Contralateral Sensorimotor Cortex Research Articles

The effect of temporal accuracy constraints on movement-related potentials

Both self-paced movements (internally generated) and movements paced by a fixed interval cue (externally cued) are preceded by a slow-rising movement-related potential (MRP) of similar timing, magnitude and topography. When the timing of the external cue is variable (temporally unpredictable), this MRP is absent. These findings have been interpreted to suggest that MRPs reflect neural activity mediating the preparation of temporally predictive movements, irrespective of whether the movement is internally generated or externally cued. However, the apparent similarity between MRPs preceding self-paced and predictably cued movements might be explained by the absence of control for the timing of movement onset, that is, MRPs preceding regularly-paced cues may simply reflect activity associated with self-paced movements initiated at times that more or less coincide with the timing of the imperative cue. The objective of this study was to reexamine the comparison of MRPs preceding temporally predictive (self-paced and predictably cued) versus reactive movements. To circumvent the potential confound of movement onset timing, constraints were placed on the temporal accuracy of movements cued by a regularly-paced tone. This design permitted post-hoc classification of trials into predictive or reactive movements to the tone. Three movement initiation conditions were tested: (1) self-paced (SP), (2) in response to an irregularly-paced cue (IC), and (3) in response to a regularly-paced cue (RC). In the latter condition, subjects were trained to initiate movement to within less than one simple reaction time in at least 50% of trials, and MRPs were compared between movements that were initiated "too early" (predictive), "too late" (reactive), or were temporally accurate (predictive). Cerebral potentials were recorded from 87 scalp surface electrodes. Consistent with previous studies, an early slow-rising MRP with maximum negativity over the midline frontal cortex was present only when the timing of movement onset could be predicted in advance (SP and RC conditions). Moreover, MRPs for movements that were temporally accurate or were initiated "too early" were significantly larger than the MRPs that preceded SP movements (P < 0.018). In contrast, movements initiated in reaction to the cue (IC condition), even when the timing of the cue could be predicted in advance (movement initiated "too late" in the RC condition), were associated with a significant attenuation of premovement activity (P < 0.005). Differences between conditions (RC > SP > IC) were significantly greater over the midline frontal cortex than the contralateral or ipsilateral sensorimotor cortex (P < 0.038). These findings show that the imposition of accuracy constraints on the timing of movement onset markedly enhances preparatory activity in the cortical or subcortical networks that mediate the predictive initiation of movement.

Deficient “sensory” beta synchronization in Parkinson’s disease

Beta rhythm movement-related synchronization (beta synchronization) reflects motor cortex deactivation and sensory afference processing. In Parkinson's disease (PD), decreased beta synchronization after active movement reflects abnormal motor cortex idling and may be involved in the pathophysiology of akinesia. The objectives of the present study were to (i) compare event-related synchronization after active and passive movement and electrical nerve stimulation in PD patients and healthy, age-matched volunteers and (ii) evaluate the effect of levodopa. Using a 128-electrode EEG system, we studied beta synchronization after active and passive index finger movement and electrical median nerve stimulation in 13 patients and 12 control subjects. Patients were recorded before and after 150% of their usual morning dose of levodopa. The peak beta synchronization magnitude in the contralateral primary sensorimotor (PSM) cortex was significantly lower in PD patients after active movement, passive movement and electrical median nerve stimulation, compared with controls. Levodopa partially reversed the drop in beta synchronization after active movement but not after passive movement or electrical median nerve stimulation. If one considers that beta synchronization reflects sensory processing, our results suggest that integration of somaesthetic afferences in the PSM cortex is abnormal in PD during active and passive movement execution and after simple electrical median nerve stimulation. Better understanding of the mechanisms involved in the deficient beta synchronization observed here could prompt the development of new therapeutic approaches aimed at strengthening defective processes. The lack of full beta synchronization restoration by levodopa might be related to the involvement of non-dopaminergic pathways.

An investigation of the cortical control of forepaw gripping after cervical hemisection injuries in rats

Previous studies in mice have demonstrated that forepaw gripping ability, as measured by a grip strength meter (GSM), is dependent on the contralateral sensorimotor cortex, but this dependency changes after hemisection injury at cervical level 4 (C4). Initially, the mouse fails to grip with the forepaw ipsilateral to the hemisection but gripping recovers. Additionally, a mouse's gripping by the contralateral paw becomes independent of the sensorimotor cortex, indicating a reorganization of cortical control of gripping function (Blanco, J.E., Anderson, K.D., Steward, O. 2007. Recovery of forepaw gripping ability and reorganization of cortical motor control following cervical spinal cord injuries in mice. Exp. Neurol. 203, 333–348.). Here we explore whether a similar reorganization occurs after cervical hemisection injuries in rats. We show that as in mice, unilateral lesions of the sensorimotor cortex impair rats' griping by the contralateral paw. We also confirm from previous studies that cervical hemisections impair rats' griping by the ipsilateral paw. In contrast to mice, however there is minimal recovery of gripping after complete lateral hemisections and secondary lesions of the sensorimotor cortex continue to impair rats' gripping by the contralateral paw. Thus, forelimb gripping ability as measured by the GSM is dependent on the contralateral sensorimotor cortex in rats even after a cervical hemisection.

Levodopa affects functional brain networks in parkinsonian resting tremor

Resting tremor in idiopathic Parkinson's disease (PD) is associated with an oscillatory network comprising cortical as well as subcortical brain areas. To shed light on the effect of levodopa on these network interactions, we investigated 10 patients with tremor-dominant PD and reanalyzed data in 11 healthy volunteers mimicking PD resting tremor. To this end, we recorded surface electromyograms of forearm muscles and neuromagnetic activity using a 122-channel whole-head magnetometer (MEG). Measurements were performed after overnight withdrawal of levodopa (OFF) and 30 min after oral application of fast-acting levodopa (ON). During OFF, patients showed the typical antagonistic resting tremor. Using the analysis tool Dynamic Imaging of Coherent Sources, we identified the oscillatory network associated with tremor comprising contralateral primary sensorimotor cortex (S1/M1), supplementary motor area (SMA), contralateral premotor cortex (PMC), thalamus, secondary somatosensory cortex (S2), posterior parietal cortex (PPC), and ipsilateral cerebellum oscillating at 8 to 10 Hz. After intake of levodopa, we found a significant decrease of cerebro-cerebral coupling between thalamus and motor cortical areas. Similarly, in healthy controls mimicking resting tremor, we found a significant decrease of functional interaction within a thalamus-premotor-motor network during rest. However, in patients with PD, decrease of functional interaction between thalamus and PMC was significantly stronger when compared with healthy controls. These data support the hypothesis that (1) in patients with PD the basal ganglia and motor cortical structures become more closely entrained and (2) levodopa is associated with normalization of the functional interaction between thalamus and motor cortical areas.

Post-movement beta synchronisation after complex prosaccade task

Objective Post-movement beta synchronisation (PMBS) has been described as an induced, localised increase of beta activity over the contralateral sensorimotor cortex after termination of voluntary limb movement. The aim of our study was to investigate whether ocular saccades also evoke movement related EEG changes. Methods Complex saccades were recorded in six healthy volunteers using electro-oculography. EEG power changes in the beta frequency band were measured before, during and after saccades. Results Significant increase of beta-power was observed over the frontocentral region of both hemispheres after the offset of the complex saccade task. The latency of ocular PMBS was about 1100 ms. Conclusions Ocular PMBS evoked by complex saccade task is similar to that of recorded after limb movements. Its presence over both hemispheres irrespective of the direction of saccades indicates bilateral activation of cortical areas connected with the execution and planning of ocular movements. Significance The present paper is the first report on eye-movement related post-movement beta synchronisation. Investigation of ocular PMBS can be used both for research and clinical purposes for the functional assessment of neuronal networks controlling eye movements.

Study on connectivity between coherent central rhythm and electromyographic activities

Whether afferent feedback contributes to the generation of cortico-muscular coherence (CMCoh) remains an open question. In the present study, a multivariate autoregressive (MVAR) model and partial directed coherence (PDC) were applied to investigate the causal influences between the central rhythm and electromyographic (EMG) signals in the process of CMCoh. The system modeling included activities from the contralateral and ipsilateral primary sensorimotor cortex (M1/S1), supplementary motor area (SMA) and the time series from extensor carpi radialis (ECR) muscles. The results showed that afferent sensory feedback could also play an important role for the generation of CMCoh. Meanwhile, significant coherence between the EMG signals and the activities in the SMA was found in two subjects out of five. Connectivity analysis revealed a significant descending information flow which possibly reflected direct recruitment on the motoneurons from the SMA to facilitate motor control.

Cortical effect and functional recovery by the electromyography-triggered neuromuscular stimulation in chronic stroke patients

We investigated the effect of electromyography (EMG)-triggered neuromuscular electrical stimulation (NMES; EMG-stim) on functional recovery of the hemiparetic hand and the related cortical activation pattern in chronic stroke patients. We enrolled 14 stroke patients, who were randomly assigned to the EMG-stim (n=7) or the control groups (n=7). The EMG-stim was applied to the wrist extensor of the EMG-stim group for two sessions (30 min/session) a day, five times per week for 10 weeks. Four functional tests (box and block, strength, the accuracy index, and the on/offset time of muscle contraction) and functional MRI (fMRI) were performed before and after treatment. fMRI was measured at 1.5 T in parallel with timed finger flexion-extension movements at a fixed rate. Following treatment, the EMG-stim group showed a significant improvement in all functional tests. The main cortical activation change with such functional improvement was shifted from the ipsilateral sensorimotor cortex (SMC) to the contralateral SMC. We demonstrated that 10-week EMG-stim can induce functional recovery and change of cortical activation pattern in the hemiparetic hand of chronic stroke patients.

Physiology and morphology of callosal projection neurons in mouse

In the mammalian neocortex, the corpus callosum serves as the major source of interhemispheric communication, composed of axons from callosal neurons located in supragranular (II/III) and infragranular (V/VI) layers. We sought to characterize the physiology and morphology of supragranular and infragranular callosal neurons in mice using retrograde tracers and whole-cell patch clamp recordings. Whole-cell patch clamp recordings were made from retrogradely labeled callosal neurons following unilateral injection of fluorescent latex microspheres in the contralateral sensory-motor cortex. Following recordings and biocytin dialysis, labeled neurons were reconstructed using computer-assisted camera lucida (Neurolucida) for morphological analyses. Whole-cell recordings revealed that callosal neurons in both supra- and infragranular layers display very similar intrinsic membrane properties and are characteristic regular-spiking neurons. Morphological features examined from biocytin-filled reconstructions as well as retrogradely BDA labeled cells did not reveal any differences. Analysis of spontaneous postsynaptic potentials from callosal neurons did reveal several differences including average amplitude, frequency, and decay time. These findings suggest that callosal neurons in both supra- and infragranular layers have similar phenotypes though belong to different local, intracortical networks.

Brain activity is similar during precision and power gripping with light force: An fMRI study

Handgrips can be broadly classified into precision and power grips. To compare central neuronal control of these tasks, functional magnetic resonance imaging was used in 14 healthy right-handed volunteers, who repetitively squeezed non-flexible force transducers with a precision grip and a power grip of the dominant hand. The relative grip force levels and movement rates (0.45 Hertz) of both tasks were comparable. Peak isometric grip forces ranged between 1% and 10% of the maximum voluntary force. Reflecting the additional recruitment of extrinsic hand muscles and the higher absolute force, activation of the contralateral primary sensorimotor cortex (M1/S1) and ipsilateral cerebellum was significantly stronger during power than during precision grip. No brain areas exhibited stronger activity during the precision grip than during the power grip. The left M1/S1 and right cerebellum showed a positive linear relationship with the grip force, while the right angular gyrus and left superior frontal gyrus showed a gradual increase in activity when less force was applied. However, these force-dependent modulations of brain activity were similar for the precision and power grip tasks. No brain region was specifically activated during one task but not during the other. Activity during precision gripping did not exceed the activity associated with power gripping possibly because the precision grip task was not challenging enough to call on dexterous fine motor control.

The “mirror-neuron system” in MS

The mirror neuron system (MNS) is an observation-execution matching system activated, in humans, during action observation, motor learning, and imitation of action. We used functional MRI (fMRI) to investigate the properties of the MNS in patients with multiple sclerosis (MS). Using a 3 tesla scanner, we acquired fMRI in 16 right-handed patients with relapsing-remitting MS and 14 controls. Two motor tasks were studied. The first consisted of repetitive flexion-extension of the last four fingers of the right hand (simple task) alternated to epochs of rest; the second (MNS task) consisted of observation of a movie showing the hand of another subject while performing the same task. During the simple task, compared to controls, patients with MS had more significant activations of the contralateral primary sensorimotor cortex and supplementary motor area. During the MNS task, both groups showed the activation of several visual areas, the infraparietal sulcus, and the inferior frontal gyrus (IFG), bilaterally. The IFG and the visual areas were significantly more active in patients than controls. The between-group interaction analysis showed that in patients with MS, part of the regions of the MNS were more active also during the simple task. This study suggests increased activation of the mirror neuron system in patients with multiple sclerosis (MS) with a normal level of function and widespread CNS damage. The potentialities of this system in facilitating clinical recovery in patients with MS and other neurologic conditions should be investigated.

Corticomuscular synchronization with small and large dynamic force output.

BackgroundOver the last few years much research has been devoted to investigating the synchronization between cortical motor and muscular activity as measured by EEG/MEG-EMG coherence. The main focus so far has been on corticomuscular coherence (CMC) during static force condition, for which coherence in beta-range has been described. In contrast, we showed in a recent study [1] that dynamic force condition is accompanied by gamma-range CMC. The modulation of the CMC by various dynamic force amplitudes, however, remained uninvestigated. The present study addresses this question. We examined eight healthy human subjects. EEG and surface EMG were recorded simultaneously. The visuomotor task consisted in isometric compensation for 3 forces (static, small and large dynamic) generated by a manipulandum. The CMC, the cortical EEG spectral power (SP), the EMG SP and the errors in motor performance (as the difference between target and exerted force) were analyzed.ResultsFor the static force condition we found the well-documented, significant beta-range CMC (15–30 Hz) over the contralateral sensorimotor cortex. Gamma-band CMC (30–45 Hz) occurred in both small and large dynamic force conditions without any significant difference between both conditions. Although in some subjects beta-range CMC was observed during both dynamic force conditions no significant difference between conditions could be detected. With respect to the motor performance, the lowest errors were obtained in the static force condition and the highest ones in the dynamic condition with large amplitude. However, when we normalized the magnitude of the errors to the amplitude of the applied force (relative errors) no significant difference between both dynamic conditions was observed.ConclusionThese findings confirm that during dynamic force output the corticomuscular network oscillates at gamma frequencies. Moreover, we show that amplitude modulation of dynamic force has no effect on the gamma CMC in the low force range investigated. We suggest that gamma CMC is rather associated with the internal state of the sensorimotor system as supported by the unchanged relative error between both dynamic conditions.

Out-of-Synch and Out-of-Sorts: Dysfunction of Motor-Sensory Communication in Schizophrenia

Phase synchronization of neural activity preceding a motor act may reflect an efference copy of the motor plan and its expected sensory consequences (corollary discharge), which is sent to sensory cortex to herald the arrival of self-generated sensations and dampen the resulting sensory experience. We performed time-frequency decomposition of response-locked electroencephalogram (EEG) to examine phase synchronization of oscillations across trials (phase-locking factor [PLF]) to self-paced button presses. If prepress PLF reflects the activity in motor cortex, it should be contralateralized. If it reflects the action of the efference copy, it should be related to subsequent sensory suppression. If efference copy/corollary discharge mechanisms are abnormal in schizophrenia, it should be reduced in patients with schizophrenia. Electroencephalogram was collected while 23 patients (20 schizophrenia; 3 schizoaffective) and 25 age-matched control subjects pressed a button, at will, every 1 to 2 sec. Phase-locking factor preceding and following button presses was calculated from single-trial EEG; averaging single trials yielded response-locked event-related potentials (ERPs) to the tactile response associated with button pressing. Consistent with its hypothesized reflection of efference copy/corollary discharge signals, prepress gamma band neural synchrony was 1) maximal over the contralateral sensory-motor cortex in healthy subjects, 2) correlated with the ipsilateralized somatosensory ERP amplitude evoked by the press, and 3) reduced in patients. Prepress neural synchrony in the beta band was also reduced in patients, especially those with avolition/apathy. These data are consistent with dysfunction of forward model circuitry in schizophrenia and suggest that the specific motor-sensory system affected is selectively linked to symptoms involving that system.

Maladaptive effects of learning with the less-affected forelimb after focal cortical infarcts in rats

It is common following stroke to focus early rehabilitation efforts on developing compensatory use of the less-affected body side. Here we used a rat model of focal cortical infarct to examine how motor skill acquisition with the less-affected (“intact”) forelimb influences sensorimotor function of the infarct-impaired forelimb and neural activity in peri-infarct cortex. Rats proficient in skilled reaching with one forelimb were given focal ischemic lesions in the contralateral sensorimotor cortex (SMC). Recovery in this forelimb was tested following a period of reach training focused on the intact forelimb or control procedures. Quantitative measures of the cumulatively expressed transcription factor, FosB/ΔFosB, were used to assay intact forelimb training effects on neuronal activity in remaining SMC of the infarcted hemisphere. Intact forelimb training worsened behavioral recovery in the impaired forelimb following unilateral focal ischemia. Furthermore, it decreased neuronal FosB/ΔFosB expression in layer II/III of peri-infarct SMC. These effects were not found in sham-operated rats trained sequentially with both forelimbs or in animals receiving bilateral forelimb training after unilateral infarcts. Thus, focused use of the intact forelimb has detrimental effects on recovery of impaired forelimb function following a focal ischemic injury and this is linked to reduced neuronal activation in remaining cortex. These results suggest that peri-infarct cortex becomes vulnerable to early post-stroke experience with the less-affected forelimb and that this experience may drive neural plasticity here in a direction that is maladaptive for functional outcome.

Neuro-Physiological Adaptations Associated with Cross-Education of Strength

Cross-education of strength is the increase in strength of the untrained contralateral limb after unilateral training of the opposite homologous limb. We investigated central and peripheral neural adaptations associated with cross-education of strength. Twenty-three right-handed females were randomized into a unilateral training group or an imagery group. A sub-sample of eight subjects (four training, four imagery) was assessed with functional magnetic resonance imaging (fMRI) for patterns of cortical activation during exercise. Strength training was 6 weeks of maximal isometric ulnar deviation of the right arm, four times per week. Peak torque, muscle thickness (ultrasound), agonist-antagonist electromyography (EMG), and fMRI were assessed before and after training. Strength training was highly effective for increasing strength in trained (45.3%; P < 0.01) and untrained (47.1%; P < 0.01) limbs. The imagery group showed no increase in strength for either arm. Muscle thickness increased only in the trained arm of the training group (8.4%; P < 0.001). After training, there was an enlarged region of activation in contralateral sensorimotor cortex and left temporal lobe during muscle contractions with the untrained left arm (P < 0.001). Training was associated with a significantly greater change in agonist muscle EMG pooled over both limbs, compared to the imagery group (P < 0.05). These results suggest that cross-education of strength may be partly controlled by adaptations within sensorimotor cortex, consistent with previous studies of motor learning. However, this research demonstrates the involvement of temporal lobe regions that subserve semantic memory for movement, which has not been previously studied in this context. We argue that temporal lobe regions might play a significant role in the cross-education of strength.

Self-paced frequency of a simple motor task and brain activation: An fMRI study in healthy subjects using an on-line monitor device

Application of fMRI to clinical neurology implies the selection of a simple task and control of the task performance. The capability to objectively monitor variables related to task execution is, therefore, important and could improve accuracy of clinical fMRI studies. We assessed the influence of different self-paced frequencies of a simple motor task on brain activation in healthy subjects. A device was developed to measure the force exerted by a subject in pressing an air-filled rubber bulb with the last four fingers of the dominant hand. The task frequency was determined by analysis of the force signal. Nine healthy subjects performed twice the task with self-paced slow (0.35±0.09 Hz), intermediate (0.58±0.21 Hz) or fast (0.98±0.32 Hz) frequency. The device revealed impaired task execution in 1 subject. The coefficient of variation of frequency was 8.7% for slow, 12.2% for intermediate and 15.8% for fast paced task. No significant differences were found comparing the activation maps obtained at slow, intermediate and fast frequencies in the contralateral sensorimotor cortex and ipsilateral cerebellum. Cluster reproducibility was good for location (standard deviation≤7.3 mm), but poor for signal intensity (coefficient of variation 0–176.8%) and extent (coefficient of variation 1.9–140.6%). In conclusion, self-paced frequency variations of a simple motor task in the 0.2–2 Hz range are not a relevant source of the variability of the fMRI results in healthy subjects. Use of the device for evaluation of the neurologically impaired patients might broaden the clinical applications of fMRI.

Shift of motor activation areas during recovery from hemiparesis after cerebral infarction: A longitudinal study with near-infrared spectroscopy

Motor functional recovery after stroke may be attributable to cerebral reorganization. We used near-infrared spectroscopy, which measures non-invasively the changes in oxy- and deoxy-hemoglobin concentrations in response to neural activation, for monitoring cerebral activation in stroke patients, and investigated the longitudinal changes in functional laterality of activations in the primary sensorimotor cortex during unilateral audio-paced (1 Hz) hand movement. We examined five ischemic stroke patients (4 females and 1 male, 52–67 years old) with mild to moderate hemiparesis at acute stages and chronic stages at least 1 month later. Normal subjects (3 females and 2 males, 47–63 years old) were also included. Unilateral hand movement activated predominantly the contralateral primary sensorimotor cortex in the normal subjects and the stroke patients when they moved unaffected hand. Affected hand movements activated bilateral sensorimotor cortices early after stroke (<25 days of stroke onset), whereas the activation pattern returned toward normal at later periods (>35 days). The contralaterality index (0.34 ± 0.12 in normal control) was reduced at early periods (0.00 ± 0.03, p < 0.01) after stroke, and returned to normal (0.35 ± 0.24) as motor function recovered. These findings suggest that a transient increase in motor activation in the ipsilateral intact hemisphere within 1 month may play an important role in the recovery from motor dysfunction after stroke.

Cortical oscillatory changes during warming and heating in humans

Warmth and heat are registered by different types of cutaneous receptors. To disentangle the cortical activation patterns of warming and heating, we analyzed the temporal evolution of the electroencephalographic 10 and 20 Hz oscillations with the time resolution of hundreds of milliseconds. Sixty heat (from 32 to 50.5 °C, rate of change 6 °C/s) and warm (from 32 to 42 °C, 6 °C/s) stimuli were applied on the right thenar using contact thermode. EEG was recorded from 111 scalp electrodes in 12 healthy subjects, and analyzed using event-related desynchronization and low-resolution electromagnetic tomography methods. During warming, the amplitudes of 10 and 20 Hz oscillations over the contralateral primary sensorimotor (SI/MI) and premotor cortices decreased, and the amplitude of 20 Hz oscillations in the anterior cingulate and ipsilateral premotor cortex increased. Heating was associated with additional profound amplitude decreases of 10 and 20 Hz oscillations over SI/MI and premotor cortex, and by amplitude increase of 20 Hz oscillations originating in the posterior cingulate cortex. Results suggest biphasic amplitude changes of the cortical oscillations during ramp increase of temperature attributable to the periods of warming and heating. The amplitude decreases of 10 and 20 Hz oscillations in SI/MI and premotor cortex possibly aid in preparation of motor withdrawal reaction in an event that temperature should reach intolerable pain. Synchronization of the 20 Hz oscillations in the anterior and especially in the posterior cingulate cortex may aid suppression of unwanted movements.

Functional anatomy of motor urgency

This PET H215O study uses a reaching task to determine the neural basis of the unconscious motor speed up observed in the context of urgency in healthy subjects. Three conditions were considered: self-initiated (produce the fastest possible movement toward a large plate, when ready), externally-cued (same as self-initiated but in response to an acoustic cue) and temporally-pressing (same as externally-cued with the plate controlling an electromagnet that prevented a rolling ball from falling at the bottom of a tilted ramp). Results show that: (1) Urgent responses (Temporally-pressing versus Externally-cued) engage the left parasagittal and lateral cerebellar hemisphere and the sensorimotor cortex (SMC) bilaterally; (2) Externally-driven responses (Externally-cued versus Self-initiated) recruit executive areas within the contralateral SMC; (3) Volitional responses (Self-initiated versus Externally-cued) involve prefrontal cortical areas.These observations are discussed with respect to the idea that neuromuscular energy is set to a submaximal threshold in self-determined situations. In more challenging tasks, this threshold is raised and the first answer of the nervous system is to optimize the response of the lateral (i.e. crossed) corticospinal tract (contralateral SMC) and ipsilateral cerebellum. In a second step, the anterior (i.e. uncrossed) corticospinal tract (ipsilateral SMC) and the contralateral cerebellum are recruited. This recruitment is akin to the strategy observed during recovery in patients with brain lesions.

Stimulus-related 20-Hz activity of human cortex modulated by the way of presenting hand actions

The neural mechanisms underlying recognition of presented hand actions are not well understood. Rolandic rhythmic activity of about 20 Hz is reproducibly induced after median nerve stimulation and has been reported to be related to various types of movements including actual movement, motor imagery and action observation. We recorded neuromagnetic brain activity from 11 healthy subjects to investigate whether the way to present hand actions modulates the 20-Hz activity after median nerve stimulation. The stimulus-related 20-Hz activity was prominently evoked in the contralateral sensorimotor cortex around 0.5–1.0 s after median nerve stimulation and was almost completely suppressed during executing actual hand action. The suppression of the stimulus-related 20-Hz activity was also observed during viewing the similar action of another person's hand. Furthermore, the suppression during viewing the action of another person's hand presented in the same direction as the subject's hand was significantly larger than that during viewing it presented in the opposite direction and was closer to that during executing subject's own hand action. These results indicate that the stimulus-related rolandic 20-Hz activity was modulated by the way to present hand actions, and suggest that the 20-Hz activity is related to neural mechanisms underlying recognition of presented hand actions.

Brain Representation of Active and Passive Hand Movements in Children

Several functional neuroimaging studies have been performed exploring the sensorimotor function in children with neurologic disorders. However, little is known about normal activation patterns of the sensorimotor system at a young age. We explored brain representation of active and passive hand movements in school-age children and young adults. Nine healthy children (7-15 y) and six adults were studied. Functional magnetic resonance imaging (fMRI) data were acquired on a 1.5-T scanner in block designs. Active movement consisted of repetitive opening and closing of the hand; passive movement consisted of the same movement performed by the examiner. Both hands were assessed separately. The pattern of brain activation (contralateral primary sensorimotor cortex (SMC), ipsilateral cerebellum, supplementary motor area (SMA), and lateral premotor cortex (PMC) was generally more widespread in the adult group, suggesting a developmental course in the organization of both motor and sensory cortex. Surprisingly, no difference was generally detected when contrasting active versus passive tasks. Our results suggest that active and passive hand movements can be used for the exploration of the sensorimotor system in children. Passive and active tasks confirmed to be tightly coupled, thus supporting the idea of the former as a helpful performance-independent paradigm in the study of brain reorganization and presurgical assessment.