Flexible photovoltaic (PV) support structure offers benefits such as low construction costs, large span length, high clearance, and high adaptability to complex terrains. However, due to the high flexibility and low damping of the cable system, wind load becomes the primary control factor for structural safety and the key consideration in the design. In this study, a 45 m span flexible PV support structure with 3 spans and 12 rows was designed. The wind loads on PV panels were obtained by wind tunnel tests on a rigid model and the wind-induced responses were investigated by wind tunnel tests on an aeroelastic model. The shielding effects and tilt angle of PV modules on the wind load and wind-induced vibration of the flexible PV support were studied. The experimental results show that in the rigid model wind tunnel test, the wind pressure on the surface of PV modules exhibits a gradient distribution along the direction of wind flow, with symmetric distribution along the mid span. With the increase in the tilt angle of the PV module, the shielding effect becomes significant and the most pronounced shielding effect on the mean wind pressure coefficient occurs in the second row of the windward zone. In aeroelastic model wind tunnel tests, the mean vertical displacement of the flexible PV support structure increases with the increase of wind speed and tilt angle of PV modules. Due to the wind-resistant anchor cables set in both the windward and leeward zones, the vibration amplitude near the edge rows is significantly smaller than that of the middle rows when the structure is subjected to wind suction. When the flexible PV support structure is subjected to wind pressure, the maximum mean vertical displacement occurs in the first rows at high wind speeds. The shielding effect has a noticeable impact on the wind-induced response of the leeward zone at α = 20° under wind pressure, resulting in the decrease of amplitude vibration by approximately 53 %. The wind vibration coefficients in different zones under the wind pressure or wind suction are mostly between 2.0 and 2.15. Compared with the experimental results, the current Chinese national standards are relatively conservative in the equivalent static wind loads of flexible PV support structure.