An effective strategy for optimizing indoor air distribution in stratum ventilation heating systems under different types of human activity has been proposed, in order to provide appropriate thermal comfort while exploiting the potential for energy savings. The stratum ventilation was optimized using strategy 1 (the optimization strategy of three ventilation performance indicators based on VlseKriterijumska Optimizacija I Kompromisno Resenje (VIKOR)), the strategy 2 (the optimization strategy with constraint based on VIKOR) and the strategy 3 (the optimization strategy aimed at energy conservation), respectively. These strategies provide optimal indoor air distribution within a stratum ventilation system that is influenced by various factors (i.e. supply air temperature, supply air vane angle, supply air velocity, metabolic rate, clothing insulation and outdoor air temperature). Firstly, the parameters of the stratum ventilation system are obtained using Computational Fluid Dynamics (CFD) software. In addition, using the simulation results as input variables, predictive models of ventilation performance (i.e., PMV, local mean air age (LMAA) and energy consumption) was developed using Artificial Neural Network (ANN). Finally, by optimizing the proposed ANN based strategy 1, strategy 2 and strategy 3, the ventilation performance is output. The proposed strategy 1 provides a comfortable indoor environment and saves energy, and compared to the strategy 1, the strategy 3 saves more energy while ensuring that thermal comfort meets the requirements. In addition, considering the optimization of clothing insulation while providing appropriate thermal comfort also indirectly saves energy. Moreover, these strategies also work well as the outdoor air temperature changes.