Objective To evaluate the effects of continuous blood purification in patients with septic shock during perioperative period. Methods Forty-seven patients with infectious shock during perioperative period were enrolled and randomly divided into experimental group(group D, n=23) and control group(group F, n=24). Patients in group D received continuous venous hemofiltration starting before surgery till 72 hours after surgery. Patients in group F were treated with blood purification for 72 hours postoperatively. The blood oxygenation index, pH, HCO, base excess(BE), BUN, serum creatinine(SCr), SBP, DBP and HR were recorded in the two groups before surgery (T0), by the end of operation (T1), and 24 h (T2), and 48 h (T3), and 72 h (T4) after operation. The duration of operation, the perioperative doses of dopamine and metaraminol, and the recovery rate of patients were recorded, as well. Results Doses of dopamine and alamin in group D were significantly lower than those in group F (P 0.05), there was significant difference in oxygenation index at T2-T4 (P 0.05). There were no significant difference in biochemical indexes between group F and group D at T0 (P>0.05). Conclusions Continuous blood purification for perioperative patients with septic shock improved patients′ outcome: stabilizing homeostasis, maintaining the hemodynamics, reducing the doses of vasoactive drugs, improving patients′ tolerance and recovery rate. Key words: Perioperative period; Septic shock; Continuous blood purification