Contract Model Research Articles

The Initial Conditions of Clustered Core Collapse: Multiwavelength Analysis of Oph A SM1N and N6 at 100 au Resolution

We present new Atacama Large Millimeter/submillimeter Array (ALMA) continuum and NH2D, N2D+, and H2D+ line emission at matched, ∼100 au resolution toward the dense star-forming cores SM1N and N6 within the Ophiuchus molecular cloud. We determine the density and temperature structure of SM1N based on radiative transfer modeling and simulated observations of the multiwavelength continuum emission at 0.8, 2, and 3 mm. We show that SM1N is best fit by either a broken power-law or Plummer-like density profile with high central densities (n ∼ 108 cm−3), and an inner transition radius of only ∼80–300 au. The free-fall time of the inner region is only a few ×103 yr. The continuum modeling rules out the presence of an embedded first hydrostatic core (FHSC) or protostar. SM1N is therefore a dynamically unstable but still starless core. We find that NH2D is likely depleted at high densities within SM1N. The nonthermal velocity dispersions increase from NH2D to N2H+ and H2D+, possibly tracing increasing (but still subsonic) infall speeds at higher densities as predicted by some models of starless core contraction. Toward N6, we confirm the previous ALMA detection of a faint, embedded point source (N6-mm) in 0.8 mm continuum emission. NH2D and N2D+ avoid N6-mm within ∼100 au, while H2D+ is not strongly detected toward N6. The distribution of these tracers is consistent with heating by a young, warm object. N6-mm thus remains one of the best candidate FHSCs detected so far, although its observed (sub)millimeter luminosity remains below predictions for FHSCs.

Active constituents of essential oil from Curcuma phaeocaulis for treatment of dysmenorrhea

This study aims to identify the active constituents of essential oil from the rhizomes of Curcuma phaeocaulis for the treatment of dysmenorrhea. The compounds were separated and purified by molecular distillation, silica gel and Sephadex LH-20 column chromatography, preparative thin layer chromatography, and semi-preparative high performance liquid chromatography. Their structures were identified by mass spectrometry and nuclear magnetic resonance spectroscopy. The animal model of primary dysmenorrhea and the contraction model of isolated uterine smooth muscle of rats were established to examine the active constituents in the essential oil for treating dysmenorrhea. Six sesquiterpenes were isolated and identified as dehydrocommiterpene A(1), comosone Ⅱ(2), 5α(H)-eudesma-3(4),7(11)-dien-9β-ol-6-one(3), guaia-6(7)-en-11-ol(4), curcumenol(5), and isocurcumenol(6), among which compound 1 was a novel compound. The animal experiments showed that the essential oil from C. phaeocaulis significantly lowered the level of PGF_(2α) in uterine tissue compared with the model group. The experiment with the contraction model of isolated uterine smooth muscle demonstrated that the components with high boiling points outperformed those with low boiling points in relaxing the uterine smooth muscle, and compounds 1, 2, 5, and 6 isolated from the fraction with a high boiling point had the effect of relaxing the uterine smooth muscle. Among them, compounds 5 and 6 inhibited the extracellular Ca~(2+) influx and intracellular Ca~(2+) release to relax the uterine smooth muscle. In conclusion, the components with high boiling points and sesquiterpenes are the active components in the essential oil of C. phaeocaulis for treating dysmenorrhea.

Mathematical analysis of left ventricular elastance with respect to afterload change during ejection phase.

Since the left ventricle (LV) has pressure (Plv) and volume (Vlv), we can define LV elastance from the ratio between Plv and Vlv, termed as "instantaneous elastance." On the other hand, end-systolic elastance (Emax) is known to be a good index of LV contractility, which is measured by the slope of several end-systolic Plv-Vlv points obtained by using different loads. The word Emax originates from the assumption that LV elastance increases during the ejection phase and attains its maximum at the end-systole. From this concept, we can define another elastance determined by the slope of isochronous Plv-Vlv points, that is Plv-Vlv points at a certain time after the ejection onset time by using different loads. We refer to this elastance as "load-dependent elastance." To reveal the relation between these two elastances, we used a hemodynamic model that included a detailed ventricular myocyte contraction model. From the simulation results, we found that the isochronous Plv-Vlv points lay in one line and that the line slope corresponding to the load-dependent elastance slightly decreased during the ejection phase, which is quite different from the instantaneous elastance. Subsequently, we analyzed the mechanism determining these elastances from the model equations. We found that instantaneous elastance is directly related to contraction force generated by the ventricular myocyte, but the load-dependent elastance is determined by two factors: one is the transient characteristics of the cardiac cell, i.e., the velocity-dependent force drops characteristics in instantaneous shortening. The other is the force-velocity relation of the cardiac cell. We also found that the linear isochronous pressure-volume relation is based on the approximately linear relation between the time derivative of the cellular contraction force and the cellular shortening velocity that results from the combined characteristics of LV and aortic compliances.

Investigation on prospective bioenergy from pyrolysis of macadamia nut shell waste using multicomponent Fraser-Suzuki kinetic model, kinetic triplet and thermodynamic parameters

The investigation of macadamia nut shell waste (MNSW) was conducted to elucidate its bioenergy potential through the analysis of physicochemical properties, kinetic triplet, reaction mechanism models, and thermodynamic parameters. The thermal degradation experiments were carried out using a thermogravimetric analyzer under nitrogen atmosphere at four different heating rates. The multicomponent Fraser-Suzuki kinetic model revealed that the primary decomposition stage could be successfully divided as the parallel devolatilization process of two, three, or four pseudo components. The thermal degradation process of MNSW can be divided into pseudo hemicellulose (PE-H), hemicellulose-lignin (PE-HL), hemicellulose-cellulose (PE-HC), cellulose (PE-C), and lignin (PE-L) employing the multicomponent Fraser-Suzuki kinetic model. The apparent activation energy (E) was calculated using Friedman, Ozawa-Flynn-Wall, Starink, and Kissinger-Akahira-Sunose four model-free methods. The average apparent activation energy calculated through the Starink model-free method was found to be 190.13 and 174.18 kJ/mol for PE-HL and PE-C, 143.79, 169.99, and 249.88 kJ/mol for PE-H, PE-C and PE-L, and 142.98, 157.15, 169.84, and 244.62 kJ/mol for PE-H, PE-HC, PE-C and PE-L, respectively. Evaluation of thermodynamic parameters showed that the pyrolysis process of each pseudo component was an endothermic non-spontaneous reaction independent of surface area and required additional heat and energy input. The pyrolysis process of all pseudo components was accurately characterized using order-based, nucleation, geometrical contraction, power law, and diffusional reaction mechanism models using master plots method. This work provides a theoretical basis for MNSW or other biomass wastes as attractive and environmentally friendly alternatives for bioenergy production, offering crucial insights for reactor design and improving conversion efficiency.

Rollover service contracts: the influences of perceived value, convenience, confusion and switching costs on consumer satisfaction and service loyalty

ABSTRACT Rollover contracts are agreements that automatically renew, or ‘roll over’, when the contracted term is completed, unless the customer has previously given notice to terminate the agreement. Although ubiquitous, academic examination of this contract model is scarce, and it is not known the extent to which rollover contracts influence consumer satisfaction and individuals’ subsequent behaviors. A conceptual model was developed and tested using structural equation modeling. The data were obtained from a survey of 994 service consumers in the United States. Perceived value emerged as the strongest enabler of consumer satisfaction with rollover contracts, followed by convenience, while consumer confusion – e.g. caused by lengthy and complex contracts – has the strongest negative effect on consumer satisfaction. The strongest relationships in our model are between satisfaction and staying intentions, word of mouth, and future rollover acceptance with other firms and products. The paper presents important theoretical contributions and managerial implications.

On the uncertainty quantification of the active uterine contraction during the second stage of labor simulation.

Uterine contractions in the myometrium occur at multiple scales, spanning both organ and cellular levels. This complex biological process plays an essential role in the fetus delivery during the second stage of labor. Several finite element models of active uterine contractions have already been developed to simulate the descent of the fetus through the birth canal. However, the developed models suffer severe reliability issues due to the uncertain parameters. In this context, the present study aimed to perform the uncertainty quantification (UQ) of the active uterine contraction simulation to advance our understanding of pregnancy mechanisms with more reliable indicators. A uterus model with and without fetus was developed integrating a transversely isotropic Mooney-Rivlin material with two distinct fiber orientation architectures. Different contraction patterns with complex boundary conditions were designed and applied. A global sensitivity study was performed to select the most valuable parameters for the uncertainty quantification (UQ) process using a copula-based Monte Carlo method. As results, four critical material parameters ( ) of the active uterine contraction model were identified and used for the UQ process. The stress distribution on the uterus during the fetus descent, considering first and second fiber orientation families, ranged from 0.144 to 1.234MPa and 0.044 to 1.619MPa, respectively. The simulation outcomes revealed also the segment-specific contraction pattern of the uterus tissue. The present study quantified, for the first time, the effect of uncertain parameters of the complex constitutive model of the active uterine contraction on the fetus descent process. As perspectives, a full maternal pelvis model will be coupled with reinforcement learning to automatically identify the delivery mechanism behind the cardinal movements of the fetus during the active expulsion process.

Agricultural subsidies in a political economy: Can collective action make smallholder agriculture contribute to development?

Malawi’s economy is heavily dependent on agriculture, of which a majority are smallholder farmers. With smallholder farmers constituting more than 80% of the population, the government’s policies have mainly focused on achieving redistribution goals of the society, minding less about the inefficiencies in smallholder farming. The current study assessed and compared the efficiency levels of large scale and small-scale farmers amidst huge government expenditures in agricultural subsidies on smallholder farmers. Through a SWOT analysis and literature review approach that dwelt much on the qualitative case study approach, the study found that it is only through attaining economies of scale that small farms can attain the efficiency levels of large-scale farms. Following this finding that large farmers are more efficient; the study proposes models that would mimic the behaviour of large farmers. In this study, we evaluated the strengths, weaknesses, opportunities and threats of various models proposed to improve efficiency of small farms. Three models were evaluated namely, contract farming, cooperative development and land consolidation models. These models were selected for review because the theory of collective action ensures that they mimic the farm behaviour of a large farmer. The paper recommends a hybrid of land consolidation model with selected elements of contract and cooperative development models.

Compliance checking for cross-border construction logistics clearance using blockchain smart contracts and oracles

ABSTRACT This research aims to develop a deployable blockchain smart contract and oracle model for automated and transparent customs compliance checking in cross-border construction logistics. A scene analysis is conducted to extract requirements, and then a blockchain-enabled model is prototyped and tested in two case studies. We find that the prototype is feasible, and the performance is satisfactory in terms of compliance checking time (t = 1523–1530 s), accuracy (a = 55.9% to 100%), private data collection (p = 100%), and information transparency (l = 0.787–1). The innovation of this research is to combine blockchain smart contracts and oracles to achieve automation and transparency in cross-border construction logistics.

Stability Analysis of EPC Consortium Cooperation Based on Evolutionary Game

Consortium contracting is a contracting model that China encourages and advocates. Due to the interest drive, members within the consortium are very prone to negative cooperation and midway withdrawal, which hinders the healthy development of the consortium. Therefore, this paper constructs a game model of EPC consortium cooperation evolution, analyzes the influence of different reward and punishment mechanisms on the cooperation of consortium members, and applies system dynamics to simulation. The results show that under the static reward and punishment and dynamic reward mechanism, the consortium cooperation is not stable; while under the dynamic punishment mechanism and the dynamic reward and punishment mechanism in which the maximum punishment is greater than the maximum reward, the evolution of consortium cooperation is gradually stable and the behavioral strategies are gradually unified. It also puts forward suggestions for measures conducive to stabilizing cooperation, which provide certain reference value for the internal management of consortium members' cooperation.

Phosphorylated CPI-17 and MLC2 as Biomarkers of Coronary Artery Spasm-Induced Sudden Cardiac Death.

Coronary artery spasm (CAS) plays an important role in the pathogeneses of various ischemic heart diseases and has gradually become a common cause of life-threatening arrhythmia. The specific molecular mechanism of CAS has not been fully elucidated, nor are there any specific diagnostic markers for the condition. Therefore, this study aimed to examine the specific molecular mechanism underlying CAS, and screen for potential diagnostic markers. To this end, we successfully constructed a rat CAS model and achieved in vitro culture of a human coronary-artery smooth-muscle cell (hCASMC) contraction model. Possible molecular mechanisms by which protein kinase C (PKC) regulated CAS through the C kinase-potentiated protein phosphatase 1 inhibitor of 17 kDa (CPI-17)/myosin II regulatory light chain (MLC2) pathway were studied in vivo and in vitro to screen for potential molecular markers of CAS. We performed hematoxylin and eosin staining, myocardial zymogram, and transmission electron microscopy to determine myocardial and coronary artery injury in CAS rats. Then, using immunohistochemical staining, immunofluorescence staining, and Western blotting, we further demonstrated a potential molecular mechanism by which PKC regulated CAS via the CPI-17/MLC2 pathway. The results showed that membrane translocation of PKCα occurred in the coronary arteries of CAS rats. CPI-17/MLC2 signaling was observably activated in coronary arteries undergoing CAS. In addition, in vitro treatment of hCASMCs with angiotensin II (Ang II) increased PKCα membrane translocation while consistently activating CPI-17/MLC2 signaling. Conversely, GF-109203X and calphostin C, specific inhibitors of PKC, inactivated CPI-17/MLC2 signaling. We also collected the coronary artery tissues from deceased subjects suspected to have died of CAS and measured their levels of phosphorylated CPI-17 (p-CPI-17) and MLC2 (p-MLC2). Immunohistochemical staining was positive for p-CPI-17 and p-MLC2 in the tissues of these subjects. These findings suggest that PKCα induced CAS through the CPI-17/MLC2 pathway; therefore, p-CPI-17 and p-MLC2 could be used as potential markers for CAS. Our data provide novel evidence that therapeutic strategies against PKC or CPI-17/MLC2 signaling might be promising in the treatment of CAS.

Labour Market Dualisation and Social Protection in South Korea: Searching for a New Social Contract and Growth Model

Labour Market Dualisation and Social Protection in South Korea: Searching for a New Social Contract and Growth Model

Optimal starting dosing regimen of intravenous oxytocin for labor induction based on the population kinetic-pharmacodynamic model of uterine contraction frequency.

Intravenous oxytocin is commonly used for labor induction. However, a consensus on the initial dosing regimen is lac with conflicting research findings and varying guidelines. This study aimed to develop a population kinetic-pharmacodynamic (K-PD) model for oxytocin-induced uterine contractions considering real-world data and relevant influencing factors to establish an optimal starting dosing regimen for intravenous oxytocin. This retrospective study included pregnant women who underwent labor induction with intravenous oxytocin at Peking University Third Hospital in 2020. A population K-PD model was developed to depict the time course of uterine contraction frequency (UCF), and covariate screening identified significant factors affecting the pharmacokinetics and pharmacodynamics of oxytocin. Model-based simulations were used to optimize the current starting regimen based on specific guidelines. Data from 77 pregnant women with 1095 UCF observations were described well by the K-PD model. Parity, cervical dilation, and membrane integrity are significant factors influencing the effectiveness of oxytocin. Based on the model-based simulations, the current regimens showed prolonged onset times and high infusion rates. This study proposed a revised approach, beginning with a rapid infusion followed by a reduced infusion rate, enabling most women to achieve the target UCF within approximately 30 min with the lowest possible infusion rate. The K-PD model of oxytocin effectively described the changes in UCF during labor induction. Furthermore, it revealed that parity, cervical dilation, and membrane integrity are key factors that influence the effectiveness of oxytocin. The optimal starting dosing regimens obtained through model simulations provide valuable clinical references for oxytocin treatment.

Organizational trust breaches among nurses and aides: A qualitative study.

Healthcare worker retention and burnout are confounding issues. Trust among workers and their employer, that is, organization, is an important yet underexplored concept in research. The aim of this qualitative study is to explore organizational actions and systems that promote or denigrate trust among registered nurses and patient care aides (aides). The study uses the Model of Psychological Contract as a theoretical framework. Focus groups were conducted to explore the concept of organizational trust and the consequences of broken trust. Registered nurses (RNs) (n=6) and aides (n=6) participated in the study. Six focus groups (three RN and three aide) were conducted, with two participants per group. Focus groups were conducted online. The study's methods were reviewed by the University of Pittsburgh Institutional Review Board. Among RNs and aides, a sense of trust and feeling valued were important to their sense of relationship with their employers. Trust was breached when resources were scarce, employees did not feel validated and listened to, and problems were not addressed. RNs and aides described feeling devalued when compensation practices were unjust or inequitable, they had limited autonomy, and the employer created an organizational climate where business needs superceded human caring. Consequences of trust breach included burnout, dejection, and feelings of non-belonging. Tangible organizational resources (compensation and staffing) and intangible resources (value, respect, autonomy) are important to RNs and aides alike. Inability to provide these resources diminishes trust and even causes a sense of betrayal. Future research can explore the concepts of organizational justice and interventions to restore lost trust and improve healthcare worker well-being. This is one of only a few identified studies to explore organizational factors and well-being among aides and more research among this healthcare worker population is warranted.

New hand dynamometer activforce isometric muscle activation on single joint muscle force of volleyball players

Isometric muscle activation of single joint to volleyball players is critic on sport performance to produce potential muscle force, however isometric measurement limited in isokinetic muscle activity measurement of volleyball players. Indeed, hand dynamometers commonly use in various body isometric force. Professional volleyball players age 16.23 ± 0.59 yr, body mass 60.22 ± 4.64 kg, hight 1.69 ± 0.04 m participated to peak and average isometric force measurement over 8 week pre and post test. Accordingly, single joint muscle force production measurement of volleyball players tested on isometric muscle activation using a new hand dynamometer activforce 2. Isometric muscle activation tests consisted of 24 body region from upper and lower compartment. For this isometric muscle action test detected on peak force outcomes (SEM: 37.90; CV: 1.79) and average force outcomes (SEM: 33.62; CV: 1.84). The high isometric muscle action joint loading performing mechanical test application recommended on athletic population to using isometric potential high contraction model by strength training performance separately in-season and off-season measurement modeling. Conclusion, peak and average force production progressive isometric modeling of volleyball athletes worked to current sport–health condition. As out, conclusion must be advanced isometric force measurement proper work in sport-specific tasks. The proper isometric force must be repeat sport performance outcome in different sport modalities.

Pyrolytic characteristics of abutilon stalk waste using TG-FTIR, Py-GC/MS, and artificial neural networks: Kinetics, thermodynamics, and gaseous products distribution

The physicochemical properties of abutilon stalk (ABUS) were investigated to assess its suitability for pyrolytic conversion into bioenergy and bio-based chemicals based on kinetic triplet state, thermodynamic parameters, decomposition mechanisms and product distributions. The pyrolysis behavior of ABUS was studied using a thermogravimetric analyzer at five heating rates in a nitrogen atmosphere. The Gaussian deconvolution function indicated that the pyrolysis process of ABUS can be successfully modeled as four parallel devolatilization events (R2 > 0.99), divided into the devolatilization of pseudo drying (PO-D), hemicellulose (PO-H), cellulose (PO-C), and lignin (PO-L), respectively. The average apparent activation energies were 34.89 kJ/mol for PO-D, 163.02 kJ/mol for PO-H, 169.55 kJ/mol for PO-C, and 107.51 kJ/mol for PO-L using four model-free methods (Ozawa-Flynn-Wall, Kissinger-Akahira-Sunose, Starink, and Tang). The pyrolysis process was accurately predicted using diffusional, power law, geometrical contraction, and order-based reaction mechanism models. Thermal degradation process for each devolatilization event was successfully reconstructed using combined kinetics (R2 > 0.96), providing a useful theoretical basis and mathematical model for predicting the pyrolysis behavior of ABUS. The volatile products produced by ABUS pyrolysis were characterized using an integrated TGA-FTIR and Py-GC/MS system, confirming the proportion of high-energy compounds (benzenes, phenols, ketones, alcohols, aldehydes, acids, esters, hydrocarbons and their derivatives, N-heterocyclic substances, and N-containing compounds) and gas emission levels (CO > CH4 > C-O > H2O > CO2 > CO > C-O(H) > HCN > NH3 > SO2). Artificial neural network (ANN) was used to predict the pyrolysis behaviors of ABUS, and the best ANN model was ANN (5 *11 *1) with high R2 of 0.99998. Based on the kinetics, thermodynamics, and gaseous products distribution, ABUS has great application potential as raw material for bioenergy production.

MRI non-rigid registration with tumor contraction correction for ablative margin assessment after microwave ablation of hepatocellular carcinomas.

This study aims to develop and assess a tumor contraction model, enhancing the precision of ablative margin(AM) evaluation after microwave ablation (MWA) treatment for hepatocellular carcinomas (HCCs). 
Approach: We utilize a probabilistic method called the Coherent Point Drift algorithm to align pre-and post-ablation MRI images. Subsequently, a nonlinear regression method quantifies local tumor contraction induced by MWA, utilizing data from 47 HCC with viable ablated tumors in post-ablation MRI. After automatic non-rigid registration, correction for tumor contraction involves contracting the 3D contour of the warped tumor towards its center in all orientations.
Main Results: We evaluate the performance of our proposed method on 30 HCC patients who underwent MWA. The Dice similarity coefficient between the post-ablation liver and the warped pre-ablation livers is found to be 0.95±0.01, with a mean corresponding distance between the corresponding landmarks measured at 3.25±0.62mm. Additionally, we conduct a comparative analysis of clinical outcomes assessed through MRI over a 3-month follow-up period, noting that the AM, as evaluated by our proposed method, accurately detects residual tumor after MWA.
Significance: Our proposed method showcases a high level of accuracy in MRI liver registration and AM assessment following ablation treatment. It introduces a potentially approach for predicting incomplete ablations and gauging treatment success.

Simple contracts with double-sided moral hazard and adverse selection

We examine a linear contract model involving a risk-neutral venture capitalist (VC) hiring a risk-averse manager to run a project. The project output is determined by the joint efforts of both parties, the manager’s private ability and a random shock. We explicitly derive a truth-telling menu of contracts, which explain that the incentives provided by VC increase with the manager’s ability, under the widely-recognized monotone hazard rate condition. The fixed compensation would be negative; thus, the manager provides a portion of the financial investment and shares risks with VC. VC’s contracts can not distinguish the types of managers in a range of low-ability managers, leading to a partially pooling equilibrium. Conversely, within a range of high-ability managers, VC’s contracts identify the types of managers, resulting in convex information rents that increase with abilities. We explicitly provide ability thresholds specifying partially or completely pooling and separating equilibrium.

The effects of dynamic learning and the forgetting process on an optimising modelling for full-service repair pricing contracts for medical devices

In order to improve the profitability and customer service management of original equipment manufacturers (OEMs) in a market where full-service (FS) and on-call service (OS) co-exist, this article extends the optimising modelling for pricing FS repair contracts with the effects of dynamic learning and forgetting. Along with considering autonomous learning in maintenance practice, this study also analyses how induced learning and forgetting process in a workplace put impact on the pricing optimising model of FS contracts in the portfolio of FS and OS. A numerical analysis based on real data from a medical industry proves that the enhanced FS pricing model discussed here has two main advantages: (1) It could prominently improve repair efficiency, and (2) It help OEMs gain better profits compared to the original FS model and the sole OS maintenance. Sensitivity analysis shows that if internal failure rate increases, the optimised FS price rises gradually until reaching the maximum value, and profitability to the OEM increases overall; if frequency of induced learning goes up, the optimal FS price rises after a short-term downward trend, with a stable profitability to the OEM.

The Model of Legal Contract Between Courier and Expedition Company in Pamekasan Regency

The Model of Legal Contract Between Courier and Expedition Company in Pamekasan Regency

Spasmolytic Activity of Gentiana lutea L. Root Extracts on the Rat Ileum: Underlying Mechanisms of Action

The roots of Gentiana lutea L. are utilized in the preparation of various beverages and herbal remedies, serving as a traditional remedy for gastrointestinal ailments. The spasmolytic activity that could substantiate the traditional use of G. lutea root had not been investigated. The main objective goal of the study was to determine the validity of its use as a traditional remedy. The extraction of G. lutea root was performed using a 50% hydroethanolic solvent with three different extraction techniques: ultrasound-assisted extraction (UAE), heat-assisted extraction, and percolation. The spasmolytic activity was tested on isolated rat ileum. The mechanism of action was monitored using the models of spontaneous contractions and acetylcholine-, histamine-, CaCl2-, Bay K8644-, L-NAME-, ODQ-, apamin-, BaCl2-, charybdotoxin-, glibenclamide-, TRAM-34-, and quinine-modified contractions. UAE, having the best bioactivity, was further subjected to a liquid–liquid extraction fractionation. HPLC phytochemical analysis was performed for all tested extracts and fractions. Gentian root extracts were rich in secoiridoids, xanthones, and flavonoids. The UAE has shown better results on spontaneous contractions in comparison to its fractions, leading to the more detailed testing of its spasmolytic mechanism of activity. The extract’s activity is primarily mediated through intermediate conductance Ca2+-activated K+ channels, ATP-sensitive K+ channels, voltage-sensitive K+ channels, and mechanisms that activate Ca2+ channels. Overall, the G. lutea root shows great potential in the treatment of spasmodic gastrointestinal ailments.