicit experimental data from. Lastly, we will show how to employ latency- and response-based methods – analyses of response times as well as of responses to the specialized items – to reliably detect inapt participants.

Morphological encoding in language production: Electrophysiological evidence from Mandarin Chinese compound words.

This study investigates the role of morphology during speech planning in Mandarin Chinese. In a long-lag priming experiment, thirty-two Mandarin Chinese native speakers were asked to name target pictures (e.g., "" /shan1/ "mountain"). The design involved pictures referring to morpheme-related compound words (e.g., "" /shan1yang2/ "goat") sharing a morpheme with the first (e.g., "" /shan1/ "mountain") or the second position of the targets (e.g., /nao3/ "brain" with prime /dian4nao3/ "computer"), as well as unrelated control items. Behavioral and electrophysiological data were collected. Interestingly, the behavioral results went against earlier findings in Indo-European languages, showing that the target picture naming was not facilitated by morphologically related primes. This suggests no morphological priming for individual constituents in producing Mandarin Chinese disyllabic compound words. However, targets in the morpheme-related word condition did elicit a reduced N400 compared with targets in the morpheme-unrelated condition for the first position overlap in the ERP analyses but not for the second, suggesting automatic activation of the first individual constituent in noun compound production. Implications of these findings are discussed.

The Effect of Core Strength Training on the Shooting Percentage and Ball Control Stability of Men's Basketball Team Players in Higher Vocational Colleges in Guangdong Province

This study selected 54 members of the freshmen men's basketball team of a higher vocational college, divided them into two groups according to the requirements, and conducted an 8-week training. The core strength training was analyzed for stance shooting, emergency stop confrontation shooting, non-confrontation ball control, and confrontation. The improvement effect of the 4 items of sexual ball control. in conclusion, the pre-test results of the players in the control group and the experimental group before training are basically the same; the players in the control group and the experimental group both improved in the post-test results after training, but the players in the experimental group improved even more; there are significant differences in the test results before and after training in the control group, but the difference in test results before and after training is not very significant; there are extremely significant differences in the test results of the experimental group before and after training; and there is a significant difference in the test results between the control group and the experimental group after training.

A study on landscape feature and emotional perception evaluation of waterfront greenway

Waterfront greenway is important spatial carriers for urban residents to engage in walking tours and fitness activities. Improving the quality of its walking spaces can have a positive impact on the mental well-being of pedestrians. This enhancement is a crucial aspect of building healthy cities. This study focused on urban waterfront greenway landscapes. Field surveys combined with questionnaire scales were used to assess pedestrians’ emotional perceptions, while concurrently collecting image data of waterfront greenway walking spaces. Semantic segmentation was employed to identify elements, and landscape metrics were calculated using relevant formulas. Correlation analysis was used to investigate the relationship between landscape metric features and emotional perceptions. And established a multiple regression model of pedestrian spatial perception on waterfront greenways to investigate the influence mechanisms of emotional perception and landscape metrics. The study indicates that greenness, proportion of water area, and vegetation diversity positively impact emotional perception of waterfront leisure greenway walking spaces, whereas path width negatively affects emotional perception. Specifically, the magnitude of influence is ranked as follows: greenness (0.491), proportion of water area (0.356), proportion of trails (−0.272), and vegetation diversity (0.130). The design guidelines for urban waterfront greenway spaces were proposed, guided by quantitative studies on landscape elements of waterfront greenway spaces and based on the measurement features of these elements. Moreover, the environmental experience of the waterfront green walking spaces was further enhanced, satisfying the public’s visual perception and psychological needs. The contribution of this study is to lay the foundation for the development of spatial control items for urban waterfront greenway.

Distress reactions and susceptibility to misinformation for an analogue trauma event

Accuracy of memory is critical in legal and clinical contexts. These contexts are often linked with high levels of emotional distress and social sources that can provide potentially distorting information about stressful events. This study investigated how distress was associated with susceptibility to misinformation about a trauma analogue event. We employed an experimental design whereby in Phase 1, participants (N = 243, aged 20–72, 122 females, 117 males, 4 gender diverse) watched a trauma film (car crash) and heard an audio summary that contained misinformation (misled items), true reminders (consistent items), and no reminders (control items) about the film. Participants rated their total distress, and symptoms of avoidance, intrusions, and hyperarousal, in response to the film. They then completed cued recall, recognition, and source memory tasks. One week later in Phase 2, participants (N = 199) completed the same measures again. Generalised linear mixed models were used. A significant misinformation effect was found, and importantly, participants with higher distress levels showed a smaller misinformation effect, owing to especially poor memory for consistent items compared to their less distressed counterparts. Distress was also associated with improved source memory for misled items. Avoidance of the film’s reminders was associated with a smaller misinformation effect during immediate retrieval and a larger misinformation effect during delayed retrieval. Findings suggest that distress is associated with decreased susceptibility to misinformation in some cases, but also associated with poorer memory accuracy in general. Limitations are discussed, and the need for further research is highlighted.

Role of inhibitory control in adults' mathematical equivalence knowledge.

Previous research has shown that naïve views of math and science concepts coexist with more formal views. The current study extended this finding to the domain of mathematical equivalence and tested whether inhibitory control relates to using more formal views over naïve ones. In the current study, we report two experiments in which undergraduate students (n = 125 for Study 1 and n = 184 for Study 2) completed a priming task involving inhibitory control and math items, an inhibitory control flanker measure, and a comprehensive mathematical equivalence assessment. We found quantitative and qualitative evidence that adults hold both naïve operational views and formal relational views of equivalence across multiple measures and under timed and untimed conditions. In contrast to our hypotheses, we did not find evidence to support a strong association between individual differences in inhibitory control and mathematical equivalence knowledge. The results call into question the role of this domain-general cognitive skill in contributing to adults' expression of naïve operational thinking.

How effective are monthly departmental tracer surveys? A 5-year retrospective study of 138 surveys in 96 departments

Repeat department-wide surveys are commonly employed for infection control. There remains debate concerning their cost-effectivess. The aim of the study was to measure the impact of repeat department-wide surveys in major in-patient departments (IPDs) and ambulatory facilities (AFs) in a tertiary care hospital. This was a retrospective study of 138 surveys condcuted in 96 departments over a 5-year period. Two itemized questionnaires were designed to assess the most frequently inadequately adhered to infection control measures: one for IPD (with 21 items) and the other for AF (with 17 items). A total of 72 surveys were conducted in 49 IPDs, of which 39 (54%) were repeat surveys, and 66 surveys in 47 AFs, of which 33 (50%) were repeat surveys. The baseline rate of adherence/department was 71%±14 for the IPD, with an increase from the first to the last survey to 82%±13 (P=.037). In 15/21 measured infection control items, adherence improved. Adherence to infection control items was lower at baseline in the AFs than in the IPDs (63±27), with an increase to 76±20 (non significant). Although adherence improved for 9 items, it deteriorated in another 8, producing an overall statistically unchanged outcome. Repeat whole-department surveys contribute moderately to increased adherence to infection control guidelines. AFs demonstrate lower rates of adherence to infection control guidelines and are less receptive to educational measures.

Availability of basic infection control items and personal protection equipment in 7948 health facilities in eight low- and middle-income countries: Evidence from national health system surveys.

Hundreds of millions of people become infected globally every year while seeking care in health facilities that lack basic needs like infection control measures and personal protective equipment (PPE). We aimed to evaluate the availability of infection control items and PPE in eight low- and middle-income countries and identify disparities in the availability of those items. In this study, we combined publicly available nationally representative cross-sectional health system surveys (Service Provision Assessments by the Demographic and Health Survey Programme) conducted in eight countries between 2013 and 2018: Afghanistan, Bangladesh, the Democratic Republic of the Congo, Haiti, Malawi, Nepal, Senegal, and Tanzania. The availability of infection control items was evaluated using a list of six items (a waste receptacle, a sharps container, disinfectant, single-use disposable or auto-disposable syringes, soap and running water, or an alcohol-based hand rub, and guidelines for standard precautions). PPE includes four items: gloves, medical masks, gowns, and eye protection. We considered these items available in a facility if they were observed in general outpatient areas or any service-specific area (i.e. delivery room). We analysed data from 7948 health facilities (694 hospitals and 7254 health centres/clinics). Overall, among the infection control items and PPE, most surveyed facilities had high availability of single-use disposable or auto-disposable syringes (91.40%) and latex gloves (92.56%). Of infection control measures, guidelines for infection control were the least available during the survey, with the lowest (6.15%) in Nepal and the highest (68.18%) in Malawi. Of the PPE items, eye protection was the least available during the survey, with the lowest (5.4% in Senegal) and the highest (28.17%) in Haiti. Only 1567 (19.71%) facilities looked to have all the basic infection control materials, and 1023 (12.87%) of the analysed facilities possessed all of the PPE. Within the same country, the availability of items varied more between hospitals and health centres/clinics than between them. All eight of our study countries experience shortages of the most fundamental standard precaution items to avert infection. Steps must be taken in each of these countries to reduce inadequacies and disparities and enhance efficiency in the conversion of health-system inputs into the facility's availability of standard precaution items for infection control - to curb the risk of infectious disease transmission.

Examining the validity of the addictions neuroclinical assessment domains in a crowdsourced sample of adults with current alcohol use.

Several dimensional frameworks for characterizing heterogeneity in alcohol use disorder (AUD) have been proposed, including the Addictions Neuroclinical Assessment (ANA). The ANA is a framework for assessing individual variability within AUD across three domains corresponding to the proposed stages of the addiction cycle: reward (binge-intoxication stage), negative emotionality (withdrawal-negative affect stage), and cognitive control (preoccupation-anticipation stage). Recent work has evaluated the ANA's three-factor structure and construct validity, primarily in treatment-seekers with AUD. We extended this research by examining the factor structure, bias across alcohol use severity, longitudinal invariance, and concurrent and predictive validity of a novel assessment of the ANA domains in adults with past 12-month regular (10 + alcohol units/week) alcohol use. Participants recruited from Prolific (N = 732), a crowdsourced data collection platform, completed various self-report measures. A test-retest subsample (n = 234) completed these measures 30 days later. Split-half exploratory factor analysis and confirmatory factor analysis supported the three-factor structure of the ANA. The overall factor structure was invariant across 30 days. Concurrently and prospectively, ANA domains demonstrated convergent validity concerning theoretically aligned alcohol-related, psychological, and personality measures. However, there was evidence of poor discriminant validity, and several cognitive control and reward items demonstrated bias across alcohol use severity. Future research is needed to improve the measurement of ANA domains using multimodal indicators, examine longitudinal changes in domains and their relationship with alcohol use severity, characterize phenotypic subgroups based on relative levels of domains, and compare the utility of the ANA with other proposed frameworks for measuring AUD heterogeneity. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Are latent working memory items retrieved from long-term memory?

Switching one's focus of attention between to-be-remembered items in working memory (WM) is critical for cognition, but the mechanisms by which this is accomplished are unclear. A long-term memory (LTM) account suggests that switching attention away from an item, and passively retaining and reactivating such "latent" items back into the focus of attention involves episodic LTM retrieval processes, even for delays of only a few seconds. We tested this hypothesis using a two-item, double-retrocue WM task that requires participants to switch attention away from and reactivate items followed by subsequent LTM tests for reactivated items from the initial WM task (vs. continuously retained or untested control items). We compared performance on these tests between older adults (a population with LTM deficits) and young adults with either full (Experiment 1) or divided (Experiment 2) attention during the WM delay periods. The effects of reactivating latent items, as well as ageing and divided attention, had significant effects on WM performance, but did not interact with or systematically affect subsequent LTM for reactivated versus control items on item-, location-, or associative-recognition memory judgements made with either high or low confidence. Experiment 3 confirmed that these effects did not depend on whether or not young participants were warned about the subsequent LTM tests before performing the WM task. These dissociations between WM and LTM are inconsistent with the LTM account of latent WM; they are more consistent with the dynamic processing model of WM (Current Directions in Psychological Science).

PROBLEMS OF DOMESTIC ENTERPRISES BANKRUPTCY UNDER MARTIAL LAW

Objective. The objective of the article is the study of modern problems of domestic enterprises bankruptcy under martial law. Methods. The research methods are the dialectical method of scientific knowledge, general scientific methods: analysis and synthesis (to assess the dynamics of unprofitable enterprises, analysis of bankruptcy risk problems, assessment of statistical data on the dynamics of bankruptcy cases), systematization and generalization (to determine the key areas of improvement of the business environment, recovery solvency and prevention of bankruptcy of enterprises), abstract-logical method (for formulating conclusions), graphic and tabular methods (for visualization of research results). The results. The share of unprofitable enterprises in Ukraine is analyzed. The problems that increase the financial difficulties and risks of bankruptcy of Ukrainian enterprises are summarized. Based on the analysis of statistical data on the consideration of bankruptcy cases and the dynamics of filing applications, a reduction in the number of bankruptcy cases and amounts demanded by creditors has been established in recent years, the vast majority of cases end in liquidation. The changes in the regulatory regulation of the bankruptcy procedure in Ukraine under martial law conditions are studied. The existence of significant difficulties for the restoration of business in the conditions of war and the problem of interaction between business and authorities are established. The main areas of revitalization of the business environment, restoration of solvency and prevention of bankruptcy of enterprises are identified. They include: eliminating corruption, carrying out judicial and tax reform, improving access to credit resources, improving the bankruptcy procedure, reducing the cost of resources, searching for new markets (including abroad), changing and diversification of business activity, increase in income, development of unique products or services, rationing of all items of expenses and strict control over the implementation of established standards, collection of overdue receivables, development of unique products and services, use of innovations, which will allow to reduce costs of production of products and increase their competitiveness.

User-Centered Development of STOP (Successful Treatment for Paranoia): Material Development and Usability Testing for a Digital Therapeutic for Paranoia.

Paranoia is a highly debilitating mental health condition. One novel intervention for paranoia is cognitive bias modification for paranoia (CBM-pa). CBM-pa comes from a class of interventions that focus on manipulating interpretation bias. Here, we aimed to develop and evaluate new therapy content for CBM-pa for later use in a self-administered digital therapeutic for paranoia called STOP ("Successful Treatment of Paranoia"). This study aimed to (1) take a user-centered approach with input from living experts, clinicians, and academics to create and evaluate paranoia-relevant item content to be used in STOP and (2) engage with living experts and the design team from a digital health care solutions company to cocreate and pilot-test the STOP mobile app prototype. We invited 18 people with living or lived experiences of paranoia to create text exemplars of personal, everyday emotionally ambiguous scenarios that could provoke paranoid thoughts. Researchers then adapted 240 suitable exemplars into corresponding intervention items in the format commonly used for CBM training and created 240 control items for the purpose of testing STOP. Each item included newly developed, visually enriching graphics content to increase the engagement and realism of the basic text scenarios. All items were then evaluated for their paranoia severity and readability by living experts (n=8) and clinicians (n=7) and for their item length by the research team. Items were evenly distributed into six 40-item sessions based on these evaluations. Finalized items were presented in the STOP mobile app, which was co-designed with a digital health care solutions company, living or lived experts, and the academic team; user acceptance was evaluated across 2 pilot tests involving living or lived experts. All materials reached predefined acceptable thresholds on all rating criteria: paranoia severity (intervention items: ≥1; control items: ≤1, readability: ≥3, and length of the scenarios), and there was no systematic difference between the intervention and control group materials overall or between individual sessions within each group. For item graphics, we also found no systematic differences in users' ratings of complexity (P=.68), attractiveness (P=.15), and interest (P=.14) between intervention and control group materials. User acceptance testing of the mobile app found that it is easy to use and navigate, interactive, and helpful. Material development for any new digital therapeutic requires an iterative and rigorous process of testing involving multiple contributing groups. Appropriate user-centered development can create user-friendly mobile health apps, which may improve face validity and have a greater chance of being engaging and acceptable to the target end users.

The impact of targeted nursing intervention on postoperative medication adherence, quality of life, and psychological flexibility of thyroid cancer patients.

To explore the effect of targeted nursing intervention on postoperative medication adherence, quality of life, and psychological flexibility of patients with thyroid cancer (TC). A total of 330 patients were randomly divided into a Control group and an Intervention group (cases in the Intervention group were given targeted nursing interventions and cases in the Control group were given routine health education), with 165 cases in each group. In the Intervention group, targeted dietary and psychological nursing interventions were conducted on TC patients, and the effects of targeted nursing interventions on the quality of life, medication adherence, and psychological flexibility were compared through the SF-36 Short Form Health Survey, Morisky Medication Adherence Scale and Psychological Resilience Scale with the Control group. Univariate analysis and multiple stepwise regression analysis were performed to analyze the influencing factors of psychological flexibility in patients after nursing intervention. The Intervention group patients, after nursing intervention, in terms of life quality, scores of social function, physical function, and mental function were all higher than those of the Control group. Note that, 160 patients in the Intervention group (96.97%) had better treatment scores, which was significantly higher than that in the Control group (84.24%). The scores of mental resilience in the Intervention group reached 67.82±13.85, and the two items of resilience, control, and optimism were significantly improved compared with the Control group (p<0.05). Factors that had greater impacts on the psychological flexibility of TC patients were: age, education, per capita monthly income, and family residence. Targeted nursing intervention had positive promoting effects on postoperative medication adherence, quality of life, and psychological flexibility of TC patients.

Online grooming among Portuguese adolescents and the COVID-19 lockdown: Relationship with other types of victimization

Background: Online grooming is the sexual solicitations and interactions between an adult and a minor, aiming to sexually abuse or obtain sexual material for the sexual satisfaction of themselves or others. Experiencing victimization during childhood or adolescence increases the probability of exposure to other types of victimization. Objectives: This study analyses the relationship between grooming, other types of juvenile victimization, and consensual sexting. We compare victims and non-victims of online grooming concerning sexting, sextortion, juvenile victimization, and online parental control. We also aim to identify the prevalence of online grooming in the present sample during and after the COVID-19 pandemic confinement and the impact of other types of juvenile victimization on grooming. Participants: The sample comprised 106 Portuguese adolescents (57 boys and 49 girls) aged 12 to 15. Method: Participants answered the sociodemographic questionnaire that contemplates online parental control and sextortion items, the Questionnaire for Online Sexual Solicitations and Interactions with Adults, the Sexting Questionnaire, and the Juvenile Victimization Questionnaire. Results: The results showed a positive correlation between online grooming, juvenile victimization, and sexting, as well as statistically significant differences between victims and non-victims of online grooming. Victims showed higher levels of sexting, sextortion, and other juvenile victimization. It also revealed higher levels of sexting and online grooming during and after the COVID-19 lockdown. Predictive validity showed that peer/sibling victimization and sexual victimization predicted online grooming. Conclusions: This study promotes a better understanding of online grooming by exploring the association between different types of victimization.

B-234 The Quality in NGS: Do You Know How Much We Lost?

Abstract Background Next generation sequencing (NGS) is a new high throughput approach for genomic sequencing and variations detection. The consumption of NGS is numerous, such as times, money and human resource, therefore, some hospitals provided the service but delivered the specimen to other laboratories. Hence, we aimed to establish a procedure to monitor the quality and integrity of report. Method Here we used one clinical case to elucidate the whole process of raw sequence data analysis by free resource, a website usegalaxy.org and the IGV visualization software, with flowchart and quality control (QC) items. A delivered case will be an example to show how to monitor the QC. Results The flow chart showed the whole steps of analysis of NGS, including evaluation genetic variants in the report from individual laboratory. We processed the FASTQ file and analyzed the quality with three parameters. An overall picture of bases showed the phred score (QV) less than 28. Distribution of sequence lengths over all sequences highlighted a prominent peak at 110–119 bp. The mean QV of reads was around 26 with low quality (QV less than 20) in some reads. We then filtered the FASTQ file and the reads with length less than 45 bp or greater than 150 bp and QV less than 20 were filtered out. The data of the BAM file mapped to the designed panel were output. There were 8252 genome regions designed over 23 chromosomes (chr). A total number of reads was 1 085 653 with the average 131.6 reads (range: 0–31034; quartiles, IQ25: 1; IQ50: 27; IQ75: 152). 7746 of designed genome regions (93.9%) had reads less than 500 (quartiles, IQ25: 0; IQ50: 20; IQ75: 118). We further used IGV to check one of mutations which showed KRAS G12V in the report. KRAS G12V (chr.12: 25245350) was read 25 times with the variant allele frequency (C to A) of 24%. Conclusion We showed how to monitor the NGS quality by free resource. It is important to ensure high-quality data after we received the individual laboratory reports. That may help increase the quality of patient care and clinical service.

#6489 UNI-494 DOES NOT SIGNIFICANTLY AFFECT RAT RESPIRATORY FUNCTION

Abstract Background and Aims Nicorandil, a selective mitochondrial ATP-sensitive potassium channel activator, may be beneficial for several disease states, including acute kidney injury. However, its clinical use is limited by serious gastrointestinal side effects and rapid absorption and elimination. UNI-494, a novel nicorandil prodrug designed to improve its pharmacologic properties, may increase the short half-life and improve the safety profile of nicorandil. We present safety results from a safety pharmacology study evaluating the effects of UNI-494 on respiratory function in a rat model. Method The effects of UNI-494 on respiratory function (peak inspiratory and expiratory flow, inspiratory and expiratory time, minute volume, and respiratory rate) were evaluated using whole body plethysmography test in 4 groups of male Wistar Han rats (n = 8 per group). In addition to a control group, 3 test groups were administered doses of 2, 20, or 200 mg UNI-494/kg. Airway function parameter data generated were acquired using specialized EMKA Technologies software (IOX version 2.9.5; DATANLYST version 2.6.1) connected to Emka plethysmographic equipment. Recordings were taken 3 hours before and 4 hours after administration of the control and test items. Effects were reported at 0, 10, 15, 20, 30, 60, 90, 120, 180, and 240 minutes after administration. Results UNI-494 had no relevant effects on rat respiratory function over the 240-minute test period at any dose (2, 20, or 200 mg UNI-494/kg). There were small but insignificant differences in peak inspiratory and expiratory flow (Figure 1, 2), minute volume, respiratory rate, and inspiratory and expiratory time between the control group and the 200 mg UNI-494/kg group. Conclusion Rat respiratory function was not significantly affected by UNI-494. Future studies should continue to evaluate the safety and efficacy of this novel drug.

A Study on Security Requirements of Shipboard Combat System based on Threat Modelling

The shipboard combat system is a key system for naval combat that supports a command and control process cycle consisting of Detect - Control - Engage in real time to ensure ship viability and conduct combat missions. Modern combat systems were developed on the basis of Open Architecture(OA) to maximize acceptance of latest technology and interoperability between systems, and actively introduced the COTS(Commercial-of-the-shelf). However, as a result of that, vulnerabilities inherent in COTS SW and HW also occurred in the combat system. The importance of combat system cybersecurity is being emphasized but cybersecurity research reflecting the characteristics of the combat system is still lacking in Korea. Therefore, in this paper, we systematically identify combat system threats by applying Data Flow Diagram, Microsoft STRIDE threat modelling methodology. The threats were analyzed using the Attack Tree &amp; Misuse case. Finally we derived the applicable security requirements which can be used at stages of planning and designing combat system and verified security requirements through NIST 800-53 security control items.

Evaluation of Image for Phantom according to Normalization, Well Counter Correction in PET-CT

Purpose: PET-CT imaging require an appropriate quality assurance system to achieve high efficiency and reliability. Quality control is essential for improving the quality of care and patient safety. Currently, there are performance evaluation methods of UN2-1994 and UN2-2001 proposed by NEMA and IEC for PET-CT image evaluation. In this study, we compare phantom images with the same experiments before and after PET-CT 3D normalization and well counter correction and evaluate the usefulness of quality control. Materials and methods: Discovery 690 (General Electric Healthcare, USA) PET-CT equiptment was used to perform 3D normalization and well counter correction as recommended by GE Healthcare. Based on the recovery coefficients for the six spheres of the NEMA IEC Body Phantom recommended by the EARL. 20kBq/㎖ of 18F was injected into the sphere of the phantom and 2 kBq/㎖ of 18F was injected into the body of phantom. PET-CT scan was performed with a radioacitivity ratio of 10:1. Images were reconstructed by appliying TOF+PSF+TOF, OSEM+PSF, OSEM and Gaussian filter 4.0, 4.5, 5.0, 5.5, 6.0, 6,5 ㎜ with matrix size 128×128, slice thickness 3.75 ㎜, iteration 2, subset 16 conditions. The PET image was attenuation corrected using the CT images and analyzed using software program AW 4.7 (General Electric Healthcare, USA). The ROI was set to fit 6 spheres in the CT image, RC (Recovery Coefficient) was measured after fusion of PET and CT. Statistical analysis was performed wilcoxon signed rank test using R. Results: Overall, after the quality control items were performed, the recovery coefficient of the phantom image increased and measured. Recovery coefficient according to the image reconstruction increased in the order TOF+PSF, TOF, OSEM+PSF, before and after quality control, RCmax increased by OSEM 0.13, OSEM+PSF 0.16, TOF 0.16, TOF+PSF 0.15 and RCmean increased by OSEM 0.09, OSEM+PSF 0.09, TOF 0.106, TOF+PSF 0.10. Both groups showed a statistically significant difference in wilcoxon signed rank test results (P value&lt;0.001). Conclusion: PET-CT system require quality assurance to achieve high efficiency and reliability. Standardized intervals and procedures should be followed for quality control. We hope that this study will be a good opportunity to think about the importance of quality control in PET-CT.

Cost assessment of optimal control strategy for brucellosis dynamic model based on economic factors

In recently years, brucellosis between humans and animals in China has shown signs of outbreak again. Brucellosis always takes a heavy toll on human health and profitability of livestock industry, but for farmers, the purpose of breeding is to make profits. Therefore, the optimal control strategy that can maximize the profits of farmers and effectively control brucellosis is needed. It is important to understand the profit mechanism of farmers and disease transmission mechanism in order to design a more effective and reasonable control strategy to maximize the profits of farmers. We propose a dynamic model combining the economic factors, behaviors of livestock farmers and transmission mechanism of brucellosis. Then we investigate the result of the optimal strategy in theory using Pontryagin Maximum Principle and its existence and uniqueness are proved. To verify the accuracy and applicability of the theory, the model are simulated by the least square method based on the price data and infected people data of Ningxia Hui Autonomous Region. The simulation results show that brucellosis is in an outbreak in Ningxia Hui Autonomous Region and the current control policy must be adjusted. Sensitivity analysis indicate economic factors have certain influence on the outbreak of diseases. Under different compositions of three control items (including reduce the contact between susceptible and infected animals, increase the vaccination of susceptible animals, and reduce the discharge of Brucella), we evaluate the optimal control strategy for Ningxia Hui Autonomous Region from profits and infected brucellosis livestock perspectives. The profit results show that the government should increase financial support for disease control and it is effective to implement control by stages.