Focusing on the actuator fault of the quadrotor unmanned aerial vehicle (QUAV), an active fault-tolerant control scheme based on fixed-time linear active disturbance rejection control is proposed. Firstly, in order to simplify the complex dynamic model, the virtual control quantity is introduced to decouple the flight control system of the QUAV. Secondly, the fixed-time extended state observer (ESO) is utilized to estimate and compensate the internal uncertainty, external disturbance and actuator fault of the QUAV in fixed time. Thirdly, a continuous output feedback controller based on fixed-time ESO is designed to keep the stability of the flight control system with actuator fault and external disturbance. Finally, the closed-loop stability of the flight control system is demonstrated by Lyapunov function. The numerical simulation is carried and the results also verify the effectiveness of the proposed control scheme.