Contents Of Volume Research Articles

Feasibility and mechanism of atmospheric pressure cold plasma jet (APCPJ) assisted micro-milling of bulk metallic glasses (BMGs)

The unique microstructures of bulk metallic glasses (BMGs) provide them with excellent mechanical, physical, and chemical properties, having important applications in the fields of medical devices, military equipment, aerospace, etc. However, the superb mechanical properties also contribute to poor machinability of the BMGs. Currently, researchers have proposed to improve the machinability by single-point diamond turning, laser-assisted machining and ultrasonic vibration-assisted machining, but their plasticity and viscous flow remain unchanged, thus restraining further enhancement of surface quality. Atmospheric pressure cold plasma jet (APCPJ), which is rich in active particles, can effectively ameliorate material machinability by modulating material properties. In this paper, we propose to use the APCPJ to regulate the properties of BMGs, and carry out nanoindentation, nanoscratching, and micro-milling experiments to investigate the influence mechanisms of APCPJ on the material properties and cutting process. The results demonstrate that after modified by APCPJ, plastic deformability of the BMGs is improved due to the increase of free volume content; meanwhile, the viscous flow is inhibited. The micro-milling experiments indicate that under the conditions of feed rate Vf = 500 μm/s, spindle speed n = 30,000 rpm, and cutting depth ap = 5 μm, the improvement effect of APCPJ on the cutting process is relatively optimum. The surface roughness Ra of the Zr-based BMG and Ti-based BMG obtained by APCPJ are respectively 0.076 μm and 0.081 μm, which can be reduced by 37.7 % and 38.2 % compared with dry micro-milling. The cutting forces Fz in the direction of cutting depth are also reduced by 30.9 % and 23.3 %, respectively. The APCPJ-assisted micro-milling method proposed in this work may ameliorate the machining quality of BMGs and promote the application of BMGs and APCPJ-assisted machining technology in aerospace and precision machining.

Pancreatic Parenchymal Atrophy and Pancreatic Fat Accumulation Measured by Multidetector Computed Tomography as a Stable Marker of Chronic Progressive Type 2 Diabetes Mellitus-A Cross Sectional Observational Study.

Background The most crucial step in the management of type 2 diabetes is identifying its pathogenesis and progression. Fat accumulation in the pancreas and decreased parenchymal volume can influence pancreatic function due to insulin resistance or β-cell dysfunction. This study aims to find out the difference in pancreatic volume and fat content by using contrast-enhanced computed tomography (CECT) between normal subjects and patients with different durations of type 2 diabetes mellitus (T2DM). Methods This was a cross-sectional study. Patients who underwent CECT abdomen for the evaluation of conditions other than pancreatic origin were included. The study group was divided into three subgroups according to the duration of diabetes as <5 years, 5 to 10 years, and >10 years. In total, 40 nondiabetic controls were included. Pancreatic fat volume and parenchymal volume were measured in cm 3 using CECT. Correlation between pancreatic parenchymal and fat volume with the duration of T2DM as well as with levels of hemoglobin A1c, random blood sugar, serum triglyceride, low-density lipoproteins, and high-density lipoproteins was done. Results T2DM patients had significantly ( p < 0.001) lower pancreatic parenchymal volume (mean value of 57.08 ± 8.26 cm 3 in diabetics and 72.23 ± 3.41 cm 3 in controls) and higher pancreatic fat volume (mean value of 3.08 ± 1.90 cm 3 in diabetics and 0.67 ± 0.27cm 3 in controls) as compared to nondiabetic controls. In patients with T2DM, as the duration of T2DM increased, pancreatic parenchymal volume decreased and pancreatic fat volume increased. Conclusion Reduction in pancreatic volume and fat deposition may have a role in the onset and progression of diabetes. Determining the pancreatic volume and fat content would be useful for identifying high-risk patients and determining the pathogenesis of the development of diabetes.

Synthesis and Evaluation of a Novel Series of Diphenylamine and Diphenylether Derivatives with Osteoblastogenic and Osteogenic Effects via CDK8 Inhibition.

Osteoporosis is induced by an imbalance between osteogenesis and bone resorption, and is treated with osteogenic drugs and/or resorption inhibitors. Resorption inhibitors, such as bisphosphonates, are orally used; however, orally active small molecules with osteogenic activity are not clinically available. We synthesized various types of small molecules and identified a series of diphenylamine and diphenylether derivatives that promoted osteoblast differentiation. Among them, diphenylether derivatives 13a, 13g, and 13h potently promoted osteoblast differentiation (EC200 for increasing alkaline phosphatase activity = 11.3, 31.1, and 12.3 nM, respectively) and inhibited cyclin-dependent kinase 8 (CDK8) activity (IC50 = 2.5, 7.8, and 3.9 nM, respectively), suggesting that their osteoblastgenic effects are mediated by the inhibition of CDK8. The ratio of the maximal plasma concentration after oral administration at 10 mg/kg in female rats and EC200 for osteoblastogenesis was 148.1 for compound 13a, 53.4 for 13g, and 101.8 for 13h, indicating possible in vivo osteoblastogenic and osteogenic effects. In ovariectomized female rats, 13g and 13h at 10 mg/kg/d for 8 weeks increased plasma bone-type alkaline phosphatase activity, indicating enhanced in vivo osteoblastogenesis. Furthermore, micro-computed tomography (micro-CT) showed that both compounds increased femoral cortical bone volume and mineral contents, which were unaffected by ovariectomy, while having negligible effects on trabecular bone volume and mineral contents, which were markedly reduced by ovariectomy. In conclusion, diphenylamine and diphenylether structures are novel scaffolds for osteoblastogenesis enhancers via the inhibition of CDK8. Among them, 13g and 13h are candidates for anti-osteoporotic drugs with cortical bone-selective osteogenic effects.

The Effect of Riboflavin on Neurological Rehabilitation after Traumatic Brain Injury in Children.

Traumatic brain injury (TBI), which is the brain impairment and lesion caused by the external force injuring the head and the underlying brain, can cause pediatric death, disability, neurological disorders, and even lifelong disability. This study was to explore the effect of riboflavin (RF) on neurological rehabilitation and functional recovery after TBI. The rat models of TBI were constructed by treating rats with controlled cortical impact (CCI). By treating TBI rats with RF, we investigated whether the administration of RF would affect the sensorimotor function and cognitive ability recovery through adhesive removal test, modified neurological severity score (mNSS), corner test, wire-grip test and the Morris water maze. The effects of RF on lesion volume and water content were investigated using hematoxylin and eosin (H&E) staining and wet-dry method. The Nissl staining and terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) staining were used to demonstrate the effect of RF on neural apoptosis. Inflammation-related cytokines of interleukin (IL)-6, IL-1β, tumor necrosis factor (TNF)-α, and transforming growth factor (TGF)-β1 were measured by enzyme-linked immunosorbent assay (ELISA) to evaluate the effect of RF on neuroinflammation. The impact of RF on oxidative stress was assessed by measuring malondialdehyde (MDA) content and superoxide dismutase (SOD) activity, and the platelet endothelial cell adhesion molecule-1 (CD31) staining for observing vessel density, the reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) for measuring vascular endothelial growth factor (VEGF) mRNA expression and western blot for VEGF protein expression were used for evaluated angiogenesis. The administration of RF could facilitate the recovery of neurological function by promoting the recovery of sensorimotor function and cognitive ability (p < 0.05). Furthermore, RF could reduce the lesion volume and water content after TBI and ameliorate neural apoptosis, neuroinflammation, and oxidative stress (p < 0.05). Finally, RF increased vessel density (p < 0.01) and VEGF levels (p < 0.01) in brain tissues after TBI, promoting angiogenesis. RF benefits neurological rehabilitation after TBI by promoting neurological function recovery, ameliorating the pathogenesis after TBI, and facilitating brain vascular remodeling. These findings provide a novel mechanism for RF treating pediatric TBI.

Graphical analysis-based calculation method of concrete strength

This study established a three-dimensional random spherical aggregate model of concrete. Models with various volume contents of coarse aggregate were sliced, and slice areas were statistically analyzed. To study the effects of the coarse aggregate volume content and the interfacial transition zone (ITZ) strength on concrete’s compressive strength, a concrete strength calculation method based on graphical analysis was proposed. The ratio of crown area B to sectional area A of the spherical aggregate model was found to be close to 1.5. At the ITZ strength below 70% of the mortar strength, the increased volume content of coarse aggregate reduced the compressive strength of concrete, with the opposite trend observed at the ITZ strength exceeding 70% of the mortar strength.

Microstructure effect analysis of carbon black-filled rubber composites

The unidirectional tensile stress-strain curves of four kinds of carbon black-filled rubbers with different volume contents were obtained by mechanical experiments, and the fine morphology maps of the carbon black-filled rubber composites were obtained by electron microscope experiments. Based on the hyperelastic constitutive model of rubber, an ellipsoidal carbon black particles randomly distributed finite element model was established using DIGIMAT and ABAQUS, and uniaxial tensile simulation was carried out on the established two-dimensional model. The effects of the volume fraction, distribution angle and number of agglomerates of carbon black particles on the stress-strain relationship curve and stress distribution of the composites were analyzed. The results show that: with the increasing volume fraction of carbon black particles, the stiffness value of the composite material becomes larger; when the particle direction is 0° to the load direction, the strength of the material is improved and the stress concentration phenomenon is less; with the increasing number of carbon black agglomerates, the strength of the composite material decreases and the stress concentration phenomenon is obvious in agglomerated area.

The Analysis of the Language Content of the First Volume of Grade 7 English Textbook of PEP

The Analysis of the Language Content of the First Volume of Grade 7 English Textbook of PEP

A maternal low-protein diet results in sex-specific differences in synaptophysin expression and milk fatty acid profiles in neonatal rats.

The developmental origins of health and disease hypothesis have highlighted the link between early life environment and long-term health outcomes in offspring. For example, maternal protein restriction during pregnancy and lactation can result in adverse metabolic and cognitive outcomes in offspring postnatal. Hence, in the present study, we assess whether an isocaloric low-protein diet (ILPD) affects the fatty acid profile in breast milk, the hippocampal synaptophysin (Syn) ratio, and the oxidative stress markers in the neonatal stage of male and female offspring. The aim of this work was to assess the effect of an ILPD on the fatty acid profile in breast milk, quantified the hippocampal synaptophysin (Syn) ratio and oxidative stress markers in neonatal stage of male and female offspring. Female Wistar rats were fed with either a control diet or an ILPD during gestation to day 10 of lactation. Oxidative stress markers were assessed in serum and liver. All quantifications were done at postnatal day 10. The results showed: ILPD led to decreases of 38.5% and 17.4% in breast milk volume and polyunsaturated fatty acids content. Significant decreases of hippocampal Syn ratio in male offspring (decreases of 98% in hippocampal CA1 pyramidal and CA1 oriens, 83%, stratum pyramidal in CA3, 80%, stratum lucidum in CA3, and 81% stratum oriens in CA3). Male offspring showed an increase in pro-oxidant status in serum and liver. Thus, the data suggest that male offspring are more vulnerable than females to an ILPD during gestation and lactation.

ПЕДАГОГИЧЕСКАЯ ТЕХНОЛОГИЯ ФОРМИРОВАНИЯ КРИТИЧЕСКОГО МЫШЛЕНИЯ КУРСАНТОВ НА ЗАНЯТИЯХ ПО ИНОСТРАННОМУ ЯЗЫКУ В ВОЕННОМ ВУЗЕ

The article is devoted to the theoretical and methodological substantiation of the structure and content of pedagogical technology for the formation of critical thinking in foreign language classes at a military university. For this purpose, an analysis of scientific literature was carried out, the structural and content characteristics of pedagogical technology were identified, the structural and content composition of the pedagogical technology for the formation of cadets critical thinking in the process of learning a foreign language was determined, and on the basis of this, a pedagogical technology was developed that increases the effectiveness of the formation of cadets critical thinking in foreign language classes language. Pedagogical technology is considered as a multidimensional, ordered system of means of the pedagogical process, based on a scientific basis, implemented within a given chronotope and leading to the achievement of the planned result. Attention is focused on the main criteria of pedagogical technology: scientific, systematic, structured and procedural. The main components of pedagogical technology and their content are determined. The conceptual component of pedagogical technology defines its main idea, patterns, methodological approaches (systemic, personality-creating, competency-based, technological and communicative), principles (systematic and consistent, subjectivity, problematic, reflexive, situational), philosophical, psychological, didactic and social and pedagogical rationale for achieving educational goals. It was revealed that the content component includes a diagnosable goal, objectives of pedagogical technology, the volume and thematic content of the program for the formation of cadets critical thinking in foreign language classes at a military university. The procedural component is considered, revealing the essence, structure, algorithm, requirements and methodological conditions for organizing the educational process. The following methods have been identified to implement the technology: brainstorming, problem-based learning, TRIZ techniques, POPS formula, case method, discussion, foresight session, business game. During the study, diagnostics of the process of the technology under consideration was determined, including criteria, indicators, levels of formation, and diagnostic tools. As a result of the study, it is concluded that the effective functioning of this technology will help improve the quality of formation of cadets critical thinking in the process of learning a foreign language

Complanatuside A Inhibits Seminal Vesicle Cell Apoptosis by Activating SerpinB1a in Type 2 Diabetic Mice

Type 2 diabetes mellitus (T2DM) can trigger cell apoptosis of seminal vesicles (SVs) and impair seminal secretory functions. Complanatuside A (CA) is known for its anti‐inflammatory and antioxidant effects, as well as its ability to repair cellular damage. This study aimed to explore the potential molecular mechanisms through which CA mitigates cell apoptosis in the SVs of type 2 diabetic mice. A streptozotocin‐induced type 2 diabetic mice model was utilized, and a 1‐month intervention using CA (70 mg/kg) was administered. We monitored body weight, blood glucose levels, SV volume, and concentration of SV fluid. Hematoxylin and eosin staining was used to assess tissue damage. RNA sequencing was applied to identify differential gene expression, and the expression of target genes (ARG2, PBK, SerpinB1a, E2F2) was verified by qRT‐PCR. Changes in the apoptosis level of SV tissues in mice were detected with TUNEL staining. Compared to the control group, mice with T2DM exhibited decreased SV volume and SV fluid content, which was improved with CA treatment. Elevated expression of SerpinB1a and reduced apoptosis were observed in the T2DM‐CA group compared to T2DM mice. In summary, CA can inhibit cell apoptosis in the SVs, there by improving tissue damage in type 2 diabetic mice. SerpinB1a may be involved in this process. This study provides a new theoretical foundation for the treatment of seminal vesicle secretory dysfunction in type 2 diabetes mellitus.

Printable Table of Contents: Informing Science Journal, Volume 27, 2024

Table of Contents for Volume 27 of Informing Science: The International Journal of an Emerging Transdiscipline, 2024

Printable Table of Contents. IJDS, Volume 19, 2024

Table of Contents for Volume 19, 2024, of the International Journal of Doctoral Studies

IJIKM Volume 19, 2024 – Table of Contents

Table of Contents for Volume 19, 2024, of the Interdisciplinary Journal of Information, Knowledge, and Management

Effects of steel fibers on the flexural fatigue performance of recycled aggregate concrete

To explore the flexural fatigue performance of steel fibers reinforced recycled aggregate concrete (SF-RAC), the flexural fatigue test and residual strength test with different stress levels were conducted. Besides, the fatigue cracks propagation under cyclic loading were observed and analyzed by digital image correlation (DIC) technology. The results show that the flexural fatigue life of SF-RAC increases when the content of steel fibers increases, and it is proved to be well in accordance with the three-parameter Weibull distribution. The flexural fatigue life equation with different stress level and reliability (S-N-P equation) is obtained based on it, which shows that when the fiber volume content is 1.5%, the fatigue strength of SF-RAC is about 37.2% higher than that of RAC without fibers. Then, a fatigue strain-based damage evolution model is established, and the derived residual strength model can well predict the damage degree and residual life of SF-RAC. Moreover, the steel fibers can improve the critical crack propagation length and loading cycles of RAC. The crack propagation rate can be decreased by 97.63% when the fiber volume content is 1.5%, and it is increased with the development of stress level. Finally, the influence mechanism of steel fibers on flexural fatigue performance of RAC were explained through microstructure tests.

Evaluation of the Cavitation Fluid Characteristics of the Bullet across the Medium into the Water at Different Velocities

This paper studies the evolution and fluid distribution characteristics of a high-speed projectile’s cavity in the water based on joint research, a method involving experiment and numerical simulation. Specifically, we develop an experimental platform and a numerical calculation model for a high-speed projectile to observe its initial cavity evolution characteristics in the water at different velocities and close ranges. Additionally, this work investigates the evolution mechanism of the cavitation process and its fluid distribution law inside the cavity and studies the evolution characteristics of the cavitation stage under different velocities. The results reveal that after the projectile enters the water, the cavity is gourd-shaped and symmetrical, with a necking phenomenon at the tail and the cavity falling off. The cavitation process can be divided into the surface closure, saturation, deep closure, and collapse stages according to the fluid distribution changes in the cavity. Suppose the projectile has a certain speed with the water, its velocity increases. In that case, the cavity generation rate decreases, the growth rate of the water vapor volume in the cavity decreases, the peak water vapor volume content reduces, and the volume of air in the saturation phase of the cavity becomes increases having a range of 6% to 9%. Additionally, the cavity surface closure dimensionless time grows logarithmically as the velocity changes from 0 m/s to 500 m/s, the cavity saturation dimensionless time decreases approximately linearly, and the cavity depth closure dimensionless time is unaffected by velocity changes.

The influence of fiber content and voltage on the impact resistance of carbon fiber reinforced concrete

The method of machine test was used in this study to analyze the influence of carbon fiber content and voltage strength on the impact resistance of carbon fiber concrete by recording the number of impacts to carbon fiber concrete fracture failure. The results show that as the volume content of carbon fiber increases, the impact resistance to the specimens increases first and then decreases. The impact resistance reaches maximum that the content of 0.24 %, and the calculation formula for the number of impacts to concrete beams under different carbon fiber content in the test is obtained. However, the impact resistance is in a state of overall reduction under the action of voltage, and the reduction range is obvious, indicating that the voltage effect has a negative impact on the impact resistance of carbon fiber concrete.

A facile and scalable fabrication method of scrolled graphene/boron nitride-based van der Waals superlattice heterostructure materials for highly stable supercapacitor electrode application.

Due to the increasing demand for the development of efficient renewable energy supply systems to reduce the mismatch between energy demand and utilization, supercapacitors have attracted increasing attention in the energy industry. However, the development of energy storage electrode materials to be applied at the industrial level is still challenging due to the unsatisfactory durability and scalable production issues. This study suggested a facile and scalable one-pot fabrication method of using graphene/hexagonal boron nitride (G/BN)-based one-dimensional (1D) van der Waals superlattice heterostructures (vdWSLs) as highly stable electrode materials to enhance the energy storage performance by improving the mesopore volume content, specific surface area, electrical properties, and interfacial interaction between the stacked G/BN layers. The G/BN-based vdWSLs were fabricated by a simple scrolling process through the electromagnetic interaction between the attached magnetic iron oxide nanoparticles (Fe3O4 NPs) on the surface of a G/BN vdW heterostructure (vdWH) and the applied magnetic field. The investigation results demonstrate that the changed morphology of the fabricated G/Fe/BN(NS) strongly affects the fine pore distribution, electrochemical performance, and electrical properties. Consequently, as a synergistic effect of an increased mesopore volume content, specific surface area, and C-B-N heterojunction interfacial area, the fabricated G/Fe/BN(NS) electrode showed a 100% enhancement of specific capacitance (207 F g-1 at 0.5 A g-1) and almost 7 times enhancement of electrical conductivity (800 S cm-1) with a nearly 2.3 times increase of carrier mobility (716 cm2 V-1 s-1) compared to that of the G/Fe/BN electrode. Furthermore, it exhibited outstanding long-term cycling stability with almost 119% capacitance retention even after 100 000 charge-discharge cycles. These results suggest that G/Fe/BN(NS) has tremendous potential as an electrode to fabricate high-performance supercapacitors with excellent cycling stability.

Efekat ojačanja kompozita glinice matriksom inkluzijama ZrB₂ i FeSiAl na dielektrična svojstva na mikrotalasnim frekvencijama

In this paper, two composites ZrB₂/Al₂O₃ and FeSiAl/Al₂O₃ were characterized using the Transmission/Reflection characterization technique. The volume contents of ZrB₂ and FeSiAl inclusions in these composites vary between 0 and 15%. The results obtained indicate that the percentage of the inclusions in the composites effectively improves the dielectric property. The comparison of the effect of ZrB₂ and FeSiAl inclusions on the dielectric properties of these composites confirms that reinforcing these composites with FeSiAl particles results in better dielectric properties. Furthermore, these results indicate that the dielectric property of the two composites studied decreases progressively with increasing frequency in the X band. This frequency dependence of the dielectric property of the composites studied is very important and shows that the composites studied are good candidates for microwave absorption applications in the X-band and for antenna design. Additionally, a comparison between the numerical results obtained in this work and the experimental results published in the literature reveals a close agreement, validating the reliability of the study's findings.

Influence of hybrid basalt fibre with varied length on the mechanical properties of normal and high strength concrete

Hybrid fibre-reinforced concrete combines different types of fibres or fibres of varying lengths to maximize their individual advantages, which can potentially lead to a synergistic enhancement in overall performance. The main aim of this study is to explore the feasibility of integrating a hybrid fibre system to enhance the efficiency and properties of basalt fibre-reinforced concrete. Specifically, the research focuses on evaluating the mechanical characteristics of basalt hybrid fibre-reinforced concrete across two concrete grades: normal strength M30 and high strength M60. Basalt fibres of 12 mm and 30 mm lengths are used to hybridize the concrete, with a total fibre volume fraction of 1.5%. By incorporating both short and long basalt fibres into the concrete matrix, this study aims to assess how these variations impact essential properties such as workability, compressive strength, flexural strength, and Modulus of Elasticity (MOE). The hybrid mix, comprising 25% of 12 mm fibres and 75% of 30 mm fibres at a volume content of 1.5%, demonstrates enhanced mechanical properties across all concrete grades. The addition of basalt fibres, particularly those with higher proportions of longer fibres, results in a decrease in workability. Notably, hybridizing fibres have no discernible effect on compressive strength or MOE in both concrete grades. From the results it was observed that the flexural strength of the optimal hybrid mixes is significantly higher, surpassing conventional concrete by 39% and 54.35% for M30 and M60 grades of concrete, respectively.

Contents of Volume 69.

Contents of Volume 69.