Summary Introduction Can aging models be used to develop a model of pharmaceutical practice that improves patient care in a context of increasing workload and budgetary constraints? Material and method A before–after observational study was performed in nine healthcare institutions to assess the impact of a context-aware computerized decision-support system designed with available software (SAP Business Object®) to automatically compare prescriptions recorded in computerized patient files (Cariatide®) against the main consensual guidelines for medical management of elderly subjects and the French Health Authority's Drug Prescription in Elderly Subjects (PMSA) program. The system generated alerts to improve medication management and displayed a list of clinical actions to be taken for individual patients. The name and localization of these patients were identified so that the pharmacist could analyze the alerts and take any necessary action to adjust potentially inappropriate prescriptions as part of a systematic individualized update of good therapeutic practice in elderly subjects. Drug interactions were not taken into consideration. During the study period, data were collected from all patients over 65 years of age receiving daily care (n = 369) with no change in the size of the pharmacy team. Results Over a 10.5-month period from 27 October 2015 to 16 September 2016, this context-aware pharmaceutical analysis tool was implemented for all patients aged more than 65 years: n = 184; 118 F, 66 M; mean age: 73.9 ± 7.1 years. Over the corresponding period of the previous year (27 October 2014 to 16 September 2015), 185 elderly patients (116 F, 69 M; mean age, 75.4 ± 7.4 years) were managed before the new computerized system had been implemented. The new tool took a mean 45 s to display the good drug management analysis, highlighting discrepancies with respect to guidelines for the treatment of elderly subjects and listing potentially inappropriate drugs per patient and per care unit. The tool generated a table displaying PMSA health-quality indicators per care unit. Another screen displayed potentially inappropriate prescriptions for the elderly. Mean hospital stay for elderly patients was comparable for the two periods: 33 and 37 days. Between the two periods, prescription of short-acting ( Discussion and conclusion The literature shows that implementation of good clinical practice guidelines is improved when they are communicated via decision-support instruments, preferably context-aware tools linked to patient files. Despite possible limitations, the project was found to comply with practice objectives and models based on recognized factors contributing to the development of clinical pharmacy departments. A study of context-aware computer-assisted drug management in nursing homes or rehabilitation units prior to hospital (re)admission is proposed, with the aim of reducing admission rates for the elderly, and with the added benefit of providing extended assessment of this model of pharmaceutical practice.