This systematic literature review examines the intricate interplay between generational differences, the Fourth Industrial Revolution (4IR), and the unanticipated effects of the COVID-19 pandemic on the contemporary world of work. In response to the pandemic, organizations worldwide rapidly reevaluated their work processes, embracing digital technologies and remote work. This unforeseen shift underscored the world's capacity for rapid adaptation to unforeseen challenges. However, the 4IR extends beyond technological advancements, involving non-technological aspects such as evolving business models, workforce well-being, job security, and the changing nature of work. Understanding these dimensions is vital in shaping the modern workforce. Generational differences add another layer of complexity. Each generation, from Baby Boomers to Millennials, brings distinct worldviews and work values. This review explores how different generations perceive and adapt to the evolving nature of work, especially in the context of the 4IR. In addition, the 4IR highlights the critical role of knowledge in driving innovation and competitiveness. Knowledge-sharing practices within organizations have become pivotal in staying ahead in this era of rapid technological change. By addressing both technological and non-technological dimensions of the 4IR and considering generational perspectives, this review offers a comprehensive understanding of how these forces intersect and influence the modern workplace. It provides insights and recommendations to guide organizations, policymakers, and individuals in navigating the complexities of the modern world of work, harnessing 4IR opportunities, and addressing its multifaceted challenges.