The continuous girder bridge is the main type of small- and medium-sized bridges; however, it has poor collapse resistance and suffers frequent earthquake damage. In order to grasp its collapse mechanism and clarify the internal and external factors affecting its collapse resistance, a 1:3-scaled, two-span bridge model subjected to shaking table test research was taken as the research object. The factors such as seismic characteristics, multi-directional seismic coupling, span, pier height, and structural system type were analyzed to determine the influences on the collapse mode of the bridge. The numerical results showed that different ground motion characteristics led to different collapse modes. Vertical ground motion had little effect on the structural response of the bridge. The change of span and pier height significantly changed the collapse resistance. A seismic isolation design could improve the anti-collapse performance, but the collapse mode varied with the system. The final anti-collapse design suggestions could provide reference for the seismic reinforcement of existing continuous girder bridges and the seismic design of continuous girder bridges that will be constructed.