Consulting Editor Research Articles

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Editorial Policy

Editorial Policy

Editorial Policy

PMTi2022: A very successful conference in Montreal

Joseph Capus, MPR Consulting Editor, describes topics covered at the recent titanium conference.

Editorial Policy

Editorial Policy

About the Authors

About the Authors

Additive Manufacturing Highlights in JMEP

Abstract The July and September issues of the Journal of Materials Engineering and Performance (JMEP) were special issues focused on additive manufacturing. The issues were guest edited by William E. Frazier, FASM, Pilgrim Consulting LLC and editor of JMEP; Rick Russell, NASA; Yan Lu, NIST; Brandon D. Ribic, America Makes; and Caroline Vail, NSWC Carderock. The highlighted articles described in this article were selected by Dr. Frazier to showcase the varied topics covered in the special issues.

Letter by Scutelnic et al Regarding Article, “Acute Neurological Deterioration in Large Vessel Occlusions and Mild Symptoms Managed Medically”

HomeStrokeVol. 51, No. 10Letter by Scutelnic et al Regarding Article, “Acute Neurological Deterioration in Large Vessel Occlusions and Mild Symptoms Managed Medically” Free AccessLetterPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyRedditDiggEmail Jump toFree AccessLetterPDF/EPUBLetter by Scutelnic et al Regarding Article, “Acute Neurological Deterioration in Large Vessel Occlusions and Mild Symptoms Managed Medically” Adrian Scutelnic, MD Simon Jung, MD Mirjam R. HeldnerMD, MSc Adrian ScutelnicAdrian Scutelnic Search for more papers by this author , Simon JungSimon Jung Search for more papers by this author , and Mirjam R. HeldnerMirjam R. Heldner https://orcid.org/0000-0002-3594-2159 Search for more papers by this author Originally published28 Sep 2020https://doi.org/10.1161/STROKEAHA.120.030856Stroke. 2020;51:e287–e288To the Editor:We thank the authors for their important work. Saleem et al1 retrospectively studied frequency, time point, and predictors of in-hospital secondary neurological deterioration (SND) in patients with admission National Institutes of Health Stroke Scale (NIHSS) score ≤5 despite large vessel occlusion managed medically (conservatively +/- with intravenous thrombolysis) initially. In-hospital SND of ≥4 NIHSS score points occurred in a fifth of patients, at a median of 3.6 (1–16) hours after admission, impacted outcome, and was not predictable in multivariate analysis. After SND, rescue reperfusion therapy improved outcome.To date, we have published 2 studies on related topics.2,3 Based thereon and in Saleem et al’s1 study, we performed the current analysis containing patients managed conservatively (+/- with rescue reperfusion therapy finally) from January 2004 until December 2019. In our prospective single tertiary care center cohort of patients with large vessel occlusion in the anterior circulation and low NIHSS score, there have been included 110 (47.6%) conservatively treated patients with occlusion of the internal carotid artery and/or M1 segment of the middle cerebral artery and without coexisting chronic vessel occlusion. Any in-hospital SND occurred at a median of 13.6 (0.8–23) hours, with an increase of the NIHSS score ≥1 in 58 (52.7%) and ≥4 in 36 (32.7%) of patients. The latter was not predictable in multivariate analysis which nearly included the same variables as in Saleem et al’s1 study. Thirty-one (28.2%) patients were finally treated with rescue reperfusion therapy: 24 (77.4%) with endovascular therapy, 6 (19.4%) with bridging therapy, and 1 (3.2%) with intravenous thrombolysis. Rescue reperfusion therapy was only performed in patients with in-hospital SND, in 51.7%/58% of patients with an increase of the NIHSS score ≥1/4. In patients with SND of NIHSS score ≥1/4 versus with no deterioration, median NIHSS score change from admission to discharge was 4 (−4 to 39)/6 (−3 to 39) versus −1 (−4 to 37) each P<0.0001, there was a reduced chance of 3 months independence (modified Rankin Scale, 0–2; 45.8%/28.6% versus 81.8%, odds ratio 0.19/0.09; each P<0.0001) and of survival (83.1%/80% versus 97.7%, odds ratio 0.11/0.9; each P<0.02). In patients with any in-hospital SND, patients treated with versus without rescue reperfusion therapy showed equal median NIHSS score change from admission to discharge: 4 (−4 to 39) versus 4 (−3 to 39); P=0.775, 2 symptomatic intracranial hemorrhages (6.5% versus 0%; P=0.494) and equal 3 months independence (50% versus 41.4%; P=0.506) and survival (83.3% versus 82.8%; P=0.953).Overall, compared to Saleem et al’s data, any in-hospital SND was more frequent in our analysis, also negatively impacted outcome and also was not predictable. Outcome after in-hospital SND was similar with versus without rescue reperfusion therapy. We have not included patients with vessel occlusions of a more distal or posterior circulation location and only those managed conservatively initially, without intravenous thrombolysis, which surely helps explain our less favorable outcome results. Also, at our center, we tend to have a rather low threshold in performing primary reperfusion therapy in this specific patient group. Likely, this caused an unfavorable selection bias for some patients left for potential rescue reperfusion therapy if SND occured.Anyway, repeatedly, rates of in-hospital SND have been shown to be around 40% in conservatively treated patients with large vessel occlusion, despite low NIHSS score. Evidence is increasing that primary reperfusion therapy probably is superior to conservative therapy or rescue reperfusion therapy in this specific patient group. However, it remains unclear yet, whether rescue reperfusion therapy is inferior, superior or equal to continued conservative therapy after SND.1–4 As suggested before, total NIHSS score and modified Rankin Scale might not show sufficient sensitivity in assessment of patients with large vessel occlusion and low NIHSS score, and there is an unmet need for multicenter randomized controlled trials addressing best therapy.3DisclosuresDr Heldner received a grant from Bangerter Foundation on the topic of best therapy in patients with large vessel occlusion and low National Institutes of Stroke Scale score.FootnotesThis manuscript was sent to Marc Fisher, Senior Consulting Editor, for editorial decision and final disposition.For Disclosures, see page e287.

Biotech Plays Critical Role in Protecting Against Coronavirus Outbreak

Industrial BiotechnologyVol. 16, No. 2 EditorialFree AccessBiotech Plays Critical Role in Protecting Against Coronavirus OutbreakStephanie BatchelorStephanie BatchelorVice President of the Industrial and Environmental Section, Biotechnology Innovation Organization, Washington, DC, USA and Consulting Editor, Industrial BiotechnologySearch for more papers by this authorPublished Online:17 Apr 2020https://doi.org/10.1089/ind.2020.29207.sbaAboutSectionsPDF/EPUB Permissions & CitationsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail First and foremost, I hope readers of the Industrial Biotechnology are safe and doing everything they can to protect themselves from the coronavirus disease 2019 (COVID-19) outbreak. At the Biotechnology Innovation Organization (BIO), we have heard and seen many requests from medical research centers, biopharmaceutical companies, testing developers and testing sites for various supplies.In this challenging and unprecedented time, we want to ensure critical research and development programs can continue. For this reason, BIO has launched a Coronavirus Hub (hub.bio.org), connecting companies that have extra capacity and resources with those that need them. The hub allows users to post requests in real time for urgently needed items and announce the availability of supplies and capacity.As a biotech community, we have the responsibility to rise to this global call for action. I echo BIO's CEO and President Jim Greenwood when saying, “The coronavirus is no match for science, but we must finish the job.”Unfortunately, as the global community works to contain the COVID-19 outbreak, other challenges like climate change continue to grip the planet. In fact, the health impacts from low air quality only increase the risk of infections from viruses such as the novel COVID-19.As we know, transportation continues to be the leading cause of greenhouse gas emissions in the United States—thanks in large part to the abundance of vehicles and airplanes that rely on fossil fuels. We've seen that policies that drive adoption of renewable fuels, like low carbon fuel standards, decrease health risks.The American Lung Association and Environmental Defense Fund found that low carbon fuel standards, combined with statewide carbon pollution limits—such as limits on emissions from manufacturing—have helped prevent almost 90,000 cases of respiratory symptoms and 8,000 cases of asthma-related health complications. These policies also helped prevent 15,000 lost workdays.With the administration continuing to diminish the intent of the Renewable Fuel Standard (RFS), adoption of low carbon fuel policies in states becomes increasingly important in order to reduce carbon emissions and improve health.Several states have considered low carbon fuel standards this year, most notably Washington and New York. BIO and the Low Carbon Fuels Coalition (LCFC) have engaged our advocates and worked tirelessly in both states to advance these policies. However, with the impact of the COVID-19, and Washington's session standing at just 60 days ending in March, this is a battle we will continue fighting into next year.The administration's expansive issuance of small refinery exemptions granted through the RFS has upended the policy and added to the uncertainty as it deliberates whether it will abide by the court ruling that deemed many of these exemptions illegal. BIO will remain vigilant in making sure the Environmental Protection Agency administers the policy as Congress intended.As the world's economies struggle, the federal government has considered various options to boost local businesses and sectors hardest hit by the novel COVID-19—including airlines. In December, Congress passed a biodiesel tax credit extension, benefiting a few qualified producers of sustainable aviation fuels (SAF). This tax credit, however, expires in 2022.As airlines and biofuel companies across the country—many in rural communities—look to get back to normal following the COVID-19 outbreak, a long-term tax credit specifically for SAF production would significantly help in speeding up efforts. The tax credit would also put the country on a sustainable path forward as we look to reignite our economy. Further, if Congress requires airlines to reduce emissions in return for support, SAF must be part of those requirements to assist biofuel producers.Fortunately, thanks to biotechnology, both the sustainable fuels and biobased manufacturing sectors are agile and finding impactful ways to help in this crisis. Crops normally marked for biofuel production are now being used by producers to make alcohol for hand sanitizer. And using biotechnology, companies are creating renewable chemicals and enzymes more efficiently to develop cleaning products for medical devices.The priority for the foreseeable future across sectors, in Congress and States, will be protecting the U.S. population from the COVID-19 outbreak. But it is important that policies to address this and possible future outbreaks also address the impact of fuels pollution and the ability of the industrial biotech sector to help protect the nation's health.FiguresReferencesRelatedDetailsCited byIT-Enabled Sustainable Innovation and the Global Digital Divides30 August 2021 | Sustainability, Vol. 13, No. 17 Volume 16Issue 2Apr 2020 InformationCopyright 2020, Mary Ann Liebert, Inc., publishersTo cite this article:Stephanie Batchelor.Biotech Plays Critical Role in Protecting Against Coronavirus Outbreak.Industrial Biotechnology.Apr 2020.43-43.http://doi.org/10.1089/ind.2020.29207.sbaPublished in Volume: 16 Issue 2: April 17, 2020Online Ahead of Print:March 27, 2020PDF download

VIEW the future of biodiagnostics

It is with our greatest pleasure to welcome you to the inaugural issue of VIEW, a new journal that focuses on biodiagnostics. This new journal is co-published by Wiley and Professional Community of Experimental Medicine, National Association of Health Industry and Enterprise Management (PCEM), China. Why the journal was named VIEW? We have been asked by many and here is the answer: Seeing is believing. VIEW represents the most fundamental aspects in the field of experimental medicine to visualize human health, and here are a dozen views about these aspects until you know the answer. VIEW will embrace all significant advances on experimental medicine, lab-on-a-chip, microfluidics, bioimaging, biomarkers, omics, biosensors and bioelectronics, drug delivery, computational diagnostics, bioinformatics, and novel diagnostic devices, etc. VIEW will endeavor to assist researchers, industry, government, academia, and community players to keep abreast of new developments in their specialist fields and to find solutions. VIEW aims to be a high-quality, interdisciplinary, and rapid-publication journal focused on “biodiagnostics” in the field of biomaterials, from in vitro to in vivo, small to mega, fundamentals to application, with particular emphasis on the biomaterials used in biotechnology and medicine. As a new journal in the biodiagnostics field, VIEW will be operated in obedience to the highest standard running by the publishing team of Wiley. Our readers will have the opportunities to discover the most interesting and important research in our regular Research Articles and Rapid Communications, insightful and discerning Reviews, Mini-reviews and Perspectives, rare Case Reports, and incisive Analysis. We would like to thank many people who have combined their effort in this very first issue of VIEW, especially our highly distinguished Editorial Board (https://onlinelibrary.wiley.com/page/journal/2688268x/homepage/editorial-board) who has been instrumental in bringing this journal to fruition by advising us with its publishing expertise and also bringing its excellent research. With the full support from Wiley's professional publishing team—Dr. Jose Oliveira, Dr. Guangchen Xu, Dr. Daping Zhang, and Dr. Tina Wang whose dedication has led VIEW toward the right direction, we are ready to embrace the challenges and excitements. In this issue, we are delighted to present Prof. Haibo Song's (Editor-in-Chief of VIEW) overview of the industry of in vitro diagnostics in China1; Prof. Chwee Teck Lim's (National University of Singapore, Singapore) insights on the future of health diagnostics2; Prof. Tiangang Liu's (Wuhan University, China) perspective on promising methods for detection of novel coronavirus SARS-CoV-23; Prof. Zhiyong Qian’s (Sichuan University, China) review of application of nanotechnology for enhancing photodynamic therapy via ameliorating, neglecting, or exploiting tumor hypoxia4; Prof. Chunru Wang’s (Institute of Chemistry, Chinese Academy of Sciences, China) review on the potential biomedical platforms based on the functionalized Gd@C82 nanomaterials5; and Prof. Amy Shen’s (Okinawa Institute of Science and Technology (OIST), Japan) most recent research of proof-of-concept modular fluid handling prototype integrated with microfluidic biochemical assay modules for point-of-care testing.6 We sincerely thank them for their fine contributions to this issue, and we believe our readers will enjoy reading these articles! Manuscripts can be submitted online through SholarOne Manuscripts (https://mc.manuscriptcentral.com/viw2). All papers will be published online as soon as they are accepted and will be fully citable. In addition, there are no article publication charges for the first three publication years of VIEW. We hope that you enjoy reading this first issue of VIEW, and you will consider this journal as one of your favorites to submit your next excellent manuscript. VIEW is on its way to facilitate researchers changing the world, visualizing human health and illuminating wellness. We look forward to receiving your outstanding manuscripts. Prof. Haibo Song Editor-in-Chief, VIEW China Association of In Vitro Diagnostics, China Prof. Hualiang Wang Executive Editor-in-Chief, VIEW Professional Community of Experimental Medicine, China Dr. Jing Zhu Consulting Editor, VIEW

Editorial introductions

Editorial introductions

Obituary: In Memoriam Professor Dr. Shoucheng Zhang, Consulting Editor

Obituary: In Memoriam Professor Dr. Shoucheng Zhang, Consulting Editor

PM personality: Dr Kalathur (Sim) Narasimhan, FASM. FAPMI, FIndPMI

After an outstanding career in the magnetic materials and PM industries, Dr Kalathur Narasimhan now advises companies globally through his own consulting firm, P2P Technologies. Metal Powder Report Consulting Editor Joseph Capus sat down with him at the Exhibition during the recent POWDERMET2018 Conference.

Social Entrepreneurship as a Norm?

Is the act of entrepreneurship itself a social good? This simple and seemingly easy question goes to the heart of the debate of this issue's Point-Counter Point articles but the answer appears not to be so straightforward. The recently released 2015/16 Global Report from the Global Entrepreneurship Monitor (GEM) provides evidence of the breadth, power, and positives of entrepreneurship: increasing participation rates across the globe by individuals of varied backgrounds (Kelley et al., 2016). The GEM report shows that individuals are starting businesses, creating jobs, and building entrepreneurship ecosystems with positive impacts on their communities. On the other hand, some research contends that entrepreneurial activities need to be more closely scrutinized for their negative externalities (Beaver and Jennings, 2005; Khan et al., 2007; Zahra and Wright, 2016). The argument here is that all entrepreneurs have to go beyond providing an economic return and be responsible for a triple bottom line. Suddenly, the simple answer to the opening question is not so simple. I have often thought of the term ‘social entrepreneurship’ as redundant. Entrepreneurs take various forms, but generally speaking they invent or innovate and then execute in the market. They can be small and local, large and global, or somewhere in between, but their function is to match their goods or services to a market segment and provide that segment with value. As such, by their existence and actions they deliver positive value to society. They treat their customers right, build a good business and do no harm. On the other hand, research has noted that entrepreneurship may also have a dark side, as illustrated by Baumol's classic work highlighting unproductive and destructive entrepreneurship (1990). Written to advocate policy change, Baumol's argument illuminated the potential ills of entrepreneurial activity as typified by organized crime and other illegal operators As entrepreneurs focused on the environment and mission-driven causes have come of age over the past two decades, the relationship between ‘social’ and ‘entrepreneurship’ has become less clear. Classifying entrepreneurs as either job creating, innovators (positive) or Ponzi schemers, scam artists, or organized criminals (negative) trivializes the argument. These two poles anchor opposite side of the spectrum and while this simplification may be clear and sufficient for practitioners, it is less so for scholars. The contribution of entrepreneurship to society is and always will be a net positive (Reagan, 1985) but what are the social obligations, if any, for entrepreneurs? The answer to this and the opening question are more nuanced than one might see on the surface. The authors of this Point-Counter Point delve more deeply for us. Entrepreneurs that focus primarily on developing for-profit organization do great things for the world. Is that enough? Is it enough for them to provide economic value and then supplement it with good corporate citizenry? Or does the social aspect of entrepreneurship need to be part of the business at every turn? Do all organizations need to be a hybrid? Does every entrepreneur need to have a social mission intertwined into the very fabric of the business? In their entry in this two article series, Zahra and Wright argue that scholars need to re-examine and redefine the social role of entrepreneurship around five pillars that argue for a balance of the financial, social, and environmental outcomes of all entrepreneurial activity (2016). They rely upon arguments from policymakers, world leaders and billionaire entrepreneurs, who advocate for a greater awareness of the potential downside to entrepreneurial activity. They surmise that scholars need to consider an entrepreneurial canvas focused on hybrid organizations pursuing the blended value that comes from corporate social responsibility and bottom-of-the-pyramid strategies. In conjunction, McMullen and Warnick argue that the criticism of ‘typical and classic’ entrepreneurship may have gone too far. These authors posit that researchers and practitioners should not try to set up norms or legal obligations that require entrepreneurs to create blended value or hybrid organizations (2016). They assert that the social component of entrepreneurship should be a guideline or aspirational ideal instead of a legislated obligation. In sum, while there is ample research on social entrepreneurship and plenty of work that incorporates non-economic factors and variables, the interplay between economic and non-economic forms of entrepreneurship is not clear. Is the singular act of entrepreneuraship in and of itself a social good? Or must we insist that all entrepreneurs bring blended value? It seems that while we as an academy have been discussing the merits of each, we have mostly been doing so in parallel tracks. This Point-CounterPoint is designed to merge the conversations in order to further our understanding. Andrew Corbett Consulting Editor

PM Personality: Dr. W. Brian James

Following a stellar 40+ year career in the ferrous PM industry, British-born Dr W. Brian James was appointed Editor-in-Chief of the International Journal of Powder Metallurgy, published by MPIF/APMI, Princeton, NJ, at the beginning of 2015. MPR Consulting Editor Joseph Capus caught up with him at the EURO PM2015 Congress in Reims, France after James had received the 2015 EPMA Distinguished Service Award.

North Atlantic Treaty Organization (NATO) Special Issue

Medical AcupunctureVol. 27, No. 5 NATO Special EditionIntegrative Medicine Interventions for Military PersonnelThe North Atlantic Treaty Organization (NATO)Human Factors and Medicine (HFM) Task Force 195 Final ReportGuest Editor: COL Richard P. Petri Jr., MCEditorialFree AccessNorth Atlantic Treaty Organization (NATO) Special IssueRichard C. NiemtzowRichard C. NiemtzowSearch for more papers by this authorPublished Online:22 Oct 2015https://doi.org/10.1089/acu.2015.29006.rcnAboutSectionsPDF/EPUB Permissions & CitationsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail In September of 2010, a North Atlantic Treaty Organization (NATO) Human Factors and Medicine (HFM)–195, “Integrative Medicine Interventions for Military Personnel” began to form under the leadership of Jean Belard, MD, PhD, COL (ret), of the French Medical Corp, consisting of experts from several NATO countries and one guest representative from South Korea. The first meeting took place in March 2011 in Paris, France. In the subsequent years that followed, I had the distinct honor and pleasure of representing the United States Air Force. As a result of the retirement of COL (ret) Dr. Belard in August 2013, COL (Dr) Richard Petri, Jr. of the U.S. Army Medical Corps was named as the new chairperson of this distinguished committee on September 1, 2013. Under the auspices of COL (Dr) Petri, Jr., and with the consensus of the Committee, it was decided to accept the invitation from the Medical Acupuncture Journal to publish the first NATO report on integrative medicine (IM). This indeed is a distinct privilege—and perhaps an historic event—for both the Journal and NATO to publish an “Official Committee Report on Integrative Medicine.”Why is there a NATO Committee on Integrative Medicine? The health and welfare of all Military armed forces is crucial to their ability to fight and win wars, but disease compromises the readiness of the Soldiers. Perhaps the most dreaded fear of any Military commander is compromise in the physical and mental health state of the troops. In this modern era, NATO is not immune to challenging health problems—not only for the Soldiers but also for their families.Turning to IM is not new for our readership. However, this shift is new to NATO. The fact that NATO established an official Integrative Medicine Committee to make recommendations demonstrates this organization's desire to seek better health solutions for the Alliance.Colonel (Dr) Petri, Jr. has taken a very active role in working on this NATO report. He has provided the leadership to help organize this Special Issue of Medical Acupuncture that presents the first guidelines for NATO to incorporate IM into medical systems to meet future health challenges.I am very pleased to present to the readership this unique Special Issue. Most importantly, I wish to thank Yael Ben-Porat, LAc, MPH, Managing Editor, Anne Hendren, PhD, Consulting Editor, and Vicki Cohn, Vice President, Mary Ann Liebert, Inc., publishers. Finally, COL (Dr) Petri, Jr., receives my utmost gratitude for his very hard labor to mastermind this NATO Special Edition.FiguresReferencesRelatedDetailsCited byA Study on Research for Utilization Acupuncture Treatment in Military MedicineJournal of Korean Medicine Rehabilitation, Vol. 26, No. 3Integrative Medicine in the Department of Defense and the Department of Veterans Affairs: Cautious Steps Forward Richard C. Niemtzow, Stephen M. Burns, Thomas R. Piazza, Arnyce R. Pock, Joan Walter, Richard Petri, Lewis Hofmann, Candy Wilson, David Drake, Kathryn Calabria, John Biery, John S. Baxter, Rollin M. Gallagher, and Wayne B. Jonas17 March 2016 | The Journal of Alternative and Complementary Medicine, Vol. 22, No. 3 Volume 27Issue 5Oct 2015 InformationCopyright 2015, Mary Ann Liebert, Inc.To cite this article:Richard C. Niemtzow.North Atlantic Treaty Organization (NATO) Special Issue.Medical Acupuncture.Oct 2015.297-297.http://doi.org/10.1089/acu.2015.29006.rcnPublished in Volume: 27 Issue 5: October 22, 2015PDF download

Introducing the Nursing Editors History Project

Introducing the Nursing Editors History Project

AT1 receptor antagonism to reduce aortic expansion in Marfan syndrome: lost in translation or in need of different interpretation?

Marfan syndrome is an inherited autosomal dominant disorder of the connective tissue caused by mutations in the gene encoding fibrillin-1 ( FBN1 ).1,2 This disease has affected the ATVB community with the loss of 1 of our highly respected members, David Williams.3 The most devastating health issues of patients with Marfan syndrome are dissection and rupture of the proximal aorta. Aortic dimensions are routinely monitored in patients with Marfan syndrome, and surgical graft imposition is performed to sustain life. However, surgical intervention is a formidable process. To abrogate surgical repair, there is a desperate need for a medical approach for attenuating aortic expansion. Presently, patients with Marfan syndrome are routinely provided with β-adrenoceptor blockade. This standard of care is derived from the study of Shores et al.4 However, the benefit derived from administration of β-adrenoceptor blockade is far from established. Although FBN1 is a component of extracellular matrix, mutations in this protein do not directly promote the structural fragility that characterizes the specific aortic regions of patients with Marfan syndrome. Instead, a concept has developed that Fbn1 mutations lead to enhanced transforming growth factor β (TGF-β) activation that is the mechanistic basis of Marfan pathology. This concept originated from the demonstration that Fbn1 deficiency led to excessive activation of TGF-β signaling because of reduced binding, sequestration, and inactivation of TGF-β.5 Activation of TGF-β in Fbn1 -deficient mice was associated with a lung pathology similar to that observed in some patients with Marfan syndrome. This paradigm of FBN1 regulation of TGF-β activation was extended to aortic disease by generating heterozygous mice that express a C1039G mutation.6 These mice develop pronounced dilation of the ascending aorta associated with thickened media containing disrupted elastin fibers. In this model, the major proof of concept for the role of …

Book Review: ECC Essentials: Teaching the Expanded Core Curriculum to Students with Visual Impairments

ECC Essentials: Teaching the Expanded Core Curriculum to Students with Visual impairments, Carol B. Allman and Sandra Lewis, Editors, Susan J. Spungin, Consulting Editor. New York: AFB Press, 2014,638 pp. Paperback, $59.95; online, $36; e-book (ePUB or Kindle), $41.95; by online chapter, $10.95 each. It is a well-established belief that students with visual impairments (that is, those who are blind or have low vision) need specific instruction in a set of skills called the expanded core curriculum (ECC) (Hatlen, 1996) in addition to the core curriculum subjects needed by all students. These specialized skills are needed because of the effect of visual impairment on the ability of students with visual impairments to observe others and the world in general, the way many skills and concepts are learned incidentally by individuals with vision. ECC Essentials: Teaching the Expanded Core Curriculum to Students with Visual Impairments is the first comprehensive publication that specifically addresses all nine areas of the ECC: compensatory access, sensory efficiency, assistive technology, orientation and mobility (O&M), independent living, social interaction, recreation and leisure, career education, and self-determination. This book is targeted for vision professionals, specifically teachers of students with visual impairments and O&M specialists, whose primary roles are to evaluate, instruct, and support the ECC with their students who are blind or visually impaired. It contains a wealth of information that will also be of value to the families of these children, other educators and related service professionals working with these students, and administrators who may not understand the significance of the ECC for students with visual impairments. The key message reiterated multiple times throughout the book is that ECC skills are necessary to access the core curriculum while in school and to function as independently as possible at home, at school, in the community, and into adulthood. The other repeated concept in this book is how all nine areas of the ECC overlap with one another. In fact, the suggestion that educators need to consistently embed other ECC areas into instruction in each specific area is one of the most important concepts purported in this publication. Teachers of students with visual impairments often feel overwhelmed when trying to determine how to address all nine areas of the ECC with all of their students. The multiple examples and scenarios in which many ECC areas are infused into one lesson are extremely valuable aspects of the book. ECC Essentials is an ideal textbook for use in a methods or strategies course for preservice teachers who are just learning how to teach students with visual impairments. It is chock-full of teaching strategies with sound rationale of the importance of each ECC area and why each is needed by students who are visually impaired. The book is divided into three parts: Part I includes the importance of the ECC, unique needs of students with visual impairments, and assessment and instruction principles and strategies. Part II has a chapter on each of the nine ECC skill areas that describes each area and provides assessment and teaching strategies, addresses the role of the teacher of students with visual impairments, offers suggestions for working with parents, and includes sample learning activities that could be used as lesson plan models. Part III focuses on ways to support the ECC in general education settings, how to align the ECC with state standards, and how to infuse the ECC into home and community. SOMETHING FOR NEW AND SEASONED EDUCATORS Considering that the book is over 600 pages long, it is probably most useful to a seasoned teacher as a reference tool that one would use to look up specific information and to get ideas for instructional strategies or to find resources when teaching an area of the ECC. It is, however, a valuable overview and reminder of the many principles of good teaching, which may have been forgotten over the years. …

Introduction to “Being Railroaded: A Candidate’s Struggle to Stay on Track”

"Introduction to “Being Railroaded: A Candidate’s Struggle to Stay on Track”." Psychoanalytic Perspectives, 11(2), pp. 138–139 Additional informationNotes on contributorsKenneth A. FrankKenneth A. Frank, PhD, is Senior Consulting Editor of this journal and NIP’s Director of Training. He is former Clinical Professor in Psychiatry, Columbia College of Physicians and Surgeons. He is an advisor to IARPP and is on the faculties of the Mitchell Center for Relational Studies and the Center for Psychotherapy and Psychoanalysis of New Jersey. His publications have appeared in books and major psychoanalytic journals. He practices in Manhattan and Englewood, New Jersey.

PM Additive Manufacturing steals the MACH Show

Kenneth J A Brookes, Metal Powder Report Consulting Editor reports from MACH, the UK's machine tool exhibition.