The strategy of scientific and technological development of the Russian Federation defines the priority areas that are believed to become a foundation for innovative development of the domestic market of products/services and will contribute to the transition to environmentally friendly and resource-saving energy, increase the efficiency of production and deep processing of hydrocarbons. In the context of global competition, emphasis is placed on the creation of institutional, financial and legislative mechanisms to ensure the harmonization of scientific, technological, innovation, industrial, economic and social policies. The need to promote technological resources of industrial manufacturing enterprises determined the relevance of research of the technological integration process, as these enterprises are the key to the economic growth of the country and are in a dire need of a technological breakthrough. The aim of the article is to study the problems of formation and development of technological integration of manufacturing enterprises in the Russian Federation in the context of priority scientific and technological development of the Russian economy. The article uses a wide range of general scientific methods: description, generalization and abstraction, construction of concepts, argumentation, and comparison. The main methodological approaches used in the article are: system and process approaches that find their refraction in the scientific and practical material of the general theory of systems, organization theory, as well as technical and technological approach. A fundamental change in the situation in the manufacturing industries entails the need to diversify the refining sector, which consists in upgrading the production capacity of high-quality semi-finished products for the petrochemical industry. World experience shows that the synergetic effect of the integration of oil refining and petrochemicals provides savings of up to hundreds of millions of dollars a year, and the main part of successful integration projects, located in the Persian Gulf countries, implements a strategy for the production of high-quality raw materials and petrochemical products. When solving the problems of transition to deep resource-saving technologies in the manufacturing industry, it becomes obvious that it is necessary to develop and implement special management technologies that will form the basis of the strategy of the technological revolution of the domestic industrial complex. According to the laws of technologization, this occurs within the framework of the formation of the sixth technological structure in the world economic system, characterized by the development of intelligent technologies such as smart plant, as well as the living design of business processes. In this regard, technological integration, as a direction of system technologization, should be a scientifically based concept, which includes a set of mechanisms, tools and methods for practical implementation in the industrial enterprises of the Russian economy.