This study aims to investigate the satisfaction of nursing students with online and constructivist-learning approach-based Obstetrics and Gynecology Nursing Course. This semi-experimental study included 101 nursing students. Data were collected between October 2020 and January 2021 using the course evaluation form, Satisfaction Scale for E-Courses and Scale on Assessing Constructivist Learning Environments. Kolmogorov Smirnov, Spearman’s correlation and Friedman tests were used in data analysis. The mean satisfaction scores of the students were 124.39±8.02, 120.01±19.42 and 118.15±21.10 in the 4th, 8th and 14th weeks (FX2= 4.617; p=0.099). The mean constructivist environment evaluation scores of them in the 4th, 8th and 14th weeks were 154.13±23.72, 150.63±28.83 and 146.10±29.09 (FX2=3.608; p= 0.165). A moderate and positive correlation was found between the students’ satisfaction levels with E-courses and their total scores regarding the constructivist learning environment (p