The International Thermonuclear Experimental Reactor (ITER) is the next step toward the realization of electricity-producing fusion power plants, and it is planned to be in operation in 2016. ITER has been designed so as to reach the plasma burning condition and to operate with high-elongated unstable plasmas. However, due to the constraints that affect the machine realization, these open-loop unstable high-performance plasmas can hardly be stabilized using the poloidal field coils placed outside the tokamak vessel. For this reason, during the ITER design review phase, it has been proposed to investigate the possibility of using in-vessel coils in order to improve the best achievable performance of the vertical stabilization (VS) system. This paper proposes a new approach for the plasma current, position, and shape control design in the presence of in-vessel coils. Two control loops are designed: a first loop that guarantees the VS driving the voltage applied to in-vessel coils, and a second loop that controls the plasma current and up to 32 geometrical shape descriptors as close as possible to the reference values. The performance of the proposed control system is shown by means of simulations of some cases of interest.