The Gulf of Mexico opened as a Late Triassic-Mid Jurassic continental rift that was first largely covered by the Mid-Jurassic Louann Salt and later split apart by a triangular-shaped oceanic crust. Salt in the Gulf of Mexico largely hampers the imaging and interpretation of underlying pre-salt and crustal geometries, which are fundamental for assessing the early kinematic evolution of the margin. To better define these deep geometries and their lateral variations, we built three seismic-based crustal-scale cross-sections across the Florida-Yucatan conjugate margins, in the areas where the Louann Salt is thinner. They were used, together with magnetic and gravity anomalies data, to build a crustal domains map for the study area. Cross-sections show a meaningful along-strike variation: the South Florida-East Yucatan area is characterized by a narrower rifted continental crust that evolves sharply to oceanic crust whereas in the North Florida and central-western Yucatan areas, the rifted continental crust is wider and the transition to the oceanic crust corresponds to a narrow magmatic or exhumed mantle domain. Bulk continental crust extension was determined using the area balancing method. Estimated horizontal extension values vary from a minimum of ∼120 km in the South Florida-East Yucatan conjugate to a minimum of ∼240 km in the North Florida-Central Yucatan conjugate, being systematically larger in the northern margin. Based on our observations and considering previous models, we propose that the study area evolved from an early rift involving magmatism, to a magma-poor margin, with continental break-up (OCT formation) being characterized by mantle exhumation and associated magmatism along the North Florida and central-western Yucatan areas. As in other analogues such as the Gulf of Guinea, the thick evaporite deposited during the late rift, while mantle was being exhumed.