Context-dependent Memory Research Articles

Gaze scan-paths affect recall strategy in context dependent memory.

Gaze scan-paths affect recall strategy in context dependent memory.

Context reinstatement requires a schema relevant virtual environment to benefit object recall.

How does our environment impact what we will later remember? Early work in real-world environments suggested that having matching encoding/retrieval contexts improves memory. However, some laboratory-based studies have not replicated this advantageous context-dependent memory effect. Using virtual reality methods, we find support for context-dependent memory effects and examine an influence of memory schema and dynamic environments. Participants (N = 240) remembered more objects when in the same virtual environment (context) as during encoding. This traded-off with falsely "recognizing" more similar lures. Experimentally manipulating the virtual objects and environments revealed that a congruent object/environment schema aids recall (but not recognition), though a dynamic background does not. These findings further our understanding of when and how context affects our memory through a naturalistic approach to studying such effects.

The influence of content-relevant background color as a retrieval cue on learning with multimedia

Color has been investigated as a signaling cue in multimedia learning environments, guiding the learner’s attention and as an emotional design element, increasing the learner’s motivation and, thus, improving learning outcomes. Retrieval cues (e.g., visual cues, odor, sound) facilitating memory retrieval have been primarily investigated in learning simple word lists. Contrary to additional retrieval cues, the background color is a component that is always present in multimedia learning environments. This study investigates if the background color of learning texts as retrieval cue can enhance learning and affect cognitive load and motivation. Hypotheses are formulated according to the Cognitive-Affective Theory of Learning with Multimedia (CATLM) and in the setting of context-dependent memory, specifically the Information, associated Context, and Ensemble Theory (ICE). A 2 (related vs. unrelated background color) × 2 (with vs. without colors in the learning test) -factorial between-subjects design with an additional control group was utilized. For the control group, the background of the learning texts and learning questions was white. In total, 191 native German speakers were randomly assigned to the five groups. The findings indicate that relying solely on the background color as a retrieval cue is insufficient. Instead of facilitating memory retrieval, the background color remains context information stored separately from the item information. However, the results should be approached carefully as learning outcomes may be subject to ceiling and floor effects.

Контекстуальная опосредованность когнитивной деятельности

<p>The article presents an analysis of the effect of context in cognitive activity. Contextual influences are expressed in changes of productivity and time of problem solving under the influence of actual irrelevant information or previously formed knowledge structures. The importance of studying contextual <strong>variables</strong> stems from their fundamental role in cognitive processes. Examples of contextual mediation are the effects of dependence of perception of an object (figure) on the perceptual environment (background), priming effects, effects of awareness of multivalued information, effects of context-dependent memory, effects of contextual cues, effects of functional fixation in solving thinking tasks, etc. By analogy with types of memory it is proposed to differentiate ultra-short-term, short-term and long-term (stable) contexts. A prospect in the study of contextual influences can become the study of types and character of interaction of contexts having different characteristics. The latter include: "homogeneity/heterogeneity" of the context, "relevance/irrelevance" to the task, "power" - the integration of local contexts in a single context, "congruence/dissociation" as the correspondence/dissimilarity of different contexts to each other.</p>

Contextual reinstatement affects semantic organization.

The Context Dependency Effect is the well-established finding in which memory performance is enhanced under conditions in which the encoding and retrieval contexts overlap (i.e., Same-Context) and diminished when the overlap between encoding and retrieval contexts is low (i.e., Different-Context). Despite much research on context-dependent memory, most prior work examined only mean performance levels. The current experiment examined the influence of context change, manipulated by using three different pieces of background music, on semantic organization during free recall. Recall driven by semantic organization captures an important, ecologically valid aspect of memory retrieval: because narratives of real-life events are typically comprised of semantically related concepts (e.g., "sea," "bathing suit," and "sand" when recalling a trip to the beach), their recall is likely driven by semantic organization. Participants in the current study were tested in the same or different context as the material was learned. The results showed that although the mean number of correctly recalled items was numerically greater in the Same-Context condition compared to the Different-Context condition, the Context Dependency Effect was not significant. In contrast, however, semantic clustering-an established measure of semantic organization-was greater in the Different-Context condition compared to the Same-Context condition. Together, these results suggest that when contextual cues at recall are relatively meager, participants instead use semantic information as cues to guide memory retrieval. In line with previous findings, temporal organization, patterns of errors, and serial position analyses showed no differences between the two context conditions. The present experiment provides novel evidence on how external context change affects recall organization.

Context-dependent memory recall in HMD-based immersive virtual environments.

The article introduces an original VR-based experiment which explores context-dependent memory recall in humans. It specifically examines the recall of correct and falsely induced semantic memories. With the aid of VR head-mounted displays, 92 students of psychology were placed in a computer-generated indoor virtual environment and asked to memorize the presented lists of words. Afterwards, the participants were placed in the same indoor virtual environment or an alternative outdoor virtual environment and asked to recall the words. The number of correct and falsely induced words was then measured. On average, women recalled significantly more correct words from the list than men, regardless of the environmental context. Despite the assumptions, we did not observe a separate effect of exposure to different environments during learning and recall of material on memory performance. Likewise, we did not detect any effects of the learning context or biological sex in the case of the production of false memories. These results provide a novel insight into previous knowledge regarding the memory processes that occur in virtual environments. Although we failed to confirm the role of context in recalling learned material in general, we found a hint that this context might interact with specific memory processes of biological sexes. However, the design of this study only captured the effect of changing the environment during memory recall and did not address the role of specific context in remembering learning material. Further research is therefore needed to better investigate these phenomena and examine the role of biological sex in context-dependent memory processes.

A Multicomponent Cognitive Intervention May Improve Self-Reported Daily Function of Adults With Subjective Cognitive Decline.

Limited evidence exists to support cognitive intervention improving the daily function of adults with subjective cognitive decline (SCD). To examine the preliminary efficacy of a group-based multicomponent cognitive intervention that integrates Lifestyle Redesign® (LR) techniques. Single-arm two-period crossover trial; 16-wk waiting period, 16-wk intervention, and 16-wk follow-up. Memory clinic in a medical center, Taiwan. Purposive sample of adults ages >55 yr with SCD. Sixteen 1.5-hr weekly multicomponent sessions of cognitive training, cognitive rehabilitation, psychological intervention, and lifestyle intervention. Primary outcomes were (1) self-reported daily function, measured with the Activities of Daily Living Questionnaire (ADLQ) and Cognitive Failure Questionnaire; (2) performance-based daily function, measured with the Brief University of California San Diego Performance-Based Skills Assessment-Traditional Chinese Version; and (3) functional cognition, measured with the Contextual Memory Test (CMT) and Miami Prospective Memory Test. Secondary outcomes included cognitive functions, anxiety, and depression. Seventeen participants completed the intervention; 4 missed the follow-up. The generalized estimating equations model showed significant changes from baseline to pretest (control) and pretest to posttest (intervention) on the ADLQ (p = .014) and CMT-delayed (p = .003). Effects remained at the 16-wk follow-up. After adjusting for the effects of covariates, the self-reported daily function of participants ages ≤ 63 yr improved more than that of other participants (p = .003). Multicomponent cognitive interventions integrating LR techniques may improve self-reported daily function and context-dependent memory function of adults with SCD, with efficacy sustained at follow-up. What This Article Adds: A group-based multicomponent cognitive intervention consisting of cognitive training, cognitive rehabilitation, psychoeducation, and lifestyle intervention may provide benefits for the daily function and cognitive function of adults with SCD.

Using preexperimental familiarity to compare the ICE and cue-overload accounts of context-dependent memory in item recognition.

In recognition, context effects often manifest as higher hit and false-alarm rates to probes tested in an old context compared with probes tested in a new context; sometimes, this concordant effect is accompanied by a discrimination advantage. According to the cue-overload account of context effects (Rutherford, 2004), context acts like any other cue, and thus context effects should be larger with lighter context loads. Conversely, the Item, Associated Context, and Ensemble (ICE) account (Murnane et al., 1999) attributes context effects to two factors: subjects erroneously attributing context familiarity to the probe, and the formation of ensembles (mnemonic combinations of item and context). Context familiarity increases as exposure at study increases, and thus ICE predicts larger effects of context as context load increases. Relatedly, ICE predicts larger effects of context as context meaningfulness increases, as meaningful contexts are more likely to be bound to the target in an ensemble. In Experiments 1 and 2, rather than manipulate context load during the study phase, we relied on subjects' preexperimental context exposure to manipulate context load. Subjects studied words superimposed on photographs of their university campus or another university campus. At test, targets and distractors were evenly divided between study and novel contexts and between familiar and unfamiliar contexts. In Experiment 3, we manipulated context familiarity within the experimental session. Results supported ICE, suggesting that context does not act as a retrieval cue in recognition. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Can different contexts affect memory recall?

To address questions about the dependence of human memory on the contingent context in which events occur, the author review research on contingent context-dependent memory in humans. The relationship between the context in which an item is stored and retrieved has a significant impact on a person's ability to recognize the item. The theoretical approach to this problem stems from Bjork's (1978) experiments on the effects of environmental context on recall and recognition. If a person learns and remembers in the same contextual environment, then learning and memory are dependent on the environmental context in which these activities occur. This paper discusses each of the three mental processes of memory in relation to their stimulus context. For example, the impact of inference methods of retrieval on context-dependent memory methods, and the improvement in retrieval of information by encoding environmental information along with plot specific objects or contexts in the storage information session. Further, this paper explores the effects of contextual stimuli in real-life contexts, particularly in classroom and examination settings of environmental context.

Impact of α‐synuclein RNA interference on Neuropathological and Clinical Phenotypes in a mouse model of Alzheimer’s Disease

AbstractBackgroundAlzheimer’s disease (AD) is a neurodegenerative disorder characterized by the pathologic accumulation of beta amyloid (Aβ), Tau and α‐synuclein (α‐syn). The role of α‐synuclein has been extensively studied in Parkinson’s disease, but less so in AD. Recent studies have shown that α‐syn may also play a role in AD and its downregulation could be protective against the toxic effects of Aβ accumulation. First, we hypothesized that selectively knocking down α‐syn improves the neuropathological, biochemical, and cognitive findings in AD. Second, we tested whether α‐syn ablation could enhance AD treatments with donepezil (pro‐cholinergic) and memantine (glutamate antagonist), which are currently ineffective at slowing progression of disease.MethodPSAPP transgenic mice were used to model AD and knockdown of a‐syn was performed by RNA interference. 43 non‐transgenic and 33 PSAPP mice were used in this study. We have selectively knocked‐down α‐syn by two differentmethodsa) first, by stereotaxic bilateral injection of either LV‐shRNA (pan) α‐syn or LV‐shRNA‐luc (control) into the hippocampus and striatum; b) second, by intraperitoneal injection of a complex of ApoB11 and shRNA‐α‐syn, which was previously shown to cross the BBB. Water maze and open field testing were used to measure cognitive deficits. Biochemistry and immunohistochemistry were performed on each hemibrain.ResultWe have successfully utilized these two strategies to down‐regulate α‐syn as shown by lower levels of α‐syn through biochemistry and immunohistochemistry. Importantly, this correlates with a significant reduction in the number of Aβ plaques and tau peptides, suggesting the overlap between Aβ, tau and α‐syn in pathology. Other findings include a reduction in Iba1 staining in mice injected with LV‐shRNA‐α‐syn suggesting involvement of microglia in pathology. Open field testing indicates that α‐synuclein reduction could restore context dependent memory. Moreover, injection of LV‐shRNA‐α‐syn into the hippocampus of mice treated with memantine rescues cognitive deficits to a non‐disease level, as shown by all variables analyzed during water maze trials with an invisible platform (time, entrances and passes in correct zone).ConclusionOverall, this study provides evidence that α‐synuclein knock‐down improves some of the neuropathological and cognitive deficits and could be of therapeutic value in AD, especially when combined with a glutamate antagonist.

Selective engram coreactivation in idling brain inspires implicit learning

Passive priming of prior knowledge to assimilate ongoing experiences underlies advanced cognitive processing. However, the necessary neural dynamics of memory assimilation remains elusive. Uninstructed brain could also show boosted creativity, particularly after idling states, yet it remains unclear whether the idling brain can spontaneously spark relevant knowledge assimilations. We established a paradigm that links/separates context-dependent memories according to geometrical similarities. Mice exploring one of four contexts 1 d before undergoing contextual fear conditioning in a square context showed a gradual fear transfer to preexposed geometrically relevant contexts the next day, but not after 15 min. Anterior cingulate cortex neurons representing relevant, rather than distinct, memories were significantly coreactivated during postconditioning sleep only, before their selective integration the next day during testing. Disrupting sleep coreactivations prevented assimilation while preserving recent memory consolidation. Thus, assimilating pertinent memories during sleep through coreactivation of their respective engrams represents the neural underpinnings of sleep-triggered implicit cortical learning.

Odor-based context-dependent memory: influence of olfactory cues on declarative and nondeclarative memory indices.

Reinstating the olfactory learning context can increase access to memory information, but it is not fully clear which memory functions are subject to an enhancing odor context reinstatement effect. Here, we tested whether congruent odor context during encoding and recall positively affected declarative and nondeclarative memory scores using a novel method for manipulation of an odorous environment; namely, intranasal Nosa plugs. Recall of a text and a complex figure as well as performance in a priming task were assessed immediately and 1 wk after encoding. We found that congruent odor exposure at encoding and recall aided free retrieval of a story at delayed testing but had no significant effect on a complex figure recall or a word completion task. Differences between the assessed memory indices suggest that olfactory environmental cues may be primarily efficient in free verbal recall tasks.

Addendum to: Murre (2021). The Godden and Baddeley (1975) experiment on context-dependent memory on land and underwater: a replication

The analysis in Murre (2021) should have been done with a repeated measures ANOVA with an order effect as a between-subjects covariate. A reanalysis reinforces the conclusion that this study was not a successful replication of Godden & Baddeley (1975).

The limbic memory circuit and the neural basis of contextual memory

The hippocampus, retrosplenial cortex and anterior thalamus are key components of a neural circuit known to be involved in a variety of memory functions, including spatial, contextual and episodic memory. In this review, we focus on the role of this circuit in contextual memory processes. The background environment, or context, is a powerful cue for memory retrieval, and neural representations of the context provide a mechanism for efficiently retrieving relevant memories while avoiding interference from memories that belong to other contexts. Data from experimental lesions and neural manipulation techniques indicate that each of these regions is critical for contextual memory. Neurophysiological evidence from the hippocampus and retrosplenial cortex suggest that contextual information is represented within this circuit by population-level neural firing patterns that reliably differentiate each context a subject encounters. These findings indicate that encoding contextual information to support context-dependent memory retrieval is a key function of this circuit.

The Godden and Baddeley (1975) experiment on context-dependent memory on land and underwater: a replication.

A replication of the experiment by Godden and Baddeley (Godden and Baddeley 1975 British Journal of Psychology 66, 325–331 (doi:10.1111/j.2044-8295.1975.tb01468.x)) on environmental context-dependent memory is described. Sixteen divers studied auditorily presented word lists on land or underwater and recalled these 4 min later on land or underwater (each diver participated in all four combinations). Contrary to the original study, we did not find that recall in the same context where the words had been learned was better than recall in the other context. We discuss differences between our replication and the original study and emphasize the importance of attempts at replicating classic studies.

Dissociated Role of Thalamic and Cortical Input to the Lateral Amygdala for Consolidation of Long-Term Fear Memory.

Post-encoding coordinated reactivation of memory traces distributed throughout interconnected brain regions is thought to be critical for consolidation of memories. However, little is known about the role of neural circuit pathways during post-learning periods for consolidation of memories. To investigate this question, we optogenetically silenced the inputs from both auditory cortex and thalamus in the lateral amygdala (LA) for 15 min immediately following auditory fear conditioning (FC) and examined its effect on fear memory formation in mice of both sexes. Optogenetic inhibition of both inputs disrupted long-term fear memory formation tested 24 h after FC. This effect was specific such that the same inhibition did not affect short-term memory and context-dependent memory. Moreover, long-term memory was intact if the inputs were inhibited at much later time points after FC (3 h or 1 d after FC), indicating that optical inhibition for 15 min itself does not produce any nonspecific deleterious effect on fear memory retrieval. Selective inhibition of thalamic input was sufficient to impair consolidation of auditory fear memory. In contrast, selective inhibition of cortical input disrupted remote fear memory without affecting recent memory. These results reveal a dissociated role of thalamic and cortical input to the LA during early post-learning periods for consolidation of long-term fear memory.SIGNIFICANCE STATEMENT Coordinated communications between brain regions are thought to be essential during post-learning periods for consolidation of memories. However, the role of specific neural circuit pathways in this process has been scarcely explored. Using a precise optogenetic inhibition of auditory input pathways, either thalamic or cortical or both, to the LA during post-training periods, we here show that thalamic input is required for consolidation of both recent and remote fear memory, whereas cortical input is crucial for consolidation of remote fear memory. These results reveal a dissociated role of auditory input pathways to the LA for consolidation of long-term fear memory.

Attentional context-dependent memory during gradual visuomotor adaptation

Attentional context-dependent memory during gradual visuomotor adaptation

The rodent object-in-context task: A systematic review and meta-analysis of important variables.

Environmental information plays an important role in remembering events. Information about stable aspects of the environment (here referred to as 'context') and the event are combined by the hippocampal system and stored as context-dependent memory. In rodents (such as rats and mice), context-dependent memory is often investigated with the object-in-context task. However, the implementation and interpretation of this task varies considerably across studies. This variation hampers the comparison between studies and-for those who design a new experiment or carry out pilot experiments-the estimation of whether observed behavior is within the expected range. Also, it is currently unclear which of the variables critically influence the outcome of the task. To address these issues, we carried out a preregistered systematic review (PROSPERO CRD42020191340) and provide an up-to-date overview of the animal-, task-, and protocol-related variations in the object-in-context task for rodents. Using a data-driven explorative meta-analysis we next identified critical factors influencing the outcome of this task, such as sex, testbox size and the delay between the learning trials. Based on these observations we provide recommendations on sex, strain, prior arousal, context (size, walls, shape, etc.) and timing (habituation, learning, and memory phase) to create more consensus in the set-up, procedure, and interpretation of the object-in-context task for rodents. This could contribute to a more robust and evidence-based design in future animal experiments.

Evidence for a gradient within the medial temporal lobes for flexible retrieval under hierarchical task rules.

A fundamental question in memory research is how the hippocampus processes contextual cues to retrieve distinct mnemonic associations. Prior research has emphasized the importance of hippocampal-prefrontal interactions for context-dependent memory. Our fMRI study examined the human medial temporal lobes (MTL) and their prefrontal interactions when retrieving memories associated with hierarchically organized task contexts. Participants learned virtual object-location associations governed by subordinate and superordinate task rules, which could be independently cued to change. On each fMRI trial, participants retrieved the correct object for convergent rule and location contextual information. Results demonstrated that hippocampal activity and hippocampal-prefrontal functional interconnectivity distinguished retrieval under different levels of hierarchically organized task rules. In explicit contrast to the hippocampal tail, anterior (body and head) regions were recruited specifically for superordinate changes in the contextual hierarchy. The hippocampal body also differed in its functional connectivity with the prefrontal cortex for superordinate versus subordinate changes. Our findings demonstrate a gradient in MTL for associative retrieval under changing task rules, and advance understanding of hippocampal-prefrontal interactions that support flexible contextual memory.

Effects of Auditory Simulation and Personality Types on Working Memory

Working memory is very crucial as it influences higher cognition. We conducted a study testing auditory simulations effect on working memory while considering personality type. 161 participants college students did the Eysenck personality questionnaire (EPQ-R) as a pretest, followed by reading a prose with an auditory simulation based assigned group (pop, classical, white noise and silence). Then they answered multiple-choice questions based on the prose in silence. We found that pop and classical groups did better, although the difference across groups was not significant. Hence auditory simulations have no negative or significant positive effects on working memory, furthermore, unlike previous studies, personality didn’t affect performance. Future studies can consider participants’ preferences and context-dependent memory to better explore this phenomenon.