Contraction Movement Research Articles

A narrative review of velocity-based training best practice: The importance of contraction intent vs. movement speed.

Explosive movements requiring high force and power outputs are integral to many sports, posing distinct challenges for the neuromuscular system. Traditional resistance training can improve muscle strength, power, endurance, and range of motion; however, evidence regarding its effects on athletic performance, such as sprint speed, agility, and jump height, remains conflicting. The specificity of resistance training movements, including velocity, contraction type, and joint angles affects performance outcomes, demonstrates advantages when matching training modalities with targeted sports activities. However, independent of movement speed, the intent to contract explosively (ballistic) has also demonstrated high velocity-specific training adaptations. The purpose of this narrative review was to assess the impact of explosive or ballistic contraction intent on velocity-specific training adaptations. Such movement intent may predominantly elicit motor efferent neural adaptations, including motor unit recruitment and rate coding enhancements. Plyometrics, which utilize rapid stretch-shortening cycle (SSC) movements may augment high-speed movement efficiency and muscle activation, possibly leading to improved motor control through adaptations like faster eccentric force absorption, reduced amortization periods, and quicker transitions to explosive concentric contractions. An optimal training paradigm for power and performance enhancement might involve a combination of maximal explosive intent training with heavier loads and plyometric exercises with lighter loads at high velocities. This narrative review synthesizes key literature to answer whether contraction intent or movement speed is more critical for athletic performance enhancement, ultimately advocating for an integrative approach to resistance training tailored for sports-specific explosive action.

Noise Suppression of ECG Signal Using Optimized Digital Butterworth Bandpass Filter

ECG devices have been widely utilized by medical experts for cardiac health detection. It generates an analog signal that has intrinsic characteristics represented by PQRST waves. Each wave is useful for diagnostic purposes. However, ECG signal is prone to noise, particularly EMG noise. This noise occurs as a result of muscle contraction or sudden body movement of a subject. Several studies have been proposed to suppress the EMG noise on ECG. However, the complexity of an algorithm is a challenging task to be solved. Considering this problem, this research aims to suppress EMG noise using a low-complexity algorithm. To achieve this objective, a method of Butterworth bandpass filter DF-II has been proposed. The findings demonstrate that the proposed method improves SNR and signal power by 0.498dB and 0.006dBm/Hz respectively. It also demonstrates the capability to perform efficiently on a microcontroller unit.

Reliability of cervicocephalic sense of force

Cervicocephalic proprioception (CCP) is an important assessment item for people with a range of clinical conditions, where reduced CCP is associated with neck pain and imbalance. Reliability has been established for a range of positional and movements tests, but there is limited data regarding sense of force, particularly across three planes of movement. The current test–retest study assessed reliability when evaluating sense of force in healthy adults (8 males, 6 females, mean age 31.50 years [SD 10.14]) over two sessions, 4–7 days apart. A force matching protocol was used to evaluate reliability of absolute error (AE), constant error (CE), and variable error (VE) for 10 % and 25 % maximal voluntary contraction (MVC) target forces for flexion, extension, lateral flexion, and rotation. Participants were strapped to a chair to limit trunk movement and data was captured using a compressive force transducer fixed to an adjustable wall mount. Six trials were performed for each contraction-type, totaling 72 submaximal MVCs per session. ICC estimates for AE (0.15–0.77), CE (0.01–0.85), and VE (0.00–0.83) were varied and confidence intervals were mostly wide. Considering lower limits of confidence intervals, CE had best reliability values generally, but more specifically the most reliable contraction type and movement was 25 % MVC flexion (ICC 0.85, confidence interval 0.54–0.95). This study found that reliability for sense of force testing was dependent upon contraction, type of error, and target force utilized. Further reliability analysis should be performed when applying this test to measure validity outcomes in clinical populations.

An experimental study of thermoacoustic instabilities in a RP-3 fueled multi-swirl stabilized lean direct injection combustor

An investigation of self-excited combustion instabilities in a RP-3 fueled, multi-swirl stabilized, lean direct injection (LDI) combustor was performed and investigated with different operating conditions (inlet Reynolds number and fuel–air ratio (FAR)). Pressure fluctuation and heat release data were simultaneously collected using a 3-channel synchronous acquisition system. The results show that as the FAR increases, combustion transitions from a low oscillation mode to a high oscillation mode. During the modal transition, the oscillating flame structure, formed by vortex shedding in the shear layer and the recirculation zone, is then transformed into contraction and expansion movements from the front of the central recirculation zone towards the downstream and radial directions of the combustor. When combustion is in a low oscillation mode, the driving capability of the flame is relatively low. Upon entering a high oscillation mode, the overall driving energy of the flame can maintain combustion in a limit cycle oscillation state.

DANNMCTG: Domain-Adversarial Training of Neural Network for multicenter antenatal cardiotocography signal classification

Intelligent classification of cardiotocography (CTG) based on machine learning (ML), a useful tool to improve the accuracy of fetal abnormality detection, can assist obstetricians with clinical decisions. With the advancement of information technologies and medical devices, there are development opportunities for multicenter clinical research and obtaining more digital CTG signals. However, most of the existing clinical multicenter CTG datasets are partially annotated and have discrepancies which do not satisfy the ML condition of independent identical distribution. Therefore, this paper focuses on an unsupervised domain adaptation (UDA) algorithm to realize cross-domain intelligent classification of multimodal CTG signals. We propose a method dubbed domain adversarial training of neural network for multicenter CTG (DANNMCTG), which mainly consists of a label classifier, a feature extractor and a domain discriminator. To match different distribution of fetal heart rate (FHR), uterine contraction (UC) and fetal movement (FetMov) signals, we condition the domain alignment on label predictions by defining the multi-linear map. For analysis, two datasets from the hospital central station and home monitoring devices were considered as the source and target domains. The results showed that the accuracy value, F1 value and area under the curve (AUC) value of the DANNMCTG were 71.25%, 76.08% and 0.7705, respectively. This method significantly improved the performance of the deep learning models without exploiting any information in the target domain, and outperformed the state-of-the-art UDA algorithms for CTG classification. In summary, the DANNMCTG can effectively mitigate the influence of domain shift for multicenter intelligent prenatal fetal monitoring.

An alternative EMG normalization method: Heterogeneous recurrence quantification analysis of isometric maximum voluntary contraction movements

This study presents an alternative method of normalizing Surface Electromyography (EMG) signals, which provide valuable insights into the musculoskeletal properties of the human body. Traditional normalization through the peak maximum voluntary contraction (MVC) method may result in variable outcomes due to its dependence on pre-processing steps such as smoothing and window length. To address this issue, the study standardizes the EMG pre-processing steps by using non-linear techniques, namely recurrence quantification analysis (RQA) and heterogeneous RQA (HRQA). RQA, specifically HRQA, functions as EMG feature extractors to explore the nonlinear dynamical system and state space trajectories of chaotic EMG signals. Principal component analysis (PCA) and kernel PCA (KPCA) were further applied to the RQA and HRQA results to obtain data with more information. The results show that the first principal components (PC1 and KPC1) of HRQA have a very strong relationship with peak MVC (ρ > |0.90|, p < 0.001), indicating their potential compared to the traditional EMG normalization technique for lower limb muscle groups. Additionally, the study investigated the dynamic differences among isometric MVC movements in lower limb muscle groups and found that the RQA and HRQA methods indicated a greater separation for detecting these differences compared to peak MVC. This study offers a valuable method for assessing the musculoskeletal characteristics of individuals who may have difficulty with activities like walking or providing maximum force during EMG data collection, such as those suffering from Parkinson's disease or walking disabilities. This enhances our understanding of their musculoskeletal properties.

Cardiac biopsies reveal differences in transcriptomics between left and right ventricle in patients with or without diagnostic signs of heart failure

New or mild heart failure (HF) is mainly caused by left ventricular dysfunction. We hypothesised that gene expression differ between the left (LV) and right ventricle (RV) and secondly by type of LV dysfunction. We compared gene expression through myocardial biopsies from LV and RV of patients undergoing elective coronary bypass surgery (CABG). Patients were categorised based on LV ejection fraction (EF), diastolic function and NT-proBNP into pEF (preserved; LVEF ≥ 45%), rEF (reduced; LVEF < 45%) or normal LV function. Principal component analysis of gene expression displayed two clusters corresponding to LV and RV. Up-regulated genes in LV included natriuretic peptides NPPA and NPPB, transcription factors/coactivators STAT4 and VGLL2, ion channel related HCN2 and LRRC38 associated with cardiac muscle contraction, cytoskeleton, and cellular component movement. Patients with pEF phenotype versus normal differed in gene expression predominantly in LV, supporting that diastolic dysfunction and structural changes reflect early LV disease in pEF. DKK2 was overexpressed in LV of HFpEF phenotype, potentially leading to lower expression levels of β-catenin, α-SMA (smooth muscle actin), and enhanced apoptosis, and could be a possible factor in the development of HFpEF. CXCL14 was down-regulated in both pEF and rEF, and may play a role to promote development of HF.

Maximal Lower Limb Strength in Patellar Tendinopathy: A Systematic Review With Meta-Analysis.

To investigate whether lower limb strength is reduced in people with patellar tendinopathy (PT) compared with asymptomatic control individuals or the asymptomatic contralateral limb. MEDLINE, PubMed, Scopus, and Web of Science. To be included in the systematic review and meta-analysis, studies were required to be peer reviewed, published in the English language, and case control investigations; include participants with a clinical diagnosis of PT and an asymptomatic control or contralateral limb group; and include an objective measure of lower limb maximal strength. We extracted descriptive statistics for maximal strength for the symptomatic and asymptomatic limbs of individuals with PT and the limb(s) of the asymptomatic control group, inferential statistics for between-groups differences, participant characteristics, and details of the strength-testing protocol. The risk of bias was assessed using the Joanna Briggs Institute critical appraisal tool for analytical cross-sectional studies. Of the 23 included studies, 21 reported knee strength, 3 reported hip strength, and 1 reported ankle strength. Random-effects models (Hedges g) were used to calculate the pooled effect sizes (ESs) of muscle strength according to the direction of joint movement and type of contraction. The pooled ESs (95% CI) for maximal voluntary isometric contraction knee-extension strength, concentric knee-extension strength, and concentric knee-flexion strength were 0.54 (0.27, 0.80), 0.78 (0.30, 1.33), and 0.41 (0.04, 0.78), respectively, with all favoring greater strength in the asymptomatic control group. Researchers of 2 studies described maximal eccentric knee-extensor strength with no differences between the PT and asymptomatic control groups. In 3 studies, researchers measured maximal hip strength (abduction, extension, and external rotation), and all within-study ESs favored greater strength in the asymptomatic control group. Isometric and concentric knee-extensor strength are reduced in people with PT compared with asymptomatic control individuals. In contrast, evidence for reduced eccentric knee-extension strength in people with PT compared with asymptomatic control individuals is limited and inconsistent. Although evidence is emerging that both knee-flexion and hip strength may be reduced in people with PT, more examination is needed to confirm this observation.

Effect of myopia-control lenses on central and peripheral visual performance in myopic children.

To evaluate the short-term effects of three myopia-control lenses, which impose peripheral myopic defocus while providing clear central vision, on central and peripheral visual performance in myopic children. Twenty-one myopic children were enrolled in the study. Central visual performance was assessed using the quick contrast sensitivity function. Peripheral visual performance was evaluated by measuring peripheral contrast threshold and global motion perception, while subjects maintained fixation through the central portion of the lens. Single-vision spectacle lenses (SVL), spectacle lenses with highly aspherical lenslets (HAL) and defocus-incorporated soft contact (DISC) lenses were evaluated in random order, followed by orthokeratology (OK) lenses. All tests were performed monocularly on the right eye. The area under the log contrast sensitivity function (AULCSF) with DISC lenses was lower than that with SVL (1.14 vs. 1.40, p < 0.001) and HAL (1.14 vs. 1.33, p = 0.001). HAL increased the temporal visual field contrast threshold compared with OK lenses (p = 0.04), and OK lenses decreased the superior visual field contrast threshold compared with that of SVL (p = 0.04) and HAL (p = 0.005). HAL also increased the peripheral coherence threshold for identifying the contraction movement compared with OK lenses (p = 0.01). The short-term use of these optical interventions for myopia control exhibited measurable differences in central and peripheral visual performance. Relevant attention could be paid to these differences, especially when children switch to different treatments. DISC lenses exhibited worse central contrast sensitivity than SVL and HAL. Imposing peripheral defocus signals did not affect children's peripheral visual performance compared with SVL. However, considering the poorer peripheral visual performance provided by HAL, OK lenses are recommended for children if there are specific demands for global scene recognition and motion perception.

A modular continuous robot constructed by Miura-derived origami tubes

Folding a flat sheet under a specific crease pattern can form a three-dimensional origami tube, which has been proven to exhibit unique mechanical properties and has wide engineering applications. In this study, a novel Miura-derived origami tube is designed, and its precise circular closing condition and mechanical properties are systematically analyzed, revealing that the proposed origami tube has programmable stiffness characteristics. Polyvinyl chloride (PVC) sheet enables the origami tube to have the characteristics of flexibility, bending, compression, and torsion resistance. Then, a modular design strategy for the novel continuous robot constructed with the Miura-derived origami tube as the backbone is proposed. A continuous robot with three origami tube modules in series is designed and fabricated as a representative case. Three steel wires drive each module to achieve independent contraction or bending movement. The unified installation of steel wire-driven motors on the base endows the robot with a lightweight, interconnected inner space, high scalability, and flexibility backbone. The kinematic relationships among the driving space, configuration space, and task space are investigated by geometric model and constant curvature assumption, with the circular trajectory tracking and reachable workspace revealed by numerical simulations. Further, the kinematic decoupling or the multi-driving model based on the stiffness difference of the origami tube between multi-segments is discussed. Finally, three prototype experiments demonstrate both the rationality of introducing origami tubes to design the continuous robot and the application potential.

Advances in In Vitro Models of Neuromuscular Junction: Focusing on Organ-on-a-Chip, Organoids, and Biohybrid Robotics.

The neuromuscular junction (NMJ) is a peripheral synaptic connection between presynaptic motor neurons and postsynaptic skeletal muscle fibers that enables muscle contraction and voluntary motor movement. Many traumatic, neurodegenerative, and neuroimmunological diseases are classically believed to mainly affect either the neuronal or the muscle side of the NMJ, and treatment options are lacking. Recent advances in novel techniques have helped develop in vitro physiological and pathophysiological models of the NMJ as well as enable precise control and evaluation of its functions. This paper reviews the recent developments in in vitro NMJ models with 2D or 3D cultures, from organ-on-a-chip and organoids to biohybrid robotics. Related derivative techniques are introduced for functional analysis of the NMJ, such as the patch-clamp technique, microelectrode arrays, calcium imaging, and stimulus methods, particularly optogenetic-mediated light stimulation, microelectrode-mediated electrical stimulation, and biochemical stimulation. Finally, the applications of the in vitro NMJ models as disease models or for drug screening related to suitable neuromuscular diseases are summarized and their future development trends and challenges are discussed.

High performance fiber-constrained plasticized PVC gel actuators for soft robotics

Plasticized Poly (vinyl chloride) (PVC) gel actuators, a type of electroactive soft actuator, have recently attracted increasing interest in soft robotics. Herein, we report a novel planar PVC gel actuator with flexible electrodes and a fiber-constrained structure for electroactive artificial muscles. PET adhesive fibers were evenly affixed on both sides of the unidirectional pre-stretched PVC gel membranes in one direction, resulting in a human-muscle-like unidirectional contraction and expansion movement. The fibers can constrain the bending motion of the PVC gel membranes, and the unidirectional pre-stretch in the direction of the attached fibers further makes the membrane anisotropic, leading to easy and fast actuation in the direction normal to the pre-stretch. The developed fiber-constrained plasticized PVC gel actuator (FCPPGA) unit exhibited high strain (>40%) and stress (>0.5 MPa) with a fast response time of about 0.1 s under a relatively low driving DC field (<15 V/μm). The simulated data were in good agreement with the experimental results. Furthermore, the designed FCPPGA was successfully used to demonstrate the mimicry of lower jaw motions in a skeleton model.

Recognition of emotional body language from dyadic and monadic point-light displays in 5-year-old children and adults

Most child studies on emotion perception used faces and speech as emotion stimuli, but little is known about children’s perception of emotions conveyed by body movements, that is, emotional body language (EBL). This study aimed to investigate whether processing advantages for positive emotions in children and negative emotions in adults found in studies on emotional face and term perception also occur in EBL perception. We also aimed to uncover which specific movement features of EBL contribute to emotion perception from interactive dyads compared with noninteractive monads in children and adults. We asked 5-year-old children and adults to categorize happy and angry point-light displays (PLDs), presented as pairs (dyads) and single actors (monads), in a button-press task. By applying representational similarity analyses, we determined intra- and interpersonal movement features of the PLDs and their relation to the participants’ emotional categorizations. Results showed significantly higher recognition of happy PLDs in 5-year-olds and of angry PLDs in adults in monads but not in dyads. In both age groups, emotion recognition depended significantly on kinematic and postural movement features such as limb contraction and vertical movement in monads and dyads, whereas in dyads recognition also relied on interpersonal proximity measures such as interpersonal distance. Thus, EBL processing in monads seems to undergo a similar developmental shift from a positivity bias to a negativity bias, as was previously found for emotional faces and terms. Despite these age-specific processing biases, children and adults seem to use similar movement features in EBL processing.

CO2-Induced Ocean Acidification Alters the Burrowing Behavior of Manila Clam Ruditapes philippinarum by Reversing GABAA Receptor Function.

Biological burrowing behavior is an important driver shaping ecosystems that is being threatened by CO2-induced ocean acidification; however, the effects of ocean acidification on burrowing behavior and its neurological mechanism remain unclear. This study showed that elevated pCO2 significantly affected the burrowing behaviors of the Manila clam Ruditapes philippinarum, such as increased foot contraction, burrowing time, and intrabottom movement and decreased burrowing depth. Delving deeper into the mechanism, exposure to elevated pCO2 significantly decreased extracellular pH and increased [HCO3-]. Moreover, an indicator GABAA receptor, a neuroinhibitor for movement, was found to be closely associated with behavioral changes. In situ hybridization confirmed that the GABAA receptor was widely distributed in ganglia and foot muscles, and elevated pCO2 significantly increased the mRNA level and GABA concentration. However, the increase in GABAA receptor and its ligand did not suppress the foot movement, but rather sent "excitatory" signals for foot contraction. The destabilization of acid-base homeostasis was demonstrated to induce an increase in the reversal potential for GABAA receptor and an alteration in GABAA receptor function under elevated pCO2. This study revealed that elevated pCO2 affects the burrowing behavior of Manila clams by altering GABAA receptor function from inhibitory to excitatory.

OROMANDIBULAR DYSTONIA: PREVALENCE, CLINICAL AND DEMOGRAPHIC DATA, THERAPEUTIC STRATEGIES OUT-COME FOR HUNDRED PATIENTS IN SANA’A CITY, YEMEN

Background and aims: Dystonia is a movement disease characterized by persistent, uncontrollable muscle contractions that often lead to abnormal postures. The tongue, jaw, and mouth are all affected by OMD, which is an uncommon focal dystonia. OMD is a rare public health problem that takes time to diagnose and treat because it is frequently identified as psychogenic. This study sought to ascertain the frequency, demographics, clinical features, and treatment outcomes of patients with mandibular dystonia (OMD) in Sana'a, Yemen. Methods: A prospective cross-sectional study was conducted; the study included 100 Yemeni adults attending the Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Sana'a University Clinics and Departments of Oral, Maxillofacial and Neurosurgery at Kuwait University Hospital and some private centers for maxillofacial medicine and neurosurgery in the city of Sana’a during the year 2022. The selected patients were complaining of contraction or involuntary movement of the masticatory, lingual and/or lower facial muscles. Age, gender, age at onset of illness, duration of illness, personal habits, type of OMD, previous and current treatments, and their outcomes were recorded on a standard, pre-designed questionnaire. Results: The incidence rate of OMD is 19/100,000/year. Most of the patients (92%) are male while only 8% are female. The first episode onset is after stress (29%), 11% after illness, 6% after dental treatment, and 48% without causes. Jaw deviation dystonia was dominant at 65%, followed by jaw closing dystonia (42%), jaw protrusion dystonia (29%), and jaw opening dystonia (27%). After current treatment out-come, there was improvement on ability to eat ( from 12% to 24%, p=0.02), to speak (from 25% to 43%, p=0.007), the rate of no pain raised from 46% to 57%, the rate of no discomfort raised from 21% to 34% (p=0.04) and the score ≤ 5 of OMD raised from 47% to 72% (p=0.0003). Conclusion: The incidence of OMD in Sana’a city is remarkably high, predominantly male, and peaks at 30, 40, and 50 years of age. Jaw deviation dystonia was the dominant type followed by jaw closing dystonia. After the current treatment outcome, the ability to eat has improved, the rate of pain and discomfort has decreased. Peer Review History: Received: 25 February 2023; Revised: 17 March; Accepted: 28 April 2023, Available online: 15 May 2023 Academic Editor: Dr. Sally A. El-Zahaby, Pharos University in Alexandria, Egypt, sally.elzahaby@yahoo.com Received file: Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Dr. Bilge Ahsen KARA, Ankara Gazi Mustafa Kemal Hospital, Turkey, ahsndkyc@gmail.com Dr. Ogbonna B. Onyebuchi, Nnamdi Azikiwe University, Awka, Nigeria, summitpharm@yahoo.com

Electromyographic signals and the starting threshold voltage of orbicularis oris muscle in healthy rhesus monkeys

Objective: To investigate the characteristics of electromyography (EMG) signals and the starting threshold voltages of the orbicularis oris muscles (OOM) in healthy rhesus monkeys under different muscle movement conditions. Methods: The EMG signals and the starting threshold voltages at different time points in 4 healthy rhesus monkeys were acquired and recorded with EMG device and evoked potentiometer. The voltage amplitude variation of EMG signals was analyzed, and the voltage amplitude range of EMG signals at the beginning of OOM contraction was established. The data were statistically analyzed by one-way ANOVA. Results: The EMG of OOM in healthy monkeys in the quiet, natural and continuous mouth-closed state was linear and relatively stable, and the absolute value fluctuated between 15 and 50 μV. The EMG waveform increased rapidly during the natural lip contraction movement, and its amplitude fluctuated greatly, with the highest absolute value of the peak value reaching hundreds of microvolts. The amplitude of EMG induced by continuous mouth closure was more than thousands of microvolts. There was no significant difference in EMG amplitudes of OOM in the healthy rhesus monkey under quiet and continuous lip closure at different time points (P>0.05). There was no significant difference in threshold voltages in the state of natural lip contraction of bilateral OOM at different time points (average range: 57.17-57.47 μV) in the healthy rhesus monkeys (P>0.05). There was no significant difference in threshold voltages of OOM induced by bilateral OOM at different time points(average range: 55.38-55.99 μV) in the healthy rhesus monkeys(P>0.05). There were significant differences in the absolute values of EMG amplitudes of OOM between the three lip movement modes: (30.67±8.72) μV in quiet and natural continuous lip closure (475.12±54.72) μV in natural lip contraction, and (921.22±312.79) μV in the induced persistent lip closure, with t values of -8.48, -9.35 and -5.01 respectively, all P<0.001. Conclusions: The EMG signals of OOM show different characteristics under different muscle movement conditions, which can be used as a basis for computer to judge and recognize the movement conditions of OOM. The upper limits of the EMG threshold voltage values of OOM under different motion states are 55-60 μV.

Amoeba-Inspired Magnetic Venom Microrobots.

Nature provides a successful evolutionary direction for single-celled organisms to solve complex problems and complete survival tasks - pseudopodium. Amoeba, a unicellular protozoan, can produce temporary pseudopods in any direction by controlling the directional flow of protoplasm to perform important life activities such as environmental sensing, motility, predation, and excretion. However, creating robotic systems with pseudopodia to emulate environmental adaptability and tasking capabilities of natural amoeba or amoeboid cells remains challenging. Here, this work presents a strategy that uses alternating magnetic fields to reconfigure magnetic droplet into Amoeba-like microrobot, and the mechanisms of pseudopodia generation and locomotion are analyzed. By simply adjusting the field direction, microrobots switch in monopodia, bipodia, and locomotion modes, performing all pseudopod operations such as active contraction, extension, bending, and amoeboid movement. The pseudopodia endow droplet robots with excellent maneuverability to adapt to environmental variations, including spanning 3D terrains and swimming in bulk liquids. Inspired by the "Venom," the phagocytosis and parasitic behaviors have also been investigated. Parasitic droplets inherit all the capabilities of amoeboid robot, expanding their applicable scenarios such as reagent analysis, microchemical reactions, calculi removal, and drug-mediated thrombolysis. This microrobot may provide fundamental understanding of single-celled livings, and potential applications in biotechnology and biomedicine.

HAND RECOGNITION SYSTEM BASED ON ELECTROMYOGRAPHY FOR REAL-TIME HAND PROSTHETIC CONTROL

Upper limb amputation is a significant limitation for achieving routine activities. Myoelectric signals detected by electrodes well-known as Electromyography (EMG) have been targeted to control upper limb prostheses of such lost limbs. Unfortunately, the acquisition, processing and use of such myoelectric signals are sophisticated. Furthermore, it necessarily requires complex computation to fulfil accuracy, robustness, and time-consumption execution for the real-time prosthesis application. Thus, machine learning schemes for pattern recognition are a potential approach to improve the traditional control for hand prostheses due to the movement of users and muscle contraction. This paper presents real-time hand posture recognition based on three hand postures using surface EMG (sEMG) signals. sEMG signals are acquired by the electrode channel and simultaneously collected while making a hand posture. Performance evaluation relies on classification accuracy and time consumption. The performance of six real-time recognition models is evaluated which combine two projection techniques and three classifiers. Results indicate that EMG-based pattern recognition (EMG-PR) control outperforms the traditional control for hand prostheses in real-time application. The highest classification accuracy is approximately 96%, whereas the lowest time consumption is 4 ms. In addition, the accuracy is dropped when the number of electrodes decreases nearly to 3%. These outcomes can apply to real-time hand prostheses to alleviate the limited prostheses available.

Micro-vibration results in vitro-derived bovine blastocysts with greater cryotolerance, epigenetic abnormalities, and a massive transcriptional change

Much effort has been employed to improve the quality of embryos obtained by in vitro production (IVP) given the relevance of this technology to current livestock systems. In this context, dynamic IVP systems have proved beneficial to the embryo once they mimic fluid flows and mechanical forces resulting from the movement of ciliated cells and muscle contraction in the reproductive tract. In the present study, we sought to confirm these initial findings as well as assess potential molecular consequences to the embryo by applying micro-vibration (45 Hz for 5 s once per 60 min) during both oocyte maturation and embryo culture in cattle. As a result, micro-vibration led to lower incidence of apoptosis in blastocysts following vitrification-thawing. Further analyses revealed epigenetic and transcriptional changes in blastocysts derived from the micro-vibration treatment, with a total of 502 differentially expressed genes. Enrichment analyses linked differentially expressed genes to ‘Oxidative phosphorylation’, ‘Cytokine-cytokine receptor interaction’, and ‘Signaling pathways regulating pluripotency of stem cells’. Yet, a meta-analysis indicated that the transcriptional changes induced by micro-vibration were not toward that of in vivo-derived embryos. In conclusion, micro-vibration increases the cryoresistance of bovine embryos, but caution should be taken given the unclear consequences of epigenetic and transcriptional abnormalities induced by the treatment.

Analysis of Intraseasonal Oscillation Features of Winter Cold Precipitation Events in Southern China

Based on the daily minimum air temperature (Tmin) data and the daily precipitation data from the NCC/CMA combined with the NCEP/DOE reanalysis data, the intraseasonal features and circulations of the winter cold precipitation events (CPEs) in southern China under the influence of strong Madden–Julian oscillation (MJO) were explored. The results show that: (1) Winter temperatures in southern China are characterized by intraseasonal oscillations (ISOs) of 10–30-d and 30–60-d, with six CPEs under strong MJO all occurring during these two intraseasonal scales in cooling phases. The invasion of cold air coupled with the availability of appropriate moisture conditions in southern China is more conducive to the CPEs. (2) A cyclone and anticyclone lying to the east of the Ural Mountains and the northwest of Lake Baikal at 925-hPa gradually move southeastward. The merging of the low-frequency (LF) blocking highs over the Ural Mountains and the North Pacific Ocean at 500-hPa leads to the contraction and southward movement of the LF cold vortex. The following anomalous northerly winds steer the cold air towards southern China. The cold advection is the dominant term in the cooling process, while the adiabatic cooling accompanied with ascending motion is also beneficial to the cooling process. (3) MJO has some effect on the LF blocking highs and the cold vortex in the mid-high latitudes and induces the CPEs over southern China. The joint effect of mid-high and low latitudes on the 30–60-d intraseasonal oscillation scale can have a significant impact on the cooling and precipitation processes of CPEs.