This article studies the problem of memory event-triggered cooperative adaptive control of heterogeneous nonlinear multiagent systems (MASs) under denial-of-service (DoS) attacks based on the multiplayer mixed zero-sum (ZS) game strategy. First, a neural-network-based reinforcement learning scheme is structured to obtain the Nash equilibrium solution of the proposed multiplayer mixed ZS game scheme. Then, a memory-based event-triggered mechanism considering the historical data is proposed. This effectively avoids incorrect triggering information caused by unknown external factors. Moreover, thanks to the idea of switching topology, the mixed ZS game problem under the influence of node-based DoS attacks is solved efficiently. In accordance with the Lyapunov stability theory, it is proved that all signals of heterogeneous MASs are bounded, all heterogeneous followers can track the trajectory of the leader during the no-attack period, the attacked follower can achieve stabilization control during the attack period, and the remaining nonattacked followers can achieve cooperative control during the attack period. Finally, the effectiveness of the designed memory-event-triggered-based mixed ZS game cooperative control strategy is tested by the given simulation results.