In order to realize the technical performance of high speed, high precision, high stability and high reliability for conjugated indexing mechanism with periodic intermittent rotary motion, a two cams structure has been designed, and its geometry size and profile curve was carefully determined. Also the calculation formula of the contour curve for CAM was deduced. Research achievement has been applied to new equipment of enterprise development, the working performance is stable and reliable, the production efficiency raised by 30% compared to the domestic industry. The mechanism has characteristics of simplified structure, improved transmission performance and low cost.