The southeastern rock base sea area is the most abundant wind resource area, and it is also the mainstream construction site of offshore wind farms (OWFs) in China. The weathered residual soil is the main seabed component in the rock base area, which is the important bearing stratum of the offshore wind turbine foundation. Previous studies on the mechanical properties of seabed materials and bearing characteristics of the pile foundations in OWFs have mainly focused on the submarine soil-based seabed, resulting in a lack of direct reference for the construction of offshore wind power in the rocky seabed. Therefore, the mechanical properties of weathered residual soil and the bearing behaviors of monopile foundations are mainly investigated in this study. Firstly, dynamic triaxial tests are conducted on the weathered residual soil, and experiments analyze insight into the evolution law of the hysteresis curve, cumulative strain, and stiffness attenuation. Then, the horizontal loading behaviors of monopile foundations in residual soil are analyzed by numerical simulations; more critically, the service performances under wind and wave coupling loads are evaluated, which provide a direct theoretical basis for the construction and design of offshore wind turbine foundations in rock base seabeds.