Alcohol Consumption Research Articles

ALCOHOL-ASSOCIATED LIVER DISEASE: NATURAL HISTORY, MANAGEMENT AND NOVEL TARGETED THERAPIES.

Alcohol consumption is a leading cause of preventable morbidity and mortality worldwide and the primary cause of advanced liver disease. Alcohol use disorder (AUD) is a chronic, frequently relapsing condition characterized by persistent alcohol consumption despite its negative consequences. Alcohol-associated liver disease (ALD) encompasses a series of stages, from fatty liver (steatosis) to inflammation (steatohepatitis), fibrosis, and, ultimately, liver cirrhosis and its complications. The development of ALD is complex, involving both genetic and environmental factors, yet the exact mechanisms at play remain unclear. Alcohol-associated hepatitis (AH), a severe form of ALD, presents with sudden jaundice and liver failure. Currently, there are no approved targeted therapies able to interfere in the pathogenesis of ALD to stop the progression of the disease, making alcohol abstinence the most effective way to improve prognosis across all stages of ALD. For patients with advanced ALD who do not respond to medical therapy, liver transplantation is the only option that can improve prognosis. Recently, AH has become an early indication for liver transplantation in non-responders to medical treatment, showing promising results in carefully selected patients. This review provides an update on the epidemiology, natural history, pathogenesis, and current treatments for ALD. A deeper insight into novel targeted therapies investigated for AH focusing on new pathophysiologically-based agents is also discussed, including anti-inflammatory and antioxidative stress drugs, gut-liver axis modulators, and hepatocyte regenerative molecules.

Environmental and Behavioral Determinants of Septicemia Mortality in Türkiye: A Ten-Year Analysis

This study examines the environmental and behavioral factors associated with variations in septicemia mortality rates across Turkish provinces. Province-level data spanning ten years were analyzed using ordinal logistic regression modeling to determine the predictors of septicemia mortality. Environmental factors such as humidity, temperature, and air pollutants, along with behavioral aspects including alcohol consumption, were evaluated. Analysis of the provided data revealed significant regional variations in septicemia mortality rates across areas with diverse environmental and social characteristics. Higher median humidity and stable environmental conditions (low variability in humidity and temperature) correlated with reduced mortality rates. Alcohol consumption was identified as a risk factor, moderately increasing the risk of septicemia mortality. The findings highlight the intricate relationship between environmental stability, personal behaviors, and septicemia outcomes. The study accentuates the need for targeted public health strategies and suggests that mitigating environmental risks and fostering healthy behaviors could effectively reduce septicemia mortality. Further studies should focus on individual-level data and explore the relationship between these factors in different climatic conditions.

Dysphonia Screening in Firefighters and Associated Factors

ObjectiveTo verify the likelihood of dysphonia in firefighters and its relationship with individual and occupational factors and mental health. MethodThis cross-sectional observational study with 442 firefighters collected data on sociodemographic, occupational, and lifestyle aspects and screening for common mental disorders. Individuals were divided into two groups: those slightly likely and those moderately/highly likely to have dysphonia, according to the Brazilian Dysphonia Screening Tool. The questionnaire’s items addressed their sex, age, race, marital status, education, work schedule, administrative or field activity, alcohol consumption, smoking, and common mental disorders. Those who answered "yes" to the question about having a hoarse voice were considered to have dysphonia with an indication for clinical voice assessment. The suspicion of a common mental disorder was measured with the SRQ-20 Self Report Questionnaire. Data were subjected to descriptive and association analysis. Statistical tests were performed assuming a significance level of 5%. ResultsThe moderate/high likelihood of dysphonia was 6.12%. Most firefighters were males (90.31%), aged over 30 (52.47%), multiracial (44.39%), living with a partner (61.39%), and with a bachelor’s or higher degree (42.35%). Individuals self-declared as Black or multiracial had a higher percentage of dysphonia (8.10%). Black and multiracial individuals were approximately 2.5 times more likely to pass the dysphonia screening than Whites and other races. Individuals with symptoms of common mental disorders were also 2.7 times as likely to have dysphonia. ConclusionThe results of the study show that Black and multiracial firefighters and those with symptoms of common mental disorders were moderately/highly likely to have dysphonia. Firefighters with the highest likelihood of having dysphonia are indicated for clinical voice assessment to confirm the diagnosis.

Oral cancer perceptions amongst adult attendees of a Dental Hospital in the Republic of Ireland: A cross-sectional pilot study

Objectives This study aimed to assess (i) awareness of the signs and symptoms of oral cancer and its risk factors and (ii) awareness and attitudes towards oral cancer screening, in an Irish cohort. Methods A cross-sectional self-administered survey was used in a convenience sample of patients > 18 years with no cancer history attending the Dublin Dental University Hospital. The data were analysed using descriptive statistics, Pearson’s Chi-squared and Fisher’s exact tests. Results 124 responses were received. 83.7% reported knowing little/nothing about oral cancer risk factors. 12.8% did not identify smoking, 35.3% alcohol consumption, 90.5% betel nut, 35.3% age and 80.2% male gender, as risk factors. 46% were unaware that a dentist is trained to check for oral cancer. Participants were more likely to seek advice regarding a persistent oral white or red patch from their doctor than their dentist but were more likely to attend their dentist in relation to a persistent ulcer, swelling or pain. The study did not find any statistically significant relationship between gender, age, educational level and either awareness of the signs and symptoms of oral cancer and its risk factors, or with experiences and attitudes towards oral cancer screening. Conclusions The study demonstrated a lack of knowledge of the risk factors, signs and symptoms of oral cancer, and of awareness of the role of dentists in screening for oral cancer. It should be repeated in a larger cohort in non-dental settings to inform the development of oral cancer awareness programmes that address those areas where awareness is lacking.

Impact of Alcohol Consumption on Cardiovascular Events in Patients Undergoing Percutaneous Coronary Intervention

Impact of Alcohol Consumption on Cardiovascular Events in Patients Undergoing Percutaneous Coronary Intervention

Effects of Alcohol Consumption and Anxiety on Health-related Quality of Life in Postmenopausal Middle-aged Women

Effects of Alcohol Consumption and Anxiety on Health-related Quality of Life in Postmenopausal Middle-aged Women

The impact of alcohol consumption and binge drinking on the risk of dental trauma in South Korean adolescents

Objectives: This study aimed to investigate the impact of alcohol consumption and binge drinking on the occurrence of dental trauma in South Korean adolescents. Methods: Data were analyzed from the South Korean Youth Risk Behavior Survey, which used a complex sampling design to ensure representativeness. A total of 52,875 adolescent were included in this study. Logistic regression analysis was conducted to assess the association between alcohol consumption and tooth fractures. Confounders such as gender, education, city, academic performance, economic status, etc. were adjusted. Results: Logistic regression analysis revealed that alcohol consumption was significantly associated with tooth fractures in adolescents. After adjusting for all factors in Model 3 of binge drinking, the odds ratio remained statistically significant at 1.331 (95% CI: 1.064-1.664). Conclusions: Alcohol consumption and binge drinking increase the risk of tooth fractures in adolescents. Preventive measures targeting alcohol-related behaviors in this population are crucial for improving oral health outcomes.

The non-linear correlation between the severity of alcohol consumption and depressive symptoms in the Chinese Wa ethnic minority

ObjectiveThe aim of this research was to examine the association between alcohol consumption and depressive symptoms in the Wa ethnic minority of China, a population where this relationship has been insufficiently explored.MethodsA cross-sectional analysis was conducted on a sample of 317 current drinkers from the Wa ethnic minority, a “direct fast-forward” group in Cangyuan County, between December 1, 2022, and February 28, 2023. Utilizing a multi-stage cluster sampling approach, participants were selected, each of whom exhibited an Alcohol Use Disorder Identification Test (AUDIT) score exceeding 0. Data were collected via face-to-face interviews employing a uniform questionnaire. Quantification of alcohol use was achieved through the application of the AUDIT, while the Patient Health Questionnaire (PHQ)-9 was employed to gauge depressive symptoms. The relationship between the severity of alcohol consumption and depressive symptoms was evaluated using a multivariable logistic regression model. Subsequently, potential non-linear associations were scrutinized through the application of a smoothing plot.ResultsThe study included 317 current drinkers (196 males [61.83%]; mean age 41.78 ± 12.91 years), of which 94 (29.65%) exhibited comorbid depressive symptoms. Multivariable logistic regression analysis, adjusting for confounders, revealed that higher AUDIT scores were significantly associated with an increased probability of depressive symptoms (OR = 1.09, 95% CI: 1.02–1.18, p = 0.008). The risk of depressive symptoms was notably greater in the group with alcohol dependent range in contrast the group at low-risk range (OR = 7.01, 95% CI: 1.66–29.62, p = 0.008). The smoothing plot indicated a J-shaped non-linear relationship with an inflection point at an AUDIT score of 15. To the left of this inflection point, no significant relationship was observed, whereas to the right, a positive correlation emerged (OR = 1.39, 95% CI: 1.11–1.74, p < 0.001).ConclusionThe findings reveal a non-linear relationship between alcohol consumption and the probability of depressive symptoms within the Wa ethnic minority in China, with implications for the development of nuanced and effective treatment strategies tailored to this population.

Lifestyle related health risk factors regarding non-communicable diseases among adults in Morang District

Introduction: Non-communicable diseases are the leading causes of disease burden worldwide. According to World Health Organization estimates, NCDs are responsible for 74% of all deaths globally, with around 77% of premature deaths from NCDs occurring in low- and middle-income countries. This study aims to assess the lifestyle related health risk factors of non-communicable diseases among adults in Nepal, in which two- third of annual deaths are attributable to non-communicable diseases. Methods: A cross sectional study was conducted among adults in Morang district, Nepal. Data collection involved the assessment of the risk factors of obesity, smoking, alcohol consumption, inadequate fruits and vegetable consumption, inadequate physical activity, are raising blood pressure. Ethnical approval was obtained. Results: Two hundred forty participants participated in the study, of which the most prevalent risk factor was obesity (58.3%). Out of total participants, 41.6% had consumed tobacco, 31.2% had consumed alcohol, 41.6% had consumed inadequate fruits and vegetables, 30.4% had inadequate physical activity, and 29.1% had raised blood pressure. Similarly, education is statistically associated with lifestyle risk factors. Male participants of age above 40 years were found to be statistically associated with current tobacco and alcohol consumption. Conclusion: Health related risk factors are causes of non-communicable disease. Most of the participants had two or more risk factors for non-communicable disease. Education is significantly associated with all the risk factors among the participants.

Risk Factors for Colorectal Adenoma and Cancer in Comprehensive Health Checkups: Usefulness of Gamma-Glutamyltransferase

Background/Objectives: In this study, we aimed to determine the risk factors for colorectal adenoma/cancer by studying patients who underwent comprehensive health checkups and were referred to a hospital because of positive fecal occult blood. Methods: A total of 529 patients were referred to hospital for a positive fecal occult blood test after a comprehensive health checkup at the participating center over a period of 5 years, from January 2018 to December 2022. Patients diagnosed with colorectal adenoma or cancer using colonoscopy were included in the case group, while those diagnosed with no abnormality, diverticulum, or hemorrhoids were included in the control group. Results: Of the 529 referred patients, 503 underwent colonoscopy. A total of 18 colorectal cancers and 191 colorectal adenomas were detected, and there were no tumors, diverticula, or hemorrhoids in any of the 208 patients. Polyps, either hyperplastic or of unknown pathology, were found in 86 patients. A comparison of the case and control groups showed that gamma-glutamyltransferase (GGT) was an independent and significant risk factor for colorectal adenoma or cancer, in addition to previously known risk factors such as male sex, older age, high body mass index, and alcohol consumption. Conclusions: For patients with a positive fecal occult blood test, in addition to traditional risks such as obesity, older age, male sex, and alcohol consumption, identifying those with high GGT levels is recommended to help find colorectal adenoma/cancer.

Integrated Cardiorespiratory Rehabilitation and Its Impact on Cardio–Renal–Metabolic Profile After Cardiac Surgery

Background: Cardiovascular diseases (CVDs) and chronic kidney disease (CKD) are common causes of morbidity and mortality. However, the impact of changes in lifestyle and rehabilitation programs on the progression of cardiovascular, renal, and metabolic (CRM) conditions, remains unclear. Methods: In a retrospective manner, we analyzed charts of 200 patients admitted for cardiorespiratory rehabilitation at our facility in 2023. A 6 min walk test, echocardiographic features, and laboratory values were investigated to evaluate the impact of cardiorespiratory rehabilitation in patients post cardiac surgery. This study examined the impact of combined lifestyle and exercise scores (diet, alcohol consumption, smoking, aerobic physical activity, sedentary behavior, sleep duration, and social connection) on cardio–renal–metabolic profiles and on a quality-of-life score measured by the Borg Scale. Results: During the rehabilitation program, left ventricular ejection fraction (LVEF) significantly increased (51.2 vs. 54.3%, SEM 0.51 p = 0.001). The six-minute walk test (6 MWT) significantly improved in terms of meters (133 vs. 373 m, SEM 6.41, p < 0.001) and Borg scale (6.6 vs. 2.5, SEM 0.06, p < 0.001). Glycemia levels reduced significantly (114.5± vs. 107.4± mg/dL, SEM 2.45, p = 0.001). While total cholesterol levels (119.4 vs. 129.6 mg/dL, SEM 2.4, p < 0.001) as well as HDL levels (29.9 vs. 40 mg/dL, SEM 0.62, p < 0.001) significantly increased, triglyceride levels significantly decreased (128.5 vs. 122.1 mg/dL, SEM 3.8, p = 0.048). There was no change in LDL levels. Creatinine levels remained stable throughout the period of rehabilitation. Conclusions: Cardiorespiratory rehabilitation has a significant impact on myocardial function, quality of life in terms of exercise capacity and symptoms (6 MWT) as well as laboratory levels relevant for cardiovascular prevention such as glycemia and lipid profile.

Hybrid multi-criteria decision-making model for assessing perceived significance of 23 potentially modifiable cancer risk factors among senior nursing officers

BackgroundPotentially modifiable cancer risk factors have been increasingly recognized among the Chinese population. In this study, we aimed to investigate the perceived significance of these risk factors among senior nursing officers, who play a crucial role in providing healthcare services. We also sought to determine senior nursing officers’ performance in reducing these risk factors.MethodsA questionnaire survey regarding 23 potentially modifiable cancer risk factors was conducted in November 2023 with 58 senior nursing officers at Taizhou Hospital in Zhejiang Province, China. The consistent fuzzy preference relation method and importance–performance analysis were used to determine the attribute weights and performance levels.ResultsThe senior nursing officers considered diabetes, ultraviolet radiation exposure, PM2.5 exposure, excess body weight, physical inactivity, alcohol consumption and secondhand smoking significant. However, performance in reducing secondhand smoking, physical inactivity, excess body weight, PM2.5 exposure, and ultraviolet radiation exposure required improvement.ConclusionsThe proposed hybrid multiple-criteria decision-making model enhances our understanding of the perceived significance of 23 modifiable cancer risk factors and performance in reducing them, which could facilitate improvements in health education efforts.

Quarantine Experience-Based Differences in Factors Associated with Depression Among Koreans During the COVID-19 Pandemic

Background/Objectives: The strict preventive measures implemented globally during the COVID-19 pandemic affected mental health, with most countries reporting a rise in depression and suicide. This study examined factors affecting depression among Korean adults based on quarantine experiences during 2020 and identified key areas for mental health support. Methods: Data were obtained from South Korea’s 2020 Community Health Survey. Responses from 219,228 adults (1893 with quarantine experience and 217,335 without) to questions about quarantine experience, depression (Korean version of PHQ-9 score ≥ 10 or a response of ‘several days’ or more on item 9), and individual/environmental factors were analyzed. Complex sampling analysis, including descriptive statistics and logistic regression, was conducted using SPSS 29.0. Results: This study found that 158 (weighted 7.5%) of those with quarantine experience, and 12,833 (weighted 5.8%) without quarantine experience, reported depression. Regardless of quarantine, being female, having a low income, a history of depression, and increased stress were associated with a higher depression rate, while good subjective health was linked to lower depression rates. Smoking, living-alone, and a lack of sleep among non-quarantined individuals were linked to increased depression risk, while adequate physical activity was linked to reduced risk. Interestingly, alcohol consumption and being overweight (BMI 23–<25) were associated with lower depression rates. Environmental factors, like unmet medical needs and reduced daily activity, were linked to increased depression. Strong social support and social distancing adherence were associated with reduced depression. Conclusions: These findings underscore the importance of targeted interventions considering quarantine experiences to reduce depression during pandemics.

Clinical and Demographic Profile of Syrian Patients with Malignant Glioma: A Six-Month Retrospective Analysis

This study presents a retrospective analysis of glioblastoma cases admitted to Tishreen University Hospital in Lattakia, Syria, between February and August 2024. The study examines the several potential risk factors including age, sex, genetic predispositions, and lifestyle factors such as smoking and alcohol consumption. It also explores the most commonly encountered tumor grade and the presence of various neurological symptoms, as well as treatment outcomes. A total of 30 glioblastoma were enrolled in this study, 63% of which were males, and the highest age incidence was between 40 and 50 years. Only 6% had a family history of glioblastoma, and 66% of the patients were smokers. Memory disorders, visual impairments, and headaches were common symptoms, with 100% of the patients reporting nausea and vomiting. Glioblastoma diagnosis was primarily established through MRI with contrast (76%), and the predominant treatment modality was surgery combined with radiotherapy and chemotherapy (80%). Post-treatment relapse occurred in 26% of the patients, with a median remission period of four months. These findings provide important insights into the clinical characteristics and treatment outcomes of glioblastoma patients in this region.

Association of periodontal disease with stress levels and drinking frequency in adults: analysis using data from the 7th National Health and Nutrition Examination Survey

Objectives: This study aimed to investigate the association of stress level and alcohol consumption with periodontal disease in adults. Methods: Data from the 7th Korean National Health and Nutrition Examination Survey were used for this study, which included 13,199 Korean adults aged >19 years. The variables analyzed included demographic characteristics (sex and age) and socioeconomic factors (income, education, and marital status). Multiple logistic regression analysis was performed to evaluate the association between periodontal disease, stress level, and drinking frequency after considering confounding factors such as income quartile and marital status. Results: After correcting for all confounding factors, the analysis showed that the group that drank more than four times a week had a 1.541 times higher risk of developing periodontal disease than the group that drank less than once a month (odds ratio [OR]=1.541, 95% confidence interval [CI]=1.245-1.906, p<0.001). The prevalence of periodontal disease was higher in men, in those over 60 years of age, and in those with lower levels of education and income. Interestingly, those with lower perceived stress had a significantly higher disease prevalence (31.5%) than those with higher stress levels (28.0%; p<0.001). Conclusions: The results of this study suggested that the higher the frequency of drinking, the higher the prevalence of periodontal disease.

Determination of Bone Fracture Risk in Kidney Transplant Recipients With FRAX Score

Background:It is thought that the Fracture Risk Assessment Tool(FRAX) score of the World Health Organization determines a 10-year fracture risk.The study aimed to investigate the major osteoporotic fracture(MOF) and hip fracture(HF) values determined with the FRAX score and practicality of the FRAX score in kidney transplant recipients(KTRs).Methods:The study was conducted with 44 female and 59 male KTRs and 100 healty control group.Bone mineral density(BMD) was measured by dual-energy X-ray absorptiometry.FRAX scores were calculated from baseline information (age, height, weight, BMD femur neck T score,previous fracture history, glucocorticoid use, smoking status, alcohol consumption,and presence of rheumatoid arthritis).Results:In KTRs, FRAX score MOF, and FRAX score HF were found to be significantly elevated, while BMD femur T score was determined to be significantly low. No significant relationship was found between FRAX score MOF and HF and kidney function tests and bone parameters. In the ROC analysis performed based on the determination of the FRAX score the cutoff point was determined as≥3.4 for MOF and≥0.4 for HF.Conclusion:In KTRs, increased FRAX score MOF and HF compared to healthy individuals were determined.FRAX score MOF≥3.4 and HF≥0.4 values indicate high-risk patients for increased fracture risk.The high accuracy rates determined suggest that the use of the FRAX score in KTRs is a valuable method for determining fracture risk.

Predicting mid- and late-life dementia risk in primary care: A prognostic study from a national health screening cohort

The objective of this study is to develop and validate dementia risk prediction models for mid- and late-life individuals that are based on accessible variables within a primary care setting. Using the Korean National Health Insurance Service database (2010–2019), we analyzed 6,696,073 individuals aged 40 and older who participated in a national health screening program over a mean follow-up of 8.95 years. Potential predictors were selected based on a literature review and the available data. Dementia cases were identified using claim-based codes and validated by corresponding prescription information. 5-year dementia risk prediction models for mid-life (40–59 years), and late-life (60+ years) stages were developed using the Cox proportional hazards model. Model performance was assessed through discrimination and calibration. Both models included age, sex, body mass index, smoking, alcohol consumption, physical activity, diabetes, hypertension, dyslipidemia, and chronic kidney disease. The models’ AUROCs were 0.764 for mid-life and 0.743 for late-life. The impact of predictors on dementia risk was consistently stronger in mid-life than in late-life stages. Our models showed good calibration with low-risk estimates in mid-life and overall in late-life. These findings underscore the crucial role of managing modifiable risk factors, particularly during mid-life to reduce dementia risk.

Determinants of cognitive health in the elderly: a comprehensive analysis of demographics, health status, and lifestyle factors from NHANES.

This study analyzes data from the National Health and Nutrition Examination Survey (NHANES) to identify factors influencing cognitive performance among the elderly, as measured by the Digit Symbol Substitution Test (DSST). Employing multivariable linear regression, we evaluated the impact of demographic, lifestyle, and health-related factors on cognitive function in U.S. adults aged 60 and older. Our findings indicate that advanced age, particularly in those aged 70-79 and 80 + years, is associated with lower DSST scores. Male gender is linked with reduced cognitive performance, while higher educational attainment appears protective. Lifestyle factors, including current smoking and higher alcohol consumption, negatively impact cognitive outcomes, and excessive sleep duration (over 9h) is also detrimental. Among health conditions, diabetes, chronic heart failure, and a history of stroke were associated with cognitive declines. Furthermore, increasing severity of depression correlates with lower cognitive function. These results underline the need for comprehensive public health strategies that integrate lifestyle modifications and chronic disease management to maintain cognitive health in older adults.

Association of METS-IR index with psoriasis in US adults: a cross-sectional study.

Psoriasis is linked to insulin resistance (IR). Nevertheless, the applicability of the METS-IR index, a new IR evaluation tool, for evaluating changes in insulin sensitivity in psoriasis populations is currently unknown. This study aimed to investigate the relationship between the METS-IR index and psoriasis in a US adult population. This cross-sectional study utilized data from adults aged 20 to 80 years from the U.S. National Health and Nutrition Examination Survey (NHANES) spanning 2003-2006 and 2009-2014. The associations between the METS-IR index and psoriasis were examined using multivariate logistic regression and smoothed curve fitting. Subgroup analyses and interaction tests were conducted to verify the stability of the association within the population. This study included 5,966 participants, of whom 182 had psoriasis. In the fully adjusted model, the METS-IR index was positively associated with psoriasis, showing a 1.7% increase in psoriasis prevalence for each one-unit increase in the METS-IR index (Model 2: OR 1.017, 95% CI 1.006-1.028). Participants in the highest quartile group were 91.9% more likely to develop psoriasis compared to those in the lowest quartile group (OR = 1.919, 95% CI 1.180-3.118). Smooth curve fitting revealed a nonlinear association between the METS-IR index and psoriasis, with an inflection point of 41.675. This positive association was more pronounced in females, non-obese individuals, those with light alcohol consumption, comorbid coronary heart disease and hyperlipidemia, non-hypertensive and non-diabetic individuals. The results of the study suggest that higher METS-IR scores are associated with an increased likelihood of psoriasis among U.S. adults. The METS-IR index is specifically recommended as a clinical indicator for the management and treatment of psoriasis in women, non-obese individuals, light alcohol consumers, individuals with comorbid coronary artery disease andhyperlipidemia, non-hypertensive and non-diabetic individuals. However, Considering the many known and unknown covariates that may be associated with psoriasis and influence theresults of the study, we remain cautious about the results obtained and look forward to the addition of subsequent studies.

Mediterranean diet and atrial fibrillation: a case-control study from China

ObjectiveThe aim of this study was to assess the association between adherence to Mediterranean diet and the presence of atrial fibrillation (AF) in a Northern Chinese population.MethodsThis study was a single center, case–control study. A total of 952 low risk participants in Beijing Anzhen Hospital from 2016 to 2021 were collected, including 476 patients with first diagnosed of atrial fibrillation and 476 age and sex matched controls. According to the food frequency questionnaire (FFQ), the alternate Mediterranean diet score (AMED) was calculated, which was 0–9 points, indicating the adherence to the Mediterranean diet from low to high.ResultsThe average age of the participants was 57.6 ± 9.1 years old, and 70.2% were men. After analyzing every component of AMED, vegetable consumption shows a negative correlation with the risk of AF, whereas alcohol consumption demonstrates a positive correlation with it (OR = 0.61, 95% CI 0.44–0.80, p < 0.001; OR = 1.99, 95% CI 1.48–2.58, p < 0.001). All patients were grouped according to AMED score. A significant inverse association between AMED and the risk of AF was observed. Compared with participants with AMED<4, the multivariable-adjusted ORs of AF were 0.75 (95% CI 0.55–1.06) for AMED 4–5 and 0.61 (95% CI 0.43–0.89) for AMED ≥6, with a trend in risk (p = 0.008). Results were consistent in stratified analyses of gender, age, BMI and smoking.ConclusionThe Mediterranean diet was inversely associated with the risk of AF in this Northern Chinese population.