You have accessJournal of UrologyScience & Technology Posters1 Apr 2016S&T-30 COMPARISON OF QUALITY OF LIFE IN PATIENTS WITH LOCALLY ADVANCED PROSTATE CANCER TREATED WITH NEOADJUVANT ENDOCRINE, EXTERNAL BEAM RADIATION AND ADJUVANT CONTINUOUS/INTERMITTENT ENDOCRINE THERAPY IN RANDOMIZED PHASE III TRIAL Akira Yokomizo, Hirofumi Koga, Kazuto Ito, Kazuhiro Suzuki, Hidetoshi Yamanaka, and Seiji Naito Akira YokomizoAkira Yokomizo More articles by this author , Hirofumi KogaHirofumi Koga More articles by this author , Kazuto ItoKazuto Ito More articles by this author , Kazuhiro SuzukiKazuhiro Suzuki More articles by this author , Hidetoshi YamanakaHidetoshi Yamanaka More articles by this author , and Seiji NaitoSeiji Naito More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.2859AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To evaluate the quality of life (QOL) of locally advanced prostate cancer (Pca) patients who were treated by neoadjuvant androgen deprivation therapy (ADT), external beam radiation (EBRT) and adjuvant continuous/intermittent ADT in prospective randomized phase III trial. METHODS Between 2001 and 2003, 280 intention-to-treat (ITT) patients with locally advanced Pca patients (cT3 or T4(bladder neck invasion only) N0M0) were treated 6 months of ADT, followed by 72 Gy of external beam radiation therapy. After 14 months, patients were randomly assigned to be treated with continuous ADT (arm 1) or intermittent ADT (arm 2) as shown in Figure 1. The QOL questionnaires were assesses in six points as shown in Fig.1. The QOL was evaluated by the FACT-G, P plus urinary, bowel and sexual subscales of EPIC. The 228 patients out of 280 ITT patients completed the protocol treatment. The number of patients who fit the FACT scoring manual in each QOL points were 270 (baseline), 258 (6 months, (M)), 254 (8M), 226 (14M), 201(20M) and 192 (28M). RESULTS FACT-P total scores significantly decreased after the EBRT (8M) but recovered to baseline at 14M. Physical subscale was similar change as FACT-P total score. The emotional subscale continuously increased but social/family subscale continuously decreased sequentially, suggesting that the patients’ anxiety improved but supports from their family and friends decreased as the treatment progressed. The urinary subscale were significantly improved after the neoadjuvant ADT (6M), decreased after EBRT(8M) and improved at 14M. The bowel subscale decreased after EBRT (8M) but recovered soon at 14M. The sexual subscales were continuously decreased after ADT. Comparing the arm1 and 2, functional and FACT-P Trial Outcome Index (TOI) were significant better in intermittent ADT group (Figure 1). CONCLUSIONS Fact-P total score and urinary and bowel subscale were rapidly decline after EBRT but recover soon after 6 month of EBRT (14M). The functional and FACT-P (TOI) score were significant better in intermittent ADT group. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e320 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Akira Yokomizo More articles by this author Hirofumi Koga More articles by this author Kazuto Ito More articles by this author Kazuhiro Suzuki More articles by this author Hidetoshi Yamanaka More articles by this author Seiji Naito More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...