Concentration Ratio Research Articles

Mechanistic insights on stabilization and destabilization effect of ionic liquids on type I collagen fibrils

Tuned assembly of collagen has tremendous applications in the field of biomedical and tissue engineering owing to its targeted biological functionalities. In this study, ionic liquids choline dihydrogen citrate (CDHC) and diethyl methyl ammonium methane sulfonate (AMS) have been used to regulate the self-assembly of collagen at its physiological pH by probing the assembled systems at certain concentration ratios of ionic liquids and the systems were studied using various characterization methods. Due to interaction with collagen, choline dihydrogen citrate causes delay in the collagen fibrillisation process showing no binding interactions with collagen. In contrast, diethyl methyl ammonium methane sulfonate shows crosslinking effect on collagen fibrillisation due to the electrostatic interaction with the tetrahedral hydration shell of collagen moieties. From rheological studies it was observed that the AMS treated collagen fibril at 1:1 % (w/v) has highest linear viscoelastic range, this can bear the stress under high strain compare to native collagen fibril as well as all CDHC composites. For a sustainable biomaterial or bio-scaffold, mechanical property plays pivotal role on it and from our experimental analysis we found certain composites of ionic liquid treated collagen fibrillar assembly which may act as a sustainable biomaterial or bio-scaffold. It was also evolved that, how the structure-function relationship of ionic force modulated fibrillar assembly controlling the mechanical properties of the tuned system. This self-assembled, ionic-liquid treated collagen-fibrillar system would accelerate various force modulated fibrillar network study, for mimicking the ECM and tissue engineering application.

Spectroscopic analysis of single and multiphase electrical discharge for clean energy conversion

Abstract In this study, we examined non-thermal atmospheric pressure plasma processes operating under varying conditions using different liquid and gaseous hydrocarbon materials. The light emission from the discharges were analyzed through optical emission spectroscopy to comprehend the products generated in different parameter space. The gaseous products from each of these analyses were also collected and analyzed through gas chromatography. Analysis of the optical emission from the discharge and concentration of the gaseous products show a linear trend between emission intensity ratio Hα/C2 and gas concentration ratio H2/C2Hx. Gas temperature and electronic excitation temperature of different experimental conditions were also compared and indicates that spark discharge relates to higher electronic excitation temperature compared to glow discharge of similar medium. Higher electronic excitation temperature leads to generation of different products from spark discharge compared to glow discharge. Glow discharge generates more of the intermediate products. Whereas spark discharge, because of its higher electronic excitation temperature, leads to higher rate of dissociation and therefore generates more of the dissociated products. Glow discharge, for example generates more of OH and H from the moisture present in the carrier gas as impurity, whereas spark discharge would generate more of Hα and O particles further breaking down the OH bonds. Finally, UV-Vis analysis was performed on the liquid products of the discharge and reveals that the photo-centers and the newly generated soot nano particles absorb the UV range lights and some of the visible range light emission mostly up to ~600nm.

Enhancing building energy efficiency: Numerical analysis of a hybrid thermoelectric ventilation system and earth-air heat exchange with photovoltaic-thermoelectric power integration for heating and cooling loads

The lack of studies on hybrid systems combining thermoelectric ventilation (TEV) and earth-air heat exchangers with a photovoltaic-thermoelectric generator (PV-TEG) as the power supply for the hybrid system is addressed in this research. This study aims to investigate the effectiveness and performance of such a combined system in providing the required thermal load of a building. To simulate the performance of TEV and PV-TEG systems, energy conservation equations for various components of the system were formulated for the quasi-state mode. The performance of the earth-air heat exchanger system was evaluated using the effectiveness-number of transfer units method. The resulting set of algebraic equations was then solved using a MATLAB code. Results indicated significant preheating (5.41–15.03 °C) and precooling (0.7–10.22 °C) effects during the daily hours of 15-February and 15-July, respectively. Additionally, the TEG component effectively reduced PV temperatures by 3.54 °C–16.99 °C in 15-February and 3.99 °C–21.54 °C in 15-July. The system also demonstrated a high monthly useful thermal energy output (1215–1584 kWh) in the cold months (December to March), contrasting with higher monthly useful thermal exergy (712–763 kWh) in the summer months. Furthermore, increasing the number of TEGs from 10 to 50 resulted in significant improvements in the yearly average energy and exergy proficiency indexes (PIya,en and PIya,ex) by 164.97 % and 459.82 %, respectively. The supply air mass flow rate and the length and depth of the earth-air duct were identified as the second and third most influential parameters affecting these indexes. Moreover, the system at CPV concentration ratio of 3 provided the highest PIya,en and PIya,ex of 1.512 and 14.65, respectively.

Virtual Instruments for Peak-Overlapping Studies to Determine Low- and High-Concentration Components with Ion Chromatography: Potassium and Sodium.

We developed the LabVIEW-based virtual instruments (VIs) to bridge a gap in commercial software and to enable systematic peak-overlapping studies to recognise the concentration levels enabling reliable simultaneous determination of major and minor constituents in samples with wide concentration proportions. The VIs were applied to a case study of the ion chromatographic determination of potassium as minor and sodium as a major ion with an IonPac CS12A column and 50 μL injection loop. Two successive studies based on multilevel two-factorial response surface experimental designs, (1) a model peak-overlapping study based on single-ion injections, and (2) an accuracy and precision study, provided guidelines for real sample analyses. By adjusting sample dilutions so that the sodium mass concentration was set to 340 mg/L, the simultaneous determination of potassium in the presence of sodium was possible in samples with sodium over potassium concentration ratios between 14 and 341. The relative expanded uncertainty associated with potassium ion determination was between 0.52 and 4.4%, and the relative bias was between -3.8 and 1.9%. We analysed Ringer's physiologic solutions, standard sea, trisodium citrate anticoagulant, and buffered citrate anticoagulant solutions. We confirmed that the VI-supported peak-overlapping studies contributed to the quality of results by enabling the evidence-based choices of concentration levels adjusted by a dilution.

Building Integrated Heliostats

Heliostats offer a means of improving solar access in densely populated cities. Ocular and skin health considerations recommend control of UV radiation from heliostats in the urban environment. Lessons from integration of polycarbonate filter systems for UV control with building integrated heliostats are discussed, including the impact of solar concentration ratios, thermal stresses, material properties and fatigue. Options for further increasing solar concentration ratios in building integrated heliostat systems are proposed.

Research of the dynamics of wholesale segment concentration level in the regional pharmaceutical market

Introduction: The study of the competitive environment in the pharmaceutical market is an element of the analysis of the drug supply system. The purpose of the study is to analyze the dynamics of concentration levels in the wholesale segment of the regional pharmaceutical market. Materials and methods: Data on market shares of key players were collected and summarized based on the executed contracts (461 contracts in total) for the supply of pharmaceutical products in the model region. For the competitive analysis of pharmaceutical distributors, the Herfindahl-Hirschman Index (HHIn) calculation method was used. We also used the method of constructing the SV matrix, which has the form of a graph consisting of four quadrants divided on the abscissa scale by the obtained values of market concentration ratios (CRSV) and on the ordinate scale by the values of Hall-Teidman indices (HTSV). Results: Market concentration indicators in the wholesale segment of the regional pharmaceutical market indicate the formation of oligopoly. The constructed SV matrix demonstrated the dynamics of market concentration levels corresponding to the changing economic situation. Based on the results of the analysis, proposals to improve the competitiveness of regional pharmaceutical distributors were formed. Conclusion: The study of the dynamics of market concentration indicators allowed to analyze their state, establish the vectors of their drift, and propose measures to optimize the wholesale supply of pharmaceutical goods.

Photo‐cationic polymerizable ceramic slurry for the fabrication of ceramic structures in three‐dimensional printing

AbstractCycloaliphatic epoxides exhibit post‐light irradiation heat‐induced polymerization, creating warp‐resistant green bodies during sintering. However, their use in light polymerization three‐dimensional (3D) printing is limited by slow photo‐curing speeds. In this study, a photo‐cationic polymerizable ceramic slurry was developed for 3D printing by mixing oxetane with cyclo‐aliphatic epoxide. This mixture improved photo‐curing speed, reduced resin viscosity, and enhanced the ceramic slurry's solid content. Additionally, we optimized the slurry by considering the specific and content ratio of photosensitizers and light absorbers. The optimized slurry polymerized unreacted functional groups in the polymer, improving the fracture strength of the green bodies through enhanced crosslinking density and uniformity in each layer. Ultimately, a sintered body without warpage was produced by the improved green bodies. This approach provides a solution related to controlling the photocuring speed and expands the potential applications of 3D printing in areas where the precision and stability of the printing material are required.

Association of plasma arachidonic acid levels with a bipolar disorder and the effects of a FADS gene variant

Recent genome-wide association studies (GWASs) have identified fatty acid desaturase (FADS) genes, which code key enzymes involved in polyunsaturated fatty acid (PUFA) desaturation as susceptibility genes for bipolar disorder (BD). Several quantitative changes in PUFAs suggest their involvement in BD pathogenesis. Therefore, this study aimed to clarify the relationship between BD and PUFAs by conducting lipidomics covariating with the FADS gene variant (rs174550), which is associated with PUFA levels and BD susceptibility. The concentrations of 23 fatty acids were measured using plasma samples from the BD group (n = 535) and the control group (n = 107). Differences in each PUFA concentration ratio were compared between the two groups. Also, differences in each PUFA concentration ratio were compared for each genotype in rs174550. Our results showed that the BD group had significantly lower concentrations of linoleic acid (LA) (β = −0.36, p = 0.023) and arachidonic acid (AA) (β = −0.18, p = 0.013) than the control group. Concerning the effect of FADS on the PUFA concentration ratio, carriers of C-allele at rs174550 had significantly decreased γ-linolenic acid and AA concentration ratios. A previous GWAS reported that the presence of a C-allele at rs174550 increased the BD risk. This direction is consistent with the lipidomic results of the present study. In conclusion, both the FADS and BD were considered to regulate the AA concentration. Thus, as the FADS gene variant is crucial for conducting lipidomics of BD we believe that the allele frequency of FADS must be analyzed.

Simulation of lunar soil compressive strength performance test based on grey correlation analysis

Detecting water ice in the permanent shadow area of the lunar south pole is an important task of China's Chang'e-7. For this purpose, a simulation study was carried out under the earth environment, and a test sample of polar water-containing simulated lunar soil was prepared. The mechanical properties of the lunar soil simulant were tested under ultra-low temperature conditions, and the changes in water content, relative density, temperature, loading rate, and base material ratio with compressive strength were analyzed. The results show that the compressive strength of the frozen lunar soil simulant increases with the increase of water content, increases with the increase of density, and increases with the decrease of temperature. It is less affected by the change of loading rate. The order of compressive strength affected by different base material ratios is: 100%anorthosite, <90%anorthosite, +10%basalt <70%, +30%anorthosite <100%, basalt, lunar soil simulant. Finally, the correlation between the basic physical properties of lunar soil simulant such as water content, relative density, temperature, loading rate, and ratio and compressive strength is explored through grey correlation analysis. The correlation order is: water content> density> temperature> ratio> loading rate. This paper prepared and tested the mechanical properties of hydrated lunar soil, and proposed a more systematic and standardized implementation plan. It serves as the basis for studying the properties of hydrated lunar soil in the polar region, and provides a theoretical basis and reference for subsequent lunar soil simulation research.

Screening and quantification of pesticides in wetland water, ice, sediment and soil: Occurrence, transport and risk assessment

Current researches on pesticides in wetlands are limited in terms of screening and quantification of many types of pesticides. Understanding the spatial and temporal dynamics, distribution patterns, and environmental risks of pesticides in multiple media is important for wetland ecological conservation. In this study, 222 pesticides were determined in multimedia samples collected simultaneously from the Songhua Wetland during four seasons. Concentrations of target pesticides in water, ice, sediment and soil ranged from 94.1 to 7445 ng/L, 62.6–953 ng/L, 0.82–50.2 ng/g dw, and 4.32–146 ng/g dw. Large spatial differences (p < 0.05) in pesticide concentrations in ice were found. However, there were no significant differences in the spatial and temporal distribution of pesticides in water, sediment, and soil (p > 0.05), suggesting that there were no correlation between the spatial and temporal use of pesticides. The dynamic exchange of pesticides between water-ice indicated that most pesticides were more enriched in water. However, there were still some pesticides (Dichlorvos and Biphenyl) that showed a stronger tendency to transfer from water to ice. Sediment-water exchange suggested that sediment is a source of secondary releases of most pesticides in wetland ecology, but is a sink for Biphenyl and Oxadiazon. The correlation between concentration ratios and fugacity fraction supported this finding. Most individual pesticides in wetland water and ice had shown low or moderate ecological risk conducted using risk quotient. The cumulative toxic effects of multiple pesticides had a high potential to pose a threat to wetland aquatic organisms.

Stability analysis of CO2 microbubble for CO2 sequestration and mobility control in enhanced oil recovery

This study addresses the challenge of CO2 microbubble stability in enhanced oil recovery (EOR), with a focus on the combined effects of surfactant concentration, brine concentration, brine-oil ratio, and gas flow rate. Microbubble destabilization, driven by phase separation and improper brine-oil ratios, is a critical issue in EOR. The novelty of this research lies in the use of Acacia concinna, a natural, non-ionic surfactant, to enhance microbubble stability sustainably. The study systematically investigates foamability, drainage kinetics, surface tension, rheology, and bubble size distribution to assess microbubble stability. The results showed that increasing surfactant concentration and brine-oil ratio significantly impacted foam stability and bubble size distribution, with optimal stability conditions observed at 2 wt% surfactant concentration (53.6 min), 5000 ppm brine concentration (47.6 min), a brine-oil ratio of 1:2 (52.4 min), and a CO2 gas flow rate of 1 lpm. Key findings also indicate that increasing NaCl concentration from 5000 to 20,000 ppm caused an increase in microbubble diameter, while higher gas flow rates reduced bubble size. The work introduces new empirical correlations for predicting bubble size distribution based on column diameter, surfactant and brine concentrations, viscosity, density, and gas superficial velocity. These correlations provide a more accurate means of optimizing EOR processes, improving oil recovery efficiency while enhancing CO2 sequestration, contributing to both energy production and environmental sustainability.

Numerical modeling of graded sediment transport with limited bed material supply – A case study in the Middle Yangtze River

Suspended sediment concentration in the Middle Yangtze River (MYR) has reduced sharply below the Three Gorges Dam since 2003, and led to significant channel degradation and riverbed coarsening. However, the complex interaction between riverbed coarsening and sediment transport is essential for channel evolution processes but is poorly understood. This paper presents a one-dimensional model for simulating graded sediment transport when the bed material supply is limited. The model takes account of the effect of bed material composition (BMC) and threshold probability on graded sediment transport, and thus improve the accuracy of recovery coefficient. The modeling results of graded sediment concentrations was calibrated and then satisfactorily verified using field observations in the JingJiang Reach from 2015 to 2016. The results showed bed material composition affect the simulated fine, medium, and coarse sediment concentrations, and the improvements of normalized errors are 17.6%, 45.9%, and 330.7%, respectively. With the BMC effect considered, the recovery factor of fine and medium were far less than coarse sediment in the MYR. In addition, the recovery ratios of medium and coarse sediment concentrations along the MYR were improved by 88.6%-265.4% and 75.1%-105.9% respectively, owing to the bed material supply after the TGD operation; however, there was no significant effect on fine sediment, with a low recovery ratio of 8.3%-8.6%. Therefore, the effect of bed material composition on graded sediment transport and channel evolution needs to be considered for higher simulation accuracy in the MYR.

Effect of Paenibacillus favisporus CHP14 inoculation on selenium accumulation and tolerance of Pakchoi (Brassica chinensis L.) under exogenous selenite treatments

The effects of Paenibacillus favisporus CHP14 inoculation on selenium (Se) accumulation and Se tolerance of Pakchoi were studied by a pot experiment conducted in greenhouse. The results revealed that the growth traits such as plant height, root length, and biomass were significantly elevated during CHP14 treatment at 0 ∼ 8.0 mg·kg−1 Se(IV) levels. CHP14-inoculated plants accumulated more Se in root and shoot, which were 24.1%∼57.3% and 7.5%∼50.9% higher than those of non-inoculated plants. The contents of leaf nitrogen (N), phosphorus (P), magnesium (Mg), and iron (Fe), as well as the ratio of indoleacetic acid and abscisic acid contents (IAA/ABA) were increased by CHP14 inoculation, and positively associated with photosynthetic pigment contents (p < 0.05). At ≥ 4.0 mg·kg−1 Se(IV) levels, superoxide dismutase, peroxidase, and glutathione peroxidase activities of Pakchoi roots were increased with CHP14 inoculation, by 9.9%∼17.1%, 28.4%∼40.7%, and 7.4%∼15.3%, respectively. Moreover, CHP14 inoculation enhanced ascorbate-glutathione (AsA-GSH) metabolism in roots by upregulating the related enzymes activities and antioxidant contents under excess Se(IV) stress. These findings suggest that CHP14 is beneficial to improve plant growth and enhance Se(IV) resistance of Pakchoi, and can be exploited as potential inoculants for phytoremediation process in Se contaminated soil.

NO Emission Characteristics of Pulverized Coal Combustion in O2/N2 and O2/H2O Atmospheres in a Drop-Tube Furnace.

Oxy-steam combustion is a new oxy-fuel combustion technology. This paper focuses on the NO emission characteristics during the combustion of SF (Shen Fu) coal in O2/N2 and O2/H2O mixtures. Experiments were performed in a drop-tube furnace. Combustion tests were carried out in O2/N2 and O2/H2O atmospheres for various O2 concentrations (21%, 30%, 40%, and 60%) at different temperatures (1173 K, 1273 K, and 1373 K). In addition, combustion experiments at different excess oxygen ratios (λ) were conducted in O2/N2 and O2/H2O atmospheres. The influences of the atmosphere, oxygen concentration, temperature, and excess oxygen ratio on NO emissions were analyzed. The results show that the NO concentrations of SF coal combustion in the 21% O2/79% H2O atmosphere were much lower than those in the 21% O2/79% N2 atmosphere at the three temperatures considered. This was because a large amount of NO was decomposed during the SF coal combustion in the O2/H2O atmospheres. The reasons for the decomposition of NO include the selective non-catalytic reaction (SNCR) mechanism and char's important role as a catalyst for the destruction of NO, either directly or by reacting with CO or H2. In oxy-steam combustion, the NO concentrations significantly increased with the increase in the oxygen concentration from 21 vol.% to 60 vol.% and the temperature from 1173 K to 1373 K. The excess oxygen ratio (λ) slightly impacted the NO emissions in the O2/H2O atmosphere.

Innovation and application of inter-provincial carbon emission transfer accounting model in China’s domestic production network

The New Development Paradigm will result in the significant development of domestic production networks and the accelerated growth of carbon transfers among provinces in China. However, the existing value chain or the trade of intermediate goods decomposition method cannot completely account for the carbon content of intermediate goods. So the paper developed a accounting model for inter-regional intermediate goods trade based on input-output model. The most significant advantage of this accounting model is that by further decomposing final output into three components—final consumption within the region, final consumption flowing to other regions, and final output flowing to other regions as intermediate goods that are not returned to the region—it achieves a more comprehensive decomposition of the value chain in comparison to the established models. This approach allows for the tracking of longer value chains and the accounting for intermediate goods inflows and outflows simultaneously. Furthermore, the accounting of trade in intermediate goods can be conducted for any number of countries, regions, and sectors within the input-output system, thereby providing a foundation for the comprehensive accounting of inter-regional carbon transfers within production networks. With the input-output tables and carbon emission inventories from the CEADs (the China Carbon Emissions Accounting Database), the paper has calculated the changes of the carbon transfer among provinces in the China’s domestic production network from 2012 to 2017 and find that the inter-provincial intermediate goods trade and carbon transfer among provinces is increasing significantly. Each province has a strong incentive to overuse the carbon embodied in the intermediate goods from others, but lacks the motivation to reduce their own carbon emission. In the inter-provincial transfer of the carbon content of intermediate goods in China’s domestic production network, the difference between the average value of the ratio of the carbon content of intermediate goods from other provinces used by each province and that supplied for use by other provinces to the ratio of the carbon content of intermediate goods produced by itself increased by 13.6% between 2012 and 2017. Only a few provinces are evolving towards a win-win between economic and environmental benefits, while most are still facing the evolutionary dilemma in choosing between economic and environmental benefits. In the future, we should comprehensively explore the cooperative governance of carbon emission reduction in the domestic production network, including establishing a national standard for calculating the carbon transfer in domestic production network, improving the carbon emission responsibility sharing mechanism and carbon emission reduction compensation systems.

Therapeutic Drug Monitoring of Imatinib: Is There a Rationale for Also Quantifying Its Active Metabolite?

Therapeutic drug monitoring of imatinib is widely performed to individualize imatinib dosage. While N-desmethyl imatinib is an active metabolite of imatinib, its concentrations are not routinely determined. Imatinib and N-desmethyl imatinib trough plasma concentrations at steady-state were obtained from 295 patients with either chronic myeloid leukemia or gastrointestinal stromal tumor to see whether N-desmethyl imatinib provided additional information. Pharmacokinetic data were analyzed using a nonlinear mixed effect approach. Correlations between several pharmacokinetic metrics of drug exposure were evaluated. The mean value of the N-desmethyl imatinib/imatinib ratio of trough concentrations was 0.31 with half of the values between 0.23 and 0.37. N-desmethyl imatinib and total (i.e., N-desmethyl imatinib plus imatinib) trough plasma concentrations or area under the curve values were closely correlated with imatinib values. The distribution of imatinib or total concentrations between patients requiring imatinib dosage adjustment, or not, was similar. These results do not clearly support routine N-desmethyl monitoring since it does not provide additional information to imatinib data.

Preparation and properties of bio-based PA56/SiO2–NH2 composite nanofiber membranes for high efficiency oil-water separation

With the continuous development of environmental protection and resource recycling demands, the development of bio-based separation membrane materials has increasingly attracted attention. Bio-based polyamide 56 (PA56), exhibiting excellent hydrophilicity, spinnability, and mechanical properties, is expected to complement and replace traditional separation membrane materials. In this study, the electrospinning preparation and structural control of PA56 nanofiber membranes were achieved through the optimization of PA56 content and mixed solvent ratios. The study found that when the PA56 content was 16 wt% and the formic acid to acetone ratio in the mixed solvent was 8:2, the nanofiber diameter distribution was the most uniform. Building on this, amino-functionalized modified silica (SiO2–NH2) nanoparticles were introduced to prepare PA56/SiO2–NH2 composite nanofiber membranes featuring a cobweb-like nanofiber network and micro-nodule structure. The effects of the addition of SiO2–NH2 nanoparticles on the morphology, structure, and properties of the fiber membranes were studied. The results indicate that the control of the mixed solvent ratio and the addition of SiO2–NH2 nanoparticles led to the formation of a cobweb-like nanofiber network and micro-nano nodular structure on the nanofiber surface, enhancing the hydrophilicity of PA56 nanofiber membranes. The M − 3 membrane with a nanoparticle addition amount of 0.8 wt% exhibited high hydrophilicity and underwater superoleophobic properties, achieving efficient separation of stable oil-in-water emulsions with a separation efficiency of 99.8 %. This work provides a new bio-based membrane material and its preparation method for treating oily wastewater using the membrane separation method.

Fabrication and Properties of Hydrogel Dressings Based on Genipin Crosslinked Chondroitin Sulfate and Chitosan.

Multifunctional hydrogel dressings remain highly sought after for the promotion of skin wound regeneration. In the present study, multifunctional CHS-DA/HACC (CH) hydrogels with an interpenetrated network were constructed using hydroxypropyl trimethyl ammonium chloride modified chitosan (HACC) and dopamine-modified chondroitin sulfate (CHS-DA), using genipin as crosslinker. The synthesis of HACC and CHS-DA was effectively confirmed using Fourier transform infrared (FT-IR) analysis and 1H nuclear magnetic resonance (1H NMR) spectroscopy. The prepared CH hydrogels exhibited a network of interconnected pores within the microstructure. Furthermore, rheological testing demonstrated that CH hydrogels exhibited strong mechanical properties, stability, and injectability. Further characterization investigations showed that the CH hydrogels showed favorable self-healing and self-adhesion properties. It was also shown that increasing HACC concentration ratio was positively correlated with the antibacterial activity of CH hydrogels, as evidenced by their resistance to Escherichia coli and Staphylococcus aureus. Additionally, Cell Counting Kit-8 (CCK-8) tests, fluorescent images, and a cell scratch assay demonstrated that CH hydrogels had good biocompatibility and cell migration ability. The multifunctional interpenetrated network hydrogels were shown to have good antibacterial properties, antioxidant properties, stable storage modulus and loss modulus, injectable properties, self-healing properties, and biocompatibility, highlighting their potential as wound dressings in wound healing applications.

Clinical research for saliva-based therapeutic drug monitoring of linezolid.

Linezolid is primarily used to treat of methicillin-resistant Staphylococcus aureus and multidrug-resistant tuberculosis infections. Thrombocytopenia due to linezolid usage is a concern, and therapeutic drug monitoring has been reported to be effective in its prevention. Plasma concentrations provide valuable information for treatment decisions; however, collecting plasma samples can be burdensome for both patients and healthcare providers. Therefore, there is interest in saliva as an alternative for monitoring, considering its potential to replace plasma samples. Patients hospitalized at Hokkaido University Hospital and Hokkaido Spinal Cord Injury Center between April 2022 and July 2024, who received oral or intravenous linezolid treatment, were enrolled. The concentrations of linezolid were simultaneously measured in plasma and saliva samples. We determined the concentration profiles of linezolid in the saliva and examined the correlation between saliva and plasma linezolid concentrations. Eighteen patients receiving linezolid were enrolled. The average of saliva/plasma (S/P) concentration ratios of linezolid were 1.018. A strong correlation was found between the salivary and plasma concentrations of linezolid (R= .833, P< .001). Notably, in patients receiving intravenous administration of linezolid, the correlation was even more pronounced (R= .885, P< .001). Additionally, when focusing on the S/P ratio of the trough concentrations in the morning and at night, the S/P ratios at night were much closer to 1.0. The concentrations of linezolid in plasma and saliva were similar, indicating their potential applicability in clinical settings. The monitoring of linezolid concentrations in saliva has been shown to be particularly suitable for patients receiving intravenous administration.

Numerical study on drag reduction and heat collection efficiency of oil based on solar concentrating system

Traditional onshore crude oil storage and transportation consumes a lot of energy. In this paper, a concentrating type of high-temperature crude oil transportation pipeline heating system is proposed, which uses concentrators to collect and focus sunlight on the pipeline. The high-temperature oil flows through the heat exchanger at the end of the pipeline, where it exchanges heat with water to store and recover heat for utilization in the heat collector. The temperature rise is significant and the uniformity improves as oil extends through the pipeline under various multiples of solar radiation achieved with concentrators. The inlet rate of oil is a negative factor affecting the outlet temperature. Compared to non-concentrated light, the friction coefficient and viscosity of oil are reduced, resulting in a more effective drag reduction effect. To validate the accuracy of simulation results and compare them with theoretical calculations, ensuring that the margin of error is within 8.5%. The type of concentrators, laying distance of the concentrators below the pipeline, concentration ratio (CR), and the inlet rate can be adjusted based on climatic conditions and required oil temperature. This paper is of great significance for reducing energy consumption in long-distance oil transportation and realizing the energy transition.