Contact Points Research Articles

Regulate drain‐shield relative positioning and contact for mitigating radiated emission from USB cables

AbstractThis letter delves into the influence of drain wire design on electromagnetic radiated emission (RE) from a commercial universal serial bus (USB) cable operating in a high‐speed data transfer mode. The investigation involves an experimental comparison of measured RE across various retrofitted cables. Notably, it is demonstrated that the distribution of contact points on the drain‐shield has negligible effects on RE. Conversely, relocating the drain wire externally to the shields and minimizing the distance with respect to the grounding connector leads to a significant reduction in RE, particularly within the sub‐MHz frequency range. Consequently, regulatory proposals are put forth to diminish overall RE and enhance the RE compliance of USB cables.

Impact of Selective Posterior Cruciate Ligament Fiber Release on Femoral Rollback in Cruciate-Retaining Total Knee Arthroplasty: A Computational Study

BackgroundPartial or total release of the posterior cruciate ligament (PCL) is often performed intraoperatively in cruciate-retaining total knee arthroplasty (CR-TKA) to alleviate excessive femoral rollback. However, the effect of the release of selected fibers of the PCL on femoral rollback in CR-TKA is not well understood. Therefore, we used a computational model to quantify the effect of selective PCL fiber releases on femoral rollback in CR-TKA. MethodsComputational models of 9 cadaveric knees (age: 63 years, range 47 to 79) were virtually implanted with a CR-TKA. Passive flexion was simulated with the PCL retained and after serially releasing each individual fiber of the PCL, starting with the one located most anteriorly and laterally on the femoral notch and finishing with the one located most posteriorly on the medial femoral condyle. The experiment was repeated after releasing only the central PCL fiber. The femoral rollback of each condyle was defined as the anterior-posterior distance between tibiofemoral contact points at 0° and 90° of flexion. ResultsRelease of the central PCL fiber in combination with the anterolateral (AL) fibers, reduced femoral rollback a median of 1.5 [0.8, 2.1] mm (P = .01) medially and by 2.0 [1.2, 2.5] mm (P = .04) laterally. Releasing the central fiber alone reduced the rollback by 0.7 [0.4, 1.1] mm (P < .01) medially and by 1.0 [0.5, 1.1] mm (P < .01) laterally, accounting for 47 and 50% of the reduction when released in combination with the AL fibers. ConclusionsReleasing the central fibers of the PCL had the largest impact on reducing femoral rollback, either alone or in combination with the release of the entire AL bundle. Thus, our findings provide clinical guidance regarding the regions of the PCL that surgeons should target to reduce femoral rollback in CR-TKA.

IJCM_25A: Effect of one-to-one counselling of mothers attending an immunization clinic on breastfeeding among infants- A Randomised Controlled Trial

Background: To improve breastfeeding practices, many interventions have been studied at various critical contact points. Our study aimed to improve exclusive breastfeeding by integrating a limited number of counselling sessions with routine immunization visits. Objective: To find out the effect of one-to-one counselling on six months of exclusive breastfeeding among infants attending immunization clinic. Methodology: An open-labelled, randomised controlled trial was conducted from September 2022 in the Immunization clinic at the Urban Health Training Centre of Dept of Community Medicine, UCMS, at Ghazipur, New Delhi. Mother-Child dyads visiting the clinic (child between 1 ½ to 3 ½ months) were recruited for the study based on certain appropriate inclusion and exclusion criteria. One-to-one counselling on breastfeeding and complementary feeding were provided, respectively, in the first visit (at the time of Pentavalent 1 or 2 vaccination,) and the second visit (at the time of Pentavalent 3 vaccination) to the intervention group. The control group received routine care. In the follow-up visit at 9 months for measles vaccination, a final assessment was done for both the groups. Analysis was done based on Intention to treat and per protocol approaches. Results: 92 Mother-child dyads were recruited in the study, of which 46 were randomized each in the intervention and control group. 6 were lost to follow-up on the second visit and 13 on the third (follow-up) visit. At the first visit, 56.5% of the mothers in the intervention group and 63% of mothers in the control group were exclusively breastfeeding. The proportion of mothers who exclusively breastfed their infant till six months of age were 65.2% in the intervention and 39.1% in the control group with an OR of 2.92(1.25, 6.81). Conclusion: One-to-one counselling at an immunization clinic has an effect on increasing rates of exclusive breastfeeding for 6 months.

INFLUENCE OF CROSSING WEAR ON ROLLING CONTACT FATIGUE DAMAGE OF FROG RAIL

The damage of the frog rail significantly affects the wear of the crossing rail and restricts the passing speed of the train. A geometric 3D modeling of the vehicle passing through the crossing center is particularly concerned with the cumulative wheel-rail contact of the traffic volume. The frog rail wear is simulated to obtain the dynamic change of the impact force of the wheel on the frog rail as the rail wears. By summarizing the existing experimental results of other scholars, it is clear that the important factors, that cause the damage of the frog rail, are vehicle load, friction coefficient, slip roll ratio and shear stress. This paper combines the theoretical analysis of mechanics and 3D simulation to obtain the position change of the wheel-rail contact point with the wear of the frog rail, and finally compares it with the actual measurement results. It can more accurately predict the area where the maximum damage occurs after a certain amount of traffic for a certain fixed model, the change of wheel-rail contact point at frog rail is simulated with the wear of each component. Through theoretical analysis, the main factors determining frog rail damage were determined. Then evaluate the possible damage area of the frog track and control the prediction range to 5-10 cm, which reduces the detection time and cost. The worst state of distraction will be detected in time to facilitate replacement or polishing. Through further research in this area, the service life of the frog rail can be predicted.

Low-frequency ultrasonic array imaging for detecting concrete structural defects in blind zones

Ultrasonic array (UA) imaging is a promising non-destructive testing (NDT) method that is extensively used for defect detection. Due to the high attenuation characteristics of ultrasonic wave propagation in concrete structures and the directivity of sensors, the total focus method (TFM) easily misses specific defects in blind zones that are far from the sensors or located at a large deflection angle. To overcome this limitation, the diffusion attenuation compensation factor and solid directivity correction factor are adopted to improve the scattered signal energy of defects that are in blind zones. On this basis, the diffusion attenuation compensation method (DACM), the solid directivity correction method (SDCM), and the diffusion attenuation compensation-based solid directivity correction method (DAC-SDCM) are proposed. These methods are applied to characterize multiple circular holes in concrete structures using the dry point contact (DPC) low-frequency UA, and the detection results are evaluated from the intensity curve and detection area of ultrasonic images. The numerical and experimental results indicate that DACM is suitable for detecting defects located at longer distances, SDCM is capable of detecting defects located at larger deflection angles, and DAC-SDCM can significantly improve the detection performance of defects that are distant and have large deflection angles. The findings demonstrate that the proposed methods can significantly improve the detection ability of defects in blind zones and broaden the application of DPC low-frequency UA in the health monitoring of concrete structures.

From Finite Element Simulations to Equivalent Circuit Models of Extracellular Neuronal Recording Systems Based on Planar and Mushroom Electrodes.

define a new methodology to build multi-compartment lumped-elements equivalent circuit models for neuron/electrode systems. the equivalent circuit topology is derived by careful scrutiny of accurate and validated multiphysics finite-elements method (FEM) simulations that couple ion transport in the intra- and extracellular fluids, activation of the neuron membrane ion channels, and signal acquisition by the electronic readout. robust and accurate circuit models are systematically derived, suited to represent the dynamics of the sensed extracellular signals over a wide range of geometrical/physical parameters (neuron and electrode sizes, electrolytic cleft thicknesses, readout input impedance, non-uniform ion channel distributions). FEM simulations point out phenomena that escape an accurate description by equivalent circuits; notably: steric effects in the thin electrolytic cleft and the impact of extracellular ion transport on the reversal potentials of the Hodgkin-Huxley neuron model. our multi-compartment equivalent circuits match accurately the FEM simulations. They unveil the existence of an optimum number of compartments for accurate circuit simulation. FEM simulations suggest that while steric effects are in most instances negligible, the extracellular ion transport affects the reversal potentials and consequently the recorded signal if the electrolytic cleft becomes thinner than approximately 100 nm. the proposed methodology and circuit models improve upon the existing area and point contact models. The coupling between the extracellular concentrations and reversal potential highlighted by FEM simulations emerges as a challenge for future developments in lumped-element modeling of the neuron/sensor interface.

Transient mixed thermal elastohydrodynamic lubrication under startup and shut down conditions

The transient mixed lubrication behaviors in thermal elastohydrodynamic lubrication (TEHL) contacts during startup and stop are investigated. A transient mixed TEHL model for point contacts under time-varying speed conditions is proposed with comprehensive consideration of surface roughness, thermal effect, and transient behavior. The model is validated by the comparison to available published data. Based on the developed model, significant differences have been found compared with transient EHL and steady TEHL models. In addition, the transient mixed TEHL performance during start–stop with different acceleration rates and surface roughness is investigated. It shows that the lubrication behaviors during start–stop have an irreversible process. The roughness can significantly enhance the transient behavior. The roughness effect has a remarkable impact on lubrication performance in mixed lubrication. The evolution of lubrication behaviors during start–stop is highly related to the acceleration rate and surface topography.

Levitons in correlated nano-scale systems.

In this short review (written to celebrate David Campbell's 80th birthday), we provide a theoretical description of quantum transport in nanoscale systems in the presence of single-electron excitations generated by Lorentzian voltage drives, termed Levitons. These excitations allow us to realize the analog of quantum optics experiments using electrons instead of photons. Importantly, electrons in condensed matter systems are strongly affected by the presence of different types of non-trivial correlations, with no counterpart in the domain of photonic quantum optics. After providing a short introduction about Levitons in non-interacting systems, we focus on how they operate in the presence of two types of strong electronic correlations in nanoscale systems, such as those arising in the fractional quantum Hall effect or in superconducting systems. Specifically, we consider Levitons in a quantum Hall bar of the fractional quantum Hall effect, pinched by a quantum point contact, where anyons with fractional charge and statistics tunnel between opposite edges. In this case, a Leviton-Leviton interaction can be induced by the strongly correlated background. Concerning the effect of superconducting correlations on Levitons, we show that, in a normal metal system coupled to BCS superconductors, half-integer Levitons minimize the excess noise in the Andreev regime. Interestingly, energy-entangled electron states can be realized on-demand in this type of hybrid setup by exploiting crossed Andreev reflection. The results exposed in this review have potential applications in the context of quantum information and computation with single-electron flying qubits.

Grievance Central Hub

Abstract: The Grievance Central Hub is a revolutionary approach to managing grievances within organizations. It offers a confidential, user-friendly, transparent system, fostering open communication and accountability. This portal efficiently handles grievances raised by individuals in the organization, promoting transparency and efficiency. Accessible to all with a userfriendly interface, it prioritizes security and confidentiality when handling complaints. Real-time tracking and updates on grievance status ensure that both students and faculty members are well-informed throughout the resolution process. The portal streamlines complaint management across various departments, providing a single point of contact for grievance submission. Powered by technologies like PHP, PHP mailer (for email communication), MySQL (for database management), Apache Tomcat, HTML, CSS, and JavaScript (for an interactive user interface), this system offers a seamless and responsive solution. It contributes to a more harmonious and accountable organizational environment, making grievance management efficient and effective.

Полигенетическая природа поэтики К.Д. Бальмонта и культурные традиции древнего Китая

The article discusses the polygenetic nature of K.D. Balmont's poetics on the basis of underinvestigated materials related to ancient Chinese cultural traditions by using the principles of comparative studies, historical poetics, hermeneutics and the mythopoetic method. The object of the analysis is the “Chinese” cycle, consisting of five sonnets included in Balmont's collection of poems “Sonnets of the Sun, Honey and Moon. Song of the Worlds” (1917). Special attention is paid to the analysis of the mythological images, motives and plots in these poems, identifying their sources and revealing the poet's creative intention. It is taken into account that S.M. Georgievsky's book “Mythical beliefs and myths of the Chinese” (1892) had a significant influence on Balmont's perception of Chinese mythology and it is an important basis for the creation of these sonnets. It is claimed that the source of this cycle is the Chinese treatise “Huainan Tzu” (Philosophers from Huainan, no later than 139 BC), which is essentially a Taoist philosophical work. It is noted that Balmont's reference to “Huainan Tzu” testifies to his continuing attention to Taoism, which turned out to be one of the main sources of the poet's spiritual exploration. The theme of the Eternal Femininity in this cycle is considered as a point of contact between the Silver Age culture and ancient Chinese culture, primarily Solovyov's doctrine of Sophia and Lao Tzu's philosophy. It is concluded that, firstly, Balmont's sonnets can be perceived not only as an attempt to stylize ancient Chinese myths, as researchers often assume, but also as a phenomenon indicating the transformation of the semantics of the myth created by the poet and its deepening on the basis of mythological traditions of ancient China. Secondly, the use of common motifs in Eastern and European mythology and the combination of Chinese mythology with the European poetic form reflects the polygenetic nature of Balmont's poetics and the contamination of traditions.

Abnormal cleavage up to Day 3 does not compromise live birth and neonatal outcomes of embryos that have achieved full blastulation: a retrospective cohort study.

Do embryos displaying abnormal cleavage (ABNCL) up to Day 3 have compromised live birth rates and neonatal outcomes if full blastulation has been achieved prior to transfer? ABNCL is associated with reduced full blastulation rates but does not impact live birth rates and neonatal outcomes once full blastulation has been achieved. It is widely accepted that ABNCL is associated with reduced implantation rates of embryos when transferred at the cleavage stage. However, evidence is scarce in the literature reporting birth outcomes from blastocysts arising from ABNCL embryos, likely because they are ranked low priority for transfer. This retrospective cohort study included 1562 consecutive autologous in vitro fertilization cycles (maternal age 35.1 ± 4.7 years) performed at Fertility North, Australia between January 2017 and June 2022. Fresh transfers were performed on Day 3 or 5, with remaining embryos cultured up to Day 6 before vitrification. A total of 6019 embryos were subject to blastocyst culture, and a subset of 664 resulting frozen blastocysts was included for live birth and neonatal outcome analyses following single transfers. ABNCL events were annotated from the first mitotic division up to Day 3, including direct cleavage (DC), reverse cleavage (RC) and <6 intercellular contact points at the 4-cell stage (<6ICCP). For DC and RC in combination, the ratios of affected blastomeres over the total number of all blastomeres up to Day 3 were also recorded. All pregnancies were followed up until birth with gestational age, birthweight, and sex of the baby being recorded. Full blastulation rates for embryos showing DC (19.5%), RC (41.7%), <6ICCP (58.8%), and mixed (≥2) ABNCL types (26.4%) were lower than the rates for those without ABNCL (67.2%, P < 0.01 respectively). Subgroup analysis showed declining full blastulation rates with increasing ratios of combined DC/RC affected blastomeres over all blastomeres up to the 8-cell stage (66.2% when 0 affected, 47.0% when 0.25 affected, 27.4% when 0.5 affected, 14.5% when 0.75 affected, and 7.7% when all affected, P < 0.01). However, once full blastulation had been achieved, no difference was detected between DC, RC, <6ICCP, and no ABNCL blastocysts following single frozen transfers in subsequent live birth rates (25.9%, 33.0%, 36.0% versus 30.8%, P > 0.05, respectively), gestational age (38.7 ± 1.6, 38.5 ± 1.2, 38.3 ± 3.5 versus 38.5 ± 1.8 weeks, P > 0.05, respectively) and birthweight (3343.0 ± 649.1, 3378.2 ± 538.4, 3352.6 ± 841.3 versus 3313.9 ± 509.6 g, P > 0.05, respectively). Multiple regression (logistic or linear as appropriate) confirmed no differences in all of the above measures after accounting for potential confounders. Our study is limited by its retrospective nature, making it impossible to control every known or unknown confounder. Embryos in our dataset, being surplus after selection for fresh transfer, may not represent the general embryo population. Our findings highlight the incremental impact of ABNCL, depending on the ratio of affected blastomeres up to Day 3, on subsequent full blastulation. The reassuring live birth and neonatal outcomes of ABNCL blastocysts imply a potential self-correction mechanism among those embryos reaching the blastocyst stage, which provides valuable guidance for clinical practice and patient counseling. This research is supported by an Australian Government Research Training Program (RTP) Scholarship. All authors report no conflict of interest. N/A.

3D cotton-type anisotropic biomimetic scaffold with low fiber motion electrospun via a sharply inclined array collector for induced osteogenesis

Electrospinning is an effective method to fabricate fibrous scaffolds that mimic the ECM of bone tissue on a nano- to macro-scale. However, a limitation of electrospun fibrous scaffolds for bone tissue engineering is the structure formed by densely compacted fibers, which significantly impedes cell infiltration and tissue ingrowth. To address this problem, several researchers have developed numerous techniques for fabricating 3D fibrous scaffolds with customized topography and pore size. Despite the success in developing various 3D electrospun scaffolds based on fiber repulsion, the lack of contact points between fibers in those scaffolds has been shown to hinder cell attachment, migration, proliferation, and differentiation due to excessive movement of the fibers. In this article, we introduce a Dianthus caryophyllus-inspired scaffold fabricated using SIAC-PE, a modified collector under specific viscosity conditions of PCL/LA solution. The developed scaffold mimicking the structural similarities of the nature-inspired design presented enhanced cell proliferation, infiltration, and increased expression of bone-related factors by reducing fiber movements, presenting high space interconnection, high porosity, and controlled fiber topography.

Detecting and locating chemical intrusion in water distribution systems using 911 calls

ABSTRACT Intentional or unintentional chemical contamination of water distribution systems (WDSs) could have severe health and socio-economic consequences. High potency chemicals constituting, in essence, “super poisons” have the potential to be used in such intrusion scenarios. Some of these contaminants are capable of killing the victim in less than 1 h. Due to their high toxicity levels and short time from exposure to onset of symptoms, 911 call centers are likely the first point of contact for victims or their families with the authorities. Information such as 911 calls could be used to identify the ongoing event and potential intrusion locations. In this way, such emergency calls could function as an intrusion warning system. This study employs network hydraulic modelling to synthesize the 911 call patterns in the aftermath of such events. It then defines the scenarios as a multi-label pattern recognition problem. The synthesized data then was used to train a Convolutional Neural Network (CNN). The trained AI was applied to a real-world WDS with approximately 4000 km of pipe and 26,000 demand nodes. The results indicated that CNN is capable of accurately recognizing the pattern and pinpointing the originating location of the intrusion with an accuracy greater than 93%.

Mechanism of asphalt concrete reinforced with industrially recycled steel slag from the perspectives of adhesion and skeleton

This research investigated the reinforcement mechanism of steel slag recycling in asphalt concrete from the perspective of adhesion and skeleton. Bonding performance between steel slag and bitumen was assessed by the calculation of coating area and peeling area, as well as the area detection by Scanning Electron Microscope (SEM) and Energy Dispersive Spectrometer (EDS). Computed Tomography (CT) scanning was used to determine the bitumen absorption characteristics of steel slag. Mechanical characteristics of steel slag mixture during compaction period and service period were evaluated by continuous compression test with Universal Testing Machine (UTM-25). A combination of CT scanning and image processing technology were used to quantify skeleton contact characteristics. The results indicated that bonding performance of bitumen with steel slag was obviously better than basalt after long-term erosion. The surface pores of steel slag absorbed excessive bitumen as anchoring and embedding effect, accounting for 20.24% of the total steel slag bitumen absorption in maximum. Steel slag skeleton of SMA gradation was found easily to be compacted during construction period and more resistant to loading during service period. In addition, there were more contact points in steel slag asphalt concrete, resulting that steel slag asphalt concrete had better stability. The contact points were different in different particle size ranges, and it was suggested that steel slag with particle size of 9.5–16.0 mm and 2.36–4.75 mm should be preferred.

Translocator Protein TSPO (Peripheral Benzodiazepine Receptor): The Modern Story of the Ancient Preserved Protein with Ambiguous Functions

In several tissues, including the brain, heart, blood, intestines, adrenal glands, and liver, the 18 kDa translocator protein (TSPO) was shown to be the peripheral benzodiazepine receptor. There is strong evidence that TSPO is expressed in microglial cells in the central nervous system. Five transmembrane regions are seen at the cellular level in TSPO at the contact points between the outer and inner layers of mitochondria. The cytosolic region of the complex of amino acids that binds cholesterol is where cholesterol is taken up. TSPO is found as a monomer of 18 kDa and homomultimers and homodimers. Different factors, such as cholesterol concentration and reactive oxygen species, change the multimeric structure. As a result, TSPO gains responsibility for transferring cholesterol to the mitochondrial intermembrane space, transforming it into a steroid. Additionally, TSPO appears to collaborate with other mitochondrial membrane proteins to play a part in regulating the activity of the MPTP (mitochondrial permeability transition pore) and, therefore, in the elements of apoptosis. In vivo imaging of TSPO addresses a significant test in examining brain pathology like neuroinflammatory, Alzheimer’s, and schizophrenia. Additionally, TSPO’s use as a biomarker may have important implications for developing more viable diagnostic and therapeutic approaches. The current work surveys the TSPO cellular origin and attempts to comprehend its role in various physiological and pathological conditions.

A clinical study to compare the efficacy of crushing of middle turbinate with lateral partial turbinectomy for concha bullosa

Background: Concha bullosa (CB), a pneumatized middle turbinate is most common variations of sino-nasal anatomy. Identified in approximately ~35% (range 14-53%) of patients, a large CB cause nasal obstruction, recurrent sinus infections and headache, may develop into mucocele or mucopyocele or affect olfaction. Endoscopic lateral partial turbinectomy (LPT) is the standard procedure for the treatment of CB. However, the recurrence of contact points and postoperative synechiae with subsequent frontal recess obstruction are common complications of this technique. Crushing of a pneumatized turbinate preserves the mucosa, less time consuming and carry less risk of complications. The aim of the study was to compare the efficacy of crushing with LPT for the treatment of CB. Methods: This was a prospective cohort study conducted by convenient sampling in the Department of ENT, KIMS, Hubli, Karnataka, India. In 53 patients, 43 with unilateral and 10 with bilateral CB satisfying the inclusion and exclusion criteria were subjected to either crushing (group A) or LPT (group B). The success of both techniques were compared based on the relief of symptoms assessed by the visual analogue scale, nasal endoscopy and computed tomography (CT) scan after 6 months of surgery. Results: The overall success rate of the outcome was equal between the two groups, with no statistical (p&gt;0.05) difference. Conclusions: Crushing the CB is as efficient as LPT for the treatment of pneumatized middle turbinate. However, surgically crushed CB can get re-pneumatization in some patients.

New Computerized Planning Algorithm and Clinical Testing of Optimized Nuss Bar Design for Patients with Pectus Excavatum.

BACKGROUND Computer-aided design (CAD) has been used in the Nuss procedure to determine the bar length and shape. Despite computer aid, the shape and design remain quite intuitive. We tested a new algorithm to determine the optimal bar shape. MATERIAL AND METHODS The normal sterno-vertebral distance was defined on computed tomography (CT) scans of patients without pectus excavatum (PEx) at the same level where the deepest depression was found on CT scans of 97 patients with PEx. Four points were marked on the CT scan of 60 patients with PEx at the deepest deformity: P1: edge of the vertebra; P2: edge of the deformity; P3: the expected contact point of the bar and the rib; and P4: the expected end of the bar. The algorithm generated 3 circles upon these points, and the fusion of the arcs drew the line of the ideal bar. Corrected and normal sterno-vertebral distance values were compared with the Mann-Whitney U test. Ten bars were bent manually guided by a 1: 1 printout of the designed bar and were implanted in 10 adolescents. RESULTS The shortest sterno-vertebral distance was 3 cm below the intermammillary line in PEx patients. The normal mean sterno-vertebral distance at this level was 10.16±1.35 cm in non-PEx patients. The mean virtually corrected sterno-vertebral distance was 10.28±1.27 cm. No significant difference was found (P=0.44). The bars were seamless and were successfully implanted. No bar needed adjustment, the operation time was shorter, and the patient satisfaction score was 9.4/10. CONCLUSIONS With our new algorithm, an optimal Nuss bar can be designed.

Sanidinite facies metamorphism at Nagarahal Village of Bilgi taluk, Bagalkot district, Karnataka, India

&#x0D; &#x0D; &#x0D; Nagarahal village in the Bilgi taluk of Bagalkot district in Karnataka state shows the contact between the younger Bilgi granites and the Deccan basalts. The thermal impact that has happened on the pre-existing granites by the basalts has been studied by identifying the field occurrence of the contact zone of granites and basalts. The unaffected portion of the granites and the basalts that are far away from the contact are studied as well. The petrographic studies of the contact rocks between the granites and basalts show the polygonal recrystallized quartz with the triple point contact with other grains indicating the decussate texture indicating the high-temperature conditions, crushed quartz grains having contact with each grain appear as sugary crystals from the granoblastic texture, the irregular oriented mafic and felsic crystals show the hornfelsic texture and micrographic, and intergrowth textures showing the effect of thermal metamorphism near to the contact between the granite and basalt. The post-hydrothermal solution activity is at the peripheral region of the contact between granite and basalt which is seen by the formation of tourmaline. The mineral assemblages that are identified by the petrographic studies are muscovite, quartz, orthoclase, sanidine, sillimanite, chlorite, and Fe-Ti oxide minerals. The mineral chemistry data shows the high potash K-feldspar that consists of Or from 84% to 97.97%, Ab2%- 4.26%, and An0.09%-1.34% was identified as sanidine variety of K-feldspar, the plagioclase feldspar shows the dominant composition of Ab ranging from 84.92% to 97.10%, An content in plagioclase was found to be ranging from 0.87% to 14.02%, and the Or content is ranging from 1.06%-7.41%. indicating the presence of the albite variety of plagioclase, the Fe2+ dominating chlorite, and the presence of tourmaline indicates the hydrothermal effects at the periphery of the contact. The two feldspar thermometry indicates the formation temperature was 750°C at the contact and the chlorite formation temperature calculated is found to be 313°C which shows a decrease in the temperature away from the contact of the basalt and the granitic rocks. Whereas the granite and the basalts that are far away from the contact do not show any changes. The mineral assemblages, mineral chemistry data, and thermometric results indicate the high temperature and low-pressure sanidine facies of contact metamorphism in the studied area.&#x0D; &#x0D; &#x0D;

Expert System for Web Graphical User Interface Test Case Generation for Usability Test

The ease of use test (UT) process is used to evaluate the usability of a website or its point of contact without involving actual site visitors. UT can be done manually or with the use of mechanized equipment. The manual course of ease of use test is time-consuming and expensive. Manual labor needs additional resources (analyzers) and exceptional possibilities to counteract those consequences. The goal of this investigation is to improve the competency and reliability of experiments' (TC) age through; the test system is communicated using programmed test instruments. Robotized testing (RT) may be effective and precise. There are several robotized devices available for programming testing, with limited access to TC computerization. The efficient writing audit (SLR) was directed in this examination to sort out the gap(s) in current AT and huddle in TC age. Furthermore, the review was aimed at identifying the primary problems examined by various neighborhood analyzers during the process of physically generating TC. Fluffy reasoning master structure was used to generate TC based on the selected reasonable experiments. The fluffy rationale can emphasize non-probabilistic concerns, vulnerability, and multi-esteemed rationale. The information investigation was carried out to get access to the login page and trials were carried out provided the GRAPHIC USER INTERFACE instances using flowery reasoning. The framework extracted the watchwords, attributes, and conditions from the information examination code and displayed the results as experiments. A close examination was conducted among behavioral test system age processes using the fluffy-based master framework for evaluation. The assessment findings obtained through quantifiable examination show that the proposed framework is more productive and trustworthy for creating experiments than the manual framework.

Potential targets for the treatment of MI: GRP75-mediated Ca2+ transfer in MAM

After myocardial infarction (MI), there is a notable disruption in cellular calcium ion homeostasis and mitochondrial function, which is believed to be intricately linked to endoplasmic reticulum (ER) stress. This research endeavors to elucidate the involvement of glucose regulated protein 75 (GRP75) in post-MI calcium ion homeostasis and mitochondrial function. In MI rats, symptoms of myocardial injury were accompanied by an increase in the activation of ER stress. Moreover, in oxygen-glucose deprivation (OGD)-induced cardiomyocytes, it was confirmed that inhibiting ER stress exacerbated intracellular Ca2+ disruption and cell apoptosis. Concurrently, the co-localization of GRP75 with IP3R and VDAC1 increased under ER stress in cardiomyocytes. In OGD-induced cardiomyocytes, knockdown of GRP75 not only reduced the Ca2+ levels in both the ER and mitochondria and improved the ultrastructure of cardiomyocytes, but it also increased the number of contact points between the ER and mitochondria, reducing mitochondria associated endoplasmic reticulum membrane (MAM) formation, and decreased cell apoptosis. Significantly, knockdown of GRP75 did not affect the protein expression of PERK and hypoxia-inducible factor 1α (HIF-1α). Transcriptome analysis of cardiomyocytes revealed that knockdown of GRP75 mainly influenced the molecular functions of sialyltransferase and IP3R, as well as the biosynthesis of glycosphingolipids and lactate metabolism. The complex interaction between the ER and mitochondria, driven by the GRP75 and its associated IP3R1-GRP75-VDAC1 complex, is crucial for calcium homeostasis and cardiomyocyte's adaptive response to ER stress. Modulating GRP75 could offer a strategy to regulate calcium dynamics, diminish glycolysis, and thereby mitigate cardiomyocyte apoptosis.