Objective: To summarize and compare the diagnostic accuracy of contrast and subtraction arthrography in the assessment of aseptic loosening of total hip arthroplasties. Design: This meta-analysis was performed using methods described by the Cochrane Methods Group on Systematic Reviews of Screening and Diagnostic Tests. We included original, English-language papers published between January 1975 to October 2004 that examined contrast-enhanced arthrography with or without subtraction for diagnosis of loosening of total hip prostheses. A qualitative and quantitative analysis was performed by two investigators. Results: With regard to the acetabular component, pooled sensitivity and specificity for contrast arthrography was 70% (95% confidence interval, 52–84) and 74% (95% CI, 53–87), respectively. Subtraction arthrography had a significantly higher sensitivity of 89% (95% CI, 84–93) ( p = 0.01), with a similar specificity of 76% (95% CI, 68-82). For the femoral component, pooled sensitivity and specificity for contrast arthrography were 63% (95% CI, 53–72) and 78% (95% CI, 68–86). Pooled estimates for subtraction arthrography revealed a significantly higher sensitivity of 86% (95% CI, 74–93) ( p = 0.003). Specificity was 85% (95% CI, 77–91) and was similar to the data of contrast arthrography ( p = 0.23). Conclusion: Using the present data we found that the subtraction arthrography is a sensitive technique for detection of loosening of total hip prostheses, offering added value over contrast arthrography, especially for evaluation of the femoral component.
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