In order to study the influence of different closing schemes on the non-symmetrical high-pier multi-span continuous rigid frame bridge, this paper uses Midas/Civil finite element software to simulate the vertical displacement of main beam, stress of main beam, horizontal displacement of pier top and bending moment of pier bottom under four different closing schemes. The results show that the vertical displacement of the main beam is small when scheme 3 is adopted. The stress of the main beam and the bending moment of the bottom of the pier are smaller after adopting the scheme 4 closing scheme. The maximum horizontal displacement of the top pier is smaller after the closure of scheme 1 and Scheme 3. After comprehensive consideration, it is suggested that the closure of Hegou Bridge should be carried out in scheme 4.