Contemporary Medicine Research Articles

Awareness and current knowledge of medicinal plants

Abstract Objectives This research attempts to investigate the historical applications of plants for therapeutic reasons, follow the development of these applications, and comprehend the influence of artificial methods on the use of medicinal plants. Methods The study involves the examination of antique writings from Mesopotamia, Egypt, Greece, and the Islamic world, as well as a 5000-year-old Sumerian clay tablet discovered in Nagpur. The study examined historical reports of a number of therapeutic plants, including Glycyrrhiza glabra, Cupressus sempervirens, Commiphora myrrha, Cedrus duham, and Papaver somniferum. It also looked at how improved methods of separating active plant components were developed in the early 19th century, as opposed to more crude treatments like tinctures and powders. Key findings Historical evidence reveals that ancient cultures used a wide variety of plants for medicinal reasons, preparing them in different ways. The development of synthetic methods in the 19th century completely changed the manufacture of pharmaceuticals by making it possible to replicate active ingredients precisely and in large quantities. With more than 250 000 plant species recognized, nature’s wide diversity of plant metabolites highlights the importance of plants in both traditional and contemporary medicine. Conclusions The development of contemporary synthetic approaches from traditional plant-based medicines serves as an example of how far medicine has come. While modern techniques have increased the effectiveness and scalability of medicinal manufacturing, the historical usage of plants demonstrates a profound grasp of their curative potential. The vast diversity of plant metabolites continues to be important for health and medicine despite advancements in synthetic approaches, highlighting the ongoing importance of natural resources in pharmaceutical research.

Lithium’s renaissance: From psychiatric staple to multifaceted medical marvel

Abstract: Lithium, long established as a cornerstone in the treatment of bipolar disorder, has recently emerged as a potential therapeutic agent across a broad spectrum of medical fields. This narrative review examines the expanding role of lithium in contemporary medicine, highlighting its transition from a psychiatric staple to a versatile therapeutic tool. The objective of the study was to synthesize and critically evaluate recent literature on lithium’s applications beyond psychiatry, focusing on its mechanisms of action, therapeutic potential, and challenges in various medical domains. A comprehensive literature search was conducted using PubMed, Scopus, and Web of Science databases, focusing on peer-reviewed articles published within the last 5 years. Keywords included “lithium” combined with terms such as “neuroprotection,” “cancer,” “stem cells,” “viral infections,” and “aging.” Case studies, clinical trials, systematic reviews, and meta-analyses were included to provide a broad perspective on lithium’s emerging roles. Recent studies have revealed lithium’s potential in several key areas: neuroprotection in neurodegenerative disorders, cancer therapy enhancement, stem cell mobilization for regenerative medicine, antiviral properties, cardioprotection against ischemia-reperfusion injury, circadian rhythm regulation, and potential effects on longevity and healthy aging. Lithium’s renaissance in medical research reveals its potential as a multifaceted therapeutic agent. While challenges remain, including its narrow therapeutic index and side effect profile, ongoing research into novel delivery methods and personalized medicine approaches may optimize its use. The expanding applications of lithium underscore the need for continued investigation to fully harness its therapeutic potential across various medical disciplines.

Phytochemical Analysis, Cytotoxic, Antioxidant, and Anti-coccidian Activities of Vitis vinifera Leaves Grown in Saudi Arabia

Background: Natural products are essential for medicinal purposes in developing countries. Traditional and contemporary medicine utilized plant products as alternative treatments for parasitic diseases. Objectives: The purpose of the investigation is to analyze and assess the bioactive compounds in Vitis vinifera leaf extracts, as well as their effect on coccidiosis. Materials and methods: Several analytical techniques were utilized, such as infrared spectroscopy (IR) and gas chromatography-mass spectrometry (GC-MS). Additionally, we assessed the total phenol, tannin, flavonoid examination, and cytotoxicity of the plant extracts using an MTT assay and UV-visible spectrophotometry (UV-Vis). Moreover, the samples’ levels of antioxidant activity (measured with DPPH and ABTS) were analyzed. Results: The leaf extract's GC-MS study identified many bioactive elements linked to plant secondary metabolites. Further, the total phenol, tannin, and flavonoid were 160.217 ± 0.652, 65.872 ± 0.263, and 34.0463 ± 0.545 (mg TAE/g DW), respectively. It also contains these extracts with a high antioxidant and DPPH radical scavenging activity. This reflects the number of bioactive chemicals that are present in these extracts. Conclusions: The findings of this research discuss techniques in phytochemical analysis of Vitis vinifera leaf extracts and the identification of biologically active components that support and justify the utilization of grape leaves in folk medicine in developing countries.

Research Advances in Electrospun Nanofiber Membranes for Non-Invasive Medical Applications

Non-invasive medical nanofiber technology, characterized by its high specific surface area, biocompatibility, and porosity, holds significant potential in various medical domains, including tissue repair and biosensing. It is increasingly becoming central to healthcare by offering safer and more efficient treatment options for contemporary medicine. Numerous studies have explored non-invasive medical nanofibers in recent years, yet a comprehensive overview of the field remains lacking. In this paper, we provide a comprehensive summary of the applications of electrospun nanofibers in non-invasive medical fields, considering multiple aspects and perspectives. Initially, we introduce electrospinning nanofibers. Subsequently, we detail their applications in non-invasive health, including health monitoring, personal protection, thermal regulation, and wound care, highlighting their critical role in improving human health. Lastly, this paper discusses the current challenges associated with electrospun nanofibers and offers insights into potential future development trajectories.

The Role of Incubation in Ancient Greek Asklepieions

The sanctuaries of Asklepios served a healing function in the Greek world throughout antiquity. In modern historiography, it is believed that the sick were treated there by incubation, i.e., sleeping in the temple to obtain a divinatory dream. However, the sources are not clear on this matter. In this article, I analyse four sources that, in my opinion, are the most representative of the issue of treatment methods in the Asklepieions. From the classical period, inscriptions describing healings from Epidauros and the comedy "Wealth" by Aristophanes are extremely important, while from Roman times they include "The Sacred Tales" by Aelius Aristides and the Apellas’ inscription from Epidauros. It is significant that none of these sources describes the incubation ritual, and the treatment methods presented in them are rational from the viewpoint of contemporary medicine. Incubation was practiced in the Asklepieions, but its role, in my opinion, was much smaller than commonly believed.

Multi-level exploration of auricular acupuncture: from traditional Chinese medicine theory to modern medical application.

As medical research advances and technology rapidly develops, auricular acupuncture has emerged as a point of growing interest. This paper delves into the intricate anatomy of auricular points, their significance and therapeutic principles in traditional Chinese medicine (TCM), and the underlying mechanisms of auricular acupuncture in contemporary medicine. The aim is to delve deeply into this ancient and mysterious medical tradition, unveiling its multi-layered mysteries in the field of neurostimulation. The anatomical structure of auricular points is complex and delicate, and their unique neurovascular network grants them a special status in neurostimulation therapy. Through exploration of these anatomical features, we not only comprehend the position of auricular points in TCM theory but also provide a profound foundation for their modern medical applications. Through systematic review, we synthesize insights from traditional Chinese medical theory for modern medical research. Building upon anatomical and classical theoretical foundations, we focus on the mechanisms of auricular acupuncture as a unique neurostimulation therapy. This field encompasses neuroregulation, pain management, psychological wellbeing, metabolic disorders, and immune modulation. The latest clinical research not only confirms the efficacy of auricular stimulation in alleviating pain symptoms and modulating metabolic diseases at the endocrine level but also underscores its potential role in regulating patients' psychological wellbeing. This article aims to promote a comprehensive understanding of auricular acupuncture by demonstrating its diverse applications and providing substantial evidence to support its broader adoption in clinical practice.

Enhancing Health Wellbeing of Chronic Patient Through Digital Health; A Systematic Review of Best Nursing Practices and Lessons Learned

Background: Context: Digital health interventions have become essential instruments in contemporary medicine, providing viable means of improving patient outcomes and healthcare provision. The goal of this study is to examine the impact, difficulties, and potential future directions of digital health interventions across a range of healthcare situations by synthesizing results from 12 carefully chosen studies. Aim: This study's objective is to thoroughly examine and summarize the body of research on digital health interventions, with an emphasis on acceptance and utilization as well as implementation and efficacy. Method: Twelve pertinent papers published between 2016 and 2024 were found after a thorough search of electronic databases. Numerous digital health interventions were covered by these research, such as remote monitoring systems, telemedicine, and mobile applications. In order to find common themes, sub-themes, and patterns among the chosen research, thematic analysis was used in the data synthesis process. Results: A number of important themes emerged from the thematic analysis, including interoperability problems, patient engagement, healthcare provider acceptability, regulatory concerns, and usability issues. The sub-themes that fell under these categories emphasized the variables that affect the uptake and efficacy of digital health interventions. Conclusion: The synthesis of data emphasizes how digital health initiatives can increase clinical results, improve patient care, and streamline the delivery of healthcare. But in order to fully reap the benefits, major obstacles like interoperability problems, regulatory difficulties, and usability impediments need to be solved. The recommendations put forth aim to promote innovation and evidence-based practice in digital health by stressing user-centered design, improving digital literacy among medical practitioners, and encouraging interdisciplinary collaboration.

EFFICACY OF VEDANASTHAPANA MAHAKASHAYA NIRUHABASTI IN GRIDHRASI VIS-À-VIS SCIATICA: A SINGLE CASE STUDY

Sciatica is an excruciatingly painful ailment that affects one or both legs' sciatic nerves. It's a prevalent illness that impairs leg movement. It is frequently linked to low back discomfort. Because of its intensity, sciatica pain can occasionally interfere with a person's daily activities. It is defined by discomfort or pain along the sciatic nerve. The prevalence of sciatica varies considerably, ranging from 1.2% to 43% worldwide, mainly affecting persons aged 30-60 years. As per the Ayurveda system of medicine, it is named Gridhrasi (Sciatica) one of the most common disorders of Vata. Based on the clinical presentations, it is bifurcated as Vataja and Vata-Kaphaja. Regarding management, contemporary medicine has limitations in providing short-term relief from pain or surgical intervention with side effects. This case study aimed to assess the efficacy of Ayurvedic management, including Shodhana (purification therapies) and Shamana Chikitsa (pacifying therapies) in Gridhrasi. A 45-year-old man who was already diagnosed with Inter vertebral disc prolapsed in L4-L5, correlated with Gridhrasi of both legs two years approached GAMC & H, Mysore and was treated with Panchakarma Chikitsa including Vedanasthapana Maha Kashaya Niruha Basti. Kati Basti, and Patra Pinda Pottali Sweda along with Shamana Chikitsa. The treatment was continued for consecutive 15days. An asymptomatic assessment of the patient was carried out after 15 days, and it got satisfactory results, and the overall quality of life of the patient was significantly improved. For the management of Gridhrasi, the previously indicated therapy provides symptomatic alleviation.

The Multifaceted Therapeutic Profile of Madecassoside: A Scholarly Review

Medicinal plants are indispensable in both modern and traditional healthcare, offering a diverse array of bioactive compounds with therapeutic properties, including anti-inflammatory, antimicrobial, and anticancer effects. They provide accessible and affordable treatment options and play a crucial role in drug discovery, enhancing holistic health and promoting biodiversity conservation. Ongoing scientific research continues to validate and expand their applications in contemporary medicine, underscoring their enduring significance. Centella asiatica, a medicinal plant known for its therapeutic properties in traditional medicine and increasingly recognized in modern pharmacology for various health benefits. Madecassoside, stands out as a phytoactive constituent of Centella asiatica, renowned for its wide-ranging pharmacological properties, encompassing anti-inflammatory, antioxidant, wound-healing, and skin-protective effects. The present review illuminates madecassoside's pharmacological properties and its mechanistic roles, as documented by various researchers. Keywords: Madecassoside, Centella asiatica, anti-inflammatory, antioxidant, wound-healing

Clinical outcomes of endovascular therapy for chronic limb-threatening ischemia in renal transplant recipients.

Endovascular treatment (EVT) for peripheral artery disease in patients with chronic limb-threatening ischemia (CLTI) is a common practice in contemporary medicine and its effectiveness is widely acknowledged. However, refractory ulcers can occasionally be encountered, particularly in patients who underwent renal transplantation (RT), even after successful EVT. To date, there have been no data on prognosis reported following EVT for CLTI in RT recipients. We included all RT recipients who underwent EVT in our hospital between 2010 and 2022. We analyzed data from 43 limbs with ischemic ulcerations classified as Rutherford class 5 or 6, which were managed solely with EVT (i.e., no bypass surgery was performed). The primary and secondary outcomes of our study were the incidence of complete wound healing and major adverse limb events (MALE), including clinically driven target vessel revascularization, major amputation, and all-cause death. The median follow-up was 31months. The mean age of the study population was 64.7 ± 8.7years, with predominantly male participants (79.1%). The overall wound healing rate was 34.9%. Kaplan-Meier curve revealed that wound healing rates at 1 and 3years were 33.6% and 40.9%, respectively. The wound healing rates of RT recipients who underwent EVT for CLTI were found to be less than satisfactory.

Generalized Seizure Masquerading the Cause of Coma

Background: Diagnosis is traditionally made by taking a medical history and performing a medical examination. These have become less useful in contemporary emergency and critical care medicine.  Objective: The objective was to show the importance of obtaining the medical history and re-evaluating it in medical emergencies for diagnosis and management.  Methods and Materials: In our instance, a female patient, age 22, was taken to the emergency room by her parents when she was unconscious and exhibiting tonic posture in all limbs. Due to our insufficient medical history, we ended up doing unnecessary and expensive investigations. The re- evaluation of the patient played a crucial role in diagnosis and management.  Results: The patient's re-evaluation to obtain a proper medical history revealed the actual cause of unconsciousness in our case, which led to proper management.  Conclusion: Our case showed the importance of obtaining a medical history in a medical emergency.  Key message: In cases of unconsciousness or other medical emergencies, taking a proper medical history and conducting a clinical examination are crucial. A re- evaluation of the patient helps in taking a proper medical history. It helps in proper diagnosis and management.

Enhanced propagation of free films with fast spread-out phenomena under the influence of megahertz surface acoustic waves

In this study, a novel approach for enhancing the rapid spreading of free liquid film on lithium niobate (LiNbO3) substrate under megahertz (MHz) surface acoustic wave (SAW) excitation is presented by treating it with surfactants. Through the design of a specific interdigital transducer structure, it was discovered that exciting the SAW at a frequency of 32.3 MHz can achieve optimal spreading performance for water droplets on the surface of surfactant-treated LiNbO3 substrate. The maximum average velocity reaches 1.76 mm/s at position P2 = 1250 μm in the water film front, and the stable film spreading speed shows a 204.9% increase compared to the existing research. Simultaneously, through the investigation of the spreading experiment phenomenon of silicone oil and de-ionized water droplets at varying frequencies, we have discovered the dynamic mechanism of “reverse phase” propagation in liquid film for the first time. This entails that the advancing edge of the wetting film demonstrates a spreading motion law that is opposite to the traditional spreading phenomena, with the spreading velocity in the central exceeding that on both sides. Our research demonstrates that this microfluidic device developed by SAWs enhances the spreading efficiency of the free films, enabling rapid expansion of the target liquid to form a high-surface area film layer. This advancement holds promise for overcoming the limitations of low sensitivity and short response time in the field of rapid pathological diagnosis in contemporary medicine.

Enactivism: a contemporary perspective of a reconceptualization of Osteopathy

Enactivism is a philosophical and scientific approach that emphasizes the role of the body and its interactions with the environment in shaping cognitive processes and subjective experiences. Meanwhile, osteopathy is a person-centered health care discipline, highlighting the structure-function interrelationship of the body and its selfregulation mechanisms. Both approaches value the body and the environment in health. Several authors have been discussing the urgent need for a reconceptualization of osteopathy and also suggesting integrate biological, psychological and social aspects. Thinking osteopathy as a Therapeutic Rationality, implies recognize its fundamental dimensions: Human Morphology, Vital Dynamics, Medical Doctrine, Diagnostic System and Therapeutic System, all integrated by a philosophical Cosmology, as the original term Medical rationality states, but also embrace a broader perspective allowing an individual and unique process of each person, reflecting the transformation of contemporary medicine to a person approach. Enactivism principles can serve as a basis for a reconceptualization of osteopathy, integrating environmental, psychological, social, and spiritual factors. Osteopathic concepts can probably be updated through the convergence between enactivism and osteopathy, promoting more meaningful and evidence-based clinical practice. Advancing in this direction requires a collaborative dialogue between researchers, health professionals and interested people, seeking an integrated understanding of the relationship between body, mind, environment and health.

MANAGEMENT OF JALODARA (ASCITES) THROUGH AYURVEDIC PRINCIPLES: A CASE STUDY

The accumulation of fluid in the peritoneum is called ascites. It is the most prevalent sign of liver damage. In contemporary medicine, there is currently no proven cure for ascites patients. It only relieves symptoms, and recurrence occurs over time. Such cases benefit from the side-effect-free results of ayurvedic treatment. Eight categories of Udara roga are stated in Ayurveda, and this case is correlated with Jalodara. A 44-year-old male patient came to Rognidan OPD in Government Ayurveda College, Nagpur, India, with symptoms including abdominal distension, anorexia, bipedal edema, icterus, dyspnea on exertion, interrupted sleep, and overall weakness. In addition to being a persistent alcoholic, the patient had no prior history of diabetes or hypertension. He was treated in accordance with the Jalodara therapeutic principles as stated in the Charaka Samhita, which included nitya virechana (daily purgation) using Ayurvedic medicines, strotoshodhana (microchannel cleaning), and a few hepatoprotectives. After receiving therapy for one month, the patient's symptoms showed significant improvement; hence, it was concluded that Ayurvedic treatments benefit Jalodara.

Non-Coding RNAs in Peritoneal Carcinomatosis: From Bench to Bedside.

Peritoneal carcinomatosis represents an advanced stage of tumors within the peritoneal cavity. Once considered an incurable terminal cancer metastasis, contemporary medicine is on the hunt for certain potentially curative options alongside the present day's palliative disease management. However, for most patients, peritoneal carcinomatosis continues to pose a fatal late-stage prognosis with a grim future outlook. Over the past two decades, non-coding RNAs have garnered significant attention due to their undeniable significance in regulating cellular processes across all levels. Disruption of the intricate regulation led by non-coding RNAs has been demonstrated to have a substantial impact on various human diseases, particularly in cancer, including solid tumors originating from the organs of the peritoneal cavity. This review aims to offer a comprehensive overview of the current state of knowledge in the under-researched field of peritoneal carcinomatosis, focusing specifically on the role of non-coding RNAs in the development of this condition and delineating potential avenues for future research.

Phytochemical Composition Antioxidant and Anti-Inflammatory Activity of Artemisia dracunculus and Artemisia abrotanum.

This study aimed to investigate the antioxidant and anti-inflammatory activities mechanism of Artemisia dracunculus (A. dracunculus) and Artemisia abrotanum (A. abrotanum) ethanol extracts in acute rat inflammation induced in Wistar male rats with turpentine oil. The characterization of the polyphenolic compounds in the extracts was conducted using UV-Vis and Fourier-transform infrared spectroscopy and high-performance liquid chromatography coupled with mass spectrometry techniques. The antioxidant activity of the extracts was evaluated in vitro by DPPH, FRAP, H2O2, and NO scavenging tests and in vivo by measuring the total oxidative status (TOS), total antioxidant capacity (TAC), oxidative stress index (OSI), 8-hydroxy-deoxyguanosine (8-Oxo-dG), advanced oxidation protein products (AOPP), malondialdehyde (MDA), nitric oxide (NO), 3-nitrotyrosine (3NT), and total thiols (SH). Inflammation was evaluated by measuring nuclear factor-kB-p65 (NfkB-p65) and NLRP3 inflammasome activation with IL-1β, IL-18, and gasdermin D. Liver and renal toxicity was determined following transaminases (ALT and AST), creatinine, and urea. The experimental results indicated that A. dracunculus and A. abrotanum ethanol extracts have moderate in vitro antioxidant activity and had in vivo antioxidant activity and an anti-inflammatory effect by NfkB-p65, IL-1b, IL-18, and gasdermin D serum level reduction. The antioxidant activity correlated with the chemical composition of the extracts. These results bring evidence-based use of A. dracunculus and A. abrotanum's in traditional and contemporary medicine.

Green Innovation and Synthesis of Honeybee Products-Mediated Nanoparticles: Potential Approaches and Wide Applications.

Bee products, abundant in bioactive ingredients, have been utilized in both traditional and contemporary medicine. Their antioxidant, antimicrobial, and anti-inflammatory properties make them valuable for food, preservation, and cosmetics applications. Honeybees are a vast reservoir of potentially beneficial products such as honey, bee pollen, bee bread, beeswax, bee venom, and royal jelly. These products are rich in metabolites vital to human health, including proteins, amino acids, peptides, enzymes, sugars, vitamins, polyphenols, flavonoids, and minerals. The advancement of nanotechnology has led to a continuous search for new natural sources that can facilitate the easy, low-cost, and eco-friendly synthesis of nanomaterials. Nanoparticles (NPs) are actively synthesized using honeybee products, which serve dual purposes in preventive and interceptive treatment strategies due to their richness in essential metabolites. This review aims to highlight the potential role of bee products in this line and their applications as catalysts and food preservatives and to point out their anticancer, antibacterial, antifungal, and antioxidant underlying impacts. The research used several online databases, namely Google Scholar, Science Direct, and Sci Finder. The overall findings suggest that these bee-derived substances exhibit remarkable properties, making them promising candidates for the economical and eco-friendly production of NPs.

Occurrence and Antibiotic Resistance Profiles of Metallo Beta Lactamase Producing Pseudomonas aeruginosa among Clinical Isolates in Enugu Metropolis, Nigeria

Introduction: Antibiotic resistance is rising worldwide, posing a challenge for contemporary medicine. Metallo-beta-lactamases (MBLs) confer resistance to beta-lactam antibiotics other than monbactams. It threatens public health because of its vast scope of action and quick spread. The study was undertaken to assess the occurrence of MBL in clinical isolates of Pseudomonas aeruginosa in the Enugu metropolis and to determine their resistance profile. Materials and Methods: The work was conducted from October 2020 to July 2021 in the microbiology laboratory of the University of Nigeria Teaching Hospital, Ituku-Ozalla. A total of 127 non-duplicate bacterial isolates recovered from clinical samples including wounds, urine, sputum, ear discharge, and catheter tip processed in the microbiology laboratory of four referral hospitals within the Enugu metropolis was used for the study. Isolates were identified and characterized using standard microbiology protocols. Antimicrobial susceptibility was done using the Kirby-Bauer disc diffusion method. Phenotypic detection of Metallo-beta-lactamase production was done using the Combined Disk diffusion Test (CDDT). Results: Of the 127 isolates, 68 (53.5%) were resistant to imipenem. Among these, 35 strains were positive for MBL production while 33 isolates were non-MBL producers. The highest percentage occurrence of MBL producers was recorded from catheter tips 33% followed by urine 30.6%. Both MBL producers and non-MBL producers displayed high resistance to most of the antibiotics used except Aztreonam. Conclusion: The overall occurrence of MBL among Pseudomonas aeruginosa in our study was found to be 27.6%. MBL-producing strains showed higher resistance than the non-MBL-producing strains. Aztreonam was the most potent antibiotic. The most effective approaches to combating this organism include early detection, stringent antibiotic regimens, and adherence to infection control measures.

Yashadamritamalaharam Application in the Management of Parikarthika - A Comprehensive Analytical Review

Parikartika is one among the anorectal diseases, which can be correlated with fissure in ano in the contemporary medicine. Parikartika is a disease condition rather than a single entity disease, which is usually triggered by other factors as per Ayurveda classics. It is usually described as a very painful condition which mostly affects the quality living. The disease pathology should be analyzed, studied and appropriate therapeutic measures should be advised to tackle and prevent the recurrence. There are many therapeutic methods available today for the treatment of Parikartika both in modern and Ayurveda. Modern methods are no replace oral pain medications, topical ointments, botulin injections surgical interventions etc. These have usually side effects and cause inconvenience to the patients. Ayurvedic preparations are also very effective, out of which a convenient, patient friendly easy method must be chosen. Yashadamrita malahara is a Malahara preparation from classical rasa text Rasatarangini which has wound healing properties which can be applied as an ointment or as Pichu. Aims and Objectives: This is an in-depth review analysis of Parikartika samprapti and the effect of Yashadamrita malahara in the management of the disease. Materials and methods: An attempt has been made to analyze the Samprapti ghatakas of Parikartika and the pharmacological actions of Yashadamrita malahara, and to explain the probable mode of action of the drug in the disease. Discussion and conclusion: Evaluation of the effect of Yashadamrita malahara and its therapeutic benefits in Parikartika by its mode of action.

Management of Primary Dysmenorrhoea with Gandharvahastadi Kashayam

Menstruation pain is literally defined as dysmenorrhoea. It can cause lower abdominal pain and discomfort and usually happens right before or during the menstrual cycle. Primary dysmenorrhoea occurs frequently. It is the most common gynaecological issue affecting young women, especially those in their teens. According to Ayurveda, dysmenorrhoea and ailments like Udavartini Yonivyapad or kashtartava may be connected. Vata is prevalent in this Tridoshaja vyadhi. In addition to the disruption of Rasa Dhatu, there is an imbalance of Apana Vayu. In contemporary medicine, antispasmodics, analgesics, prostaglandin synthesis inhibitors, hormone treatment, and other medications are frequently used to treat primary dysmenorrhoea. In order to effectively reduce dysmenorrhoea, Ayurveda suggests adhering to Ritucharya and Dinacharya, as well as modifying food and practicing yoga on a regular basis, including Asanas, Pranayama, and meditation and the use of Samana aushada, which can reduce Vata along with Snehana (oleation), Swedana (sudation), and Vasti (enema). Ayurvedic medicine seeks to achieve Vatanulomana. Therefore, Ayurveda treats primary dysmenorrhoea with a more comprehensive approach.