Capacity Consumption Research Articles

Abstract 45: Driving AMPK signaling in CD4+ CART cells enhances metabolic capacity, memory formation, and anti-leukemia activity

Abstract Background: While Chimeric Antigen Receptor (CAR)T cell therapy has seen great success in pediatric and young adult acute lymphoblastic leukemia, up to 50% of patients will relapse following treatment. Increased memory formation and mitochondrial capacity, particularly in the CD4+ subset, have been linked to improved CART cell function and enhanced in vivo persistence, leading to long-term relapse-free survival. AMP-activated protein kinase (AMPK) is a cellular energy sensor responsible for promoting metabolic efficiency and T cell memory formation. We have previously demonstrated AMPK activity can be increased in human T cells via overexpression of the AMPKγ2 domain. We hypothesized that overexpression of AMPKγ2 in CART cells would enhance their metabolic capacity and improve their anti-leukemia function. Methods: Human CART cells bearing a CD19-CAR utilizing a 41BB costimulatory domain were generated from healthy human donors via lentiviral transduction and co-transduced with AMPKγ2 (AMPK) or an empty vector (EV) control. Flow sorting for the co-transduced populations yielded >95% CD4+ CART cells. CARTs were expanded in IL-2 for approximately 2 weeks, followed by overnight stimulation and subsequent metabolic analysis using the Seahorse Metabolic Analyzer. Memory status was assessed by CD62L and CCR7 co-expression. In vitro CART function was assessed using Zs-green+ NALM6 targets, with loss of green fluorescence over time measured on the Incucyte analyzer. Where indicated, tumor conditioned media was harvested from 72-hour NALM6 cultures. For in vivo experiments, immunodeficient NOD-scid IL2Rγnull (NSG) mice were injected with luciferase+ NALM6 targets, followed one week later by AMPK- or EV-CARTs. Leukemia burden, via IVIS imaging, and survival were followed over time. Results: CD4+ CARTs co-transduced with AMPKγ2 (AMPK-CARTs) increased oxygen consumption, maximal respiration, and spare respiratory capacity following overnight stimulation by ~20% compared to CARTs co-transduced with the EV (EV-CARTs) (p<0.05). Following expansion, CD62L+CCR7+ central memory cells were 4.5-fold more abundant in the AMPK-CART group (2.4-6.2-fold, p<0.01). In vitro, while AMPK-CARTs demonstrated similar cytotoxicity against NALM6 targets as EV-CARTs in standard media, they mediated faster killing of NALM6 targets when challenged in tumor conditioned media (p<0.001). In vivo, recipients of AMPK-CARTs showed a consistent decrease in tumor burden as measured by median radiance values, translating to a significant survival advantage (p<0.05). Conclusions: Increasing AMPK signaling in CD4+ CARTs via overexpression of AMPKγ2 improved metabolic profile, increased memory generation, and enhanced toxicity against leukemia targets both in vitro and in vivo. Together, these features make elevating AMPK signaling an attractive method to increase the efficacy of CART therapy. Citation Format: Erica Braverman, Herbert Schuler, Mengtao Qin, Craig Byersdorfer. Driving AMPK signaling in CD4+ CART cells enhances metabolic capacity, memory formation, and anti-leukemia activity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 45.

Does Economic Stability Influence Family Development? Insights from Women in Korea with the Lowest Childbirth Rates Worldwide

The aim of this study is to explore the multidimensional relationships among factors influencing decision-making processes regarding women’s willingness to marry and childbirth in South Korea with recognizing the context of family development in East Asian cultures. To this end, we employed three different analytical approaches, including classification tree modeling, Cox proportional hazard modeling, and permutation feature importance evaluation. Leveraging longitudinal data specific to Korean women, we highlighted the significance of socio-economic factors in family development dynamics. Our findings revealed that financial stability played a crucial role. Unmarried women’s willingness to marry was influenced by their perspectives on economic stability, while households’ consumption capacity and financial capability determined childbirth decisions and timing. We observed a trend of postponed marriage among women in their marriageable age range, particularly those with stable economic situations, reflecting a prevalent trend of skepticism of marriage in Korean society. Additional findings related to values, cultural factors, and personal happiness also suggested the challenges that discourage younger generations from entering into marriage and starting families in South Korea. By offering insights into these dynamics, our study provides practical implications for addressing the obstacles faced, contributing to a better understanding of family development dynamics.

N2O consumption, uptake, and microbial reduction processes in flooded sandy loamy paddy soils

AbstractSandy loamy soils are widely distributed in fluvial floodplains and experience flooding events frequently, resulting in a large amount of nitrous oxide (N2O) emissions. This case is more serious when the soil use is changed to paddies. It is of great significance to figure out the N2O consumption and its influencing factors in sandy loamy paddy soils to mitigate N2O emissions. In this study, three sandy loamy paddy soils (0–5 cm) originated from lake deposits were selected (S1, S2, and S3) as objectives. A certain concentration of exogenous N2O was added at the bottom of the flooded soil column to monitor the dynamics of N2O and nitrogen (N2) on the soil surface. Total N2O consumption, N2O uptake, and N2 production were quantified, and the abundance of nitrous oxide reductase genes (nosZI, and nosZII) and other soil properties (ammonium‐nitrogen, nitrate‐nitrogen, and dissolved organic carbon [DOC] content) were analyzed. The results showed that the sandy loamy paddy soil column with a depth of 0–5 cm could intercept more than 95% of the exogenous N2O under the flooded anaerobic condition, indicating that the three sandy loamy paddy soils all had extremely strong N2O consumption capacities. And the increment of N2 accounted for 68.73%–76.09% of the total N2O consumption, which had a stronger relationship with the increase of nosZI gene abundance than nosZII gene. In addition, the total N2O consumption and N2 increment of S1 and S3 soils were significantly higher than those of S2 soil. This difference was mainly related to soil organic matter content, total nitrogen content, DOC consumption, and the increase of nosZI gene abundance (p < 0.05). The strong N2O consumption potential of sandy loamy soils can provide feasible solutions for regulating N2O emissions in a wide range of similar environments in fluvial floodplains.

Resilience, efficiency fluctuations, and regional heterogeneity in disaster: An empirical study on logistics

While resilience analysis can provide important insights into risk management strategies, research gaps exist in terms of logistics efficiency, regional economic environment, and spatial clustering patterns. Therefore, our study capitalizes on the dramatic variations in logistics activities among regions during COVID-19 to examine regional logistics resilience in the disaster and explore potential spatial clustering patterns. We measure regional logistics resilience through changes in performance outcomes, specifically efficiency fluctuation. To analyze spatial clustering patterns, (regional heterogeneity) presented by logistics efficiency, we propose a new multi-stage approach that integrates the data envelopment analysis with the K-medoids algorithm and analyzes data from the Chinese logistic industry. The results reveal that efficiency fluctuations exhibit distinct spatial distribution characteristics, with more pronounced negative fluctuations in areas of important logistics activities nodes and islands, and more widespread negative trends in coastal areas. Moreover, regions with high freight volumes and logistics specialization demonstrate a sustained high level and quality of logistics efficiency. Furthermore, consumption capacity and economic development appear to positively influence fluctuations in logistics efficiency. The findings hold implications for enhancing regional logistics resilience in the disaster and contribute valuable insights to regional logistics risk management.

MiR-548ag promotes DPP4 expression in hepatocytes through activation of TLR(7/8)/NF-κB pathway

ObjectiveIn our previous study, we identified a notable increase in miR-548ag content after obesity, which contributes to the progression of Type 2 diabetes Mellitus(T2DM) through the up-regulation of Dipeptidyl Peptidase-4(DPP4) expression within the liver. However, the precise molecular mechanisms underlying the upregulation of DPP4 by miR-548ag remain elusive. Mature miRNAs rich in GU sequences can activate the TLR(7/8)/NF-κB signalling pathway, which transcriptionally activates DPP4 expression. Notably, the proportion of GU sequences in hsa-miR-548ag was found to be 47.6%. The study proposes a hypothesis suggesting that miR-548ag could potentially increase DPP4 expression in hepatocytes by activating the TLR(7/8)/NF-κB signalling pathway.MethodsMale C57BL/6J mice were fed normal chow diet (NCD, n = 16) or high-fat diet (HFD, n = 16) for 12 weeks. For a duration of 6 weeks, NCD mice received intraperitoneal injections of a miR-548ag mimic, while HFD mice and db/db mice (n = 16) were administered intraperitoneal injections of a miR-548ag inhibitor. qRT-PCR and Western Blot were used to detect the expression level of miR-548ag, DPP4 and the activation of TLR(7/8)/NF-κB signalling pathway. HepG2 and L02 cells were transfected with miR-548ag mimic, miR-548ag inhibitor, TLR7/8 interfering fragment, and overexpression of miR-548ag while inhibiting TLR7/8, respectively.Results(1) We observed elevated levels of miR-548ag in the serum, adipose tissue, and liver of obese mice, accompanied by an upregulation of TLR7/8, pivotal protein in the NF-κB pathway, and DPP4 expression in the liver. (2) miR-548ag promotes DPP4 expression in hepatocytes via the TLR(7/8)/NF-κB signalling pathway, resulting in a reduction in the glucose consumption capacity of hepatocytes. (3) The administration of a miR-548ag inhibitor enhanced glucose tolerance and insulin sensitivity in db/db mice.ConclusionsMiR-548ag promotes the expression of DPP4 in hepatocytes by activating the TLR(7/8)/NF-κB signalling pathway. MiR-548ag may be a potential target for the treatment of T2DM.

Research on the Problem of Elderly Consumption Under the Background of Population Aging

With the continuous progress of medical technology and the gradual improvement of the social security system, the life expectancy of the elderly in China has been significantly extended and the number of people has increased sharply. At the same time, with the transformation of the consumption capacity and consumption concept of the elderly population, the consumption of the elderly contains great potential for development and is expected to become an important part of the future consumer market. By sorting out and analyzing the existing literature, this paper points out the characteristics of China’s elderly consumption market under the background of population aging, analyzes the spatial evolution trend of elderly consumption, and summarizes the existing problems of elderly consumption. Lastly, according to the above analysis, this paper puts forward corresponding suggestions from the government, enterprises, and non-profit organizations.

Quantitative and qualitative yield loss caused by red deer (Cervus elaphus L.) grazing on permanent organic grasslands

ABSTRACT This paper addresses yield loss due to red deer (Cervus elaphus) grazing on permanent grasslands on three organic farms in SE Slovenia over two consecutive years. Deer graze on permanent grasslands throughout the year, but the resulting crop loss varies during the growing season. Accounting for three mowings, the quantitative yield loss due to deer grazing totalled 48–52%, or 3.9–4.3 t/ha. Deer had the highest consumption capacity in the spring (first mowing: yield loss of 1.7–1.9 t of air-dried hay/ha), and towards the end of the growing season, consumption decreased (third mowing: loss of 0.9 t/ha). A floristic inventory indicated low species diversity and production in permanent grasslands in SE Slovenia. The crude protein content in unprotected plots was generally greater than that in protected plots, but due to a large quantitative yield loss, the yield of crude protein and net energy for lactation on heavily grazed land were much lower than those on protected land in all mowings. The average additional cost per unit of heavily grazed area ranged from 182 to 344 EUR/ha, and the differences are the result of the different intensities of game grazing in individual locations and grassland production capacities.

Seismic response and failure mechanism of ordinary concrete and UHTCC short columns reinforced with negative Poisson's ratio steel bars

The replacement of ordinary steel bars by negative Poisson's ratio (NPR) steel bars to improve the seismic performance of short columns is investigated in this study. NPR steel bars is a new type of reinforcement with negative Poisson's ratio effect and high strength and ductility. In this paper, six short column members were designed. Among them, P-RC1 and P-UHTCC1 short columns were used as controls, and the remaining four specimens were reinforced by NPR steel bars. The failure mode, cracking pattern, hysteresis characteristics, plastic deformation capacity, shear strength, stiffness degradation and energy dissipation capacity of the specimens were investigated through lateral cyclic loading tests. The experimental results showed that the shear capacity of short concrete columns reinforced with NPR steel bars increased by 20.91%−22.64% and the cumulative energy dissipation capacity increased by 45.7%−63.3%. The short UHTCC columns reinforced with NPR steel bars showed an increase in shear capacity of 23.08%−35.48% and an increase in cumulative energy consumption capacity of 17.3%−28.5%. And the RC columns shear strength prediction model based on GB50010–2010 specification is relatively reasonable to be used for the evaluation of shear strength of short columns reinforced with NPR steel bars.

Integrated energy system scheduling optimization considering vertical-axis wind turbines and thermal inertia in oilfield management areas

Traditional horizontal-axis wind turbines (HAWTs) have limited efficiency in low-wind speed regions. In this paper, an integrated energy system (IES) incorporating vertical-axis wind turbines (VAWTs) is proposed; this IES is located in an oilfield management area, which can utilize the low-wind speed resources more efficiently and improve renewable energy consumption, and it also introduces a demand response model based on thermal inertia (TI), thus smoothing out the volatility caused by the VAWT. Typical output scenarios are obtained through stochastic optimization to deal with wind turbine and photovoltaic output uncertainties, and an optimal scheduling model is proposed to minimize the system operating cost. Finally, a simulation study was conducted in a micro-oilfield management area in Shandong Province, China, to demonstrate the performance of the proposed system. The results show that the IES using a VAWT and TI can increase the renewable energy consumption capacity by 87% over the conventional HAWT system, change the user behavior, increase the economic efficiency by 12%, and achieve the smoothing of load-side fluctuation of electric and thermal loads, peak shaving, and valley filling. This paper provides a feasible solution for an IES in low-wind speed areas.

Coordinated planning of DGs and soft open points in multi‐voltage level distributed networks based on the Stackelberg game

AbstractThere are significant differences in distributed generators (DGs) distribution and load characteristics between different voltage levels, which makes it difficult to match sources and loads. We focus on the problem of different consumption capacities at different voltage levels and the divergence of interests among investment entities, and propose a coordinated planning model for DGs and soft open points (SOPs) based on the Stackelberg game. Firstly, a model of a multi‐voltage level distribution networks (DNs) is constructed based on SOPs. Next, the source‐load matching degree is proposed as a measure of the degree of matching between sources and loads in the DN, and the source‐load consumption rate is selected as an indicator to evaluate the impact of the load on DG consumption. Following this, the interest demands of DG investors and distribution company (DisCo) in multi‐voltage levels DN are analyzed, a planning mode based on the Stackelberg game is proposed, and this is solved by combining the genetic algorithm with second‐order cone programming. Finally, the effectiveness of the planning model is tested and verified using an improved IEEE 28‐node system. The results show that the proposed model improves the DG consumption capacity of DNs with multiple voltage levels while protecting the interests of DG investors and DisCo.

Fixed and mobile energy storage coordination optimization method for enhancing photovoltaic integration capacity considering voltage offset

Mobile energy storage has the characteristics of strong flexibility, wide application, etc., with fixed energy storage can effectively deal with the future large-scale photovoltaic as well as electric vehicles and other fluctuating load access to the grid resulting in the imbalance of supply and demand. To this end, this paper proposes a coordinated two-layer optimization strategy for fixed and mobile energy storage that takes into account voltage offsets, in the context of improving the demand for local PV consumption. Among them, the upper layer optimization model takes into account the minimum operating cost of fixed and mobile energy storage, and the lower layer optimization model minimizes the voltage offset through the 24-h optimal scheduling of fixed and mobile energy storage in order to improve the in-situ PV consumption capacity. In addition, considering the multidimensional nonlinear characteristics of the model, the interaction force of particles in the Universe is introduced, and the hybrid particle swarm-gravitational search algorithm (PSO-GSA) is proposed to solve the model, which is a combination of the individual optimization of the particle swarm algorithm and the local search capability of the gravitational search algorithm, which improves the algorithm’s optimization accuracy. Finally, the feasibility and effectiveness of the proposed model and method are verified by simulation analysis with IEEE 33 nodes.

A revision of maximal oxygen consumption and exercise capacity at altitude 70 years after the first climb of Mount Everest.

On the 70th anniversary of the first climb of Mount Everest by Edmund Hillary and Tensing Norgay, we discuss the physiological bases of climbing Everest with or without supplementary oxygen. After summarizing the data of the 1953 expedition and the effects of oxygen administration, we analyse the reasons why Reinhold Messner and Peter Habeler succeeded without supplementary oxygen in 1978. The consequences of this climb for physiology are briefly discussed. An overall analysis of maximal oxygen consumption ( ) at altitude follows. In this section, we discuss the reasons for the non-linear fall of at altitude, we support the statement that it is a mirror image of the oxygen equilibrium curve, and we propose an analogue of Hill's model of the oxygen equilibrium curve to analyse the fall. In the following section, we discuss the role of the ventilatory and pulmonary resistances to oxygen flow in limiting , which becomes progressively greater while moving toward higher altitudes. On top of Everest, these resistances provide most of the limitation, and the oxygen equilibrium curve and the respiratory system provide linear responses. This phenomenon is more accentuated in athletes with elevated , due to exercise-induced arterial hypoxaemia. The large differences in that we observe at sea level disappear at altitude. There is no need for a very high at sea level to climb the highest peaks on Earth.

Dynamic optimal control strategy for distributed electric heating system under electricity pricing lever

To address wind curtailment, a method is proposed to improve wind power consumption by controlling user demand response. Considering residents’ comfort demand for heating in winter, a distributed electric heating system is established and an optimal control model is established to enhance wind power consumption capacity. By considering the influence of electricity price and comparing the optimal model under basic tariffs, time-of-use and real-time tariffs, a dynamic optimal control method for distributed electric heating systems driven by electricity price leverage is proposed. The simulation results show that the method can effectively guide electric heating users to actively participate in load regulation, significantly improve wind curtailment and ensure economic and stable power grid operation. Using different electricity prices as leverage can systematically incorporate a large number of distributed electric heating users into the controllable load of wind power consumption, providing a new method for large-scale wind power consumption.

Optimal scheduling for wind-solar-hydro hybrid generation system with cascade hydropower considering regulation energy storage requirements

Large-scale integration of renewable energy into the grid can lead to significant changes in the net load, peak-to-valley difference, peak and valley occurrence time of the power system. As a result, the power of hydropower plants must take a rapid adjustment response. Aiming at the coordinated operation of multiple energy sources, such as wind power, solar power, cascade hydropower station and energy storage pumping station, a coordinated scheduling model is proposed which can fully improve the consumption capacity of wind and solar power by aiming at the maximum power generation, minimum net load fluctuation and minimum wind and solar abandonment. Through the configuration of three different pumping station capacities, the influence of energy storage pumping station capacity on the complementary power generation system is analyzed. When the pumping station capacity is large enough, the output of the wind and solar can be completely consumed. The studies show that the cascade power station and pump energy storage regulation have a strong net load filling valley effect, which can effectively reduce the impact of wind and solar access on system operation, maintain the efficient and stable operation of the unit, and ensure the absorption rate of renewable energy.

Spreading potential and spatial layout of circulating fluidized bed in China under the background of low-carbon development

Abstract Circulating fluidized bed (CFB) technology plays a pivotal role as a clean thermal power generation technology in China. This paper delves into the prospective development potential and strategic deployment of CFB technology within the country. Initially, an integrated intelligent algorithm is devised to forecast future coal consumption. Leveraging the projected scope of existing CFB installations and the estimated volume of waste products from coal production, the development capacity of China’s CFB sector is quantitatively assessed. Subsequently, the regional deployment of CFB technology is examined. The projections indicate that coal production will likely range from 0.79 to 1.44 billion tons by 2030 and 1.23 to 2.30 billion tons by 2040. Furthermore, the ‘waste’ output from coal is anticipated to reach 700 to 900 million tons in 2020, escalating to 900 million to 1.2 billion tons by 2030. CFB technology exhibits a robust capacity for waste consumption, currently accounting for approximately 20% to 25% of the actual coal production. Spatially, North China presents the greatest development potential, while Northeast China shows the least, and South China experiences a declining demand. In the future spatial distribution, both coal-producing regions and environmental conservation considerations must be given due attention.

Differential consumption of malic acid and fructose in apple musts by Pichia kudriavzevii strains.

To assess the capability of Pichia kudriavzevii strains isolated from wine, cider, and natural environments in North Patagonia to produce ciders with reduced malic acid levels. Fermentation kinetics and malic acid consumption were assessed in synthetic media and in regional acidic apple musts. All P. kudriavzevii strains degraded malic acid and grew in synthetic media with malic acid as the sole carbon source. Among these strains, those isolated from cider exhibited higher fermentative capacity, mainly due to increased fructose utilization; however, a low capacity to consume sucrose present in the must was also observed for all strains. The NPCC1651 cider strain stood out for its malic acid consumption ability in high-malic acid Granny Smith apple must. Additionally, this strain produced high levels of glycerol as well as acceptable levels of acetic acid. On the other hand, Saccharomyces cerevisiae ÑIF8 reference strain isolated from Patagonian wine completely consumed reducing sugars and sucrose and showed an important capacity for malic acid consumption in apple must fermentations. Pichia kudriavzevii NPCC1651 strain isolated from cider evidenced interesting features for the consumption of malic acid and fructose in ciders.

Optimal scheduling of the CSP–PV–wind hybrid power generation system considering demand response

In order to solve the problem of there being a high proportion of wind and photovoltaic (PV) abandonment in the new energy system, an optimal dispatching method of concentrated solar power (CSP)–PV–wind hybrid power generation considering demand response is proposed. First, on the basis of the combination of wind and PV power stations and CSP stations, electric heating (EH) devices are used to convert unconsumed wind and PV power into thermal energy stored in the thermal storage system of the CSP station. Second, based on the difference in response time and response volume of customers, a stepped incentive-based demand response (IBDR) approach is introduced. Thus, a CSP–PV–wind power optimal dispatch model taking into account IBDR is established to achieve coordinated source-load dispatch. Finally, the CPLEX solver is invoked to optimize day-ahead scheduling with the goal of the lowest system comprehensive cost. Example analysis is used to confirm the proposed method’s usefulness in enhancing the system’s wind and PV power consumption capacity and reducing the system’s comprehensive cost.

Where Is the Path to Sustainable Marine Development? Evaluation and Empirical Analysis of the Synergy between Marine Carrying Capacity and Marine Economy High-Quality Development

Enhancing the marine carrying capacity (MCC) is of important value in hastening the transformation of the marine economy and realising the marine economy high-quality development (MEHD). We explore the synergistic mechanism between the MCC and MEHD and its comprehensive indicator system, measure the synergistic relationship between China’s MCC and MEHD from 2006 to 2020 using the improved TOPSIS model and the composite system synergism model, and explore the influencing factors and their interactions using geographic probes. The research findings are (1) that China’s MCC and MEHD show a growing trend during the study period, in which marine green development is at a higher level and the cultivation of marine knowledge improves most significantly, but the general value of the MEHD is relatively low. (2) In terms of the synergistic relationship, the degree of ordering of the two shows a sustained rising trend, and the degree of ordering of the marine economy development as a whole is higher than the MCC; the degree of synergy is increasing, but the general value of synergistic development is low. (3) The main factors driving the MCC and MEHD are the marine consumption capacity, the marine opening, and the marine industrial structure; the explanatory power of most factor interactions tends to decrease, and the explanatory power of the interactions among the development of land-based economy, the marine industry structure, and the marine economy increase, and the impacts of the different factor interactions on the synergistic development are all greater than the factors. The influence of different factors on synergistic development is greater than the influence of each factor alone.

Parametric Study and Optimization of Hydrogen Production Systems Based on Solar/Wind Hybrid Renewable Energies: A Case Study in Kuqa, China

Based on the concept of sustainable development, to promote the development and application of renewable energy and enhance the capacity of renewable energy consumption, this paper studies the design and optimization of renewable energy hydrogen production systems. For this paper, six different scenarios for grid-connected and off-grid renewable energy hydrogen production systems were designed and analyzed economically and technically, and the optimal grid-connected and off-grid systems were selected. Subsequently, the optimal system solution was optimized by analyzing the impact of the load data and component capacity on the grid dependency of the grid-connected hydrogen production system and the excess power rate of the off-grid hydrogen production system. Based on the simulation results, the most matched load data and component capacity of different systems after optimization were determined. The grid-supplied power of the optimized grid-connected hydrogen production system decreased by 3347 kWh, and the excess power rate of the off-grid hydrogen production system decreased from 38.6% to 10.3%, resulting in a significant improvement in the technical and economic performance of the system.

Retrofitting of squat RC column by using TRM strip under axial load

This study investigates the retrofitting of reinforced concrete columns with TRM strips. Seventeen test specimens were produced, and one was chosen as a reference test specimen. Damaged by loading up to 50% of their maximum axial load-carrying capacity test specimens were retrofitted with two different carbon textiles. In addition to the textile type, TRM strip width, strip spacing, and the use of anchors were determined as experimental variables. Maximum bearing capacity, displacement at bearing capacity, initial stiffness, displacement ductility ratio, and energy consumption capacity were calculated using the axial load-displacement graphs obtained from the experimental study. Depending on the obtained results, the effects of experimental variables on the behavior of damaged reinforced concrete columns were interpreted and compared. It has been determined that the retrofitting method presents very successful results. It has been observed that the fan-type anchor, which is rarely used in literature studies, significantly increases the maximum bearing capacity and energy consumption capacity values of test specimens. Finally, the experimental results were compared with those obtained from the numerical models created by the ABAQUS finite element software.