Flourishing, an ethical theory founded in Stoic philosophy, centers around emotional control and learning how to live well. It connects strongly with the modern construct of psychological well-being (PWB). PWB programs are increasingly included in workplaces and factors contributing to their success can include individual motivations, accountability and responsibility, organizational support systems and design, and an understanding of mental health conditions. Anxiety, the most commonly experienced mental health condition, is an emotional state that can directly affect PWB, yet it is often neglected in research, as is the concept of who is responsible for PWB. This paper outlines a study to test the hypotheses that: emotional states can affect PWB: emotion can be considered an ethical construct; improving PWB benefits both individuals and organizations and that shared responsibility can optimize organizational PWB program outcomes. Existing information was gathered from a systematic literature review and new information was gathered from a study conducted with the Australian Institute of Health and Safety (AIHS). Mixed method research incorporated quantitative and qualitative data collection, testing occupational health and safety (OHS) practitioners’ views on anxiety, and perceptions of factors affecting success or failure of PWB programs.Findings included strong indications that: anxiety can affect PWB and impact performance and productivity; shared responsibility between employees and organizations may improve the outcomes for PWB programs; information and education around self-care, and motivational principles connected to virtue ethics can all assist individuals and organizations to assume responsibility for their role with PWB initiatives.