Based on the problems of development and modernization of urban transportation in China, it introduces the fact that the widely construction of expressway over the past decade as a starting point to analyze its characteristics. Firstly, it analyzes the features of intersection and general design principles of intersection, and studies the specific design methods of intersection. Secondly, the paper studies the span arrangement of Prestressed Concrete Continuous Girder Bridge based on the structural characteristics of the bridge itself. Finally, it studies the span arrangement concerning the traffic design of intersection, and the writer designs the traffic arrangement of intersection and the span arrangement of the bridge above, which is located at the middle ring expressway, Kunshan, Jiangsu and eastern part of Jianghai expressway, Nantong, Jiangsu to give an example.