Introduction. The treatment of burst fractures at the thoracolumbar junction remains a contentious issue in vertebrology. Despite a broad array of surgical interventions available, many surgeons favor isolated posterior stabilization, which can be performed using either minimally invasive or open approaches. However, the biomechanical properties of these methods have not been thoroughly investigated. Objective: This study aims to evaluate the biomechanical stability of the thoracolumbar junction following transpedicular stabilization of a burst fracture at the Th12 vertebra, under different system configurations influenced by lateral flexion. Materials and Methods: A mathematical finite element model of the human thoracolumbar spine, featuring a burst fracture at the Th12 vertebra, was developed. The model included a transpedicular stabilization system with eight screws, simulating “long” stabilization. We examined four variants of transpedicular fixation using both mono- and bicortical screws, with and without the inclusion of two cross-links. Results: The study found that the load borne by the damaged Th12 vertebral body varied depending on the fixation system employed. Specifically, stress levels were 24.0 MPa, 27.3 MPa, 18.4 MPa, and 25.8 MPa for models with short screws without cross-links, long screws without cross-links, short screws with cross-links, and long screws with cross-links, respectively. At the screw entry points in the vertebral arch, the highest stress values were recorded at the L2 vertebra, showing 11.8 MPa, 14.0 MPa, 9.4 MPa, and 13.4 MPa for each respective model. Among the metal construct elements, the connecting rods consistently exhibited the highest stress, with values of 226.7 MPa, 313.4 MPa, 212.4 MPa, and 293.98 MPa, respectively. Conclusion: The results underscore that utilizing cross-links in the stabilization of burst fractures at the thoracolumbar junction, which is only feasible through an open installation, somewhat mitigates stress within the stabilized spinal segment. Meanwhile, the modeling of lateral flexion revealed only minimal differences in stress values between open and minimally invasive installations.