Calcium Consumption Research Articles

Deficit Consumption of Protein and Calcium on Children Aged 2-5 years old in Yogyakarta Indonesia

In Indonesia, stunting cases are estimated to be a problem and some areas are likely to experience stunting due to its high prevalence including Yogyakarta Province. There are several causes of stunting, including a lack of macro and micronutrients. This study has objective to determine the relationship between protein and calcium intake in children aged 2-5 years height. This research was an analytical survey research with a cross-sectional approach. In this study, the primary data was collected using the SQ-FFQ questionnaire to determine the intake of protein and calcium. Stunting was measured using height for age (standard deviation). Subjects were 64 children as respondents and were distributed using a purposive sampling method. The data was processed with the help of SPSS software by performing multiple regression tests. In normal children, they tend to have higher average protein adequacy (111.1±84.5g) than stunted children (25.4±6.3g). Hence, the average calcium intake was 1707,3±1273,88mg in normal children and 291,2±253.8mg in stunted children. The results of the regression test explained that there was a significant relationship between children's height and protein and calcium intake (p<0.05). The relationship between protein and calcium intake with children's height is shown in the percentage of 10.3% and the other 89.7% is explained by variables outside the study. There is a significant relationship between protein and calcium intake with stunting and non-stunted children's height at the age of 2-5 years in Yogyakarta.

Enhancing nutritional knowledge and practices: The impact of nutrition education on iron and calcium consumption among cricket players

Background Problems: This study emphasises the critical importance of maintaining a balanced intake of nutrients relative to individual needs, as deficiencies or excesses can significantly impact health and nutritional status. Among these essential nutrients are iron and calcium. Research Objectives: The aim of this research is to assess the impact of nutrition education on the knowledge and dietary practices related to iron and calcium among athletes. Methods: The research used a pre-experimental design with a one-group pretest-posttest. To evaluate the effect of the intervention, the subjects were given a pretest, nutrition education, and posttest. The study was conducted on a total of 30 cricket players from the Special Capital Region of Jakarta over a period of 1 month, with a frequency of 4 intervention meetings, each session lasting 60 minutes. Data analysis was performed using an independent t-test. The participants in this research were cricket players from Jakarta. Findings and Results: The results indicated that nutrition education significantly improved athletes' nutritional knowledge (p-value 0.000) and dietary practices (p-value 0.011). Conclusion: This research demonstrates the effectiveness of targeted nutrition education interventions in enhancing athletes' knowledge and adoption of healthier dietary practices, particularly concerning iron and calcium consumption. These findings contribute valuable insights to the field of sports nutrition, emphasising the importance of well-designed educational programs in promoting good nutritional behaviour and supporting overall health and performance in athletes. This study underscores the critical role of nutrition education in the advancement of both the scientific understanding and practical application of sports nutrition.

Dietary calcium intake among Iranian adults: Iranian Multicenter Osteoporosis Study (IMOS-2021).

Adequate dietary consumption of calcium is crucial in the preservation of bone health and the prevention of osteoporosis. This study investigated the prevalence of insufficient dietary calcium intake among individuals aged ≥50 years in Iran. We analyzed data from the Iranian Multicenter Osteoporosis Study (IMOS-2021). Participants aged 50 years and older completed a 168-item food frequency questionnaire. Insufficient dietary calcium intake was characterized as a daily calcium intake of <1000 mg for men aged 50-70 years, and <1200 mg for men over 70 years and women over 50 years and older. Stata v17 statistical software facilitated a survey set analysis to estimate the population's mean and median dietary calcium intake and the prevalence of insufficient dietary calcium intake. The study included 1450 participants with a mean age of 60.7±7.9 years. The estimated mean dietary calcium intake in Iran was 1062.7 mg/day (95% CI: 1029.6-1095.8), with a median intake of 943.5 mg/d (95% CI: 910.5-976.4). The prevalence of insufficient dietary calcium intake in Iran was estimated to be 62.9% (95% CI: 60.0%-65.7%). Notably, the prevalence was higher among women at 75.5% (95% CI: 71.9%-78.8%), compared to men at 47.8% (95% CI: 43.4%-52.3%) with a significant difference (P<0.001). In age-related findings, individuals aged 65 years and older had a higher prevalence of insufficient intake, at 69.0% (95% CI: 63.9%-74.0%), versus those under 65 years, at 60.3% (95% CI: 56.9%-63.8%), with this difference being statistically significant (P = 0.007). Furthermore, a significant inverse relationship was identified between both educational years and socioeconomic status and the prevalence of insufficient dietary calcium intake (Ps for trends<0.001). Our findings revealed a significant prevalence of insufficient dietary calcium intake in women and those aged 65 and older. We advocate for targeted public health strategies to ensure sufficient dietary calcium intake across these populations.

Dietary calcium intake in relation to metabolic syndrome in adults: A systematic review and dose-response meta-analysis of epidemiological studies with GRADE assessment.

Numerous studies have examined the relationship of calcium intake and metabolic syndrome (MetS) in adults in previous decades; but the results were inconsistent across different societies. This systematic review and dose-response meta-analysis assessed the relation between calcium consumption and MetS in adults. We did a systematic search of all articles published up to July 2023 in Scopus, PubMed/Medline, ISI Web of Science electronic databases, and Google Scholar. Observational studies investigated the association between dietary calcium (Ca) intake and MetS in adults were eligible to be included. For computing the estimates, a random effects model was applied. Combining 24 effect size from 17 investigations (15 cross-sectional and two cohort studies) with 74,720 participants and 18,200 cases showed that highest versus lowest level of dietary Ca intake was related to 23% significant decreased odds of MetS (OR = 0.77; 95% CI: 0.66, 0.89). Linear dose-response analysis of estimates from 12 investigations showed that each 100 mg/day increment in dietary Ca intake was associated with 3% marginally significant decreased odds in MetS (OR = 0.97; 95%CI: 0.93, 1.01). In nonlinear dose-response analysis of 12 studies with 67,896 participants, a significant association between dietary calcium intake and MetS was found (Pnonlinearity <0.001); such that 500 mg/day dietary calcium intake was related to maximum decrease in odds of MetS. According to this meta-analysis, the likelihood of MetS was significantly lower in adults with higher level of dietary calcium intake. Further large-scale prospective cohort investigations are needed to obtain stronger and more accurate results.

Insight into prostate cancer osteolytic metastasis by RelB coordination of IL-8 and S100A4.

Although RANK-LRANK interaction is essential for osteoclastogenesis, the mechanisms by which cancer cells invade bone tissues and initiate osteolytic metastasis remain unclear. Here, we show that the hyperactivation of RelB fosters prostate cancer (PCa) osteolytic metastasis by coordinating interleukin-8 (IL-8) and calcium-binging protein A4 (S100A4). The factors promoting PCa bone metastasis were investigated in sera from PCa patients and tumour tissues derived from nude mice using immunohistochemical analysis and enzyme-linked immunosorbent assays (ELISA). Cell mobility and mineralization were quantified using BioStation CT and Osteolmage assay. The relative cistrome was investigated in advanced PCa cells by standard transcriptional analyses, including the luciferase reporter response, site-directed mutagenesis, and chromatin immunoprecipitation (ChIP) assay. PCa cell-initiated tumour formation, expansion, and bone metastasis were validated in mice using multiple approaches, including orthotopic, intraskeletal, and caudal arterial implantation models. IL-8 and S100A4 correlated with patient Gleason scores and bone metastasis. RelB upregulated IL-8, facilitating androgen receptor (AR)-independent growth. RelB-Sp1 interaction enhanced epithelial-mesenchymal transition (EMT) by activating Snail and Twist. RelB-NFAT1c super-enhancer upregulated S100A4 in the organization of the cytoskeleton and bone metastasis. The RelB-IL-8-S100A4 signalling axis was confirmed to promote osteolytic metastasis in nude mice. RelB-IL-8 reciprocally promoted EMT by activating inflammatory signalling and inactivating AR signalling. IL-8 is essential for provoking PCa metastasis but insufficient to drive bone metastasis. IL-8-S100A4 cooperation was necessary for metastatic cells to target the bone. RelB activates inflammatory signalling by upregulating IL-8 and suppressing AR. RelB upregulates S100A4 by cooperating with NFATC1. IL-8 boosts EMT by activating Snail 1 and Twist 1, and S100A4 exacerbates osteolytic metastasis via calcium consumption. RelB harnesses IL-8 and S100A4 to drive PCa osteolytic metastasis.

Calcium deficiency and its implications for cardiovascular disease and cancer: Strategies for resolution via agronomic fortification.

Calcium (Ca) is a vital nutrient essential for structural development and signal transmission in both plants and animals. In humans, inadequate calcium intake has been correlated with various diseases, including osteoporosis, cardiovascular and cerebrovascular diseases, and cancer. In areas where plants serve as a main dietary source, calcium intake is significantly lower than the recommended adequate intake, notably in low- and middle-income countries (LMICs). Exploring the connections between calcium consumption and cardiovascular disease (CVD) and cancer has significant implications for public health, given that these two conditions are the primary contributors to global mortality. This study conducted a systematic review of existing literature to assess the evidence regarding calcium intake and its effect on blood pressure control, stroke prevention, and the controversial association with myocardial infarction. Furthermore, the preventive effect of calcium intake on tumor development, particularly in cancer prevention, was discussed. The study explores the potential of agronomic biofortification as a key strategy to enhance plant-based dietary calcium density and improve human health. By advocating for the incorporation of calcium-rich plants and plant-derived products, alongside appropriate calcium supplementation, the study emphasizes the economic and practical benefits of plants as a calcium source. This approach is aligned with global dietary patterns and socioeconomic disparities. The review also highlights the need for further research to better understand the mechanisms through which agronomic biofortification can increase dietary calcium intake and reduce the risks of CVD and cancer associated with calcium deficiency. Ultimately, this study aims to deepen our understanding of the complex relationship between calcium intake and health.

Recalibrating the Genetics and Epidemiology of Colorectal Cancer Consortium Environmental Risk Score for Use in US Veterans.

Risk for colorectal cancer may accumulate through multiple environmental factors. Understanding their effects, along with genetics, age, and family history, could allow improvements in clinical decisions for screening protocols. We aimed to extend the previous work by recalibrating an environmental risk score (e-Score) for colorectal cancer among a sample of US veteran participants of the Million Veteran Program. Demographic, lifestyle, and colorectal cancer data from 2011 to 2022 were abstracted from survey responses and health records of 227,504 male Million Veteran Program participants. Weighting for each environmental factor's effect size was recalculated using Veterans Affairs training data to create a recalibrated e-Score. This recalibrated score was compared with the original weighted e-Score in a validation sample of 113,752 (n cases = 590). Nested multiple logistic regression models tested associations between quintiles for recalibrated and original e-Scores. Likelihood ratio tests were used to compare model performance. Age (P < 0.0001), education (P < 0.0001), diabetes (P < 0.0001), physical activity (P < 0.0001), smoking (P < 0.0001), NSAID use (P < 0.0001), calcium (P = 0.015), folate (P = 0.020), and fruit consumption (P = 0.019) were significantly different between colorectal cancer case and control groups. In the validation sample, the recalibrated e-Score model significantly improved the base model performance (P < 0.001), but the original e-Score model did not (P = 0.07). The recalibrated e-Score model quintile 5 was associated with significantly higher odds for colorectal cancer compared with quintile 1 (Q5 vs. Q1: 1.79; 95% CI, 1.38-2.33). Multiple environmental factors and the recalibrated e-Score quintiles were significantly associated with colorectal cancer cases. A recalibrated, veteran-specific e-Score could be used to help personalize colorectal cancer screening and prevention strategies.

Association between dietary calcium and pregnancy induced hypertension

Background: Pregnancy induced hypertension (PIH) is one of the major complications of pregnancy. Inadequate calcium (Ca) intake is considered a public health problem in some vulnerable groups, especially pregnant women. A balanced diet during pregnancy with adequate Ca should be the ideal solution, and to proceed in this direction, evidence is required on the nature and extent of Ca deficiency in the diet of PIH mothers. Objectives: To assess the dietary intake of Ca in PIH (compared to non-PIH) mothers and to explore the factors affecting the intake of those nutrients. Methods: Under an observational case-control design, we recruited 300 Bangladeshi pregnant women in two groups (150 with and 150 without PIH), aged between 20-40 years (from 3 hospitals in Dhaka) at the 3rd trimester of pregnancy. A pre-tested questionnaire was used to collect the data. The first part of the questionnaire was allocated to general socio-demographic and clinical characteristics. Secondly, a food frequency questionnaire was used to estimate individual dietary Ca intake. Results: The dietary Calcium intake [(mg/day), median (range)] was significantly lower [265(111-487)] (p&lt;0.001) in the PIH compared to the non-PIH [350(201-984) ;(p&lt;0.001)] group. On bivariate analysis, the dietary Calcium intakes had a significantly negative correlation with mean blood pressure which was considered an indicator of the severity of PIH (r=-0.276; p&lt;0.001) for Ca. On regression analysis, PIH was found to be significantly associated with a lower intake of Ca (b=-0.009; p&lt;0.001) when the effects of age, family history of HTN and family income were adjusted. Conclusion: Dietary consumption of Calcium during pregnancy is much lower than those recommended in our population, PIH seems to have an association with dietary deficiency of Calcium in pregnant women. Bioresearch Commu. 10(2): 1612-1618, 2024 (July)

Inorganic phosphate additives in meals and adaptations to 5-days of dietary inorganic phosphate loading alter acute calcium homeostasis in two randomized cross-over studies in healthy adults.

Diets containing inorganic phosphate additives are unbalanced with respect to calcium and these diets have been linked to the development of altered bone metabolism. Using 2 randomized cross-over studies in healthy humans, we (1) characterized the hormonal and urinary response to 2 meals with the same reported phosphorus amount (562-572mg), where one was manufactured with inorganic phosphate additives and a comparatively lower Ca:P molar ratio (0.26 vs 0.48), and (2) assessed how acute homeostatic mechanisms adapt following 5-d exposure to recommended dietary phosphorus amount (~700mg P/d) compared to a diet enriched with inorganic phosphate additives (~1100mg P/d). Participants were then challenged with 500mg of oral phosphorus in the form of inorganic phosphate after an overnight fast following each diet condition. Measurements included serum calcium, phosphate, PTH, and fibroblast growth factor 23 , vitamin D metabolites, and urine calcium and phosphate excretion. Following the meal containing inorganic phosphate additives with a low Ca:P ratio, serum phosphate was higher and more phosphate was excreted in the urine compared to the low additive meal. Although the Ca:P and calcium content was lower in the high additive meal, the same amount of calcium was excreted into the urine. Subsequently, increasing only dietary phosphate through additives resulted in lower 24-h excretion of calcium. The oral phosphate challenge promoted urinary calcium excretion, despite no consumption of calcium, which was attenuated when pre-acclimated to a high phosphate diet. These data suggest that ingestion of inorganic phosphate promotes calcium excretion, but homeostatic mechanisms may exist to reduce calcium excretion that are responsive to dietary intake of phosphate. Future studies are required to evaluate potential implication of diets enriched with inorganic phosphate additives on bone health.

Multi-stage calcium-based chemical oxo-precipitation application to treat boron-containing flue gas desulfurization wastewater from coal-fired power plant

Chemical oxo-precipitation (COP) is a peroxo-aided process that was successfully applied to remove boron from the solution in the previous report. In this study, three-stage Ca-based COP was introduced to treat boron-contained flue gas desulfurization (FGD) wastewater that came from coal-fired power plants in Taiwan. Operating parameters, including pHi, [H2O2]i/[B]0, and [Ca]i/[B]0 (‘i’ represents the stage number) were optimized to reach the permissible effluent boron concentration of 5 mg/L. The effect of sulfate and magnesium in boric acid solution as the interference ions was preliminary investigated. The presence of sulfate and high magnesium concentration ([Mg]0/[B]0 > 0.5) are negatively affected the deboronation process due to the consumption of calcium and hydrogen peroxide, respectively, to form the unrequired precipitate. The optimum condition was resulting in residual boron concentration of 2.5 mg/L reached under the pH1 = pH2 = 10.5, pH3 = 11.0, [H2O2]1/[B]0:[H2O2]2/[B]0:[H2O2]3/[B]0 = 2:2:2, [Ca]2/[B]0:[Ca]3/[B]0 = 1.5:1. FTIR and RAMAN analysis show that most of the boron was removed via Ca(B(OH)3OOH)2 and CaB(OH)3OOB(OH)3 precipitation at 1st and 2nd stage. However, the predominated formation of metal peroxide, metal carbonate, and metal sulfate at 3rd stage provided different removal mechanism of boron through adsorption and co-precipitation. It can be concluded that Multi-stage Ca-based COP has a big potential to be applied to treat boron-contained industrial wastewater, but the re-adjustment is needed due to the varying concentration of wastewater components.

CALCIUM METABOLISM AND FEATURES OF ITS ABSORPTION IN THE BODY OF ATHLETES

Calcium is certainly one of the most important elements of the human body. Calcium is necessary for the transmission of nerve impulses, blood clotting, secretory activity, cell differentiation and death, the implementation of the immune response,some enzymatic processes, the process of muscle contraction, etc. The concentration of calcium in the blood can vary by no more than 3% and is subject to strict control by the homeostasis system, and is also regulated by the hormonal system.The level of calcium in the blood is regulated by two hormones, as well as calcitriol. In addition, the level of calcium in the blood can change under the influence of heavy metals. The process of calcium absorption and the processes of its removal from the body are influenced by many factors -the state of the hormonal system, the quality of food, the intensity of the training process, etc. At the same time, uncontrolled consumption of calcium by athletes entails extremely negative consequences.

Valorization of the Salmon Frame as a High-Calcium Ingredient in the Formulation of Nuggets: Evaluation of the Nutritional and Sensory Properties.

In the Chilean population, calcium consumption is deficient. Therefore, several strategies have been implemented to increase calcium intake, such as consuming dairy products and supplements. In this study, an ingredient composed of bone flour (BF) and protein hydrolysate (PH) obtained from salmon frame was used as an innovative source of calcium. The objective was to evaluate the effect of the incorporation of BF and PH in a 1:1 ratio (providing two calcium concentrations to the nuggets, 75 and 125 mg/100 g) on calcium content and sensory attributes of salmon nuggets submitted to baking or shallow frying. Proximal chemical analyses, fatty acid composition, calcium content, and sensory evaluation (acceptability and check-all-that-apply test) were tested in the nuggets. The incorporation of BF/PH (1:1) in both concentrations increased the calcium content of salmon nuggets being higher for the 125 mg/100 g. On the other hand, no negative effects were observed on sensory properties where all samples showed good overall acceptability for baked and fried nuggets. Therefore, the incorporation of BF/PH (1:1) into salmon nuggets enhances the nutritional quality of these products by providing a higher calcium content without significantly affecting their sensory properties.

Assessment of nutritional status, physical fitness and physical activity of school going adolescents (12–15 years) in Delhi

BackgroundAdolescence is a distinct period that is crucial for setting the foundation for long-term health.ObjectiveTo assess the nutritional status, physical fitness, and physical activity of adolescents.MethodsThe present cross-sectional study recruited 100 adolescents purposively. Information regarding general profile and lifestyle-related factors was collected using a questionnaire. Anthropometric data such as height, weight, BMI, and body fat% were collected using appropriate equipment. Physical fitness was assessed using a battery adapted from FITNESSGRAM® and PAQ-A assessed the physical activity. Dietary intake was analysed using a 2-day 24-hour dietary recall.ResultThe study revealed, 19% of the participants were overweight and 6% were obese. The majority (74%) were physically inactive and 15% had high body fat %. There was lower consumption of energy, carbohydrates, iron, and calcium, than the recommendations. Also, physical activity scores were negatively associated with macronutrient intake and trunk lift (strength and flexibility) [p < 0.05]. Data showed lower physical fitness scores. BMI and hand-grip strength was positively correlated [p < 0.05]. Push Ups (endurance) and Standing Broad Jump (power) showed a negative correlation with body fat%. Tennis ball throw and PACER (cardiorespiratory fitness) were positively associated with protein intake. A multiple regression analysis significantly showed that a unit increase in cell phone usage increases body fat% by 11.64 units. Standing broad jump increases by 38.6 cm and decreases with 28.76 cm with a unit increase in playing outside and tuitions timings respectively.ConclusionPoor nutritional status, physical fitness, and physical activity were reported among adolescents. It is imperative to plan intervention strategies to improve the overall health of adolescents.

Causal roles of educational duration in bone mineral density and risk factors for osteoporosis: a Mendelian randomization study.

Educational duration might play a vital role in preventing the occurrence and development of osteoporosis(OP). To assess the causal effect of educational duration on bone mineral density(BMD) and risk factors for OP by Mendelian randomization(MR) study. The causal relationship was analyzed using data from genome-wide association study(GWAS). Inverse variance weighting (IVW) was used as the main analysis method. Horizontal pleiotropy was identified by MR-Egger intercept test, MR pleiotropy residual sum and outlier (MR-PRESSO) test. The leave-one-out method was used as a sensitivity analysis. The IVW results indicated that there was a positive causal relationship between educational duration and BMD (OR = 1.012, 95%CI:1.003-1.022), physical activity(PA) (OR = 1.156, 95%CI:1.032-1.295), calcium consumption (OR = 1.004, 95%CI:1.002-1.005), and coffee intake (OR = 1.019, 95%CI:1.014-1.024). There was a negative association between whole body fat mass (OR = 0.950, 95%CI:0.939-0.961), time for vigorous PA (OR = 0.955, 95%CI:0.939-0.972), sunbath (OR = 0.987, 95%CI:0.986-0.989), salt consumption (OR = 0.965, 95%CI:0.959-0.971), fizzy drink intake (OR = 0.985, 95%CI:0.978-0.992), smoking (OR = 0.969, 95%CI:0.964-0.975), and falling risk (OR = 0.976, 95%CI:0.965-0.987). There was no significant association between educational duration and lean mass, time for light-to-moderate PA, milk intake, and alcohol intake. Horizontal pleiotropy was absent in this study. The results were robust under sensitivity analyses. A longer educational duration was causally linked with increased BMD. No causal relationship had been found between educational duration and lean mass, time for light-to-moderate PA, milk intake, and alcohol consumption as risk factors for osteoporosis.

Effect of a 12-week nutritional intervention in the food intake of patients on the waiting list for liver transplantation: A secondary analysis of a randomized controlled trial

BackgroundInadequate food intake contributes to malnutrition in patients with cirrhosis on the waiting list for liver transplantation (LTx). ObjectiveTo evaluate food intake during 12 weeks of nutritional follow-up and assess factors independently associated with the difference between caloric and protein intake in LTx patients. MethodsA secondary analysis of data from a randomized controlled trial that evaluated the effects of HMB supplementation in patients on a liver transplant waiting list. Dietary guidelines for patients with cirrhosis were used to prescribe the nutritional plan (35kcal/kg; 1.5g/kg dry weight for protein) and to evaluate the nutritional goals (30kcal/kg; 1.2g/kg dry weight for protein). Food intake was assessed in six moments: Baseline, week 0(W0), week 2(W2), week 4(W4), week 8(W8), and week 12(W12). ResultsForty-seven patients (55.0±10.6y;72.3% male) were evaluated. Only 25.5% (n=12) of patients achieve nutritional goals at the end of the study. The mean energy intake in baseline was 1782±784kcal (27.6±13.2kcal/kg) without difference between times. The protein intake increased between week W0 [63.4±29.8g; 0.8(0.2-2.2g/kg)] and W8 [72.0±28.0g; 1.0(0.4–2.6g/kg); p=0.03; p=0.03, respectively]. The consumption of cholesterol, calcium, phosphorus, magnesium, iron, and niacin increased (p<0.05), as well as the consumption of the leguminous; roots and tubers; dairy; and meat, poultry, and fish groups through the time (p<0.05). The presence of ascites, patients nourished, frailty index classification, short physical performance battery score, systemic symptoms, and emotional function were independently associated with the caloric intake difference W12-Baseline (p<0.05). Diabetes mellitus, patients with moderately malnourishment, poor performance, fatigue, systemic symptoms, and emotional function were independently associated with the difference in protein intake between W12-Baseline (p<0.05). ConclusionPatients on the liver transplant waiting list showed slight food intake improvement during the follow-up, but few met nutritional guidelines. Various clinical and nutritional factors independently affected energy and protein intake from W12 to baseline.

Severity of premenstrual symptoms among women with musculoskeletal pain: relation to vitamin D, calcium, and psychological symptoms.

Premenstrual syndrome (PMS) has various symptoms that occur during the luteal phase of the menstrual cycle and subside after menstruation. Anxiety and depression are prevalent in women with PMS and may exacerbate the severity of PMS. Vitamin D and calcium deficiency may have a role in developing anxiety, depression, and musculoskeletal pain (MSP). The aim of this study was to evaluate selected premenstrual symptoms in relation to serum vitamin D levels, daily calcium consumption, and psychological symptoms among women with MSP. The study population consisted of 108 women with MSP and 108 healthy controls. Information about premenstrual symptoms and calcium consumption were collected. Psychological symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS). Vitamin D was determined by electrochemiluminescence immunoassay. Women with MSP had lower serum vitamin D levels, lower daily calcium consumption, higher HADS scores for anxiety and depression, and higher frequency of severe premenstrual symptoms including fatigue, headache, irritability, mood swings, anxiety, depression, and social withdrawal compared to controls (P < 0.01). Abnormal HADS scores for anxiety and depression were associated with increased severity of premenstrual symptoms (P < 0.05). Deficient vitamin D and calcium consumption were associated with abnormal HADS scores for anxiety and depression (P < 0.05) and with increased severity of premenstrual headache, irritability, anxiety, and depression (P < 0.05). Low calcium consumption was associated with increased severity of premenstrual irritability, anxiety, depression, and social withdrawal (P < 0.05). The results suggest that vitamin D deficiency, low calcium consumption, psychological symptoms, and MSP could be interrelated and implicated in the etiology severe premenstrual symptoms. Further studies are necessary to assess whether vitamin D and calcium supplements can relieve MSP and premenstrual symptoms.

Nutrition Education Improves the Dietary Habits and Clinical Outcomes of Patients Undergoing Orthopedic Care

This study evaluated the effects of a well-organized nutrition education program on the dietary habits and clinical outcomes of patients with orthopedic conditions. A nutrition education program was implemented for 140 participants, focusing on the significance of proteins, calcium, vitamin D, and anti-inflammatory foods in the process of recovery. Food frequency questionnaires and 24-h dietary recalls were used to evaluate dietary habits, and routine orthopedic examinations were performed to determine clinical outcomes. The nutrition education program remarkably enhanced the consumption of proteins, calcium, and vitamin D (P &lt; 0.05), with substantial effect sizes indicating significant benefits relevant to clinical practice. The clinical results showed a reduction in the bone healing time and enhancements in muscle strength and overall progress in recovery (P &lt; 0.05) after the program. Importantly, there was a significant improvement in nutrition knowledge after the program, as seen by the 94% increase from low to moderate or high levels and the 98% increase from moderate to high levels (P &lt; 0.05). Hence, implementing the nutrition education program resulted in significant improvements in dietary behaviors and treatment outcomes among orthopedic patients, suggesting that inclusion of nutrition education in orthopedic treatment has a substantial impact on the recovery process.

Combined effect of dietary calcium consumption and physical activity on dental caries in children and adolescents: a study of the NHANES database

BackgroundCalcium (Ca) is a nutritional factor that associated with dental caries. A recent study showed that in the case of adequate Ca intake, a higher level of physical activity may contribute to bone mass accumulation. However, the combined effect between Ca intake and physical activity on caries experience is unclear. Herein, we aimed to explore the above combined effect on dental caries in children and adolescents.MethodsData of 5,917 children and adolescents were extracted from the National Health and Nutrition Examination Surveys (NHANES) database in 2015–2020 in this cross-sectional study. The NHANES assessed the dietary Ca intake through the 24-hour dietary recalls, and the physical activity level was self-reported using the questionnaires. Also, the dental caries was diagnosed according to the Decayed, Missing and Filled Teeth/Surfaces (DMFT/S) index. Weighted univariate and multivariate logistic regression analyses were utilized to screen the covariates and to investigate the associations of dietary Ca intake and physical activity with dental caries, respectively, and assess the combined effect between dietary Ca intake and physical activity on dental caries. The evaluation indexes were odd ratios (ORs) and 95% confidence intervals (CIs). Subgroup analyses of age, obesity, and total sugar intake were also performed.ResultsAmong the eligible participants, 2,687 had caries experience. After adjusting for the covariates, we found that children and adolescents who not reach the recommendation level of Ca intake combined with physical activity less than 7 time in 1 week seemed to have higher odds of dental caries [OR = 1.77, 95%CI: (1.38–2.27)], compared with those who reached the standards. In addition, this potential combined effect was also found in age < 12 years old [OR = 1.62, 95%CI: (1.23–2.14)], non-obesity [OR = 1.88, 95%CI: (1.49–2.35)], and total sugar intake (all P < 0.05) subgroups.ConclusionsCa intake and physical activity had a potential combined effect on dental caries in children and adolescents, but the causal relationships between them needed further clarification.

Dietary calcium, phosphorus, and potassium intake associated with erectile dysfunction in the National Health and Nutrition Examination Survey (NHANES) 2001 to 2004.

Erectile dysfunction is now a common disorder of sexual function, and its relationship to dietary calcium, phosphorus, and potassium has not been well studied. We set out to determine if dietary intakes of calcium, phosphorus, and potassium are related to erectile dysfunction in U.S. men. For this cross-sectional investigation, we used data from NHANES 2001-2004. To investigate the connection of dietary calcium, phosphorus, and potassium intake with erectile dysfunction, we employed multivariate logistic regression, smoothed curve fitting, and subgroup analysis. This cross-sectional study comprised 3,556 eligible male subjects in total, with a weighted mean age of 49.93±18.13 years. After controlling for race and age, the greatest tertile of calcium consumption was found to have a 34% lower risk of erectile dysfunction than the lowest tertile (OR = 0.66; 95% CI = 0.52-0.84; p = 0.0006). The risk of erectile dysfunction was found to be reduced by 33% (OR = 0.67; 95% CI = 0.52-0.87; p = 0.0024) for the highest tertile of phosphorus intake compared to the lowest tertile of phosphorus intake and by 35% (OR = 0.65; 95% CI = 0.50-0.83; p = 0.0006) for the highest tertile of potassium intake compared to the lowest tertile of potassium intake in the fully adjusted model. Erectile dysfunction and dietary consumption of calcium, phosphorus, and potassium are inversely associated with the U.S. population. To confirm the accuracy of our findings, additional prospective studies are necessary. Furthermore, it is imperative to do further fundamental research at the molecular level to gain a deeper understanding of the underlying mechanisms.

Expert opinions on the prevalence, diagnosis and treatment choice for osteoarthritis management in Indian settings

Studies have reported the capability of bisphosphonates to delay the progression of structural deterioration associated with osteoarthritis (OA). Limited studies exist regarding OA management in India and the determinants influencing patients' decisions regarding surgical interventions. So, this study aimed to assess the prevalence, diagnostic practices, and treatment options available for OA management in Indian clinical practice with a special focus on alendronate, a bisphosphonate medication for OA pain management. The cross-sectional, multiple-response questionnaire-based study collected a survey response using a 25-item questionnaire from 276 clinicians across India. Additionally, the survey focused on determining the diagnostic practices helpful in determining osteoporosis and the preference of treatment options for OA management. Based on the responses of 276 participants, 43% indicated that the diagnosis of OA was predominant in both genders. Moreover, about 51% of the respondents suggested that mass screening for osteoporosis in Indian patients should be conducted using the one-minute risk test developed by the International Osteoporosis Foundation. Additionally, 47% of the respondents highlighted hip fractures as the most common type of bone fracture observed in these patients. Furthermore, around 51% of the study participants emphasized that adequate calcium consumption during childhood can potentially reduce the incidence of osteoporosis. For the effective management of OA, alendronate was preferred by 49% of respondents over the other bisphosphonates.As per the expert consensus,patients who have osteoporosis risk factors and osteopenia without fragility fractures were recommended to adhere to dietary and lifestyle modifications, coupled with calcium and vitamin D supplementation, and bisphosphonate therapy. Alendronate was preferred over other bisphosphonates for the effective management of OA.