Continuous Discharge Research Articles

Effects of nonionic surfactants on life history traits of Drosophila melanogaster.

Surfactants are used for a variety of applications such as emulsifiers, solubilizers, or foaming agents. Their intensive production and use in pharmaceutical, cosmetic and agricultural products have resulted in their continuous discharge in the environment, especially via wastewaters. Surfactants have become a threat to living organisms as they interact with, and disrupt, cell membranes and macromolecules. Their effects have mainly been studied in aquatic species; however, terrestrial organisms are also threatened by these emerging contaminants. This study investigates the effects of two widely used nonionic surfactants, Tween-20 and Triton X-100, on key traits of larvae and adults of the fruit fly Drosophila melanogaster. We assessed the toxicity of the two surfactants on viability, development time, body size and food intake of the flies. The results revealed that both surfactants induced toxic effects on the drosophila flies leading to decreased viability, delayed development and lowered food consumption at the highest tested concentrations. Both surfactants proved to be toxic to flies, and, for all tested traits, Triton X-100 appeared more toxic than Tween-20. Our results might extend to other invertebrates. The widespread use of these substances, which then end up in the environment, should be regulated to mitigate their impacts on biodiversity and ecosystems.

Exploring the distribution and fate of bisphenol A in an aquatic microcosm combined with a multimedia model.

Bisphenol A (BPA), a well-known endocrine-disrupting chemical, has garnered significant attention in environmental science and policy. BPA can enter the aquatic environment through different routes, posing potential risks even at a low concentration. In this study, a four-compartment system [water, sediment, biota (zebrafish), and submerged aquatic vegetation (Vallisneria natans)] of a point source continuous discharge microcosm was established to investigate the distribution and fate of BPA in an aquatic microcosm. The fugacity model generated predicted values were highly consistent with those of the experiments. The distribution of BPA in the model indicates that sediment was the dominant sink. The residence time of reaction and advection was 5.8 and 75.2 d, respectively, which showed that BPA was mainly removed from the aquatic microcosm through the reaction in biota (58 %). Sensitivity analysis revealed that emission data were the most influential parameters for the model output. Transfer processes between the water and biota phases had a closer relationship. This study provides technical support for pollution source management and risk assessment for BPA.

Methodology for Surface Reconstruction and Prediction Based on the Electrical Discharge Machining Removal Mechanism of Cf-UHTC Materials.

Cf-UHTC is an ideal aerospace material because of its exceptional properties, but its machinability is facing great challenges. Electrical discharge machining (EDM) offers a potential solution, but its removal mechanism remains unclear, lacking reliable prediction tools to guide the actual production. This paper deeply explores the EDM removal mechanism of Cf-ZrB2-SiC through single-pulse experiments, high-speed camera observations, and thermal-fluid coupling simulations, revealing key processes like heat transfer, phase transformation, molten pool dynamics, crater formation, and reinforcing phase effects. And the prediction of single-pulse removal with different parameters is also realized. Based on experimental and simulation results, a random continuous discharge model is developed, which deeply studies the dynamic erosion process, reconstructs EDM surfaces, and accurately predicts surface roughness. Furthermore, the thickness of the recast layer can be predicted based on the equivalent temperature method. Undoubtedly, this model provides an ideal approach for efficient production.

Machine Learning Driven Optimization of Electrolyte for Highly Reversible Zn-Air Batteries with Superior Long-Term Cycling Performance.

Aqueous alkaline Zn-air batteries (ZABs) have garnered widespread attention due to their high energy density and safety, however, the poor electrochemical reversibility of Zn and low battery round-trip efficiency strongly limit their further development. The manipulation of an intricate microscopic balance among anode/electrolyte/cathode, to enhance the performance of ZABs, critically relies on the formula of electrolytes. Herein, the Bayesian optimization approach is employed to achieve the effective design of optimal compositions of multicomponent electrolytes, resulting in the remarkable enhancement of ZAB performance. Notably, ethylene glycol has been successfully employed as both electrolyte additive and fuel, playing key roles in changing the reaction pathways of ZABs, especially the storage form of discharge products from ZnO deposition on the anode to Zn2+-based hybrid particle colloids in the electrolyte. As a result, the as-obtained novel ZABs can deliver superior battery reversibility and stability (1700 h at 2 mA cm-2 and 1400 h at 20 mA cm-2), greatly improved round-trip efficiency as high as 76.3%, and even continuous discharge until complete Zn anode depletion. This work has demonstrated enormous potential for long-term energy storage applications and holds promise for bringing new opportunities to the development of ZABs.

Study on the mechanism and characteristics of pulsed corona discharge in water

Abstract Plasma pulse is a safe and environmentally friendly unconventional technology for enhancing
oil and gas production. However, during the pulsed discharge process, an abnormal discharge
phenomenon often occurs, which severely affects the performance of the equipment and is
referred to as corona discharge. This paper combines laboratory discharge test data to
theoretically analyze and validate through Comsol simulation the mechanism of corona
discharge generation under the same electrode gap distance. A comparative analysis with arc
discharge is also conducted to further examine its characteristics, and nonlinear regression
analysis is used to study the impedance variation of the plasma channel during corona
discharge. Results indicate that the decrease in switch breakdown voltage in the later stages of
continuous discharge leads to the generation of corona discharge. The impedance of the
plasma channel can be characterized by a time-varying resistance model based on a double
exponential function. Finally, validation through theoretical calculations and Simulink
simulations achieves a fitting rate of over 99%. The research provides significant guidance
for further analysis of corona discharge and the development of suppression methods in
plasma pulse technology, contributing to the optimization of the equipment and enhancing its
operational performance.

Distinctive adsorption and transport behaviors of short-chain versus long-chain perfluoroalkyl acids in a river sediment.

Perfluoroalkyl acids (PFAAs) embrace perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and other concerning chemicals of different chain length and terminal moieties. PFAAs can leach from municipal wastewater facilities as point sources discharging into rivers and receiving streams. In this study, we investigated the adsorption and transport behaviors of six select PFAAs in a Hudson River (USA) sediment in both batch and mesocosm studies. The adsorption capacities single and dual solute systems followed the order: PFBA < PFHxA ≈ PFBS < PFHxS < PFOA << PFOS. Mesocosm experiment that receives a continuous point source discharge of a mixture of these six PFAAs reached equilibrium after 4 weeks of operation. Total adsorbed PFAAs in the sediment was extracted and analyzed, following PFHxS (0.85 mg, 20.4%) ≈ PFBS (0.92 mg, 21.7%) < PFOA (1.02 mg, 27.3%) ≈ PFHxA (1.04 mg, 29.8%) < PFBA (1.12 mg, 30.1%) << PFOS (1.55 mg, 39.2%). PFOS showed highest adsorption, concentrating on the surface layer. Noticeably, two short-chain PFAAs, PFBA and PFHxA, were found with high vertical mobility, partitioning into deeper sediment. Two hotspots for PFAA sediment contamination were formed near the sediment surface downstream from the point source, providing new prospects to guide PFAA sediment cleanup and monitoring. Graphical abstract.

Thermal management design and optimization of the pulse inductor for electromagnetic launch under continuous discharge condition

Abstract As the key component of electromagnetic launch (EML) system, insulation packaging structure and the existence of internal resistance leads to the continuous temperature rise of the pulse inductor under the continuous discharge condition, which greatly reduces the reliability and safety of the EML. This paper takes the solenoid pulse inductor as the research object and proposes a thermal management scheme that using hollow conductor to wind the coil and pumping coolant into the coil. And an optimization design method with flow resistance and thermal resistance as the objectives is proposed. By establishing coupling analysis model, it is demonstrated that the scheme can meet the temperature control requirements of solenoid inductor under continuous pulse discharge conditions. To improve the environmental applicability of thermal management scheme, the feasibility of glycol-deionized water solution as an alternative coolant at low temperature is proposed and demonstrated. The research are of great significance for promoting the engineering application process of EML.

Ternary metal oxide carbon composite as high-performance electrode material for supercapacitor applications

Recently, ternary metal oxides carbon composites recognized as metal organic frameworks (MOFs) have gained striking attention for supercapacitor electrode material due to high surface area, porosity, chemical stability, tunable properties, redox activity, and eco-friendly material. ZIF-67 is a novel MOF possessing these characteristics. Therefore, the present work reports the development of ternary iron-nickel–cobalt ZIF-67 composites (FeNiCo ZIF-67) using co-precipitation method with the variation in molar concentration of iron oxide, nickel oxide, and cobalt oxide. Physico-chemical characterizations of developed materials were investigated through X-ray diffraction (XRD), Raman spectroscopy, energy dispersive X-ray (EDX), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS) to confirm the successful formation of composites and structure, morphology. Then, the electrodes were fabricated for all three synthesized composites and electrochemical analyses such as cyclic voltammetry (CV), galvanic charge–discharge (GCD), and electrochemical impedance spectroscopy (EIS) were performed. The results revealed the porous polyhedral structure of FeNiCo ZIF-67 with different compositions consisting of interconnected nanoparticles played an important role in increasing the charge storage capacity of the material. Among the composites, FeNiCo ZIF-67 (1:2:1) electrode material achieved the highest specific capacitance of 532.7 F/g at a current density of 1 A/g. FeNiCo ZIF-67 (1:2:1) exhibited maximum electrochemical active surface area 89.12. Electrochemical impedance spectroscopy (EIS) demonstrated the minimal resistance of 7.8 Ω by FeNiCo ZIF-67 (1:2:1) composite electrode compared to the other two electrode materials. Cyclic stability study revealed the capacitance retention of 91 % after 10,000 continuous charge discharge cycles at a current density of 10 A/g. Electrode material demonstrated an outstanding electrochemical performance, and this work could provide a simple strategy to fabricate FeNiCo ZIF-67 nanostructured electrode materials for supercapacitors.

Graphene Composite Modified Manganese Dioxide Cathode Materials for Thermal Batteries

Abstract Limitations on rated voltage and discharge current density pose challenges to battery miniaturisation, affecting their application in missiles and other weapon systems. A modification method of graphene composite manganese dioxide (MnO2) cathode material has been proposed. This method enhances the performance of lithium manganese dioxide thermal batteries (heat activated reserve batteries) by achieving a continuous discharge time from milliseconds to seconds, with a single-cell voltage exceeding 2.6V and a cathode output of 160 mA/cm2. Experimental results indicate that graphene-composite modification improves the output performance of individual lithium manganese dioxide thermal cells and facilitates the reduction of thermal battery design volume. However, further research is necessary to address the relatively low output current density of this thermal battery system.

Hansen Solubility Parameter-Guided Solvent Selection for Solution-Phase Discharge in Li-CO2 Batteries.

Surface discharge mechanism-induced cathode passivation is a critical challenge that blocks the full liberation of the ultrahigh theoretical energy density of Li-CO2 batteries. Herein, we propose a novel concept based on Hansen solubility parameters (HSPs) to guide the selection of solvents for inducing the dissolution of discharge products, facilitating the detachment of in situ-formed metastable Li2C2O4 from the electrode surface and enabling a continuous Li2C2O4-dominated discharge process. Combining theoretical calculations with HSP predictions, we identified Pd-OCNTs as an ideal catalyst, with tetraethylene glycol dimethyl ether as the optimal solvent for Li2C2O4 production and stabilization. This combination facilitates the rapid diffusion of Li2C2O4 generated in situ near the catalyst surface out of the inner Helmholtz layer. Consequently, the system exhibits high energy efficiency of 96.7% and remarkable stability over 3200 h. This work provides critical insights into the solution-mediated dissolution process of Li2C2O4, informing strategies for multiphase interfacial reactions in Li-CO2 batteries.

Anesthesia Management of Patients with Esophageal Atresia/Traceoesophageal Fistula undergoing Thoracostomy and Esophagostomy Procedures

Esophageal atresia is a congenital disorder characterized by a disruption in the continuity of the esophageal lumen. Esophageal atresia may be accompanied by tracheoesophageal fistula, which is a lumen connection between the proximal and or distal part of the esophagus and the airway (trachea). Type C atresia is the most prevalent, which is approximately 88.5% to 90% of cases, where there is proximal esophageal atresia with distal tracheoesophageal fistula. In this case, a 9-day-old infant was admitted to Arifin Ahmad Hospital for thoracostomy and esophagostomy surgery due to continuous mucus discharge. The patient underwent awake intubation and was positioned intraoperatively, with a tilt to the right when an orogastric tube was placed. During surgery, the patient maintained stable hemodynamic and was subsequently admitted to the NICU using a ventilator. Infants with esophageal atresia often show symptoms of hypersalivation and shortness of breath caused by aspiration pneumonia. When the nasogastric tube cannot pass through the esophagus, atresia can be suspected. Radiology studies play an important role in diagnosing esophageal atresia, confirming esophageal atresia with or without fistula and diagnosing other anomalies associated with VACTERL.

Release of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) from cigarette butts into the aquatic environment: Levels and ecotoxicity

Discarded cigarette waste may leach toxic elements and can contaminate different environments. In this study, the levels of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in cigarette butts (CBs) leachates were determined, and the release rate of these pollutants from three CBs types such as smoked CBs with and without tobacco (SCBs and SFs) and unsmoked filters (USFs) were examined. The mean concentration levels of PCBs compounds were <LOD-1.36, <LOD-1.02 and <LOD-0.86 μg/L in SCBs, SFs, and USFs leachates, respectively. The concentrations of OCPs in SCBs and SFs leachates were <LOD-0.14 and <LOD-0.10 μg/L, respectively. The toxic equivalent (TEQ) of the dioxin-like PCBs from the CBs leachate samples ranged from 2 × 10−6-1 × 10−4 ng/L. Notwithstanding the insignificant TEQ values in CBs leachates, continuous discharge and the toxicities of the PCBs in the aquatic environments could have harmfully impacts on the water boddies and/or human health. Globally, considering all the littered CBs and their chemical contents, further efforts are needed to investigate address, and mitigate this type of contamination.

Breaking barriers of CeO2 in energy storage: Hydrothermal energized preparation of mesoporous carbon added CeO2 nanohybrids as supercapacitor electrodes

Inspired by the excellent physio-chemical properties of nano-sized materials, this study details the hydrothermal preparation and electrochemical characterization of mesoporous carbon added CeO2 nanostructures towards the energy storage applications. Cubic CeO2 is observed for the crystal structure and phase of the prepared materials. The formation of nano-sized (∼ 7 nm) quasi spherical-like structure is found from the TEM analysis and it is mainly ascribed to the combined effect of mesoporous carbon and hydrothermal treatment. The charge storage performance of the prepared composites is examined using three-electrode mode. The capacitive behaviour of mesoporous carbon is additionally supported for electrochemical performance in addition to the battery-like behavior of the CeO2 electrodes resulting in an increase of specific capacity by 102.6 %. Hybrid supercapacitor cell is devised and it could yield a specific energy of 31 W h kg–1 (562 W kg–1) and retain 81 % capacity after 3000 continuous charge discharge cycles. With this efficient composite, the future of energy storage may pave the way for more sustainable and powerful energy solutions.

Stretchable, transparent and multifunctional PVC-gel heater: a novel approach to skin-mountable, wearable thermal devices

Electric heaters based on functional materials and innovative designs have been developed for various applications. In this paper, we propose a soft dielectric heater (SDH) using polyvinyl chloride-gel (PVC-gel) as the dielectric heater and hydrogel as stretchable electrodes. Under an AC voltage, the leakage current in the PVC-gel leads to continuous injection and discharge of charges, causing the polarized plasticizers and flexible PVC chains to vibrate and collide, thereby generating heat through dielectric heating. Furthermore, the SDH generates a uniform temperature distribution even under strains up to 400%. Besides, high transmittance over 86% across the visible range renders it suitable for wearable or skin-mountable heaters from an esthetic viewpoint. Its capacitor-like structure achieves a scalable design, enabling extension from a singular cell to a row/column addressable and pixelated array of heaters. The 5 × 5 SDH array can deliver varied thermal information and sensations while maintaining performance even when stretched.

Detangling past and modern zinc anthropogenic source contributions in an urbanized coastal river by combining elemental, isotope and speciation approaches

The accumulation of trace metals in the environmental compartments of coastal rivers is a global and complex environmental issue, requiring multiple tools to constrain the various anthropogenic sources and biogeochemical processes affecting the water quality of these environments. The Valao fluvio-estuarine system (Rio de Janeiro, Brazil) presents a challenging case of a coastal river contaminated by both modern and historical anthropogenic metal sources, located in the land and in the intra-estuary, continuously mixed by tidal cycles. This study employed a combination of spatial distribution analysis of trace metals including gadolinium (Gd), zinc (Zn) isotopic analyses, and X-ray absorption spectroscopy (XAS) to distinguish between these sources. The concentrations of metals in both dissolved (water samples) and surficial sediment compartments (Suspended Particulate Matter and sediment samples) display an overall enrichment trend from upstream to downstream. Multivariate statistical analysis allows to discriminate geogenic elements derived from watershed geology (Ti, K, and Mg) vs anthropogenic contaminants from urban runoff and domestic sewage discharges (Cu, Cr, Pb, Zn, and Gd); and legacy metal contaminants (Zn and Cd) remobilized from ancient metallurgical wastes and transported upstream in the estuary during tidal cycles. The anthropogenic Gd concentration in the dissolved compartment increases along the watercourse, highlighting continuous ongoing sewage discharge. Zinc solid speciation also indicates that Zn contribution from legacy metallurgy waste is primarily associated with sulfide-Zn and Zn-phyllosilicate in the outlet estuary, while in upstream sediments of fluvio-estuarine system, Zn is found bound to organic matter. Zinc isotope systematically reveals a progressive downstream shift to heavier isotope compositions. Upstream, the relatively pristine site and the urbanized section of the river exhibit a relatively uniform δ66/64Zn value (+0.20 ± 0.07 ‰) in suspended particulate matter (SPM) and surficial sediments. These results indicate that domestic sewage discharges contribute to Zn enrichment in sediments of the Valao fluvio-estuarine system but without modifying its isotope signature in sediments. The sediment of the downstream estuarine section shows a heavier δ66/64Zn value (+0.48 ± 0.08 ‰), indicating the strong influence of the intra-estuarine source identified as the historical metallurgic contamination. An integrated view of the geochemical tracers allows thus inferring that the untreated sewage and legacy metallurgical contamination are the primary sources of anthropogenic Zn contamination. It highlights the progressive mixing along the estuarine gradient under tidal dynamics. The influence of the former source continuously expands from the headland towards the estuary.

Experimental study on multi-point ignition of NH3/air by high-frequency nanosecond dielectric barrier discharge

Non-equilibrium plasma ignition technology, with its ability to expand ignition limits and increase ignition volume, is considered an important development direction of advanced ignition systems, and has significant advantages in improving ignition stability and combustion rate. This study investigates the ignition and combustion assistance effect of high-frequency nanosecond surface dielectric barrier discharge (nSDBD) on NH3/air mixture in a constant volume combustion chamber (CVCC). The study reveals the influence of high-frequency nSDBD on the growth process of the flame kernel in NH3/air mixture. As the discharge pulse number (PN) increases, the flame kernel develops from the middle position of the discharge filament to the head of the discharge filament, while there is no obvious flame at the root and middle of the discharge filament. Continuous discharge causes the flame kernel to appear concave and the center of the flame kernel to shift towards the wall of the CVCC. In the NH3/air mixture, the initial flame kernels exhibit dissipation phenomenon, resulting in a discrepancy between the number of initial flame kernels and the number of stable combustion flame kernels. As the discharge frequency or pulse number increases, and the number of stable combustion flame kernel increases. The adjustment of discharge frequency and pulse number can effectively control the flame development time (FDT) and flame rise time (FRT) of NH3/air mixture. As PN increases, both FDT and FRT are shortened. When discharge frequency is 20 kHz, the maximum shortening of FDT and FRT are 30 ms and 14 ms, respectively, about 55 % and 30 %. The effects of discharge frequency on FDT and FRT exhibit a non-monotonic variation pattern, and it is necessary to comprehensively consider various discharge parameters to achieve the best ignition effect. The ignition success rate curve of high-frequency nSDBD in NH3/air mixture is steep. The study results of this paper provide new discoveries and experimental data for advanced ignition systems.

Properties of a continuous optical discharge sustained by short-wave infrared laser radiation in high pressure argon

Abstract The paper is devoted to the experimental study of the characteristics of continuous optical discharge (COD) sustained by high power continuous wave laser radiation at a wavelength λ = 1.08 μm in high pressure argon. New data on COD threshold laser power dependence on argon pressure in the range 20-50 bar are obtained. COD threshold laser power is shown to be in good agreement with the data obtained by other authors and theoretical evaluations provided the contribution of plasma energy loss due thermal radiation is taken into account properly. A study of the convective plume oscillations around COD in argon has been carried out. It was found that in a pressure range 25-35 bar the growth of the laser radiation power leads to a decrease in convection oscillation frequency from 33 to 29 Hz, while the radius of the convective plume grows accordingly. The oscillation frequency ν and characteristic radius of the convective plume r0 were found to obey the similarity relation previously established in experiments with COD in xenon.&amp;#xD;

Continuous Slag Discharge Construction Technology for Shield Tunneling in Narrow Space Environment

The shield tunneling method is the main construction method in subway tunnel construction, which has the characteristics of safety, efficiency, mechanization, and high degree of automation. However, the shield tunneling equipment is huge, the supporting facilities are numerous, and the site requirements are high. In response to the problems of slow slag removal speed and low construction efficiency in shield tunneling under the construction conditions of small wellhead shield tunneling sections in urban subways, taking the shield tunneling section of Guangzhou Metro Line 13 Phase II as the background,This article introduces the main components, working principles, installation and transportation processes, fault handling, and benefit analysis of the continuous belt conveyor slag removal system,This article elaborates on the method of using a continuous belt conveyor in the tunnel combined with a vertical lifting system at the wellhead to achieve continuous slag removal during underground shield tunneling construction in a narrow wellhead construction site. This not only improves excavation efficiency but also reduces construction costs, solves construction problems, and provides reference for similar projects in the future.

Numerical investigation on thermal management performance of soft packing Li-ion batteries with oblique multi-channel cold plates

During the driving process of electric vehicles (EVs), the continuous high-rate discharge of the power battery causes significant heat accumulation. An efficient battery thermal management system (BTMS) is critical for the safe and stable operation of EVs. In this study, an oblique channel cold plate (OCCP) is designed based on the traditional straight channel cold plate (SCCP) in order to addresses the problem of excessive and uneven temperatures during the high-rate discharge of soft packing lithium-ion batteries. Effects of glycol solution concentration, coolant mass flow rate, coolant inlet temperature, oblique angle for cooling channel, ambient temperature and discharge rate for the cell on the performance characteristics of BTMS, including the cooling efficiency (φ) and pressure drop (ΔP), are analyzed numerically with Ansys Fluent software. The results show that the OCCP has better cooling performance and lower pressure loss than the SCCP. Based on the analysis with the orthogonal design method, when the glycol solution concentration is 20 %, the mass flow rate is 1.0 g/s, and the inlet temperature is 25 °C, the BTMS with SCCP could obtain the optimal performance, corresponding to that the maximum temperature (Tmax) of the battery is controlled at 32.056 °C, while the φ is 0.581, and the ΔP across the cold plate is 52.652 Pa. Furthermore, the cooling efficiency φ of the cold plate decreases with the increase in the oblique angle. When the ambient temperature is 35 °C, the OCCP with a 20° oblique angle provides the best cooling effect for the battery during a 10C discharge. This work is helpful for the design of liquid cold plates in BTMS under high-rate discharge conditions for power battery of EVs.

Phase-Dependent Response to Electrical Stimulation of Cortical Networks during Recurrent Epileptiform Short Discharge Generation In Vitro.

The closed-loop control of pathological brain activity is a challenging task. In this study, we investigated the sensitivity of continuous epileptiform short discharge generation to electrical stimulation applied at different phases between the discharges using an in vitro 4-AP-based model of epilepsy in rat hippocampal slices. As a measure of stimulation effectiveness, we introduced a sensitivity function, which we then measured in experiments and analyzed with different biophysical and abstract mathematical models, namely, (i) the two-order subsystem of our previous Epileptor-2 model, describing short discharge generation governed by synaptic resource dynamics; (ii) a similar model governed by shunting conductance dynamics (Epileptor-2B); (iii) the stochastic leaky integrate-and-fire (LIF)-like model applied for the network; (iv) the LIF model with potassium M-channels (LIF+KM), belonging to Class II of excitability; and (v) the Epileptor-2B model with after-spike depolarization. A semi-analytic method was proposed for calculating the interspike interval (ISI) distribution and the sensitivity function in LIF and LIF+KM models, which provided parametric analysis. Sensitivity was found to increase with phase for all models except the last one. The Epileptor-2B model is favored over other models for subthreshold oscillations in the presence of large noise, based on the comparison of ISI statistics and sensitivity functions with experimental data. This study also emphasizes the stochastic nature of epileptiform discharge generation and the greater effectiveness of closed-loop stimulation in later phases of ISIs.