Consumption Of Anabolic Steroids Research Articles

Adverse effects of consumption of anabolic steroids on heart: An Experimental Study

Adverse effects of consumption of anabolic steroids on heart: An Experimental Study

The Benevolent Wen-Hepatocellular Adenoma

Hepatocellular adenoma emerges as a benign, solitary neoplasm of hepatocellular origin preponderantly arising within non cirrhotic hepatic parenchyma. Lesion occurs secondary to obesity, metabolic syndrome and consumption of anabolic steroids or non-contraceptive oestrogen supplements. Concurrent to genetic mutations, hepatocellular adenoma is categorized as hepatocellular adenoma associated with HNF1A genetic mutation, hepatocellular adenoma associated with β catenin genetic mutation, inflammatory hepatocellular adenoma, sonic hedgehog (SHH) hepatocellular adenoma or hepatocellular adenoma, not otherwise specified. Cytological assessment exhibits bland, uniform hepatocytes permeated with regular nuclei and decimated nucleocytoplasmic ratio. Tumefaction may display a pseudo-acinar arrangement, foci of steatosis and attenuated, mildly thickened one to two cell thick cell plates with a well-defined perimeter and characteristic unpaired arterial configurations. Hepatocellular adenoma appears immune reactive to HepPar1 or reticulin and immune non-reactive to glypican 3, CD34 or HSP70. Neoplasm requires segregation from neoplasms such as focal nodular hyperplasia, well differentiated hepatocellular carcinoma, mass effect due to an adjacent mass lesion, haemangioma, lymphoma, echinococcal cyst, hepatoblastoma, and localized fatty change or metastatic lesions arising from various primaries, confined to hepatic parenchyma. Hepatocellular adenoma may be appropriately managed with surgical extermination.

Assessment of the excretion of oxidative stress biomarkers and anabolic steroids based on sewage: A case study of college students and the general population

The use of wastewater-based epidemiology to evaluate the health and lifestyle of the population is a novel research interest. However, studies concerning the excretion of endogenous metabolites due to oxidative stress and the consumption of anabolic steroids have rarely been involved. In this study, we compared the effects of events such as final examination and sports meeting on the levels of four oxidative stress biomarkers (8-isoPGF2α, HNE-MA, 8-OHdG, and HCY) and four prohibited anabolic steroids (Testosterone, Androstenedione, Boldenone, and Metandienone) in sewage, using university students and urban populations as studying target. It was found that the per capita mass load of the four oxidative stress biomarkers 8-isoPGF2α, HNE-MA, 8-OHdG, and HCY in the sewage of Guangzhou urban area and university town were 256.6±76.1, 9.4±3.8, 1.1±0.5, and 0.9±0.4mg/d/1000, respectively. The mean mass load of 8-isoPGF2α was significantly higher than that before the COVID-19 pandemic (74.9±29.6mg/d/1000 people, P<0.05). The per capita load levels of oxidative stress biomarkers were significantly higher (P<0.05) during the 2022 exam week relative to the pre-exam period, indicating that the exams caused transient stress to students. The per capita mass load of androgenic steroids was 77.7mg/d/1000 people. There was an increase in the per capita load level of androgenic steroids during the provincial sports meeting. In this study, we quantified the concentration of oxidative stress biomarkers and androgenic steroids in the sewage and better realized the application of WBE on the health level and lifestyle of the population during special events.

ANABOLIC STEROID ABUSE AND CARDIOVASCULAR TOXICITY: CASE REPORT

Despite the development of tests for the detection of doping, Anabolic steroids, are still used to increase sports performance. Unfortunately, studies have clearly shown that overdose of anabolic steroids can induce serious cardiovascular complications that can be life-threatening. This implies the determining role of health professionals in informing the general population and athletes in particular about the lethal effect of these substances. We report the case of a young high-level athlete who consults for palpitations and in whom cardiac imaging reveals abnormalities related to chronic consumption of anabolic steroids.

The Effect of Resistance Training on Malondialdehyde and Protein Carbonyl Concentration in the Heart Tissue of Rats Exposed to Stanozolol

Background: Consumption of anabolic steroids causes damage to various tissues, including the heart. &#x0D; Objectives: This study aimed to investigate the effect of Resistance Training (RT) on Malondialdehyde (MDA) and Protein Carbonyl (PC) in the heart tissue of rats exposed to stanozolol (S).&#x0D; Methods: In this experimental study, 18 rats with the mean age of 8 weeks and weight range of 150 to 200 g were selected and divided into three groups of 6 rats: 1. Sham (normal saline consumption) (Sh), 2. S, and 3. S+RT. For 8 weeks, the S and S+RT groups received 5 mg/kg/d S, and the S+RT group performed 5 RT sessions per week. Measurement of MDA and PC in the heart tissue was performed with the enzyme-linked immunosorbent assay.&#x0D; Results: Stanozolol had a significant effect on increasing MAD (P=0.001) and PC (P=0.03) in the heart tissue. However, RT led to a decrease in MDA and PC in the heart tissue of rats exposed to S (P=0.001).&#x0D; Conclusion: It appears that S consumption leads to an increase in MDA and PC levels in the heart tissue, while RT can improve the elevated levels of MDA and PC.

GC–MS quantitative analysis of black market pharmaceutical products containing anabolic androgenic steroids seized by the Brazilian Federal Police

The use of counterfeit or substandard medicines can have an important health impact, resulting in therapeutic failure, be toxic or even cause death. Anabolic steroids are a frequent target for counterfeiters worldwide, being the second most frequent counterfeited class in Brazil. The aims of this work were to optimize and validate a GC-MS method for the quantitative determination of anabolic steroids in tablet, aqueous suspension and oil solution forms, and to analyze pharmaceutical products sent to Brazilian Federal Police (BFP) for forensic analysis. Sample preparation included extraction with methanol in ultrasonic bath followed by centrifugation. The method was successfully validated and 345 samples of pharmaceutical products were analyzed (328 medicines and 17 dietary supplements). About 42% of the medicines were counterfeits, 28.7% of tablets, 12.0% of suspensions and 65.2% of oil solutions; 11% were considered substandards. Five dietary supplements contained undeclared anabolic steroids, including two containing methandrostenolone at 5.4 and 5.8mg/capsule, equivalent to levels found in medicines. The proposed method is suitable for implementation in routine analysis for identification of counterfeits and substandard products. The analytical results show the need to raise awareness of consumers over the risks from the consumption of anabolic steroids from the clandestine market and for more incisive actions from government agencies aiming at decreasing the availability of these products.

EFECTOS SECUNDARIOS DERIVADOS DEL CONSUMO DE ESTEROIDES ANABÓLICOS EN EL DEPORTISTA

Anabolic androgenic steroids are chemically modified synthetic analogs of testosterone. Since they were discovered, at the beginning of the 20th century, they have been used extensively in professional sports, and more disturbing, in adolescents and young adults. Some current cultural values provide a thematic line that can lead to the consumption of these substances. The consumption of anabolic steroids represents a public health problem. Adverse effects have been extensively documented, affecting a multitude of systems. Among the most relevant, we can mention the adverse effects at cardiovascular, psychological, hepatic, reproductive, neuro-cognitive, genetic and musculo-skeletal. Despite evidenced findings, many of them irreversible, new studies are necessary for greater evidence´s matter.

The Risk of Hormone Anabolic Steroids and Oral Contraceptives Consumption in the Young

Introduction: The consumption of hormone anabolic steroids and oral contraceptives is a growing phenomenon difficult to quantify and accurately control due to partial recognition or hiding consumption and lack of knowledge of youth on this issue on the side effects as hypertension plays an important role with youth. Materials and methods: The study was conducted in ambulatory specialty in Clinical Hospital Oradea City, Bihor County, Internal Cabinet. It is a prospective longitudinal study conducted over a period of approximately three years. In this study a number of 321 young patients aged 18-35 years have been included who were diagnosed with hypertension: BP>140/90 mmHg confirmed in at least three repeated measurements in one week to exclude “white coat phenomenon”, which is very common especially with young women, or have a severe amount of BP ≥ 170/110 mmHg, at the first determination. Results and discussions: The consumption of oral contraceptives was 2.80% and that of anabolic steroids was present at 1.55% in young hypertensive in the study. Conclusions: The percentage of young hypertensive after consumption of anabolic steroids and ACO hormones (oral contraceptives), with young women can be completely canceled by avoiding consumption of information and youth programs on the subject, they run the risk of consuming them.

La consommation d’anabolisants à l’adolescence. Quelle réalité ? Quelle signification ?

Based on three national surveys (European School Survey on Alcohol and Other Drugs [ESPAD] 1999, ESPAD 2003, ESPAD 2007) on a representative sample of 16-year-old young people (N > 2500 for each survey), the author has observed an increase in the consumption of anabolic steroids, more important among girls (from 0.6% in 1999 to 1.6% in 2007, P Language: fr

Consumption of anabolic steroids in sport, physical activity and as a drug of abuse: an analysis of the scientific literature and areas of research

Objective:The consumption of anabolic steroids (AS) has been growing continuously in recent years. It has gone beyond the sports world; AS are now widely used as drugs of abuse in...

Esteróides anabólicos androgênicos

There are evidences of the increase in the consumption of anabolic steroids and the damages to health caused by their indiscriminate use, mainly among children and youngsters. The anabolic-androgenic steroids (AAS) consist in testosterone and its derivatives. They are produced endogenously in the testicles and adrenal cortex and are responsible for the secondary sexual characteristics associated to masculinity. Although the results of the exogenous use of AAS are still controversial, they have been used for the increase of physical strength and muscle mass. These substances are directly related to different clinical conditions such as: bladder cancer, coronary disease, gynecomastia, hepatic disorders and cancer, and sterility. This study aimed at approaching relevant topics related to the drugs action mechanisms, ways of use and metabolism, and side effects, besides the importance of the prevention in the use of those drugs in most diverse age groups. The abusive use of anabolic-androgenic steroids consists in a problem that has gradually occurred, which has given rise to laws, rules and support groups turned to the prevention, education and restriction of their use

Prevalence of anabolic steroids usage by physical education students in the city of Campos dos Goytacazes

Despite current therapeutic use, steroids are important targets in drugs abuse by athletes, and have, more recently, become popular among young people. This survey aimed at assessing the use of anabolic steroids by Physical Education students. The study group was made up of n = 248 of subjects. The group answered a questionnaire on consumption of anabolic steroids. Results indicated high consumption of anabolic steroids. Individuals preferred Deca (21%). Findings allowed concluding that students consume high amounts of anabolic steroids probably due to ignorance and unawareness of the benefits and damages of those products.

Uso de álcool, tabaco e drogas por estudantes da área de saúde de uma Universidade de Curitiba

The aim of this research was to investigate the consumption of alcohol, tobacco and other drugs by students of health services from a private university in Curitiba, the state capital of Parana, Brazil. The sample was composed of 538 students between 18 and 54 years old, taking major degrees in Physical Education, Physiotherapy, Nutrition and Psychology. An anonymous self-completed questionnaire has been used to collect socio-demographic data and to identify patterns of non-medical use of psychoactive drugs, as well as getting information about the history of use of these substances. The results have shown an elevated consumption of alcohol and tobacco, mostly from Physical Education and Psychology majors, which have also stood out as consumers of others substances. An elevated consumption of anabolic steroids by the students of Physical Education and a high consumption of amphetamines in Nutrition and Physiotherapy majors was detected. Concerning the history of consumption, friends and acquaintances have been pointed out as the main inductors for these kinds of substances and as regular company when consuming the drugs, recreation and pleasure have been highlighted as the motives for using the drugs for the first time, and breaking up routines, to enjoy the effects and to reduce anxiety/stress are highlighted as motives to maintain consumption. Around 30% of the students have used one or more substances before attending university.

Anabolizantes esteroideos y ginecomastia: Revisión de la literatura

Gynaecomastia is a common situation, with a proliferation of glandular component of male breast secondary to an imbalance in sexual hormones in mammary tissue. A main cause of gynaecomastia is anabolic steroids consumption. Few studies have been performed in patients with high consumption of anabolic steroids, showing a high prevalence (52%). In this article we present a case of bilateral gynaecomastia secondary to anabolic steroids intake, with a partial response to tamoxifen. In summary, a patient with sportive habits and gynaecomastia, an early suspicious diagnosis is anabolic steroid intake. After suppression of anabolic steroid intake and treatment with tamoxifen, a high remission rate can be achieved. If gynaecomastia persisted, surgery is a good option.